Estimated dermal exposure to nebulized pharmaceuticals for a simulated home healthcare worker scenario

References

• American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE). 2017. Standard 170-2017: Ventilation of health care facilities (ANSI/ASHRAE/ASHE Approved). ASHRAE Standards and Guidelines, www.ashrae.org.
   Google Scholar
• Ari A, Fink JB, Pilbeam SP. 2016. Secondhand aerosol exposure during mechanical ventilation with and without expiratory filters. A in-vitro study. Ind J Respir Care. 5:677–682.
   Google Scholar
• Barrett KE, Barman S, Boitano S, Brooks H. 2012. Ganong’s review of medical physiology. 24th Ed. New York, NY: McGraw-Hill Education.
   Google Scholar
• Bauer A, McGlynn P, Bovet LL, Mims PL, Curry LA, Hanrahan JP. 2009. Output and aerosol properties of 5 nebulizer/compressor systems with arformoterol inhalation solution. Respir Care. 54(10):1342–1347.
   PubMed Web of Science ®Google Scholar
• Beltrani VS. 2003. Occupational dermatoses. Curr Opin Allergy Clin Immunol. 3(2):115–123. doi:10.1097/00130832-200304000-00005
   PubMedGoogle Scholar
• Center for Disease Control and Prevention (CDC). 2019. Glossary. Oral health home. Washington DC. [accessed 2019 Feb 7]. www.cdc.gov/oralhealth/infectioncontrol/glossary.htm.
   Google Scholar
• Connor TH, Anderson RW, Sessink PJ, Broadfield L, Power LA. 1999. Surface contamination with antineoplastic agents in six cancer treatment centers in Canada and the United States. Am J Health Syst Pharm. 56(14):1427–1432. doi:10.1093/ajhp/56.14.1427
   PubMed Web of Science ®Google Scholar
• Connor TH, Anderson RW, Sessink PJ, Spivey SM. 2002. Effectiveness of a closed-system device in containing surface contamination with cyclophosphamide and ifosfamide in an I.V. admixture area. Am J Health Syst Pharm. 59(1):68–72. doi:10.1093/ajhp/59.1.68
   PubMed Web of Science ®Google Scholar
• Darquenne C, Prisk GK. 2004. Aerosol deposition in the human respiratory tract breathing air and 80:20 heliox. J Aerosol Med. 17(3):278–285. doi:10.1089/jam.2004.17.278
   PubMedGoogle Scholar
• Dennis JH. 1998. A review of issues relating to nebulizer standards. J Aerosol Med. 11(Suppl 1):S73–S79. PMID: 10180736.
   PubMedGoogle Scholar
• Denyer J, Dyche A, Nikander K. 1997. Breathing patterns in adult patients (abstract). J Aerosol Med. 10(1):99.
   Google Scholar
• Diepgen TL, Coenrads PJ. 2000. The epidemiology of occupational contact dermatitis. In: Kanerva L, Elsner P, Wahlberg JE, Maibach HI, editors. Handbook of occupational dermatology. Heidelberg, Germany: Springer-Verlag; p. 1.
   Google Scholar
• Doepke A, Kuhlmann J, Guo X, Voorhees RT, Heineman WR. 2013. A system for characterizing Mg corrosion in aqueous solutions using electrochemical sensors and impedance spectroscopy. Acta Biomaterialia. 9(11):9211–9219. doi:10.1016/j.actbio.2013.07.011
   PubMed Web of Science ®Google Scholar
• Elmashae Y, Yermakov M, Frank E, Benjamin M, Maier A, Newman N, Reponen T, Grinshpun SA. 2019. Exposure of home-attending healthcare workers to aerosolized medications (simulation study). J Aerosol Sci. 133:49–55. doi:10.1016/j.jaerosci.2019.04.006
   Web of Science ®Google Scholar
• Frank E, Ishau S, Maier A, Reutman S, Reichard JF. 2019. An occupational exposure limit (OEL) approach to protect home healthcare workers exposed to common nebulized drugs. Regul Toxicol Pharmacol. 106:251–261. doi:10.1016/j.yrtph.2019.04.021
   PubMed Web of Science ®Google Scholar
• Hamberg O. 1982. Particle fallout predictions for clean rooms. J Environ Sci. 25:15–20.
   Google Scholar
• Hui DS, Chow BK, Chu LCY, Ng SS, Hall SD, Gin T, Chan MTV. 2009. Exhaled air and aerosolized droplet dispersion during application of a jet nebulizer. Chest. 135(3):648–654. doi:10.1378/chest.08-1998
   PubMed Web of Science ®Google Scholar
• Hui DS, Chow BK, Lo T, Ng SS, Ko FW, Gin T, Chan MTV. 2015. Exhaled air dispersion during non-invasive ventilation via helmets and a total mask. Chest. 147(5):1336–1343. doi:10.1378/chest.14-1934
   PubMed Web of Science ®Google Scholar
• Keegel T, Moyle M, Dharmage S, Frowen K, Nixon R. 2009. The epidemiology of occupational contact dermatitis (1990–2007): A systematic review. Intern J Dermatol. 48(6):571–578. doi:10.1111/j.1365-4632.2009.04004.x
   PubMed Web of Science ®Google Scholar
• Kiffmeyer TK, Kube C, Opiolka S, Schmidt KG, Schöppe G, Sessink PJM. 2002. Vapor pressures, evaporation behaviour and airborne concentrations of hazardous drugs: Implications for occupational safety. Pharmaceut J. 268:331–337.
   Google Scholar
• Lindh WQ, Pooler M, Tamparo C, Dahl BM. 2009. Delmar’s comprehensive medical assisting: Administrative and clinical competencies. 4th Ed. Clifton Park, NY: Cengage Learning, p. 573.
   Google Scholar
• Lund CC, Browder NC. 1944. The estimation of areas of burns. Surg Gynecol Obstet. 79:352–358.
   Google Scholar
• McDevitt JJ, Lees PSJ, McDiarmid MA. 1993. Exposure of hospital pharmacists and nurses to antineoplastic agents. J Occup Med. 35(1):57–60.
   PubMedGoogle Scholar
• McGrath JA, O’Sullivan A, Bennett G, O’Toole C, Joyce M, Byrne MA, MacLoughlin R. 2019. Investigation of the quantity of exhaled aerosols released into the environment during nebulization. Pharmaceutics. 11(2):75. doi:10.3390/pharmaceutics11020075
   Web of Science ®Google Scholar
• McGrath JA, O’Toole C, Bennett G, Joyce M, Byrne MA, MacLoughlin R. 2019. Investigation of fugitive aerosols released into the environment during high-flow therapy. Pharmaceutics. 11(6):254. doi:10.3390/pharmaceutics11060254
   PubMed Web of Science ®Google Scholar
• Micoli G, Turci R, Arpellini M, Minoia C. 2001. Determination of 5-fluorouracil in environmental samples by solid-phase extraction and high-performance liquid chromatography with untraviolet detection. J Chromatogr B. 750(1):25–32. doi:10.1016/S0378-4347(00)00377-7
   PubMedGoogle Scholar
• Minoia C, Turci R, Sottani C, Schiavi A, Perbellini L, Angeleri S, Draicchio F, Apostoli P. 1998. Application of high-performance liquid chromatography/tandem mass spectrometry in the environmental and biological monitoring of healthcare personnel occupationally exposed to cyclophosphamide and ifosfamide. Rapid Commun Mass Spectrom. 12(20):1485–1493. doi:10.1002/(SICI)1097-0231(19981030)12:20<1485::AID-RCM333>3.0.CO;2-N
   PubMed Web of Science ®Google Scholar
• Mosteller RD. 1987. Simplified calculation of body-surface area. N Engl J Med. 317(17):1098. doi:10.1056/NEJM198710223171717
   PubMed Web of Science ®Google Scholar
• National Institute for Occupational Safety and Health (NIOSH). 2004. Preventing Occupational Exposure to Antineoplastic and Other Hazardous Drugs in Health Care Settings. Atlanta (GA) Publication 2004-165.
   Google Scholar
• Occupational Safety and Health Administration (OSHA). 2017. Safety and Health Topics: Home healthcare: Overview. [accessed 2017 Jul 1]. https://www.osha.gov/STLC/homehealthcare.html.
   Google Scholar
• Occupational Safety and Health Administration (OSHA). 2019. Safety and Health Topics: Dermal exposure. Overview. [accessed 2019 Feb 7]. www.osha.gov/STLC/dermalexposure/index.html.
   Google Scholar
• Ollier K, Leppänen M, Wu B, Yermakov M, Newman NC, Reponen T, Grinshpun SA. 2019. Inhalation exposure and respiratory protection of home healthcare workers administering aerosolized medications (simulation study). Aerosol Air Qual Res. 19(5):937–944. doi:10.4209/aaqr.2018.10.0366
   Web of Science ®Google Scholar
• Pethran A, Hauff K, Hessel H, Grimm C-H. 1998. Biological, cytogenetic, and ambient monitoring of exposure to antineoplastic drugs. J Oncol Pharm Practice. 4:57.
   Google Scholar
• Reichman R, Shirazi E, Colliver DG, Pennell KG. 2017. US residential building air exchange rate: New perspectives to improve decision making at vapor intrusion sites. Environ Sci Processes Impacts. 19(2):87–100. doi:10.1039/C6EM00504G
   PubMed Web of Science ®Google Scholar
• Rodríguez-Molinero A, Narvaiza L, Ruiz J, Gálvez-Barrón C. 2013. Normal respiratory rate and peripheral blood oxygen saturation in the elderly population. J Am Geriatr Soc. 61(12):2238–2240. doi:10.1111/jgs.12580
   PubMed Web of Science ®Google Scholar
• Rubino FM, Floridia L, Pietropaolo AM, Tavazzani M, Colombi A. 1999. Measurement of surface contamination by certain antineoplastic drugs using high-performance liquid chromatography: Applications in occupational hygiene investigations in hospital environments. Med Lav. 90(4):572–583.
   PubMedGoogle Scholar
• Saeed H, Mohsen M, Fink JB, Dailey P, Eldin AS, Abdelrahman MM, Elberry AA, Rabea H, Hussein RS, Abdelrahim EA. 2017. Fill volume, humidification and heat effects on aerosol delivery and fugitive emissions during noninvasive ventilation. J Drug Deliv Sci Tech. 39:372–378. doi:10.1016/j.jddst.2017.04.026
   Web of Science ®Google Scholar
• Schmaus G, Schierl R, Funck S. 2002. Monitoring surface contamination by antineoplastic drugs using gas chromatography mass spectrometry and voltammetry. Am J Health Syst Pharm. 59(10):956–961. doi:10.1093/ajhp/59.10.956
   PubMed Web of Science ®Google Scholar
• Sessink PJM, Anzion RBM, Van der Broek PHH, Bos RP. 1992a. Detection of contamination with antineoplastic agents in a hospital pharmacy department. Pharmaceutisch Weekblad Scientific Edition. 14:16–22. doi:10.1007/BF01989220
   PubMedGoogle Scholar
• Sessink PJM, Boer KA, Scheefhals APH, Anzion RBM, Bos RP. 1992b. Occupational exposure to antineoplastic agents at several departments in a hospital: Environmental contamination and excretion of cyclophosphamide and ifosfamide in urine of exposed workers. Int Arch Occup Environ Heath. 64(2):105–112. doi:10.1007/BF00381477
   PubMed Web of Science ®Google Scholar
• Sessink PJM, Bos RP. 1999. Drugs hazardous to healthcare workers: Evaluation of methods for monitoring occupational exposure to cytostatic drugs. Drug Saf. 20(4):347–359. doi:10.2165/00002018-199920040-00004
   PubMed Web of Science ®Google Scholar
• Smaldone GC, Cruz-Rivera M, Nikander K. 1998. In vitro determination of inhaled mass and particle distribution for budesonide nebulizing suspension. J Aerosol Med. 11(2):113–125. doi:10.1089/jam.1998.11.113
   Google Scholar
• Vandenbroucke J, Robays H. 2001. How to protect environment and employees against cytotoxic agents, the UZ Ghent experience. J Oncol Pharm Pract. 6(4):146–152. doi:10.1177/107815520100600403
   Google Scholar
• Wick C, Slawson MH, Jorgenson JA, Tyler LS. 2003. Using a closed-system protective device to reduce personnel exposure to antineoplastic agents. Am J Health Syst Pharm. 60(22):2314–2320. doi:10.1093/ajhp/60.22.2314
   PubMed Web of Science ®Google Scholar