Chronic Effort Dyspnea Explained by Lung Function Tests and by HRCT and CRX Radiographic Patterns in COPD: A Post-Hoc Analysis in 51 Patients

REFERENCES

• Camiciottoli G, Bartolucci M, Maluccio N M, Moroni C, Mascalchi M, Giuntini C, Pistolesi M. Spirometrically-gated high-resolution CT findings in COPD: lung attenuation vs. lung function and dyspnea severity. Chest 2006; 129: 558–564
   PubMed Web of Science ®Google Scholar
• American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis 1991; 144: 1202–1208
   PubMed Web of Science ®Google Scholar
• Siafakas N M, Vermeire P, Pride N B, Paoletti P, Gibson J, Howard P, Yernault J C, Decramer M, Higenbottam T, Postma D S, Rees J on behalf of the European Respiratory Society Task Force. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). Eur Respir J 1995; 8: 1398–1420
   PubMed Web of Science ®Google Scholar
• Fletcher C M, Elmes P C, Fairbairn A S, Wood C H. The significance of respiratory symptoms and diagnosis of chronic bronchitis in a working population. Br Med J 1959; 5147: 257–266
   Google Scholar
• American Thoracic Society. Single breath carbon monoxide diffusing capacity (transfer factor): recommendations for a standard technique. Am J Respir Crit Care Med 1995; 152: 2185–2198
   PubMed Web of Science ®Google Scholar
• Milne E NC, Pistolesi M. Reading the Chest Radiograph. A Physiologic Approach. Mosby, St Louis 1993; 267–310
   Google Scholar
• Kalender W A, Rienmüller R, Seissler W, Behr J, Welke M, Fichte H. Measurement of pulmonary parenchymal attenuation: use of spirometric gating with quantitative CT. Radiology 1990; 175: 265–268
   PubMed Web of Science ®Google Scholar
• Kalender W A, Fichte H, Bautz W, Skalej M. Semiautomatic evaluation procedures for quantitative CT of the lung. J Comput Assist Tomogr 1991; 15: 248–255
   PubMed Web of Science ®Google Scholar
• Mahler D A, Weinberg D H, Wells C K, Feinstein A R. The measurement of dyspnea: contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 1984; 85: 751–758
   PubMed Web of Science ®Google Scholar
• Eltayara L, Becklacke M R, Volta C A, Milic-Emili J. Relationship between chronic dyspnea and expiratory flow limitation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996; 154: 1726–1734
   PubMed Web of Science ®Google Scholar
• Hajiro T, Nishimura K, Tsukino M, Ikeda A, Koyama H, Izumi T. Analysis of clinical methods used to evaluate dyspnea in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 158: 1185–1189
   PubMed Web of Science ®Google Scholar
• Bestall J C, Paul E A, Garrod R, Garnham R, Jones P W, Wedzicha J A. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax 1999; 54: 581–586
   PubMed Web of Science ®Google Scholar
• Sakai F, Gamsu G, Im J G, Ray C S. Pulmonary function abnormalities in patients with CT- determined emphysema. J Comput Assist Tomogr 1987; 11: 963–968
   PubMed Web of Science ®Google Scholar
• Gould G A, MacNee W, McLean A, Warren P M, Redpath A, Best J JK, Lamb D, Flenley D C. CT measurements of lung density in life can quantitate distal airspace enlargement – an essential defining feature of human emphysema. Am Rev Respir Dis 1988; 137: 380–392
   PubMed Web of Science ®Google Scholar
• Sanders C, Nath P H, Bailey W C. Detection of emphysema with computed tomography: correlation with pulmonary function tests and chest radiography. Invest Radiol 1988; 23: 262–266
   PubMed Web of Science ®Google Scholar
• Morrison N J, Abboud R T, Ramadan F, Miller R R, Gibson N N, Evans K G, Nelems B, Müller N L. Comparison of single breath carbon monoxide diffusing capacity and pressure volume curves in detecting emphysema. Am Rev Respir Dis 1989; 139: 1179–1187
   PubMed Web of Science ®Google Scholar
• Kinsella M, Müller N L, Abboud R T, Morrison N J, DyBuncio A. Quantitation of emphysema by computed tomography using a “density mask” program and correlation with pulmonary function tests. Chest 1990; 97: 315–321
   PubMed Web of Science ®Google Scholar
• Knudson R J, Standen J R, Kaltenborn W T, Knudson D E, Rehm K, Habib M P, Newell J D. Expiratory computed tomography for assessment of suspected pulmonary emphysema. Chest 1991; 99: 1357–1366
   PubMed Web of Science ®Google Scholar
• Klein J S, Gamsu G, Webb W R, Golden J A, Müller N L. High-resolution C T diagnosis of emphysema in symptomatic patients with normal chest radiographs and isolated low diffusing capacity. Radiology 1992; 182: 817–821
   PubMed Web of Science ®Google Scholar
• Miniati M, Filippi E, Falaschi F, Carrozzi L, Milne E NC, Sostman H D, Pistolesi M. Radiologic evaluation of emphysema in patients with chronic obstructive pulmonary disease: chest radiography versus high resolution computed tomography. Am J Respir Crit Care Med 1995; 151: 1359–1367
   PubMed Web of Science ®Google Scholar
• Gevenois P A, De Vuyst P, de Maertelaer V, Zanen J, Jacobovitz D, Cosio M G, Yernault J C. Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med 1996; 154: 187–192
   PubMed Web of Science ®Google Scholar
• Gelb A F, Hogg J C, Müller N L, Schein M J, Kuei J, Tashkin D P, Epstein J D, Kollin J, Green R H, Zamel N, Elliot W M, Hadjiaghai L. Contribution of emphysema and small airways in COPD. Chest 1996; 109: 353–359
   PubMed Web of Science ®Google Scholar
• Mishima M, Hirai T, Itoh H, Nakano Y, Sakai H, Muro S, Nishimura K, Oku Y, Chin K, Ohi M, Nakamura T, Bates J HT, Alencar A M, Suki B. Complexity of terminal airspace geometry assessed by lung computed tomography in normal subjects and patients with chronic obstructive pulmonary disease. Proc Natl Acad Sci U SA 1999; 96: 8829–8834
   PubMed Web of Science ®Google Scholar
• Baldi S, Miniati M, Bellina C R, Battolla L, Catapano G, Begliomini E, Giustini D, Giuntini C. Relationship between extent of pulmonary emphysema by high-resolution computed tomography and lung elastic recoil in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164: 585–589
   PubMed Web of Science ®Google Scholar
• Gevenois P A, De Vuyst P, Sy M, Scillia P, Chaminade L, de Maertelaer V, Zanen J, Yernault J C. Pulmonary emphysema: quantitative CT during expiration. Radiology 1996; 199: 825–829
   PubMed Web of Science ®Google Scholar
• Hosmer D W, Lemeshow S. Applied Logistic Regression. John Wiley & Sons, New York 1989; 83
   Google Scholar
• Heath D, Smith P. Pulmonary vascular disease. Med Clin North Am 1977; 61: 1279–1307
   PubMed Web of Science ®Google Scholar
• Barst R J, McGoon M, Torbicki A, Sitbon O, Krowka M J, Olschewski H, Gaine S. Diagnosis and differential assessment of pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43: 40S–47S
   PubMed Web of Science ®Google Scholar
• Rubin L J, Badesch D B, Barst R J, Galiè N, Black C M, Keogh A, Pulido T, Frost A, Roux S, Leconte I, Landzberg M, Simonneau G, for the Bosentan Randomized Trial of Endothelin Antagonist Therapy Study Group. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002; 346: 896–903
   PubMed Web of Science ®Google Scholar
• Hoeper M M, Oudiz R J, Peacock A, Tapson V F, Haworth S G, Frost A E, Torbicki A. End points and clinical trial designs in pulmonary arterial hypertension. Clinical and regulatory perspectives. J Am Coll Cardiol 2004; 43: 48S–55S
   PubMed Web of Science ®Google Scholar
• Speizer F, Comstock G. Recommended respiratory disease questionnaires for use with adults and children in epidemiological research, In: Ferris B G, ed. Epidemiology standardization project. Am Rev Respir Dis 1978; 118: 7–53
   PubMedGoogle Scholar
• Enright P L, Sherrill D L. Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med 1998; 158: 1384–1387
   PubMed Web of Science ®Google Scholar