Quercetin Attenuates Acute Lung Injury Caused by Cigarette Smoke Both In Vitro and In Vivo

References

• Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3(11):e442. doi:10.1371/journal.pmed.0030442.
   PubMed Web of Science ®Google Scholar
• Asma S, Song Y, Cohen J, et al. CDC grand rounds: global tobacco control. Morb Mortal Wkly Rep. 2014;63(13):277–280.
   PubMed Web of Science ®Google Scholar
• Crotty Alexander LE, Shin S, Hwang JH. Inflammatory diseases of the lung induced by conventional cigarette smoke: a review. Chest. 2015;148(5):1307–1322. doi:10.1378/chest.15-0409.
   PubMed Web of Science ®Google Scholar
• Kumar A, Cherian SV, Vassallo R, et al. Current concepts in pathogenesis, diagnosis, and management of smoking-related interstitial lung diseases. Chest. 2018;154(2):394–408. doi:10.1016/j.chest.2017.11.023.
   PubMed Web of Science ®Google Scholar
• Dalrymple A, Ordonez P, Thorne D, et al. An improved method for the isolation of rat alveolar type II lung cells: Use in the Comet assay to determine DNA damage induced by cigarette smoke. Regul Toxicol Pharmacol. 2015;72(1):141–149. doi:10.1016/j.yrtph.2015.03.013.
   PubMed Web of Science ®Google Scholar
• Austin V, Crack PJ, Bozinovski S, et al. COPD and stroke: are systemic inflammation and oxidative stress the missing links? Clin Sci. 2016;130(13):1039–1050. doi:10.1042/CS20160043.
   PubMed Web of Science ®Google Scholar
• Zinser JW. Tobacco use and lung cancer. Salud Publica Mex. 2019;61(3, may-jun):303–307. doi:10.21149/10088.
   PubMed Web of Science ®Google Scholar
• Aghapour M, Raee P, Moghaddam SJ, et al. Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure. Am J Respir Cell Mol Biol. 2018;58(2):157–169. doi:10.1165/rcmb.2017-0200TR.
   PubMed Web of Science ®Google Scholar
• Durham AL, Adcock IM. The relationship between COPD and lung cancer. Lung Cancer. 2015;90(2):121–127. doi:10.1016/j.lungcan.2015.08.017.
   PubMed Web of Science ®Google Scholar
• Seifart C, Plagens A. Genetics of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2007;2(4):541–550.
   PubMedGoogle Scholar
• Campos KKD, Araujo GR, Martins TL, et al. The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke. J Nutr Biochem. 2017;48:9–20. doi:10.1016/j.jnutbio.2017.06.004.
   PubMed Web of Science ®Google Scholar
• Valenca SS, Pimenta WA, Rueff-Barroso CR, et al. Involvement of nitric oxide in acute lung inflammation induced by cigarette smoke in the mouse. Nitric Oxide. 2009;20(3):175–181. doi:10.1016/j.niox.2008.11.003.
   PubMed Web of Science ®Google Scholar
• Dye JA, Adler KB. Effects of cigarette smoke on epithelial cells of the respiratory tract. Thorax. 1994;49(8):825–834. doi:10.1136/thx.49.8.825.
   PubMed Web of Science ®Google Scholar
• Billatos E, Faiz A, Gesthalter Y, et al. Impact of acute exposure to cigarette smoke on airway gene expression. Physiol Genomics. 2018;50(9):705–713. doi:10.1152/physiolgenomics.00092.2017.
   PubMed Web of Science ®Google Scholar
• Ponce-Gallegos MA, Ramírez-Venegas A, Falfán-Valencia R. Th17 profile in COPD exacerbations. COPD. 2017;12:1857–1865. doi:10.2147/COPD.S136592.
   Google Scholar
• Zinellu E, Zinellu A, Fois AG, et al. Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review. Respir Res. 2016;17(1):17. doi:10.1186/s12931-016-0471-z.
   PubMedGoogle Scholar
• Lushchak VI. Free radicals, reactive oxygen species, oxidative stresses and their classifications. UkrBiochemJ. 2015;87(6):11–18. doi:10.15407/ubj87.06.011.
   Google Scholar
• Lee IT, Yang CM. Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol. 2012;84(5):581–590. doi:10.1016/j.bcp.2012.05.005.
   PubMed Web of Science ®Google Scholar
• Chiş IC, Mureşan A, Oros A, et al. Protective effects of Quercetin and chronic moderate exercise (training) against oxidative stress in the liver tissue of streptozotocin-induced diabetic rats. Physiol Int. 2016;103(1):49–64. doi:10.1556/036.103.2016.1.5.
   PubMed Web of Science ®Google Scholar
• Birben E, Sahiner UM, Sackesen C, et al. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5(1):9–19.
   PubMedGoogle Scholar
• Kashyap D, Garg VK, Tuli HS, et al. Fisetin and quercetin: promising flavonoids with chemopreventive potential. Biomolecules. 2019;9(5):174. doi:10.3390/biom9050174.
   PubMed Web of Science ®Google Scholar
• Farazuddin M, Mishra R, Jing Y, et al. Quercetin prevents rhinovirus-induced progression of lung disease in mice with COPD phenotype. PLoS One. 2018;13(7):e0199612. doi:10.1371/journal.pone.0199612.
   PubMed Web of Science ®Google Scholar
• Li N, Li Q, Zhou XD, et al. The effect of quercetin on human neutrophil elastase-induced mucin5AC expression in human airway epithelial cells. Int Immunopharmacol. 2012;14(2):195–201. doi:10.1016/j.intimp.2012.07.008.
   PubMed Web of Science ®Google Scholar
• Ganesan S, Faris AN, Comstock AT, et al. Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression. Respir Res. 2010;11(1):131. doi:10.1186/1465-9921-11-131.
   PubMedGoogle Scholar
• Li Y, Yao J, Han C, et al. Quercetin, inflammation and immunity. Nutrients. 2016;8(3):167. doi:10.3390/nu8030167.
   PubMed Web of Science ®Google Scholar
• Veith C, Drent M, Bast A, et al. The disturbed redox-balance in pulmonary fibrosis is modulated by the plant flavonoid quercetin. Toxicol Appl Pharmacol. 2017;336:40–48. doi:10.1016/j.taap.2017.10.001.
   PubMed Web of Science ®Google Scholar
• Palozza P, Simone R, Catalano A, et al. Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-kappaB nuclear binding and increase in PPARgamma expression. J Nutr Biochem. 2011;22(3):259–268. doi:10.1016/j.jnutbio.2010.02.003.
   PubMed Web of Science ®Google Scholar
• Ahmed SA, Gogal RM, Jr., Walsh JE. A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay. J Immunol Methods. 1994;170(2):211–224. doi:10.1016/0022-1759(94)90396-4.
   PubMed Web of Science ®Google Scholar
• Xiao J, Zhang Y, Wang J, et al. Monitoring of cell viability and proliferation in hydrogel-encapsulated system by resazurin assay. Appl Biochem Biotechnol. 2010;162(7):1996–2007. doi:10.1007/s12010-010-8975-3.
   PubMed Web of Science ®Google Scholar
• Wang S, Holyoak GR, Panter KE, et al. Resazurin reduction assay for ram sperm metabolic activity measured by spectrophotometry. Proc Soc Exp Biol Med. 1998;217(2):197–202. doi:10.3181/00379727-217-44223.
   PubMed Web of Science ®Google Scholar
• Green LC, Wagner DA, Glogowski J, et al. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 1982;126(1):131–138. doi:10.1016/0003-2697(82)90118-X.
   PubMed Web of Science ®Google Scholar
• Valenca SS, da Hora K, Castro P, et al. Emphysema and metalloelastase expression in mouse lung induced by cigarette smoke. Toxicol Pathol. 2004;32(3):351–356. doi:10.1080/01926230490431466.
   PubMed Web of Science ®Google Scholar
• Pena K, Ramos C, Soares N, et al. The administration of a high refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to cigarette smoke. COPD. 2016;11:3207–3217. doi:10.2147/COPD.S119485.
   Google Scholar
• Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47(3):469–474. doi:10.1111/j.1432-1033.1974.tb03714.x.
   PubMedGoogle Scholar
• Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121–126.
   PubMed Web of Science ®Google Scholar
• Griffith OW. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem. 1980;106(1):207–212. doi:10.1016/0003-2697(80)90139-6.
   PubMed Web of Science ®Google Scholar
• Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302–310.
   PubMedGoogle Scholar
• Levine RL, Williams JA, Stadtman ER, et al. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 1994;233:346–357.
   PubMed Web of Science ®Google Scholar
• Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72(1-2):248–254. doi:10.1016/0003-2697(76)90527-3.
   PubMed Web of Science ®Google Scholar
• Campos KK, Manso RG, Goncalves EG, et al. Temporal analysis of oxidative effects on the pulmonary inflammatory response in mice exposed to cigarette smoke. Cell Immunol. 2013;284(1-2):29–36. doi:10.1016/j.cellimm.2013.07.002.
   PubMed Web of Science ®Google Scholar
• de Araújo GR, Rabelo ACS, Meira JS, et al. Baccharis trimera inhibits reactive oxygen species production through PKC and down-regulation p47phox phosphorylation of NADPH oxidase in SK Hep-1 cells. Exp Biol Med (Maywood)). 2017;242(3):333–343. doi:10.1177/1535370216672749.
   PubMed Web of Science ®Google Scholar
• Schuliga M. NF-kappaB signaling in chronic inflammatory airway disease. Biomolecules. 2015;5(3):1266–1283. doi:10.3390/biom5031266.
   PubMed Web of Science ®Google Scholar
• Phipps JC, Aronoff DM, Curtis JL, et al. Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of streptococcus pneumoniae▿. Infect Immun. 2010;78(3):1214–1220. doi:10.1128/IAI.00963-09.
   PubMed Web of Science ®Google Scholar
• Murugan V, Peck MJ. Signal transduction pathways linking the activation of alveolar macrophages with the recruitment of neutrophils to lungs in chronic obstructive pulmonary disease. Exp Lung Res. 2009;35(6):439–485. doi:10.1080/01902140902759290.
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Alveolar macrophages in chronic obstructive pulmonary disease (COPD). Cell Mol Biol (Noisy-le-Grand). 2004;50.
   PubMed Web of Science ®Google Scholar
• Thomassen MJ, Kavuru MS. Human alveolar macrophages and monocytes as a source and target for nitric oxide. Int Immunopharmacol. 2001;1(8):1479–1490. doi:10.1016/S1567-5769(01)00092-3.
   PubMed Web of Science ®Google Scholar
• Kasmi S, Bkhairia I, Harrabi B, et al. Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250. Toxicol Mech Methods. 2017;25:1–11.
   Google Scholar
• Gavrilovska-Brzanov A, Shosholcheva M, Kuzmanovska B, et al. The influence of smoking on the variations in carboxyhemoglobin and methemoglobin during urologic surgery. Med Arch. 2017;71(3):178–182. doi:10.5455/medarh.2017.71.178-182.
   PubMedGoogle Scholar
• Zeng Q, Shen LJ, Li S, et al. The effects of hemoglobin levels and their interactions with cigarette smoking on survival in nasopharyngeal carcinoma patients. Cancer Med. 2016;5(5):816–826. doi:10.1002/cam4.647.
   PubMed Web of Science ®Google Scholar
• Heunks LM, Vina J, van Herwaarden CL, et al. Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am J Physiol. 1999;277(6):R1697–704. doi:10.1152/ajpregu.1999.277.6.R1697.
   PubMedGoogle Scholar
• Kayyali US, Budhiraja R, Pennella CM, et al. Upregulation of xanthine oxidase by tobacco smoke condensate in pulmonary endothelial cells. Toxicol Appl Pharmacol. 2003;188(1):59–68. doi:10.1016/S0041-008X(02)00076-5.
   PubMed Web of Science ®Google Scholar
• Ramos CO, Campos KKD, Costa GP, et al. Taurine treatment decreases inflammation and oxidative stress in lungs of adult mice exposed to cigarette smoke. Regul Toxicol Pharmacol. 2018;98:50–57. doi:10.1016/j.yrtph.2018.07.008.
   PubMed Web of Science ®Google Scholar
• Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J. 2006;28(1):219–242. doi:10.1183/09031936.06.00053805.
   PubMed Web of Science ®Google Scholar
• Lee SU, Ryu HW, Lee S, et al. Lignans Isolated From Flower Buds of Magnolia fargesii Attenuate Airway Inflammation Induced by Cigarette Smoke in vitro and in vivo. Front Pharmacol. 2018;9:970.
   PubMed Web of Science ®Google Scholar
• D’Andrea G. Quercetin: a flavonol with multifaceted therapeutic applications? Fitoterapia. 2015;106:256–271.
   PubMed Web of Science ®Google Scholar
• Chang KH, Park JM, Lee CH, et al. NADPH oxidase (NOX) 1 mediates cigarette smoke-induced superoxide generation in rat vascular smooth muscle cells. Toxicol in Vitro. 2017;38:49–58. doi:10.1016/j.tiv.2016.10.013.
   PubMed Web of Science ®Google Scholar
• Jiang X, Chen C, Liu Y, et al. Critical role of cellular glutathione homeostasis for trivalent inorganic arsenite-induced oxidative damage in human bronchial epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014;770:35–45. doi:10.1016/j.mrgentox.2014.04.016.
   PubMed Web of Science ®Google Scholar
• Monostori P, Wittmann G, Karg E, et al. Determination of glutathione and glutathione disulfide in biological samples: an in-depth review. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877(28):3331–3346. doi:10.1016/j.jchromb.2009.06.016.
   PubMed Web of Science ®Google Scholar
• Ballatori N, Krance SM, Notenboom S, et al. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009;390(3):191–214.
   PubMed Web of Science ®Google Scholar
• Cantin AM, North SL, Hubbard RC, et al. Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol. 1987;63(1):152–157. doi:10.1152/jappl.1987.63.1.152.
   PubMed Web of Science ®Google Scholar
• Kosinova P, Berka K, Wykes M, et al. Positioning of antioxidant quercetin and its metabolites in lipid bilayer membranes: implication for their lipid-peroxidation inhibition. J Phys Chem B. 2012;16(4):1309–1318. doi:10.1021/jp208731g.
   Google Scholar
• Dekhuijzen P, van Beurden W. The role for N-acetylcysteine in the management of COPD. Int J Chron Obstruct Pulmon Dis. 2006;1(2):99–106. doi:10.2147/copd.2006.1.2.99.
   PubMedGoogle Scholar
• Posso SV, Quesnot N, Moraes JA, et al. AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway. Int Immunopharmacol. 2018;56:330–338. doi:10.1016/j.intimp.2018.01.045.
   PubMed Web of Science ®Google Scholar
• Machado DF, Campos KKD, da Silva NP, et al. The administration of surfactant decreased oxidative stress in lungs of mice exposed to cigarette smoke. Int Immunopharmacol. 2018;54:275–279. doi:10.1016/j.intimp.2017.11.023.
   PubMed Web of Science ®Google Scholar
• Cai X, Fang Z, Dou J, et al. Bioavailability of quercetin: problems and promises. CMC. 2013;20(20):2572–2582. doi:10.2174/09298673113209990120.
   PubMed Web of Science ®Google Scholar
• Guo Y, Bruno RS. Endogenous and exogenous mediators of quercetin bioavailability. J Nutr Biochem. 2015;26(3):201–210. doi:10.1016/j.jnutbio.2014.10.008.
   PubMed Web of Science ®Google Scholar
• Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2008;22(3):659–661. doi:10.1096/fj.07-9574LSF.
   PubMed Web of Science ®Google Scholar
• Guc M, Schroeder G. Application of molecularly imprinted polymers (MIP) and magnetic molecularly imprinted polymers (mag-MIP) to selective analysis of quercetin in flowing atmospheric-pressure afterglow mass spectrometry (FAPA-MS) and in electrospray ionization mass spectrometry (ESI-MS). Molecules. 2019;24(13):2364. doi:10.3390/molecules24132364.
   Web of Science ®Google Scholar