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Research Article

Driving performance of long-term users of sedating antidepressants and benzodiazepines

F. Westerhuisa Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3051-2675View further author information
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J. H. Van Dijkena Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-5368-9353View further author information
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J. L. Veldstraa Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-1604-5321View further author information
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K. A. Brookhuisa Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-5124-437XView further author information
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J. C. Versterb Division of Pharmacology, Utrecht University, Utrecht, The Netherlands;c Centre for Human Psychopharmacology, Swinburne University, Melbourne, AustraliaORCID Iconhttps://orcid.org/0000-0002-6455-2096View further author information
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A. J. A. E. Van de Loob Division of Pharmacology, Utrecht University, Utrecht, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-0016-9151View further author information
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F. R. J. Vinckenboschd Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-1767-7742View further author information
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A. Vermeerend Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-9504-1184View further author information
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N. N. J. J. M. Van der Sluiszend Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-4523-4519View further author information
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J. G. Ramaekersd Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The NetherlandsORCID Iconhttps://orcid.org/0000-0003-4553-376XView further author information
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D. De Waarda Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0003-0262-4573View further author information
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Received 28 Feb 2024, Accepted 17 May 2024, Published online: 12 Jul 2024

References

  • Ahn S, Park S, Lee K. 2013. How to demonstrate similarity by using noninferiority and equivalence testing in radiology research. Radiology. 267(2):328–338. doi:10.1148/radiol.12120725.
  • Althunian TA, de Boer A, Groenwold RH, Klungel OH. 2017. Defining the noninferiority margin and analysing noninferiority: an overview. Br J Clin Pharmacol. 83(8):1636–1642. doi:10.1111/bcp.13280.
  • Ashton H. 1994. Guidelines for the rational use of benzodiazepines. Drugs. 48(1):25–40. doi:10.2165/00003495-199448010-00004.
  • Brody D, Gu Q. 2020. Antidepressant use among adults: United States, 2015–2018. Hyattsville (MD): National Center for Health Statistics. NCHS Data Brief, no 377. https://www.cdc.gov/nchs/products/databriefs/db377.htm.
  • Brookhuis K. 1998. How to measure driving ability under the influence of alcohol and drugs, and why. Hum Psychopharmacol Clin Exp. 13(S2):S64–S69. doi:10.1002/(SICI)1099-1077(1998110)13:2+<S64::AID-HUP51>3.0.CO;2-N.
  • Brunnauer A, Herpich F, Zwanzger P, Laux G. 2021. Driving performance under treatment of most frequently prescribed drugs for mental disorders: a systematic review of patient studies. Int J Neuropsychopharmacol. 24(9):679–693. doi:10.1093/ijnp/pyab031.
  • Bushnell G, Stürmer T, Gaynes B, Pate V, Miller M. 2017. Simultaneous antidepressant and benzodiazepine new use and subsequent long-term benzodiazepine use in adults with depression, United States. JAMA Psychiatry. 74(7):747–755. doi:10.1001/jamapsychiatry.2017.1273.
  • Dassanayake T, Michie P, Carter G, Jones A. 2011. Effects of benzodiazepines, antidepressants and opiods on driving: a systematic review and meta-analysis of epidemiological and experimental evidence. Drug Saf. 34(2):125–156.
  • Dubois S, Bédard M, Weaver B. 2008. The impact of benzodiazepines on safe driving. Traffic Inj Prev. 9(5):404–413. doi:10.1080/15389580802161943.
  • Gerlach L, Maust D, Leong S, Mavandadi S, Oslin D. 2018. Factors associated with long-term benzodiazepine use among older adults. JAMA Internal Med. 178(11):1560–1562.
  • GIP/Zorginstituut Nederland. 2022. Het aantal gebruikers van antidepressiva, 2003 - 2021. https://www.gipdatabank.nl/databank?infotype=g&label=00-totaal&tabel=85_dep&geg=gebr&item=bijlage
  • Gjerde H, Strand M, Morland J. 2015. Driving under the influence of non-alcohol drugs - an update part I: epidemiological studies. Forensic Sci. Rev. 27(2):90–113.
  • Hahn S. 2012. Understanding noninferiority trials. Korean J Pediatr. 55(11):403–407. doi:10.3345/kjp.2012.55.11.403.
  • Herrera-Gómez F, García-Mingo M, Álvarez F. 2020. Benzodiazepines in the oral fluid of Spanish drivers. Subst Abuse Treat Prev Policy. 15(1):1–8. doi:10.1186/s13011-020-00260-y.
  • Hetland A, Carr DB. 2014. Medications and impaired driving. Ann Pharmacother. 48(4):494–506. doi:10.1177/1060028014520882.
  • Hill L, Lauzon V, Winbrock E, Li G, Chihuri S, Lee K. 2017. Depression, antidepressants and driving safety. Inj Epidemiol. 4(1):1–10. doi:10.1186/s40621-017-0107-x.
  • Høye A, Hesjevoll I. 2023. Alcohol and driving - how bad is the combination? Traffic Inj Prev. 24(5):373–378. doi:10.1080/15389588.2023.2204984.
  • Leufkens T, Ramaekers J, De Weerd A, Riedel W, Vermeeren A. 2014. On-the-road driving performance and driving-related skills in older untreated insomnia patients and chronic users of hypnotics. Psychopharmacology (Berl). 231(14):2851–2865. doi:10.1007/s00213-014-3455-z.
  • Leung SY. 2011. Benzodiazepines, opioids and driving: an overview of the experimental research. Drug Alcohol Rev. 30(3):281–286. doi:10.1111/j.1465-3362.2011.00311.x.
  • Ministry of Infrastructure and Water Management. 2000. Regeling eisen geschiktheid (REG 2000). http://wetten.overheid.nl/BWBR0011362/.
  • Monshouwer K, Tuithof M, van Dorsselaer S. 2018. Factsheet riskant alcoholgebruik in Nederland [Factsheet risky alcohol use in the Netherlands]. Utrecht: trimbos-Instituut [Netherlands Institute of Mental Health and Addiction]. [accessed 2023, Feb 23]. https://www.trimbos.nl/wp-content/uploads/sites/31/2021/09/af1599-factsheet-riskant-alcoholgebruik-in-nederland.pdf
  • O’Hanlon J, Haak T, Blaauw G, Riemersma J. 1982. Diazepam impairs lateral position control in highway driving. Science. 217(4554):79–81. doi:10.1126/science.7089544.
  • Orriols L, Philip P, Moore N, Castot A, Gadegbeku B, Delorme B, Mallaret M, Lagarde E, CESIR Research Group. 2011. Benzodiazepine-like hypnotics and the associated risk of road traffic accidents. Clin Pharmacol Ther. 89(4):595–601. doi:10.1038/clpt.2011.3.
  • Piaggio G, Elbourne DR, Pocock SJ, Evans SJW, Altman DG, CONSORT Group FT. 2012. Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement. JAMA. 308(24):2594–2604. doi:10.1001/jama.2012.87802.
  • Piersma D, Fuermaier ABM, de Waard D, Davidse RJ, de Groot J, Doumen MJA, Bredewoud RA, Claesen R, Lemstra AW, Vermeeren A, et al. 2016. Prediction of fitness to drive in patients with Alzheimer’s dementia. PLoS One. 11(2):e0149566. doi:10.1371/journal.pone.0149566.
  • Ravera S, van Rein N, de Gier JJ, de Jong-van den Berg LT. 2011. Road traffic accidents and psychotropic medication use in the Netherlands: a case-control study. Br J Clin Pharmacol. 72(3):505–513. doi:10.1111/j.1365-2125.2011.03994.x.
  • Roth T, Eklov S, Drake C, Verster J. 2014. Meta-analysis of on-the-road experimental studies of hypnotics: effects of time after intake, dose, and half-life. Traffic Inj Prev. 15(5):439–445. doi:10.1080/15389588.2013.830211.
  • Sackett DL. 2004. Superiority trials, noninferiority trials, and prisoners of the 2-sided null hypothesis. ACP J. Club. 140(2):A11.
  • SAMHSA. 2017. Results from the 2016 National Survey on Drug Use and Health: Detailed Tables. Rockville (MD): Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. [accessed 2023 Aug 3]. https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2016/NSDUH-DetTabs-2016.pdf
  • SAMHSA. 2022. Results from the 2020 National Survey on Drug Use and Health: Detailed Tables. Rockville (MD): Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. [accessed 2023 Aug 3]. https://www.samhsa.gov/data/sites/default/files/reports/rpt35323/NSDUHDetailedTabs2020v25/NSDUHDetailedTabs2020v25/NSDUHDetailedTabs2020.pdf
  • Taylor B, Irving HM, Kanteres F, Room R, Borges G, Cherpitel C, Greenfield T, Rehm J. 2010. The more you drink, the harder you fall: a systematic review and meta-analysis of how acute alcohol consumption and injury or collision risk increase together. Drug Alcohol Depend. 110(1–2):108–116. doi:10.1016/j.drugalcdep.2010.02.011.
  • Van der Sluiszen N, Urbanus B, Lammers GJ, Overeem S, Ramaekers JG, Vermeeren A. 2021. On-the-road driving performance of patients with central disorders of hypersomnolence. Traffic Inj Prev. 22(2):120–126. doi:10.1080/15389588.2020.1862804.
  • Van der Sluiszen N, Vermeeren A, Jongen S, Vinckenbosch F, Ramaekers JG. 2017. Influence of long-term benzodiazepine use on neurocognitive skills related to driving performance in patient populations: a review. Pharmacopsychiatry. 50(5):189–196. doi:10.1055/s-0043-112755.
  • van der Sluiszen NN, Vermeeren A, van Dijken JH, J.a.e. van de Loo A, Veldstra JL, de Waard D, C. Verster J, A. Brookhuis K, Ramaekers JG. 2021. Driving performance and neurocognitive skills of long-term users of sedating antidepressants. Human Psychopharmacol. 36(1):e2762–12. doi:10.1002/hup.2762.
  • van der Sluiszen NN, Vermeeren A, Verster JC, van de Loo AJ, van Dijken JH, Veldstra JL, Brookhuis KA, de Waard D, Ramaekers JG. 2019. Driving performance and neurocognitive skills of long-term users of benzodiazepine anxiolytics and hypnotics. Human Psychopharmacol. 34(6):e2715. doi:10.1002/hup.2715.
  • van Dijken JH, Veldstra JL, van de Loo AJAE, Verster JC, van der Sluiszen N, Vermeeren A, Ramaekers JG, Brookhuis KA, de Waard D. 2020. The influence of alcohol (0.5‰) on the control and manoeuvring level of driving behaviour, finding measures to assess driving impairment: A simulator study. Transp Res Part F Traffic Psychol Behav. 73:119–127. doi:10.1016/j.trf.2020.06.017.
  • Van Winsum W, Van Wolffelaar P. 1993. GIDS small world simulation. In: Michon J, editor. Generic intelligent driver support. London: Taylor & Francis. p. 175–191.
  • Walker E, Nowacki A. 2010. Understanding equivalence and noninferiority testing. J Gen Intern Med. 26(2):192–196. doi:10.1007/s11606-010-1513-8.
  • Wingen M, Ramaekers JG, Schmitt JA. 2006. Driving impairment in depressed patients receiving long-term antidepressant treatment. Psychopharmacology (Berl). 188(1):84–91. doi:10.1007/s00213-006-0471-7.

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