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Original

Functional Characterization of Integrin α6β4 Adhesion Interactions Using Soluble Integrin Constructs Reveals the Involvement of Different Functional Domains in the β4 Subunit

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Pages 317-331 | Received 26 Jun 2008, Published online: 11 Jul 2009

References

  • Akiyama SK, Yamada SS, Chen WT, Yamada KM. Analysis of fibronectin receptor function with monoclonal antibodies: Roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J Cell Biol. 1989; 109: 863–875
  • Bertotti A, Comiglio P, Trusolino L. Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis. Cancer Res 2005; 65: 10674–10679
  • Bertotti A, Comiglio P, Trusolino L. Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. J Cell Biol 2006; 175: 993–1003
  • Briesewitz R, Kern A, Marcantonio EE. Ligand-dependent and -independent integrin focal contact localization: The role of the alpha chain cytoplasmic domain. Mol Biol Cell 1993; 4: 593–604
  • Browning JL, Sizing ID, Lawton P, Bourdon PR, Rennert PD, Majeau GR, Ambrose CM, Hession C, Miatkowski K, Griffiths DA, Ngam-ek A, Meier W, Benjamin CD, Hochman PS. Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes. J Immunol 1997; 159: 3288–3298
  • Chen LL, Whitty A, Lobb RR, Adams SP, Pepinsky RB. Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand. J Biol Chem 1999; 274: 13167–13175
  • Chung J, Bachelder RE, Lipscomb EA, Shaw LM, Mercurio AM. Integrin (alpha6beta4) regulation of eIF-4E activity and VEGF translation: A survival mechanism for carcinoma cells. J Cell Biol 2002; 158: 165–174
  • Clark K, Newham P, Burrows L, Askari JA, Humphries MJ. Production of recombinant soluble human integrin alpha4beta1. FEBS Lett 2000; 471: 182–186
  • Cruz-Monserrate Z, Qiu S, Evers BM, O'Connor KL. Upregulation and redistribution of integrin alpha6beta4 expression occurs at an early stage in pancreatic adenocarcinoma progression. Mod Pathol 2007; 20: 656–667
  • Dajee M, Lazarov M, Zhang JY, Cai T, Green CL, Russell AJ, Marinkovich MP, Tao S, Lin Q, Kubo Y, Khavari PA. NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 2003; 421: 639–643
  • De Melker AA, Sonnenberg A. The role of the cytoplasmic domain of alpha6 integrin in the assembly and function of alpha6beta1 and alpha6beta4. Eur J Biochem 1996; 241: 254–264
  • Denda S, Muller U, Crossin KL, Erickson HP, Reichardt LF. Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha8beta1 receptor interactions with tenascin: Murine alpha8beta1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. Biochemistry 1998; 37: 5464–5474
  • Dransfield I, Cabanas C, Craig A, Hogg N. Divalent cation regulation of the function of the leukocyte integrin LFA-1. J Cell Biol 1992; 116: 219–226
  • Eble JA, Wucherpfennig KW, Gauthier L, Dersch P, Krukonis E, Isberg RR, Hemler ME. Recombinant soluble human alpha3beta1 integrin: Purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Biochemistry 1998; 37: 10945–10955
  • Folgiero V, Bachelder RE, Bon G, Sacchi A, Falcioni R, Mercurio AM. The alpha6beta4 integrin can regulate ErbB-3 expression: Implications for alpha6beta4 signaling and function. Cancer Res 2007; 67: 1645–1652
  • Gambaletta D, Marchetti A, Benedetti L, Mercurio AM, Sacchi A, Falcioni R. Cooperative signaling between alpha6beta4 integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion. J Biol Chem 2000; 275: 10604–10610
  • Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999; 285: 1028–1032
  • Grashoff C, Thievessen I, Lorenz K, Ussar S, Fassler R. Integrin-linked kinase: Integrin's mysterious partner. Curr Opin Cell Biol 2004; 16: 565–571
  • Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004; 5: 816–826
  • Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Giancotti FG. Beta4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 2006; 126: 489–502
  • Hogervorst F, Kuikman I, Von dem Borne AE, Sonnenberg A. Cloning and sequence analysis of beta4 cDNA: An integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J 1990; 9: 765–770
  • Hynes RO. Integrins: Bidirectional, allosteric signaling machines. Cell 2002; 110: 673–687
  • Juliano RL, Haskill S. Signal transduction from the extracellular matrix. J Cell Biol 1993; 120: 577–585
  • Kennel SJ, Godfrey V, Chang LY, Lankford TK, Foote LJ, Makkinje A. The beta4 subunit of the integrin family is displayed on a restricted subset of endothelium in mice. J Cell Sci 1992; 101: 145–150
  • Lee EC, Lotz MM, Steele GD, Jr, Mercurio AM. The integrin alpha 6 beta 4 is a laminin receptor. J Cell Biol 1992; 117: 671–678
  • Lipscomb EA, Simpson KJ, Lyle SR, Ring JE, Dugan AS, Mercurio AM. The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Res 2005; 65: 10970–10976
  • Lu CF, Springer TA. The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1. J Immunol 1997; 159: 268–278
  • Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG. Signal transduction by the alpha6beta4 integrin: Distinct beta4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J 1995; 14: 4470–4481
  • Mehta RJ, Diefenbach B, Brown A, Cullen E, Jonczyk A, Gussow D, Luckenbach GA, Goodman SL. Transmembrane-truncated alphavbeta3 integrin retains high affinity for ligand binding: Evidence for an ‘inside-out’ suppressor?. Biochem J 1998; 330: 861–869
  • Merdek KD, Yang X, Taglienti CA, Shaw LM, Mercurio AM. Intrinsic signaling functions of the beta4 integrin intracellular domain. J Biol Chem 2007; 282: 30322–30330
  • Natali PG, Nicotra MR, Bigotti A, De Martino C. Localization of the alpha6 and beta4 integrin subunits in normal human non-lymphoid tissues. J Cell Sci 1992; 103: 1243–1247
  • Niessen CM, Cremona O, Daams H, Ferraresi S, Sonnenberg A, Marchisio PC. Expression of the integrin alpha6beta4 in peripheral nerves: Localization in Schwann and perineural cells and different variants of the beta4 subunit. J Cell Sci 1994; 107: 543–552
  • Peterson JA, Visentin GP, Newman PJ, Aster RH. A recombinant soluble form of the integrin alphaIIbbeta3 (GPIIb-IIIa) assumes an active, ligand-binding conformation and is recognized by GPIIb-IIIa-specific monoclonal, allo-, auto-, and drug-dependent platelet antibodies. Blood 1998; 92: 2053–2063
  • Rabinovitz I, Toker A, Mercurio AM. Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol 1999; 146: 1147–1160
  • Rabinovitz I, Tsomo L, Mercurio AM. Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol Cell Biol 2004; 24: 4351–4360
  • Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP. Alpha6beta4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha3beta1 integrin. J Cell Sci 2003; 116: 3543–3556
  • Schaapveld RQ, Borradori L, Geerts D, van Leusden MR, Kuikman I, Nievers MG, Niessen CM, Steenbergen RD, Snijders PJ, Sonnenberg A. Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180. J Cell Biol 1998; 142: 271–284
  • Shaw LM. Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion. Mol Cell Biol 2001; 21: 5082–5093
  • Sonnenberg A, Linders CJ, Daams JH, Kennel SJ. The alpha6beta1 (VLA-6) and alpha6beta 4 protein complexes: Tissue distribution and biochemical properties. J Cell Sci 1990; 96: 207–217
  • Spinardi L, Ren YL, Sanders R, Giancotti FG. The beta 4 subunit cytoplasmic domain mediates the interaction of alpha6beta4 integrin with the cytoskeleton of hemidesmosomes. Mol Biol Cell 1993; 4: 871–884
  • Staatz WD, Peters KJ, Santoro SA. Divalent cation-dependent structure in the platelet membrane glycoprotein Ia-IIa (VLA-2) complex. Biochem Biophys Res Commun 1990; 168: 107–114
  • Staatz WD, Rajpara SM, Wayner EA, Carter WG, Santoro SA. The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg+ + -dependent adhesion of platelets to collagen. J Cell Biol 1989; 108: 1917–1924
  • Stephens PE, Ortlepp S, Perkins VC, Robinson MK, Kirby H. Expression of a soluble functional form of the integrin alpha4beta1 in mammalian cells. Cell Adhes Commun 2000; 7: 377–390
  • Suzuki S, Naitoh Y. Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells. EMBO J 1990; 9: 757–763
  • Tagliabue E, Ghirelli C, Squicciarini P, Aiello P, Colnaghi MI, Menard S. Prognostic value of alpha6beta4 integrin expression in breast carcinomas is affected by laminin production from tumor cells. Clin Cancer Res 1998; 4: 407–410
  • Urlaub G, Chasin LA. Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity. Proc Natl Acad Sci U S A 1980; 77: 4216–4220
  • Watt FM. Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J 2002; 21: 3919–3926
  • Wilhelmsen K, Litjens SH, Sonnenberg A. Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis. Mol Cell Biol 2006; 26: 2877–2886
  • Yoon SO, Shin S, Lipscomb EA. A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: The alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling. Cancer Res 2006; 66: 2732–2739

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