Thermosensitive injectable hydrogels from poly(N-isopropylacrylamide)–dextran aqueous solutions: Thermogelation and drug release properties

References

• Ruel-Gariepy, E., and Leroux, J.C. (2004) In situ-forming hydrogels – review of temperature-sensitive systems. European Journal of Pharmaceutics and Biopharmaceutics, 58:409–426.
   PubMed Web of Science ®Google Scholar
• Van Tomme, S.R., Storm, G., and Hennink, W.E. (2008) In situ gelling hydrogels for pharmaceutical and biomedical applications. The International Journal of Pharmaceutics, 355:1–18.
   PubMed Web of Science ®Google Scholar
• Li, Z., and Guan, J. (2011) Thermosensitive hydrogels for drug delivery. Expert Opinion on Drug Delivery, 8:991–1007.
   PubMed Web of Science ®Google Scholar
• Huynh, C.T., Nguyen, M.K., and Lee, D.S. (2011) Injectable block copolymer hydrogels: achievements and future challenges for biomedical applications. Macromolecules, 44:6629–6636.
   Web of Science ®Google Scholar
• Overstreet, D.J., Dutta, D., Stabenfeldt, S.E., and Vernon, B.L. (2012) Injectable hydrogels. The Journal of Polymer Science Part B: Polymer Physics, 50:881–903.
   Web of Science ®Google Scholar
• Ko, D.Y., Shinde, U.P., Yeon, B., and Jeong, B. (2013) Recent progress of in situ formed gels for biomedical applications. Progress in Polymer Science, 38:672–701.
   Web of Science ®Google Scholar
• Yang, J.A., Yeom, J., Hwang, B.W., Hoffman, A.S., and Hahn, S.K. (2014) In situ-forming injectable hydrogels for regenerative medicine. Progress in Polymer Science, 39:1973–1986.
   Web of Science ®Google Scholar
• Toh, W.S., and Loh, X.J. (2014) Advances in hydrogel delivery systems for tissue regeneration. Materials Science and Engineering C, 45:690–697.
   PubMed Web of Science ®Google Scholar
• Singh, N.K., and Lee, D.S. (2014) In situ gelling pH- and temperature-sensitive biodegradable block copolymer hydrogels for drug delivery. The Journal of Controlled Release, 193:214–227.
   PubMed Web of Science ®Google Scholar
• Song, F., Li, X., Wang, Q., Liao, L., and Zhang, C. (2015) Nanocomposite hydrogels and their applications in drug delivery and tissue engineering. Journal of Biomedical Nanotechnology, 11:40–52.
   PubMed Web of Science ®Google Scholar
• Jeong, B., Kim, S.W., and Bae, Y.H. (2002) Thermosensitive sol-gel reversible hydrogels. Advanced Drug Delivery Reviews, 54:37–51.
   PubMed Web of Science ®Google Scholar
• de las Heras Alarcon, C., Pennadam, S., and Alexander, C. (2005) Stimuli responsive polymers for biomedical applications. Chemical Society Reviews, 34:276–285.
   PubMed Web of Science ®Google Scholar
• Schmaljohann, D. Thermo- and pH-responsive polymers in drug delivery. (2006) Advanced Drug Delivery Reviews, 58:1655–1670.
   Google Scholar
• Liu, R., Fraylich, M., and Saunders, B.R. (2009) Thermoresponsive copolymers: from fundamental studies to applications. Colloid and Polymer Science, 287:627–643.
   Web of Science ®Google Scholar
• Zhang, W., Cui, T., Liu, L., Wu, Q., Sun, L., Li, L., Wang, N., and Gong, C. (2015) Improving anti-tumor activity of curcumin by polymeric micelles in thermosensitive hydrogel system in colorectal peritoneal carcinomatosis model. Journal of Biomedical Nanotechnology, 11:1173–1182.
   PubMed Web of Science ®Google Scholar
• Sim, H.J., Thambi, T., and Lee, D.S. (2015) Heparin-based temperature-sensitive injectable hydrogels for protein delivery. Journal of Materials Chemistry B, 3:8892–8901.
   PubMed Web of Science ®Google Scholar
• Schild, H.G. (1992) Poly(N-isopropylacrylamide): experiment, theory and application. Progress in Polymer Science, 17:163–249.
   Web of Science ®Google Scholar
• Lutz, J.F., Akdemir, O., and Hoth, A. (2006) Point by point comparison of two thermosensitive polymers exhibiting similar LCST: Is the age of poly(NIPAM) over? Journal of the American Chemical Society, 128:13046–13047.
   PubMed Web of Science ®Google Scholar
• Han, C.K., and Bae, Y.H. (1998) Inverse thermally-reversible gelation of aqueous N-isopropylacrylamide copolymer solutions. Polymer, 39:2809–2814.
   Web of Science ®Google Scholar
• Motokawa, R., Morishita, K., Koizumi, S., Nakahira, T., and Annaka, M. (2005) Thermosensitive diblock copolymer of poly(N-isopropylacrylamide) and poly(ethylene glycol) in water: polymer preparation and solution behavior. Macromolecules, 38:5748–5760.
   Web of Science ®Google Scholar
• Teodorescu, M., Negru, I., Stanescu, P.O., Draghici, C., Lungu, A., and Sarbu, A. (2010) Thermogelation properties of poly(N-isopropylacrylamide)-block-poly(ethylene glycol)-block-poly(N-isopropylacrylamide) triblock copolymer aqueous solutions. Reactive and Functional Polymers, 70:790–797.
   Web of Science ®Google Scholar
• Negru, I., Teodorescu, M., Stanescu, P.O., Draghici, C., Lungu, A., and Sarbu, A. (2013) Poly(N-isopropylacrylamide-co-N-t-butylacrylamide)-block-poly(ethylene glycol)-block-poly((N-isopropylacrylamide-co-N-t-butylacrylamide) triblock copolymers: synthesis and thermogelation properties of aqueous solutions. Colloid and Polymer Science, 291:2523–2532.
   Web of Science ®Google Scholar
• Negru, I., Teodorescu, M., Stanescu, P.O., Draghici, C., Lungu, A., and Sarbu, A. (2013) Thermogelation properties of ABA triblock copolymers of poly(ethylene glycol) (B) and copolyacrylates of oligo(ethylene glycol)s (A) in aqueous solution. Soft Materials, 11:149–156.
   Web of Science ®Google Scholar
• Ekenseair, A.K., Boere, K.W.M., Tzouanas, S.N., Vo, T.N., Kasper, F.K., and Mikos, A.K. (2012) Synthesis and characterization of thermally and chemically gelling injectable hydrogels for tissue engineering. Biomacromolecules, 13:1908–1915.
   PubMed Web of Science ®Google Scholar
• Na, K., Park, J.H., Kim, S.W., Sun, B.K., Woo, D.G., Chung, H.M., and Park, K.H. (2006) Delivery of dexamethasone, ascorbate, and growth factor (TGF b-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes. Biomaterials, 27:5951–5957.
   PubMed Web of Science ®Google Scholar
• Virtanen, J., and Tenhu, H. (2000) Thermal properties of poly(N-isopropylacrylamide)-g-poly(ethylene oxide) in aqueous solutions: influence of the number and distribution of the grafts. Macromolecules, 33:5970–5975.
   Web of Science ®Google Scholar
• Overstreet, D.J., McLemore, R.Y., Doan, B.D., Farag, A., and Vernon, B.L. (2013) Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery. Soft Materials, 11:294–304.
   Web of Science ®Google Scholar
• Teodorescu, M., Andrei, M., Turturica, G., Stanescu, P.O., Zaharia, A., and Sarbu, A. (2015) Novel thermoreversible injectable hydrogel formulations based on sodium alginate and poly(isopropylacrylamide). International Journal of Polymeric Materials and Polymeric Biomaterials, 64:763–771.
   Web of Science ®Google Scholar
• Zhang, X.Z., Wu, D.Q., Sun, G.M., and Chu, C.C. (2003) Novel biodegradable and thermosensitive Dex-AI/PNIPAAm hydrogel. Macromolecular Bioscience, 3:87–91.
   Web of Science ®Google Scholar
• Dong, J., Chen, L., Ding, Y., and Han, W. (2005) Swelling and mechanical properties of a temperature-sensitive dextran hydrogel and its bioseparation applications. Macromolecular Chemistry and Physics, 206:1973–1980.
   Web of Science ®Google Scholar
• Metters, A.T., and Lin, C.C. (2007) Biodegradable hydrogels: tailoring properties and function through chemistry and structure, In Biomaterials, Wong, J.Y., Bronzino, J.D. eds., CRC Press, Taylor and Francis Group, Boca Raton, FL, U.S.A., pp. 5-1–5-44.
   Google Scholar
• Almeida, J.F., Ferreira, P., Alves, P., Lopes, A., and Gil, M.H. (2013) Synthesis of a dextran based thermo-sensitive drug delivery system by gamma irradiation. International Journal of Biological Macromolecules, 61:150–155.
   PubMed Web of Science ®Google Scholar
• Prabaharan, M., and Mano, J.F. (2006) Stimuli-responsive hydrogels based on polysaccharides incorporated polymers as novel biomaterials. Macromolecular Bioscience, 6:991–1008.
   PubMed Web of Science ®Google Scholar
• Kumashiro, Y., Lee, W.K., Ooya, T., and Yui, N. (2002) Enzymatic degradation of semi-IPN hydrogels based on N-isopropylacrylamide and dextran at a specific temperature range. Macromolecular Rapid Communications, 23:407–410.
   Web of Science ®Google Scholar
• Kumashiro, Y., Ooya, T., and Yui, N. (2004) Dextran hydrogels containing poly(N-isopropylacrylamide) as grafts and cross-linkers exhibiting enzymatic regulation in a specific temperature range. Macromolecular Rapid Communications, 25:867–872.
   Web of Science ®Google Scholar
• Huang, X., and Brazel, C.S. (2001) On the importance and mechanisms of burst release in matrix-controlled drug delivery systems. The Journal of Controlled Release, 73:121–136.
   PubMed Web of Science ®Google Scholar
• Lencina, M.M.S., Iatridi, Z., Villar, M.A., and Tsitsilianis, C. (2014) Thermoresponsive hydrogels from alginate-based graft copolymers. European Polymer Journal, 61:33–44.
   Web of Science ®Google Scholar
• Lin, H.H., and Cheng, Y.L. (2001) In-situ thermoreversible gelation of block and star copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) of varying architectures. Macromolecules, 34:3710–3715.
   Web of Science ®Google Scholar
• Ho, E., Lowman, A., and Marcolongo, M. (2006) Synthesis and characterization of an injectable hydrogel with tunable mechanical properties for soft tissue repair. Biomacromolecules, 7:3223–3228.
   PubMed Web of Science ®Google Scholar
• Jeong, B., Wang, L.Q., and Gutowska, A. (2001) Biodegradable thermoreversible gelling PLGA-g-PEG copolymers. Chemical Communications, 1516–1517.
   Web of Science ®Google Scholar
• Patel, T., Ghosh, G., Yusa, S., and Bahadur, P. (2011) Solution behavior of poly(N-isopropylacrylamide) in water: effect of additives. Journal of Dispersion Science And Technology, 32:1111–1118.
   Web of Science ®Google Scholar
• Cursaru, B., Teodorescu, M., Boscornea, C., Stanescu, P.O., and Stoleriu, S. (2013) Drug absorption and release properties of crosslinked hydrogels based on diepoxy-terminated poly(ethylene glycol)s and aliphatic polyamines: a study on the effect of the gel molecular structure. Materials Science and Engineering C, 33:1307–1314.
   PubMed Web of Science ®Google Scholar