The COPD Comorbidome in the Light of the Degree of Dyspnea and Risk of Exacerbation

References

• Figueira Gonçalves JM, Martín Martínez MD, Pérez Méndez LI, García Bello MA, Garcia-Talavera I, Hernández SG, et al. Health status in patients with COPD according to GOLD 2017 classification: use of the COMCOLD Score in routine clinical practice. COPD. 2018:15;326–33.
   PubMedGoogle Scholar
• Divo M, Cote C, de Torres JP, Casanova C, Marin JM, Pinto-Plata V, Zulueta J, Cabrera C, Zagaceta J, Hunninghake G, et al. Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186:155–61
   PubMed Web of Science ®Google Scholar
• Almagro P, Cabrera FJ, Diez J, Boixeda R, Alonso Ortiz MB, Murio C, Soriano JB. Comorbidities and short-term prognosis in patients hospitalized for acute exacerbation of COPD: The EPOC En Servicios de Medicina Interna (ESMI) study. Chest. 2012;142:1126–33. doi: 10.1378/chest.11-2413.
   PubMed Web of Science ®Google Scholar
• van Boven JF, Román-Rodríguez M, Palmer JF, Toledo-Pons N, Cosío BG, Soriano JB. Comorbidome, pattern, and impact of asthma-COPD overlap syndrome in real life. Chest. 2016;149:1011–20. doi: 10.1016/j.chest.2015.12.002.
   PubMed Web of Science ®Google Scholar
• Global strategy for the diagnosis, management and prevention of COPD. Global initiative for chronic obstructive lung disease (GOLD); 2017. http://www.goldcopd.org.
   Google Scholar
• Ng TP, Niti M, Tan WC, Cao Z, Ong KC, Eng P. Depressive symptoms and chronic obstructive pulmonary disease: effect on mortality, hospital readmission, symptom burden, functional status, and quality of life. Arch Intern Med. 2007;167:60e7. doi: 10.1001/archinte.167.1.60.
   Google Scholar
• Patel ARC, Donaldson GC, Mackay AJ, Wedzicha JA, Hurst JR. The impact of ischemic heart disease on symptoms, health status, and exacerbations inpatients with COPD. Chest. 2012;141:851–7. doi: 10.1378/chest.11-0853.
   PubMed Web of Science ®Google Scholar
• Kahnert K, Alter P, Young D, Lucke T, Heinrich J, Huber RM, Behr J, Wacker M, Biertz F, Watz H, et al. The revised GOLD 2017 COPD categorization in relation to comorbidities. Respir Med. 2018;134:79–85. doi: 10.1016/j.rmed.2017.12.003.
   PubMed Web of Science ®Google Scholar
• Miller J, Edwards LD, Agustí A, Bakke P, Calverley PM, Celli B, Coxson HO, Crim C, Lomas DA, Miller BE, et al. Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort. Respir Med. 2013;107:1376–84. doi: 10.1016/j.rmed.2013.05.001.
   PubMed Web of Science ®Google Scholar
• Ting SM, Hamborg T, McGregor G, Oxborough D, Lim K, Koganti S, Aldridge N, Imray C, Bland R, Fletcher S, et al. Reduced cardiovascular Reserve in Chronic Kidney Failure: a matched cohort study. Am J Kidney Dis. 2015;66:274–84. doi: 10.1053/j.ajkd.2015.02.335.
   PubMed Web of Science ®Google Scholar
• Vanfleteren LE, Spruit MA, Groenen M, Gaffron S, van Empel VP, Bruijnzeel PL, Rutten EP, Op 't Roodt J, Wouters EF, Franssen FM. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;187:728–35. doi: 10.1164/rccm.201209-1665OC.
   PubMed Web of Science ®Google Scholar
• Kim M, Tillis W, Patel P, Davis RM, Asche CV. Association between asthma-COPD overlap syndrome and healthcare utilizations among US adult population. Curr Med Res Opin. 2019: 1–6.
   PubMed Web of Science ®Google Scholar
• Söderholm M, Inghammar M, Hedblad B, Egesten A, Engström G. Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease. Eur J Epidemiol. 2016;31:159–68. doi: 10.1007/s10654-015-0113-7.
   PubMed Web of Science ®Google Scholar
• Portegies ML, Lahousse L, Joos GF, Hofman A, Koudstaal PJ, Stricker BH, Brusselle GG, Ikram MA. Chronic obstructive pulmonary disease and the risk of stroke. The Rotterdam Study. Am J Respir Crit Care Med. 2016;193:251–8. doi: 10.1164/rccm.201505-0962OC.
   PubMed Web of Science ®Google Scholar
• Kim YR, Hwang IC, Lee YJ, Ham EB, Park DK, Kim S. Stroke risk among patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Clinics (Sao Paulo). 2018;73:e177.
   PubMed Web of Science ®Google Scholar
• Lin CS, Shih CC, Yeh CC, Hu CJ, Chung CL, Chen TL, Liao CC. Risk of Stroke and Post-Stroke Adverse Events in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease. PLoS One. 2017;12:e0169429. doi: 10.1371/journal.pone.0169429.
   PubMedGoogle Scholar
• Çolak Y, Afzal S, Lange P, Nordestgaard BG. High body mass index and risk of exacerbations and pneumonias in individuals with chronic obstructive pulmonary disease: observational and genetic risk estimates from the Copenhagen General Population Study. Int J Epidemiol. 2016;45:1551–9. doi: 10.1093/ije/dyw051.
   PubMed Web of Science ®Google Scholar
• Jo YS, Kim YH, Lee JY, Kim K, Jung KS, Yoo KH, Rhee CK. Impact of BMI on exacerbation and medical care expenses in subjects with mild to moderate airflow obstruction. Int J Chron Obstruct Pulmon Dis. 2018;13:2261–9. doi: 10.2147/COPD.S163000.
   PubMed Web of Science ®Google Scholar
• Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, Kinney GL, McDonald MN, Brigham EP, Wise RA, et al. Obesity is associated with increased morbidity in moderate to severe COPD. Chest. 2017;151:68–77. doi: 10.1016/j.chest.2016.08.1432.
   PubMed Web of Science ®Google Scholar
• Marin JM, Soriano JB, Carrizo SJ, Boldova A, Celli BR. Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Am J Respir Crit Care Med. 2010;182:325–31. doi: 10.1164/rccm.200912-1869OC.
   PubMed Web of Science ®Google Scholar
• Steveling EH, Clarenbach CF, Miedinger D, Enz C, Dürr S, Maier S, Sievi N, Zogg S, Leuppi JD, Kohler M. Predictors of the overlap syndrome and its association with comorbidities in patients with chronic obstructive pulmonary disease. Respiration.2014;88:451–7. doi: 10.1159/000368615.
   PubMed Web of Science ®Google Scholar