References
- Pauwels RA, Buist AS, Calverley PM, et al. GOLD scientffic committee, global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO global initiative for chronic obstructive lung disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001;163(5):1256–1276. DOI:https://doi.org/10.1164/ajrccm.163.5.2101039
- Jelic TM. Emphysema [Online First], IntechOpen, 2019. DOI:https://doi.org/10.5772/intechopen.83273 Available from: https://www.intechopen.com/online-first/emphysema.
- Saetta M, Turato G, Maestrelli P, et al. Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163(6):1304–1309. DOI:https://doi.org/10.1164/ajrccm.163.6.2009116
- Wilson R, Rayner CF. Bronchitis. Curr Opin Pulm Med. 1995;1(3):177–182.
- Vestbo J, Anderson W, Coxson HO, ECLIPSE investigators, et al. on behalf of the ECLIPSE investigators: Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE). Eur Respir J. 2008;31(4):869–873. DOI:https://doi.org/10.1183/09031936.00111707
- Saetta M, Di Stefano A, Turato G, et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(3 Pt 1):822–826. DOI:https://doi.org/10.1164/ajrccm.157.3.9709027
- Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J. 2003;22(4):672–688.
- Mayer AS, Newman LS. Genetic and environmental modulation of chronic obstructive pulmonary disease. Respir Physiol. 2001;128(1):3–11. DOI:https://doi.org/10.1016/s0034-5687(01)00258-4
- Vestbo J, Prescott E, Almdal T, et al. Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study. Am J Respir Crit Care Med. 2006;173(1):79–83. DOI:https://doi.org/10.1164/rccm.200506-969OC
- Tuder RM, Petrache I. Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest. 2012;122(8):2749–2755. DOI:https://doi.org/10.1172/JCI60324
- Agusti AG, Sauleda J, Miralles C, et al. Skeletal muscle apopotosis and wight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;166(4):485–489. DOI:https://doi.org/10.1164/rccm.2108013
- Agusti AG, Calverley P, Celli B, et al. Characterization of COPD heterogeneity in the ECLIPSE cohort. Respir Res. 2010;11:122.
- Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3(11):e442. DOI:https://doi.org/10.1371/journal.pmed.0030442
- Cerami C, Founds H, Nicholl I, et al. Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci U S A. 1997;94(25):13915–13920. DOI:https://doi.org/10.1073/pnas.94.25.13915
- Wu L, Ma L, Nicholson LFB, et al. Advanced glycation end products and its receptor (RAGE) are increased in patients with COPD. Respir Med. 2011;105(3):329–336. DOI:https://doi.org/10.1016/j.rmed.2010.11.001
- Hoonhorst SJM, Pouwels SD, Faiz A, et al. Advanced glycation end products and their receptor in different body compartments in COPD. Resp Res. 2016;17(1):46.
- Zaigham S, Persson M, Jujic A, et al. Measures of lung function and their relationship with advanced glycation end-products. ERJ Open Res. 2020;6(2):00356–2019. DOI:https://doi.org/10.1183/23120541.00356-2019
- Schmidt AM, Vianna M, Gerlach M, et al. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem. 1992;267(21):14987–14997.
- Neeper M, Schmidt A, Brett J, et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem. 1992;267(21):14998–15004.
- Demling N, Ehrhardt C, Kasper M, et al. Promotion of cell adherence and spreading: a novel function of RAGE, the highly selective differentiation marker of human alveolar epithelial type I cells. Cell Tissue Res. 2006;323(3):475–488. DOI:https://doi.org/10.1007/s00441-005-0069-0
- Shirasawa M, Fujiwara N, Hirabayashi S, et al. Receptor for advanced glycation end-products is a marker of type I lung alveolar cells. Genes Cells. 2004;9(2):165–174. DOI:https://doi.org/10.1111/j.1356-9597.2004.00712.x
- Fehrenbach H, Kasper M, Tsherinig T, et al. Receptor for advanced glycation end products (RAGE) exhibits highly differential cellular and Sub-cellular localisation in rat and human lung. Cell Mol Biol (Noisy-le-Grand). 1998;44(7):1147–1157.
- Mukherjee TK, Mukhopadhyay S, Hoidal JR. Implication of receptor for advanced glycation end product (RAGE) in pulmonary health and pathophysiology. Respir Physiol Neurobiol. 2008;162(3):210–215. DOI:https://doi.org/10.1016/j.resp.2008.07.001
- Al-Robaiy S, Weber B, Simm A, et al. The receptor for advanced glycation end-products supports lung tissue biomechanics. Am J Physiol Lung Cell Mol Physiol. 2013;305(7):L491–L500. DOI:https://doi.org/10.1152/ajplung.00090.2013
- Reynolds PR, Kasteler SD, Cosio MG, et al. RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008;294(6):L1094–L1101. DOI:https://doi.org/10.1152/ajplung.00318.2007
- Ferhani N, Letuve S, Kozhich A, et al. Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010;181(9):917–927. DOI:https://doi.org/10.1164/rccm.200903-0340OC
- Schmidt AM, Yan SD, Yan SF, et al. The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta. 2000;1498(2–3):99–111. DOI:https://doi.org/10.1016/S0167-4889(00)00087-2
- Repapi E, Sayers I, Wain LV, Wellcome Trust Case Control Consortium, and NSHD Respiratory Study Team, et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet. 2010;42(1):36–44. DOI:https://doi.org/10.1038/ng.501
- Hancock DB, Eijgelsheim M, Wilk JB, et al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet. 2010;42(1):45–52. DOI:https://doi.org/10.1038/ng.500
- Ahmad S, Khan MY, Z. Rafi Z, et al. Oxidation, glycation and glycoxidation-The vicious cycle and lung cancer . Semin Cancer Biol. 2018;49:29–36. DOI:https://doi.org/10.1016/j.semcancer.2017.10.005
- Reynaert NL, Gopal P, Rutten EPA, et al. Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential contributions to disease . Int J Biochem Cell Biol. 2016;81(Pt B):403–418. DOI:https://doi.org/10.1016/j.biocel.2016.06.016
- Wautier MP, Chappey O, Corda S, et al. Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. The am. Am J Physiol Endocrinol Metab. 2001;280(5):E685–E694. DOI:https://doi.org/10.1152/ajpendo.2001.280.5.E685
- Mukherjee TK, Mukhopadhyay S, Hoidal JR. The role of reactive oxygen species in TNFalpha-dependent expression of the receptor for advanced glycation end products in human umbilical vein endothelial cells. Biochim Biophys Acta. 2005;1744(2):213–223. DOI:https://doi.org/10.1016/j.bbamcr.2005.03.007
- Schmidt AM, Yan SD, Yan SF, et al. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest. 2001;108(7):949–955. DOI:https://doi.org/10.1172/JCI14002
- Sanders KA, Delker DA, Huecksteadt T, et al. RAGE is a critical mediator of pulmonary oxidative stress, alveolar macrophage activation and emphysema in response to cigarette smoke. Sci Rep. 2019;9(1):231. DOI:https://doi.org/10.1038/s41598-018-36163-z
- Robinson AB, Johnson KD, Bennion BG, et al. RAGE signaling by alveolar macrophages influences tobacco smoke-induced inflammation. Am J Physiol Lung Cell Mol Physiol. 2012;302(11):L1192–L1199. DOI:https://doi.org/10.1152/ajplung.00099.2012
- Iwashima Y, Eto M, Hata A, et al. Advanced glycation end products-induced gene expression of scavenger receptors in cultured human monocyte-derived macrophages. Biochem Biophys Res Commun. 2000;277(2):368–380.
- Frommhold D, Kamphues A, Hepper I, et al. RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. Blood. 2010;116(5):841–849. DOI:https://doi.org/10.1182/blood-2009-09-244293
- Simpson JL, S. Phipps S, P.G. Gibson PG. Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis. Pharmacol. & Therap. 2009;124(1):86–95. DOI:https://doi.org/10.1016/j.pharmthera.2009.06.004
- Hori O, Brett J, Slattery T, et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of RAGE and amphoterin in developing nervous system. J Biol Chem. 1995;270(43):25752–25761.
- Chen M, Wang T, Shen Y, et al. Knockout of RAGE ameliorates mainstream cigarette smoke-induced airway inflammation in mice. Int Immunopharmacol. 2017;50:230–235. DOI:https://doi.org/10.1016/j.intimp.2017.06.018
- Serveaux-Dancer M, Jabaudon M, Creveaux I, et al. Pathological implications of receptor for advanced glycation end-product (AGER) gene polymorphism. Dis Markers. 2019; 2019:2067353. DOI:https://doi.org/10.1155/2019/2067353
- Prasad K. Low levels of serum soluble receptors for advanced glycation end products, biomarkers for disease state: myth or reality. Int J Angiol. 2014;23(1):11–16. DOI:https://doi.org/10.1055/s-0033-1363423
- Tam XHL, Shiu SWM, Leng L, et al. Enhanced expression of receptor for advanced glycation end-products is associated with low circulating soluble isoforms of the receptor in type 2 diabetes. Clin Sci. 2011;120(2):81–89. DOI:https://doi.org/10.1042/CS20100256
- Hudson BI, Carter AM, Harja E, et al. Identification, classification, and expression of RAGE gene splice variants. Faseb J. 2008;22(5):1572–1580. DOI:https://doi.org/10.1096/fj.07-9909com
- Zhang L, Bukulin M, Kojro E, et al. Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases. J Biol Chem. 2008;283(51):35507–35516. DOI:https://doi.org/10.1074/jbc.M806948200
- Raucci A, Cugusi S, Antonelli A, et al. A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10). Faseb J. 2008;22(10):3716–3727. DOI:https://doi.org/10.1096/fj.08-109033
- Smith DJ, Yerkovich ST, Towers MA, et al. Reduced soluble receptor for advanced glycation end-products in COPD. Eur Respir J. 2011;37(3):516–522. DOI:https://doi.org/10.1183/09031936.00029310
- Cockayne DA, Cheng DT, Waschki B, et al. Fine, systemic biomarkers of neutrophilic inflammation, tissue injury and repair in COPD patients with differing levels of disease severity. PLoS ONE. 2012;7(6):e38629. DOI:https://doi.org/10.1371/journal.pone.0038629
- Gopal P, Rutten EPA, Dentener MA, et al. Decreased plasma sRAGE levels in COPD: influence of oxygen therapy. Eur J Clin Invest. 2012;42(8):807–814. DOI:https://doi.org/10.1111/j.1365-2362.2012.02646.x
- Miniati M, Monti S, Basta G, et al. Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study. Respiratory Res. 2011;12:37.
- Sukkar MB, Wood LG, Tooze M, et al. Wark, soluble RAGE is deficient in neutrophilic asthma and COPD. Eur Respir J. 2012;39(3):721–729.
- Vazzana N, Santilli F, Cuccurullo C, et al. Soluble forms of RAGE in internal medicine. Intern Emerg Med. 2009;4(5):389–401. DOI:https://doi.org/10.1007/s11739-009-0300-1
- Yan SF, Ramasamy R, Schmidt AM. Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications. Nat Clin Pract Endocrinol Metab. 2008;4(5):285–293.
- Goldin JA, Beckman JA, Schmidt AM, et al. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation. 2006;114(6):597–605. DOI:https://doi.org/10.1161/CIRCULATIONAHA.106.621854
- Singh R, Barden A, T. Mori T, et al. Advanced glycation end-products: a review. Diabetologia. 2001;44(2):129–146. DOI:https://doi.org/10.1007/s001250051591
- Brett J, Schmidt AM, Yan SD, et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am J Pathol. 1993;143(6):1699–1712.
- Winden DR, Ferguson NT, Bukey BR, et al. Conditional over-expression of RAGE by embryonic alveolar epithelium compromises the respiratory membrane and impairs endothelial cell differentiation. Respir Res. 2013;14:108. DOI:https://doi.org/10.1186/1465-9921-14-108
- Wolf L, Herr C, Niederstraßer J, et al. Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke. PLoS One. 2017;12(7):e0180092. DOI:https://doi.org/10.1371/journal.pone.0180092
- Khaket TP, Kang SC, Mukherjee TK. The potential of receptor for advanced glycation end products (RAGE) as a therapeutic target for lung associated diseases. Curr Drug Targets. 2019;20(6):679–689. DOI:https://doi.org/10.2174/1389450120666181120102159
- Hoonhorst SJM, A.T. Loi LT, Hartman JE, et al. The Hacken NHT. Advanced glycation end products in the skin are enhanced in COPD. Metabolism. 2014;63(9):1149–1156. DOI:https://doi.org/10.1016/j.metabol.2014.06.006
- Gopal P, Reynaert NL, Scheijen JLJM, et al. Plasma advanced glycation end products and skin autofluorescence are increased in COPD. Eur Respir J. 2014;43(2):430–438.
- Waseda K, Miyahara N, Taniguchi A, et al. Emphysema requires the receptor for advanced glycation end products triggering on structural cells. Am J Respir Cell Mol Biol. 2015;52(4):482–491.
- Sambamurthy AS, Leme TD, Oury SD, et al. The receptor for advanced glycation end products (RAGE) contributes to the progression of emphysema in mice. PLoS One. 2015;10(3):e0118979. DOI:https://doi.org/10.1371/journal.pone.0118979
- Guerassimov A, Hoshino Y, Takubo Y, et al. The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am J Respir Crit Care Med. 2004;170(9):974–980. DOI:https://doi.org/10.1164/rccm.200309-1270OC
- Niu H, Niu W, Yu T, et al. Association of RAGE gene multiple variants with the risk for COPD and asthma in Northern Han Chinese. Aging (Albany NY). 2019;11(10):3220–3237. DOI:https://doi.org/10.18632/aging.101975
- Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet. 2012;379(9823):1341–1351. DOI:https://doi.org/10.1016/S0140-6736(11)60968-9
- Vissing H, Aagaard L, Tommerup N, et al. Localization of the human gene for advanced glycosylation end product-specific receptor (AGER) to chromosome 6p21.3. Genomics. 1994;24(3):606–608. DOI:https://doi.org/10.1006/geno.1994.1676
- Sugaya K, Fukagawa T, Matsumoto K, et al. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. Genomics. 1994;23(2):408–419. DOI:https://doi.org/10.1006/geno.1994.1517
- Ensemble genome browser 91. 2018;948–957. Available from: https://www.ensembl.org/index.html.
- Sterenczak KA, Nolte I, Escobar HM. RAGE splicing variants in mammals. Methods Mol Biol. 2013;963:265–276.
- Sterenczak KA, Willenbrock S, Barann M, et al. Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms. Gene. 2009;434(1–2):35–42. DOI:https://doi.org/10.1016/j.gene.2008.10.027
- Yonekura H, Yamamoto Y, Sakurai S, et al. Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. Biochemical J. 2003;370(3):1097–1109. DOI:https://doi.org/10.1042/bj20021371
- Koyama H, Yamamoto H, Nishizawa Y. RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases. Mol Med. 2007;13(11–12):625–635. DOI:https://doi.org/10.2119/2007-00087.Koyama
- GBD 2015 Chronic Respiratory Disease Collaborators. Chronic respiratory disease collaborators. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med. 2017;5:691–706.
- Li Y, Yang C, Ma G, et al. Association of polymorphisms of the receptor for advanced glycation end products gene with COPD in the Chinese population. DNA Cell Biol. 2014;33(4):251–258. DOI:https://doi.org/10.1089/dna.2013.2303
- Kinjo T, Kitaguchi Y, Droma Y, et al. T.he Gly82Ser mutation in AGER contributes to pathogenesis of pulmonary fibrosis in combined pulmonary fibrosis and emphysema (CPFE) in Japanese patients. Sci Rep. 2020;10(1):12811. DOI:https://doi.org/10.1038/s41598-020-69184-8
- Cheng DT, Kim DK, Cockayne DA, on behalf of the TESRA and ECLIPSE investigators, et al. Systemic soluble receptor for advanced glycation end products is a biomarker of emphysema and associated with ager genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;188(8):948–957. DOI:https://doi.org/10.1164/rccm.201302-0247OC
- Jang Y, Kim JY, Kang SM, et al. Association of the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating levels of soluble RAGE and inflammatory markers in nondiabetic and nonobese Koreans. Metabolism. 2007;56(2):199–205. DOI:https://doi.org/10.1016/j.metabol.2006.09.013
- Miller S, Henry AP, Hodge E, et al. The Ser82 RAGE variant affects lung function and serum RAGE in smokers and sRAGE production in vitro. PLoS One. 2016;11(10):e0164041. DOI:https://doi.org/10.1371/journal.pone.0164041
- Stogsdill JA, Stogsdill MP, Porter JL, et al. Embryonic overexpression of receptors for advanced glycation end-products by alveolar epithelium induces an imbalance between proliferation and apoptosis. Am J Respir Cell Mol Biol. 2012;47(1):60–66.
- Stogsdill MP, Stogsdill JA, Bodine BG, et al. Conditional overexpression of receptors for advanced glycation endproducts in the adult murine lung causes airspace enlargement and induces inflammation. Am J Respir Cell Mol Biol. 2013;49(1):128–134.
- Hudson BI, Lippman ME. Targeting RAGE signaling in inflammatory diseases. Annu Rev Med. 2018;69:349–364.
- Buckley ST, Ehrhardt C. The receptor for advanced glycation end products (RAGE) and the lung. J Biomed Biotechnol. 2010;2010:917108. DOI:https://doi.org/10.1155/2010/917108
- Sasaki M, M. Kashima M, Ito T, et al. Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1beta and TNF-alpha. Mediators Inflamm. 2000;9(3-4):155–160. DOI:https://doi.org/10.1080/09629350020002895
- Harris HE, Andersson U. Mini-review: the nuclear protein HMGB1 as a proinflammatory mediator. Eur J Immunol. 2004;34(6):1503–1512.
- Provinciali M, Cardelli M, Marchegiani F. Inflammation, chronic obstructive pulmonary disease and aging. Curr Opin Pulm Med. 2011;17:S3–S10. DOI:https://doi.org/10.1097/01.mcp.0000410742.90463.1f
- Niewoehner DE, Kleinerman J, Rice DB. Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med. 1974;291(15):755–758.
- Shapiro SD. The macrophage in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160(5 Pt 2):S29–S32. DOI:https://doi.org/10.1164/ajrccm.160.supplement_1.9
- Tetley TD. Macrophages and the pathogenesis of COPD. Chest. 2002;121(5 Suppl):156S–159S. DOI:https://doi.org/10.1378/chest.121.5_suppl.156s
- Finkelstein R, Fraser RS, Ghezzo H, et al. Alveolar inflammation and its relation to emphysema in smokers. Am J Respir Crit Care Med. 1995;152(5):1666–1672. DOI:https://doi.org/10.1164/ajrccm.152.5.7582312
- Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004;350(26):2645–2653. DOI:https://doi.org/10.1056/NEJMoa032158
- Allam VSRR, Faiz A, Lam M, et al. RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD. Allergy. 2021;76(4):1123–1135. DOI:https://doi.org/10.1111/all.14563
- Mukhopadhyay S, Mukherjee TK. Bridging advanced glycation end product, receptor for advanced glycation end product and nitric oxide with hormonal replacement/estrogen therapy in healthy versus diabetic postmenopausal women: a perspective. Biochim Biophys Acta. 2005;1745(2):145–155. DOI:https://doi.org/10.1016/j.bbamcr.2005.03.010
- Downward J. Cell cycle: routine role for Ras. Curr Biol. 1997;7(4):R258–R260. DOI:https://doi.org/10.1016/S0960-9822(06)00116-3
- Winston JT, Coats SR, Y.Z. Wang YZ, et al. Regulation of the cell cycle machinery by oncogenic Ras. Oncogene. 1996;12(1):127–134.
- Reynolds PR, Stogsdill JA, Stogsdill MP, et al. Up-regulation of receptors for advanced glycation end-products by alveolar epithelium influences cytodifferentiation and causes severe lung hypoplasia . Am J Respir Cell Mol Biol. 2011;45(6):1195–1202. DOI:https://doi.org/10.1165/rcmb.2011-0170OC
- Lee H, Lee J, Hong SH, et al. Inhibition of RAGE attenuates cigarette Smoke-Induced lung epithelial cell damage via RAGE-Mediated Nrf2/DAMP signaling. Front Pharmacol. 2018;9:684.
- Schmidt AM, Hori O, J.X. Chen JX, et al. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. J Clin Invest. 1995;96(3):1395–1403. DOI:https://doi.org/10.1172/JCI118175
- Wang Y, Wang H, Piper MG, et al. sRAGE induces human monocyte survival and differentiation. J Immunol. 2010;185(3):1822–1835. DOI:https://doi.org/10.4049/jimmunol.0903398
- Yamakawa N, Uchida T, Matthay MA, et al. Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;300(4):L516–L525. DOI:https://doi.org/10.1152/ajplung.00118.2010
- Yamamoto H, Watanabe T, Yamamoto Y, et al. RAGE in diabetic nephropathy. Curr Mol Med. 2007;7(8):752–757.
- Miłkowska-Dymanowska J, Białas AJ, Szewczyk K, et al. The usefulness of soluble receptor for advanced glycation end-products in the identification of COPD frequent exacerbator phenotype. Int J Chron Obstruct Pulmon Dis. 2018;13:3879–3884.
- Iwamoto H, Gao J, Pulkkinen V, et al. Soluble receptor for advanced glycation end-products and progression of airway disease. BMC Pulm Med. 2014;14:68.
- Li K, Dai D, Zhao B, et al. Association between the RAGE G82S polymorphism and Alzheimer’s disease. J Neural Transm (Vienna). 2010;117(1):97–104. DOI:https://doi.org/10.1007/s00702-009-0334-6
- Barnes PJ, Stockley RA. COPD: current therapeutic interventions and future approaches. Eur Resp J. 2005;25(6):1084–1106. DOI:https://doi.org/10.1183/09031936.05.00139104
- Gross NJ, Barnes PJ. New therapies for asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2017;195(2):159–166. DOI:https://doi.org/10.1164/rccm.201610-2074PP
- Barnes PJ, Bonini S, Seeger W, et al. Barriers to new drug development in respiratory disease. Eur Respir J. 2015;45(5):1197–1207.
- Wright JL, Churg A. Animal models of cigarette smoke induced chronic obstructive pulmonary disease. Expert Rev Respir Med. 2010;4(6):723–734. DOI:https://doi.org/10.1586/ers.10.68
- Jones B, Donovan C, Liu G, et al. Animal models of COPD: what do they tell us? Respirology. 2017;22(1):21–32. DOI:https://doi.org/10.1111/resp.12908
- Fricker M, Deane A, Hansbro PM. Animal models of chronic obstructive pulmonary disease. Expert Opin Drug Discov. 2014;9(6):629–645. DOI:https://doi.org/10.1517/17460441.2014.909805
- Stevenson CS, Birrell MA. Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance. Pharmacol Ther. 2011;130(2):93–105.
- Wright JL, Cosio M, Churg A. Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2008;295(1):L1–L15. DOI:https://doi.org/10.1152/ajplung.90200.2008
- Harrell CR, Miloradovic D, Sadikot R, et al. Molecular and cellular mechanisms responsible for beneficial effects of mesenchymal stem cell-derived product “exo-d-mapps” in attenuation of chronic airway Inflammation. Anal Cell Pathol (Amst). 2020;2020:3153891. Article ID 3153891. DOI:https://doi.org/10.1155/2020/3153891