1,678
Views
34
CrossRef citations to date
0
Altmetric
Original Research

MMP-8, MMP-9 and Neutrophil Elastase in Peripheral Blood and Exhaled Breath Condensate in COPD

, , &
Pages 238-244 | Received 29 Jul 2016, Accepted 11 Oct 2016, Published online: 23 Nov 2016

References

  • Vestbo J. COPD: definition and phenotypes. Clin Chest Med 2014; 35(1):1–6.
  • Noujeim C, Bou-Khalil P. COPD updates: what's new in pathophysiology and management? Expert Rev Respir Med 2013; 7(4):429–437.
  • Malerba M, Montuschi P. Non-invasive biomarkers of lung inflammation in smoking subjects. Curr Med Chem 2012; 19(2):187–196.
  • Sng JHJ, Thomas PS. COPD: immunopathogenesis and immunological markers. Adv Res 2014; 3(2):221–235.
  • Lowrey GE, Henderson N, Blakey JD, Corne JM, Johnson SR. MMP-9 protein level does not reflect overall MMP activity in the airways of patients with COPD. Respir Med 2008; 102(6):845–851.
  • Segura-Valdez L, Pardo A, Gaxiola M, Uhal BD, Becerril C, Selman M. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. CHEST J 2000; 117(3):684–694.
  • Betsuyaku T, Nishimura M, Takeyabu K, Tanino M, Venge P, Xu S, et al. Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Am J Respir Crit Care Med 1999; 159(6):1985–1991.
  • Finlay GA, Russell KJ, McMahon KJ, D'arcy EM, Masterson JB, FitzGerald MX, et al. Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients. Thorax 1997; 52(6):502–506.
  • Vernooy JH, Lindeman JH, Jacobs JA, Hanemaaijer R, Wouters EF. Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD. CHEST J 2004; 126(6):1802–1810.
  • Churg A, Zhou S, Wright JL. Matrix metalloproteinases in COPD. Eur Respir J 2012; 39(1):197–209.
  • Russell RE, Culpitt SV, DeMatos C, Donnelly L, Smith M, Wiggins J, et al. Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2002; 26(5):602–609.
  • Aldonyte R, Eriksson S, Piitulainen E, Wallmark A, Janciauskiene S. Analysis of systemic biomarkers in COPD patients. COPD: J Chron Obstruct Pulmon Dis 2004; 1(2):155–164.
  • Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Van Coillie E, Masure S, et al. Gelatinase B functions as regulator and effector in leukocyte biology. J Leukoc Biol 2001; 69(6):851–859.
  • Liu Z, Zhou X, Shapiro SD, Shipley JM, Twining SS, Diaz LA, et al. The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell 2000; 102(5):647–655.
  • Kawabata K, Hagio T, Matsuoka S. The role of neutrophil elastase in acute lung injury. Eur J Pharmacol 2002; 451(1):1–10.
  • Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med 2010; 363(23):2233–2247.
  • Pinto-Plata V, Toso J, Lee K, Parks D, Bilello J, Mullerova H, et al. Profiling serum biomarkers in patients with COPD: associations with clinical parameters. Thorax 2007; 62(7):595–601.
  • Paone G, Conti V, Vestri A, Leone A, Puglisi G, Benassi F, et al. Analysis of sputum markers in the evaluation of lung inflammation and functional impairment in symptomatic smokers and COPD patients. Dis Markers 2011; 31(2):91–100.
  • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136(2):215–233.
  • Butz H, Likó I, Czirják S, Igaz P, Korbonits M, Rácz K, et al. MicroRNA profile indicates downregulation of the TGFβ pathway in sporadic non-functioning pituitary adenomas. Pituitary 2011; 14(2):112–124.
  • Liu R, Yang M, Meng Y, Liao J, Sheng J, Pu Y, et al. Tumor-suppressive function of miR-139-5p in esophageal squamous cell carcinoma. PloS one 2013; 8(10):e77068.
  • Zhang L, Dong Y, Zhu N, Tsoi H, Zhao Z, Wu CW, et al. microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer. Mol Cancer 2014; 13(1):124.
  • Bajaj P, Ishmael FT. Exhaled breath condensates as a source for biomarkers for characterization of inflammatory lung diseases. J Anal Sci Methods Instrum 2013; 3(1):17–29.
  • Mutlu GM, Garey KW, Robbins RA, Danziger LH, Rubinstein I. Collection and analysis of exhaled breath condensate in humans. Am J Respir Crit Care Med 2001; 164(5):731–737.
  • Hunt J. Exhaled breath condensate: an evolving tool for noninvasive evaluation of lung disease. J Allergy Clin Immunol 2002; 110(1):28–34.
  • Rosias P. Methodological aspects of exhaled breath condensate collection and analysis. J Breath Res 2012; 6(2):027102.
  • Kwiatkowska S, Noweta K, Zieba M, Nowak D, Bialasiewicz P. Enhanced exhalation of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with COPD exacerbation: a prospective study. Respiration 2012; 84(3):231–241.
  • Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;163:1256–1276.
  • GOLD. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2014. Available from: http://www.goldcopd.com
  • Rouhani F, Paone G, Smith N, Krein P, Barnes P, Brantly ML. Lung neutrophil burden correlates with increased pro-inflammatory cytokines and decreased lung function in individuals with α1-antitrypsin deficiency. Chest J 2000; 117(5_suppl_1):250S–251S.
  • Fujimoto K, Yasuo M, Urushibata K, Hanaoka M, Koizumi T, Kubo K. Airway inflammation during stable and acutely exacerbated chronic obstructive pulmonary disease. Eur Respir J 2005; 25(4):640–646.
  • Gueders MM, Balbin M, Rocks N, Foidart J-M, Gosset P, Louis R, et al. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol 2005; 175(4):2589–2597.
  • Rytilä P, Plataki M, Bucchieri F, Uddin M, Nong G, Kinnula VL, et al. Airway neutrophilia in COPD is not associated with increased neutrophil survival. Eur Respir J 2006; 28(6):1163–1169.
  • Owen CA, Hu Z, Lopez-Otin C, Shapiro SD. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol 2004; 172(12):7791–7803.
  • Vincenti MP, Brinckerhoff CE. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res 2002; 4(3):157–164.
  • Higashimoto Y, Iwata T, Okada M, Satoh H, Fukuda K, Tohda Y. Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease. Respir Med 2009; 103(8):1231–1238.
  • Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, et al. The Role of Matrix Metalloproteinase-9 in Cigarette Smoke–induced Emphysema. Am J Respir Crit Care Med 2011; 183(7):876–884.
  • Ilumets H, Rytilä P, Demedts I, Brusselle GG, Sovijärvi A, Myllärniemi M, et al. Matrix metalloproteinases-8,-9 and-12 in smokers and patients with stage 0 COPD. Int J Chron Obstruct Pulmon Dis 2007; 2(3):369.
  • Dickens JA, Miller BE, Edwards LD, Silverman EK, Lomas DA, Tal-Singer R. COPD association and repeatability of blood biomarkers in the ECLIPSE cohort. Respir Res 2011; 12(1):146.
  • Higashimoto Y, Yamagata Y, Iwata T, Okada M, Ishiguchi T, Sato H, et al. Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients. Eur Respir J 2005; 25(5):885–890.
  • Cataldo D, Munaut C, Noël A, Frankenne F, Bartsch P, Foidart J-M, et al. Matrix metalloproteinases and TIMP‐1 production by peripheral blood granulocytes from COPD patients and asthmatics. Allergy 2001; 56(2):145–151.
  • Tayebjee MH, Lip GY, Blann AD, MacFadyen RJ. Effects of age, gender, ethnicity, diurnal variation and exercise on circulating levels of matrix metalloproteinases (MMP)-2 and-9, and their inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP)-1 and-2. Thromb Res 2005; 115(3):205–210.
  • Santini G, Mores N, Shohreh R, Valente S, Dabrowska M, Trové A, et al. Exhaled and non-exhaled non-invasive markers for assessment of respiratory inflammation in patients with stable COPD and healthy smokers. J Breath Res 2016; 10(1):017102.
  • Malerba M, Radaeli A, Olivini A, Damiani G, Ragnoli B, Montuschi P, et al. Exhaled nitric oxide as a biomarker in COPD and related comorbidities. Biomed Res Int 2014; 2014:1–7.
  • Bofan M, Mores N, Baron M, Dabrowska M, Valente S, Schmid M, et al. Within-day and between-day repeatability of measurements with an electronic nose in patients with COPD. J Breath Res 2013; 7(1):017103.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.