MyoD1 promotes the transcription of BIK and plays an apoptosis-promoting role in the development of gastric cancer

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 Feb;4(3):209–249. PMID: 33538338. doi: 10.3322/caac.21660
   Google Scholar
• Chen W, Zheng R, Baade PD, et al. Cancer statistics in China. 2015. CA Cancer J Clin. 2016;66(2):115–132.
   PubMed Web of Science ®Google Scholar
• Zhao L, Liu Y, Tong D, et al. MeCP2 promotes gastric cancer progression through regulating FOXF1/Wnt5a/β-catenin and MYOD1/Caspase-3 signaling pathways. EBioMedicine. 2017;16:87–100. doi: 10.1016/j.ebiom.2017.01.021
   PubMed Web of Science ®Google Scholar
• Sun R, Liu Z, Tong D, et al. miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer. Cell Death Dis. 2017;8(3):e2714. doi: 10.1038/cddis.2017.134
   PubMedGoogle Scholar
• Patel TN, Roy S, Ravi R. Gastric cancer and related epigenetic alterations. Ecancermedicalscience. 2017;11:714. doi: 10.3332/ecancer.2017.714
   PubMed Web of Science ®Google Scholar
• Buckingham M, Rigby PWJ. Gene regulatory networks and transcriptional mechanisms that control myogenesis. Dev Cell. 2014;28(3):225–238. doi: 10.1016/j.devcel.2013.12.020
   PubMed Web of Science ®Google Scholar
• Blum R, Dynlacht BD. The role of MyoD1 and histone modifications in the activation of muscle enhancers. Epigenetics. 2013;8(8):778–784. doi: 10.4161/epi.25441
   PubMed Web of Science ®Google Scholar
• Sartorelli V, Juan AH. Sculpting chromatin beyond the double helix: epigenetic control of skeletal myogenesis. Curr Top Dev Biol. 2011;96:57–83.
   PubMed Web of Science ®Google Scholar
• Dey J, Dubuc AM, Pedro KD, et al. MyoD is a tumor suppressor gene in medulloblastoma. Canc Res. 2013;73(22):6828–6837.
   PubMed Web of Science ®Google Scholar
• Rajabi HN, Takahashi C, Ewen ME. Retinoblastoma protein and MyoD function together to effect the repression of fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis. Biol Chem. 2014;289(34):23417–23427. doi: 10.1074/jbc.M113.532572
   Web of Science ®Google Scholar
• Jiang H, Wang H, Wang S, et al. Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy. Mol Med Rep. 2015;11(5):3523–3532.
   PubMed Web of Science ®Google Scholar
• Peng G, Masood K, Gantz O, et al. Neuromuscular electrical stimulation improves radiation-induced fibrosis through tgf-Β1/MyoD homeostasis in head and neck cancer. J Surg Oncol. 2016;114(1):27–31. doi: 10.1002/jso.24265
   PubMed Web of Science ®Google Scholar
• Zhang Q, Liu XY, Li S, et al. Repression of ESR1 transcription by MYOD potentiates letrozole-resistance in ERα-positive breast cancer cells. Biochem Biophys Res Commun. 2017;492(3):425–433. doi: 10.1016/j.bbrc.2017.08.082
   PubMed Web of Science ®Google Scholar
• Doerflinger M, Glab JA, Puthalakath H. BH3-only proteins: a 20-year stock-take. FEBS J. 2015;282(6):1006–1016. doi: 10.1111/febs.13190
   PubMed Web of Science ®Google Scholar
• Germain M, Mathai JP, Shore GC. BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria. J Biol Chem. 2002;277(20):18053–18060. doi: 10.1074/jbc.M201235200
   PubMed Web of Science ®Google Scholar
• Gillissen B, Essmann F, Graupner V, et al. Induction of cell death by the BH3-only bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. Embo J. 2003;22(14):3580–3590.
   PubMed Web of Science ®Google Scholar
• Mathai JP, Germain M, Shore GC. BH3-only BIK regulates BAX, BAK-dependent release of Ca2+from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death. J Biol Chem. 2005;280(25):23829–23836. doi: 10.1074/jbc.M500800200
   PubMed Web of Science ®Google Scholar
• Sturm I, Stephan C, Gillissen B, et al. Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma. Cell Death Differ. 2006;13(4):619–627. doi: 10.1038/sj.cdd.4401782
   PubMed Web of Science ®Google Scholar
• Pandya V, Githaka JM, Patel N, et al. BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer. Cell Death Dis. 2020;11(6):448. doi: 10.1038/s41419-020-2654-2
   PubMed Web of Science ®Google Scholar
• Feng L, Jing L, Han J, et al. MicroRNA 486-3p directly targets BIK and regulates apoptosis and invasion in colorectal cancer cells. Onco Targets Ther. 2018;11:8791–8801. doi: 10.2147/OTT.S180354
   PubMed Web of Science ®Google Scholar
• Zhang L, Li X, Chao Y, et al. KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer. Cell Commun Signal. 2018;16(1):53. doi: 10.1186/s12964-018-0270-x
   PubMedGoogle Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 2001;25(4):402–408. doi: 10.1006/meth.2001.1262
   PubMed Web of Science ®Google Scholar
• Zhang L, Qu J, Qi Y, et al. EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation. Nat Commun. 2022 May 10;13(1):2543. doi: 10.1038/s41467-022-30105-0
   PubMed Web of Science ®Google Scholar
• Zhao X, Wei Y, Chu YY, et al. Phosphorylation and stabilization of PD-L1 by CK2 suppresses dendritic cell function. Cancer Res. 2022 Jun 6;82(11):2185–2195. doi: 10.1158/0008-5472.CAN-21-2300
   PubMed Web of Science ®Google Scholar
• Martin M. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J. 2011;17(1):10–13. doi: 10.14806/ej.17.1.200
   Google Scholar
• Patel RK, Jain M, Liu Z. NGS QC toolkit: a toolkit for quality control of next generation sequencing data. PLoS One. 2012;7(2):e30619. doi: 10.1371/journal.pone.0030619
   PubMed Web of Science ®Google Scholar
• Kim D, Pertea G, Trapnell C, et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Bio. 2013;14(4):36. doi: 10.1186/gb-2013-14-4-r36
   PubMed Web of Science ®Google Scholar
• Trapnell C, Williams BA, Pertea G. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nature Biotechnol. 2010;28(5):511–515. doi: 10.1038/nbt.1621
   PubMed Web of Science ®Google Scholar
• Conesa A, Götz S, M G-GJ, et al. Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics. 2005;21(18):3674–3676.
   PubMed Web of Science ®Google Scholar
• Kanehisa M, Goto S, Sato Y, et al. KEGG for integration and interpretation of large-scale molecular datasets. Nucl Acids Res. 2012;40(D1):109–114.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Franceschini A, Kuhn M, et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucl Acids Res. 2011;39(Database):561–568.
   PubMed Web of Science ®Google Scholar
• Fornes O, Castro-Mondragon JA, Khan A, et al. JASPAR 2020: update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2020;48(D1):D87–D92.
   PubMed Web of Science ®Google Scholar
• Chittenden T, Flemington C, Houghton AB, et al. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. Embo J. 1995;14(22):5589–5596. doi: 10.1002/j.1460-2075.1995.tb00246.x
   PubMed Web of Science ®Google Scholar
• Pandya V, Glubrecht D, vos L, et al. The pro-apoptotic paradox: the BH3-only protein bcl-2 interacting killer (bik) is prognostic for unfavorable outcomes in breast cancer. Oncotarget. 2016;7(22):33272–33285. doi: 10.18632/oncotarget.8924
   PubMedGoogle Scholar
• Lu Y, Lemon W, Liu PY, et al. A gene expression signature predicts survival of patients with stage I non-small cell lung cancer. PLoS Med. 2006;3(12):e467. doi: 10.1371/journal.pmed.0030467
   PubMed Web of Science ®Google Scholar
• Kutuk O, Aytan N, Karakas B, et al. Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells. PLoS One. 2017;12(8):e0182809. doi: 10.1371/journal.pone.0182809
   PubMed Web of Science ®Google Scholar
• Happo L, Phipson B, Smyth GK, et al. Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs. Cell Death Dis. 2012;3(5):e306. doi: 10.1038/cddis.2012.42
   PubMedGoogle Scholar
• Li C, Li R, Grandis JR, et al. Bortezomib induces apoptosis via bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells. Mol Cancer Ther. 2008;7(6):1647–1655. doi: 10.1158/1535-7163.MCT-07-2444
   PubMed Web of Science ®Google Scholar
• Jiang K, Zhang C, Yu B, et al. Autophagic degradation of FOXO3a represses the expression of PUMA to block cell apoptosis in cisplatin-resistant osteosarcoma cells. Am J Cancer Res. 2017;7(7):1407–1422.
   PubMed Web of Science ®Google Scholar