REFERENCES
- Bruckner , J. V. and Warren , D. A. 2001 . “ Toxic effects of solvents and vapors ” . In Casarett and Doull's Toxicology: The Basic Science of Poisons , Edited by: Klaassen , C. D. 869 – 916 . New York : McGraw-Hill .
- Caprino , L. and Togna , G. I. 1998 . Potential health effects of gasoline and its constituents: A review of current literature (1990–1997) on toxicological data . Environ. Health Perspect. , 106 : 115 – 125 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9452413 http://www4.infotrieve.com/newmedline/detail.asp?NameID=9452413&Session=&searchQuery=Environ%2E+Health+Perspect%2E%5BJournal+Name%5D+AND+106%5BVolume%5D+AND+115%5BPage+Number%5D+AND+1998%5BPublication+Date%5D+AND+Caprino%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0091-6765&vol=106&iss=&firstpage=115
- Dobrev , I. D. , Andersen , M. E. and Yang , R. S. 2002 . In silico toxicology: Simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane . Environ. Health Perspect. , 110 : 1031 – 1039 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12361929 http://www4.infotrieve.com/newmedline/detail.asp?NameID=12361929&Session=&searchQuery=Environ%2E+Health+Perspect%2E%5BJournal+Name%5D+AND+110%5BVolume%5D+AND+1031%5BPage+Number%5D+AND+2002%5BPublication+Date%5D+AND+Dobrev%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0091-6765&vol=110&iss=&firstpage=1031
- Guengerich , F. P. and Shimada , T. 1991 . Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes . Chem. Res. Toxicol. , 4 : 391 – 407 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1912325 http://www4.infotrieve.com/newmedline/detail.asp?NameID=1912325&Session=&searchQuery=Chem%2E+Res%2E+Toxicol%2E%5BJournal+Name%5D+AND+4%5BVolume%5D+AND+391%5BPage+Number%5D+AND+1991%5BPublication+Date%5D+AND+Guengerich%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0893-228X&vol=4&iss=&firstpage=391
- Lof , A. and Johanson , G. 1998 . Toxicokinetics of organic solvents: A review of modifying factors . Crit. Rev. Toxicol. , 28 : 571 – 650 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9861527 http://www4.infotrieve.com/newmedline/detail.asp?NameID=9861527&Session=&searchQuery=Crit%2E+Rev%2E+Toxicol%2E%5BJournal+Name%5D+AND+28%5BVolume%5D+AND+571%5BPage+Number%5D+AND+1998%5BPublication+Date%5D+AND+Lof%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=1040-8444&vol=28&iss=&firstpage=571
- Purcell , K. J. , Cason , G. H. , Gargas , M. L. , Andersen , M. E. and Travis , C. C. 1990 . In vivo metabolic interactions of benzene and toluene . Toxicol. Lett. , 52 : 141 – 152 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2377998 http://www4.infotrieve.com/newmedline/detail.asp?NameID=2377998&Session=&searchQuery=Toxicol%2E+Lett%2E%5BJournal+Name%5D+AND+52%5BVolume%5D+AND+141%5BPage+Number%5D+AND+1990%5BPublication+Date%5D+AND+Purcell%5BAuthor+Name%5D&count=1 http://dx.doi.org/10.1016%2F0378-4274%2890%2990148-F http://www.csa.com/htbin/linkabst.cgi?issn=0378-4274&vol=52&iss=&firstpage=141
- Tardif , R. , Lapare , S. , Charest-Tardif , G. , Brodeur , J. and Krishnan , K. 1995 . Physiologically based pharmacokinetic modeling of a mixture of toluene and xylene in humans . Risk Anal. , 15 : 335 – 342 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7604167 http://www4.infotrieve.com/newmedline/detail.asp?NameID=7604167&Session=&searchQuery=Risk+Anal%2E%5BJournal+Name%5D+AND+15%5BVolume%5D+AND+335%5BPage+Number%5D+AND+1995%5BPublication+Date%5D+AND+Tardif%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0272-4332&vol=15&iss=&firstpage=335
- Imbriani , M. and Ghittori , S. 1997 . Effects of ethanol on toluene metabolism in man . G. Ital. Med. Lav. Ergon. , 19 : 177 – 181 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9775012 http://www4.infotrieve.com/newmedline/detail.asp?NameID=9775012&Session=&searchQuery=G%2E+Ital%2E+Med%2E+Lav%2E+Ergon%2E%5BJournal+Name%5D+AND+19%5BVolume%5D+AND+177%5BPage+Number%5D+AND+1997%5BPublication+Date%5D+AND+Imbriani%5BAuthor+Name%5D&count=1
- Tardif , R. , Charest-Tardif , G. , Brodeur , J. and Krishnan , K. 1997 . Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans . Toxicol. Appl. Pharmacol. , 144 : 120 – 134 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9169076 http://www4.infotrieve.com/newmedline/detail.asp?NameID=9169076&Session=&searchQuery=Toxicol%2E+Appl%2E+Pharmacol%2E%5BJournal+Name%5D+AND+144%5BVolume%5D+AND+120%5BPage+Number%5D+AND+1997%5BPublication+Date%5D+AND+Tardif%5BAuthor+Name%5D&count=1 http://dx.doi.org/10.1006%2Ftaap.1996.8096 http://www.csa.com/htbin/linkabst.cgi?issn=0041-008X&vol=144&iss=&firstpage=120
- Haddad , S. , Tardif , R. , Charest-Tardif , G. and Krishnan , K. 1999 . Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons . Toxicol. Appl. Pharmacol. , 161 : 249 – 257 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10620482 http://www4.infotrieve.com/newmedline/detail.asp?NameID=10620482&Session=&searchQuery=Toxicol%2E+Appl%2E+Pharmacol%2E%5BJournal+Name%5D+AND+161%5BVolume%5D+AND+249%5BPage+Number%5D+AND+1999%5BPublication+Date%5D+AND+Haddad%5BAuthor+Name%5D&count=1 http://dx.doi.org/10.1006%2Ftaap.1999.8803 http://www.csa.com/htbin/linkabst.cgi?issn=0041-008X&vol=161&iss=&firstpage=249
- Thrall , K. D. and Poet , T. S. 2000 . Determination of biokinetic interactions in chemical mixtures using real-time breath analysis and physiologically based pharmacokinetic modeling . J. Toxicol. Environ. Health , 59 : 653 – 670 . http://dx.doi.org/10.1080%2F009841000156646
- Barton , H. A. , Creech , J. R. , Godin , C. S. , Randall , G. M. and Seckel , C. S. 1995 . Chloroethylene mixtures: Pharmacokinetic modeling and in-vitro metabolism of vinyl-chloride, trichloroethylene, and trans-1,2- dichloroethylene in rat . Toxicol. Appl. Pharmacol. , 130 : 237 – 247 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7871537 http://www4.infotrieve.com/newmedline/detail.asp?NameID=7871537&Session=&searchQuery=Toxicol%2E+Appl%2E+Pharmacol%2E%5BJournal+Name%5D+AND+130%5BVolume%5D+AND+237%5BPage+Number%5D+AND+1995%5BPublication+Date%5D+AND+Barton%5BAuthor+Name%5D&count=1 http://dx.doi.org/10.1006%2Ftaap.1995.1029 http://www.csa.com/htbin/linkabst.cgi?issn=0041-008X&vol=130&iss=&firstpage=237
- El Masri , H. A. , Tessari , J. D. and Yang , R. S. H. 1996 . Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethylene: Utilization of a PBPK model . Arch. Toxicol , 70 : 527 – 539 . http://dx.doi.org/10.1007%2Fs002040050310
- Andersen , M. E. , Gargas , M. L. , Clewell , H. J. and Severyn , K. M. 1987 . Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods . Toxicol. Appl. Pharmacol. , 89 : 149 – 157 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3603553 http://www4.infotrieve.com/newmedline/detail.asp?NameID=3603553&Session=&searchQuery=Toxicol%2E+Appl%2E+Pharmacol%2E%5BJournal+Name%5D+AND+89%5BVolume%5D+AND+149%5BPage+Number%5D+AND+1987%5BPublication+Date%5D+AND+Andersen%5BAuthor+Name%5D&count=1 http://dx.doi.org/10.1016%2F0041-008X%2887%2990035-4 http://www.csa.com/htbin/linkabst.cgi?issn=0041-008X&vol=89&iss=&firstpage=149
- Pelekis , M. and Krishnan , K. 1997 . Assessing the relevance of rodent data on chemical interactions for health risk assessment purposes: a case study with dichloromethane-toluene mixture . Regul. Toxicol. Pharmacol. , 25 : 79 – 86 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9056503 http://www4.infotrieve.com/newmedline/detail.asp?NameID=9056503&Session=&searchQuery=Regul%2E+Toxicol%2E+Pharmacol%2E%5BJournal+Name%5D+AND+25%5BVolume%5D+AND+79%5BPage+Number%5D+AND+1997%5BPublication+Date%5D+AND+Pelekis%5BAuthor+Name%5D&count=1 http://dx.doi.org/10.1006%2Frtph.1996.1075 http://www.csa.com/htbin/linkabst.cgi?issn=0273-2300&vol=25&iss=&firstpage=79
- Occupational Safety and Health Administration (OSHA) . " “Air Contaminants,” ." Code of Federal Regulations, Title 29, Part 1910.1000 , 2004
- American Conference of Governmental Industrial Hygienists (ACGIH®) . 2003 . Documentation of the TLVs and BEIs with Other Worldwide Occupational Exposure Values , Cincinnati , Ohio : ACGIH .
- Klonne , D. R. and Miller , G. C. 1997 . “ Occupational exposure limits ” . In The Occupational Environment—Its Evaluation and Control , 23 Fairfax , Va. : AIHA Press . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=&iss=&firstpage=23
- Mumtaz , M. M. and Hertzberg , R. C. 1993 . “ The status of interactions data in risk assessment of chemical mixtures ” . In Hazard Assessment of Chemicals , Edited by: Saxena , J. 47 – 79 . Washington , D.C. : Taylor and Francis .
- United States Environmental Protection Agency (USEPA) . 2000 . Supplementary guidance for conducting health risk assessment of chemical mixtures (EPA/630/R-00/002) , Washington , D.C. : USEPA .
- Filser , J. G. , Johanson , G. , Kessler , W. , Kreuzer , P. E. , Stei , P. , Baur , C. and Csanady , G. A. 1993 . “ A pharmacokinetic model to describe toxicokinetic interactions between 1,3-butadiene and styrene in rats: Predictions for human exposure ” . In Butadiene and Styrene: Assessment of Health Hazards , IARC Scientific Publication No. 127 Edited by: Sorsa , M. , Peltonen , K. , Vainio , H. and Hemminki , K. 65 – 78 . Lyon , , France : International Agency for Research on Cancer .
- Andersen , M. E. , Clewell , H. J. , Gargas , M. L. , Smith , F. A. and Reitz , R. A. 1987 . Physiologically based pharmacokinetics and the risk assessment process for methylene chloride . Toxicol. Appl. Pharmacol. , 87 : 185 – 205 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3824380 http://www4.infotrieve.com/newmedline/detail.asp?NameID=3824380&Session=&searchQuery=Toxicol%2E+Appl%2E+Pharmacol%2E%5BJournal+Name%5D+AND+87%5BVolume%5D+AND+185%5BPage+Number%5D+AND+1987%5BPublication+Date%5D+AND+Andersen%5BAuthor+Name%5D&count=1 http://dx.doi.org/10.1016%2F0041-008X%2887%2990281-X http://www.csa.com/htbin/linkabst.cgi?issn=0041-008X&vol=87&iss=&firstpage=185
- Bois , F. Y. , Smith , M. T. and Spear , R. C. 1991 . Mechanisms of benzene carcinogenesis: Application of a physiological model of benzene pharmacokinetics and metabolism . Mechanisms of benzene carcinogenesis: Application of a physiological model of benzene pharmacokinetics and metabolism , 56 : 283 – 298 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=56&iss=&firstpage=283
- United States Environmental Protection Agency (USEPA) . 1996 . Proposed guidelines for carcinogen risk assessment (EPA/600/P-92/003C) , Washington , D.C. : USEPA .
- Haddad , S. , Tardif , R. , Viau , C. and Krishnan , K. 1999 . A modeling approach to account for toxicokinetic interactions in the calculation of biological hazard index for chemical mixtures . Toxicol. Lett. , 108 : 303 – 308 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=108&iss=&firstpage=303
- Ogata , M. , Fiserova-Bergerova , V. and Droz , P. O. 1993 . Occupational exposures to mixtures of industrial chemicals . Occupational exposures to mixtures of industrial chemicals , 8 : 609 – 617 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=8&iss=&firstpage=609
- Haddad , S. , Beliveau , M. , Tardif , R. and Krishnan , K. 2001 . A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures . A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures , 63 : 125 – 131 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=63&iss=&firstpage=125
- Lapare , S. , Tardif , R. and Brodeur , J. 1993 . Effect of various exposure scenarios on the biological monitoring of organic solvents in alveolar air . I. Toluene and m-xyleneand m-xylene , 64 : 569 – 580 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=64&iss=&firstpage=569
- Pezzagno , G. , Imbriani , M. , Ghittori , S. and Capodaglio , E. 1988 . Urinary concentration, environmental concentration, and respiratory uptake of some solvents: Effect of the work load . concentration, environmental concentration, and respiratory uptake of some solvents: Effect of the work load , 49 : 546 – 552 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=49&iss=&firstpage=546
- Baelum , J. 1990 . Toluene in alveolar air during controlled exposure to constant and to varying concentrations . Toluene in alveolar air during controlled exposure to constant and to varying concentrations , 62 : 59 – 64 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=62&iss=&firstpage=59
- Andersen , I. , Lundqvist , G. R. , Molhave , L. , Pedersen , O. F. , Proctor , D. F. , Vaeth , M. and Wyon , D. P. 1983 . Human response to controlled levels of toluene in six-hour exposures . Human response to controlled levels of toluene in six-hour exposures , 9 : 405 – 418 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=9&iss=&firstpage=405
- Olson , B. A. , Gamberale , F. and Iregren , A. 1985 . Coexposure to toluene and p-xylene in man: Central nervous functions . Coexposure to toluene and p-xylene in man: Central nervous functions , 42 : 17 – 122 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=42&iss=&firstpage=17
- Hastings , L. , Cooper , G. P. and Burg , W. 1986 . “ Human sensory response to selected petroleum hydrocarbons ” . In Advances in Modern Environmental Toxicology , Edited by: MacFarland , H. N. Vol. 6 , 255 – 270 . Princeton : Princeton Scientific . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=6&iss=&firstpage=255
- Agency for Toxic Substances and Disease Registry (ATSDR) . 2001 . Interaction profile for benzene, toluene, ethylbenzene, and xylenes (BTEX) , Atlanta , , U.S. : Department of Health and Human Services, Public Health Service .
- Kumagai , S. and Matsunaga , I. 1995 . Physiologically based pharmacokinetic model for acetone . Physiologically based pharmacokinetic model for acetone , 52 : 44 – 352 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=52&iss=&firstpage=44
- Engstrom , K. , Riihimaki , V. and Laine , A. 1984 . Urinary disposition of ethylbenzene and m-xylene in man following separate and combined exposure . Urinary disposition of ethylbenzene and m-xylene in man following separate and combined exposure , 54 : 55 – 363 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=54&iss=&firstpage=55
- Tardif , R. , Lapare , S. , Krishnan , K. and Brodeur , J. 1993 . A descriptive and mechanistic study of the interaction between toluene and xylene in humans . descriptive and mechanistic study of the interaction between toluene and xylene in humans , 65 : 135 – 137 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=65&iss=&firstpage=135
- Mortensen , B. , Osvoll , P. O. , Woldbaek , T. , Zahlsen , K. , Eide , I. and Nilsen , O. G. 1998 . In vitro screening for metabolic interactions among frequently occurring binary mixtures of volatile organic chemicals in Norwegian occupational atmosphere . vitro screening for metabolic interactions among frequently occurring binary mixtures of volatile organic chemicals in Norwegian occupational atmosphere , 83 : 49 – 56 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=83&iss=&firstpage=49
- Office of Environmental Health Hazard Assessment, Pesticide and Environmental Toxicology Section, California Environmental Protection Agency (OEHHA) . 1997 . Public Health Goal for Xylene in Drinking Water , Sacramento , Calif. : OEHHA .
- Dennison , J. E. , Andersen , M. E. and Yang , R. S. 2003 . Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach . Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach , 15 : 961 – 986 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=15&iss=&firstpage=961
- Johanson , G. and Naslund , P. H. 1988 . Spreadsheet programming a new approach in physiologically based modeling of solvent toxicokinetics . Spreadsheet programming a new approach in physiologically based modeling of solvent toxicokinetics , 41 : 115 – 127 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=41&iss=&firstpage=115
- Haddad , S. , Pelekis , M. and Krishnan , K. 1996 . A methodology for solving physiologically based pharmacokinetic models without the use of simulation softwares . A methodology for solving physiologically based pharmacokinetic models without the use of simulation softwares , 85 : 113 – 126 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=85&iss=&firstpage=113
- Nihlen , A. and Johanson , G. 1999 . Physiologically based toxicokinetic modeling of inhaled ethyl tertiary-butyl ether in humans . Physiologically based toxicokinetic modeling of inhaled ethyl tertiary-butyl ether in humans , 51 : 184 – 194 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=51&iss=&firstpage=184
- Guengerich , F. P. , Kim , D. H. and Iwasaki , M. 1991 . Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects . Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects , 4 : 168 – 179 . http://www.csa.com/htbin/linkabst.cgi?issn=&vol=4&iss=&firstpage=168
- Paustenbach , D. 2000 . “ Pharmacokinetics and unusual work schedules ” . In VI: Law, Regulation, and Management , Patty's Industrial Hygiene, Vol. 3 Edited by: Harris , R. L. New York : John Wiley & Sons, Inc. .
- Andersen , M. E. and Dennison , J. E. 2002 . Toxicokinetic models: Where we've been and where we need to go! . Hum. Ecol. Risk Assess. , 8 : 1375 – 1395 .
- Smith , T. J. 2002 . Issues in exposure and dose assessment for epidemiology and risk assessment . Issues in exposure and dose assessment for epidemiology and risk assessment , 8 : 1267 – 1294 .
- Andersen , M. E. and Dennison , J. E. 2004 . Mechanistic approaches for mixture risk assessments—Present capabilities with simple mixtures and future directions . Mechanistic approaches for mixture risk assessments—Present capabilities with simple mixtures and future directions , 16 : 1 – 11 .