973
Views
0
CrossRef citations to date
0
Altmetric
Research article

Regulation of Interferon-β-Modified Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Proliferation and Apoptosis of Prostate Cancer Cells

, , &
Article: 2285836 | Received 29 May 2023, Accepted 16 Nov 2023, Published online: 30 Nov 2023

References

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–14. doi:10.3322/caac.21660.
  • Culp MB, Soerjomataram I, Efstathiou JA, Bray F, Jemal A. Recent global patterns in prostate cancer incidence and mortality rates. Eur Urol. 2020;77(1):38–52. doi:10.1016/j.eururo.2019.08.005.
  • Schatten H. Brief overview of prostate cancer statistics, grading, diagnosis and treatment strategies. Adv Exp Med Biol. 2018;1095:1–14.
  • Mizuno K, Beltran H. Future directions for precision oncology in prostate cancer. The Prostate. 2022;82(1):S86–S96. doi:10.1002/pros.24354.
  • Desai K, McManus JM, Sharifi N. Hormonal therapy for prostate cancer. Endocr Rev. 2021;42(3):354–73. doi:10.1210/endrev/bnab002.
  • Sekhoacha M, Riet K, Motloung P, Gumenku L, Adegoke A, Mashele S. Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches. Molecules. 2022;27(17):5730. doi:10.3390/molecules27175730.
  • Brown C, McKee C, Bakshi S, Walker K, Hakman E, Halassy S, Svinarich D, Dodds R, Govind CK, Chaudhry GR. Mesenchymal stem cells: cell therapy and regeneration potential. J Tissue Eng Regen Med. 2019;13(9):1738–55. doi:10.1002/term.2914.
  • Lan T, Luo M, Wei X. Mesenchymal stem/stromal cells in cancer therapy. J Hematol Oncol. 2021;14(1):195. doi:10.1186/s13045-021-01208-w.
  • Yin S, Ji C, Wu P, Jin C, Qian H. Human umbilical cord mesenchymal stem cells and exosomes: bioactive ways of tissue injury repair. Am J Transl Res. 2019;11:1230–40.
  • da Costa VR, Araldi RP, Vigerelli H, D’Amelio F, Mendes TB, Gonzaga V, Policiquio B, Colozza-Gama GA, Valverde CW, Kerkis I, et al. Exosomes in the tumor microenvironment: from biology to clinical applications. Cells. 2021;10(10):2617. doi:10.3390/cells10102617.
  • Lorenc T, Klimczyk K, Michalczewska I, Slomka M, Kubiak-Tomaszewska G, Olejarz W. Exosomes in prostate cancer diagnosis, prognosis and therapy. Int J Mol Sci. 2020;21(6):2118. doi:10.3390/ijms21062118.
  • Rezaeian A, Khatami F, Heidari Keshel S, Akbari MR, Mirzaei A, Gholami K, Mohammadi Farsani R, Aghamir SMK. The effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines. Sci Rep. 2022;12(1):20924. doi:10.1038/s41598-022-23204-x.
  • Lazear HM, Schoggins JW, Diamond MS. Shared and distinct functions of type i and type III interferons. Immunity. 2019;50(4):907–23. doi:10.1016/j.immuni.2019.03.025.
  • Nam RK, Benatar T, Amemiya Y, Seth A. MiR-139 Induces an Interferon-beta Response in prostate cancer cells by binding to RIG-1. Cancer Genomics Proteomics. 2021;18(3):197–206. doi:10.21873/cgp.20252.
  • Sica G, Dell’acqua G, Iacopino F, Fattorossi A, Marchetti P, van der Kwast TH, Pavone-Macaluso M, van der Kwast TH. Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon. Urol Res. 1994;22(1):33–38. doi:10.1007/BF00431546.
  • Sano E, Tashiro S, Tsumoto K, Ueda T. Differential effects of IFN-beta on the survival and growth of human vascular smooth muscle and endothelial cells. Biores Open Access. 2015;4(1):1–15. doi:10.1089/biores.2014.0052.
  • Wang GX, Zhan YA, Hu HL, Wang Y, Fu B. Mesenchymal stem cells modified to express interferon-beta inhibit the growth of prostate cancer in a mouse model. J Int Med Res. 2012;40(1):317–27. doi:10.1177/147323001204000132.
  • Jiao Q, Xu W, Guo X, Liu H, Liao B, Zhu X, Chen C, Yang F, Wu L, Xie C, et al. NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells. Sci Prog. 2021;104(4):368504211058036. doi:10.1177/00368504211058036.
  • Zietzer A, Hosen MR, Wang H, Goody PR, Sylvester M, Latz E, Nickenig G, Werner N, Jansen F. The RNA-binding protein hnRNPU regulates the sorting of microRNA-30c-5p into large extracellular vesicles. J Extracell Vesicles. 2020;9(1):1786967. doi:10.1080/20013078.2020.1786967.
  • Zhu F, Chong Lee Shin OLS, Pei G, Hu Z, Yang J, Zhu H, Wang M, Mou J, Sun J, Wang Y, et al. Adipose-derived mesenchymal stem cells employed exosomes to attenuate AKI-CKD transition through tubular epithelial cell dependent Sox9 activation. Oncotarget. 2017;8(41):70707–26. doi:10.18632/oncotarget.19979.
  • Fang S, He T, Jiang J, Li Y, Chen P. Osteogenic effect of tsRNA-10277-Loaded exosome derived from bone mesenchymal stem cells on steroid-induced osteonecrosis of the femoral head. Drug Des Devel Ther. 2020;14:4579–91. doi:10.2147/DDDT.S258024.
  • Han Y, Liu C, Zhang D, Men H, Huo L, Geng Q, Wang S, Gao Y, Zhang W, Zhang Y, et al. Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle. Int J Oncol. 2019;55(3):629–44. doi:10.3892/ijo.2019.4839.
  • Booy S, Hofland L, van Eijck C, van Eijck C. Potentials of interferon therapy in the treatment of pancreatic cancer. J Interferon Cytokine Res. 2015;35(5):327–39. doi:10.1089/jir.2014.0157.
  • Mai CW, Chin KY, Foong LC, Pang KL, Yu B, Shu Y, Chen S, Cheong SK, Chua CW. Modeling prostate cancer: what does it take to build an ideal tumor model? Cancer Lett. 2022;543:215794. doi:10.1016/j.canlet.2022.215794.
  • Abd Wahab NA, Lajis NH, Abas F, Othman I, Naidu R. Mechanism of anti-cancer activity of curcumin on androgen-dependent and androgen-independent prostate cancer. Nutrients. 2020;12(3):679. doi:10.3390/nu12030679.
  • Chen L, Wang L, Zhu L, Xu Z, Liu Y, Li Z, Zhou J, Luo F. Exosomes as drug carriers in anti-cancer therapy. Front Cell Dev Biol. 2022;10:728616. doi:10.3389/fcell.2022.728616.
  • Zhang Y, Zhang Y, Liu Z. Effects of acanthopanax senticosus supplementation on innate immunity and changes of related immune factors in healthy mice. Innate Immun. 2021;27(6):461–69. doi:10.1177/1753425920955200.
  • Chen X, Wang K, Chen S, Chen Y. Effects of mesenchymal stem cells harboring the Interferon-beta gene on A549 lung cancer in nude mice. Pathol Res Pract. 2019;215(3):586–93. doi:10.1016/j.prp.2019.01.013.
  • Tracey L, Streck CJ, Du Z, Williams RF, Pfeffer LM, Nathwani AC, Davidoff AM. NF-kappaB activation mediates resistance to IFN beta in MLL-rearranged acute lymphoblastic leukemia. Leukemia. 2010;24(4):806–12. doi:10.1038/leu.2010.2.
  • He J, Ren W, Wang W, Han W, Jiang L, Zhang D, Guo M. Exosomal targeting and its potential clinical application. Drug Deliv Transl Res. 2022;12(10):2385–402. doi:10.1007/s13346-021-01087-1.
  • Yeo RW, Lai RC, Zhang B, Tan SS, Yin Y, Teh BJ, Lim SK. Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. Adv Drug Deliv Rev. 2013;65(3):336–41. doi:10.1016/j.addr.2012.07.001.
  • Jothimani G, Pathak S, Dutta S, Duttaroy AK, Banerjee A. A comprehensive cancer-associated MicroRNA expression profiling and proteomic analysis of human umbilical cord mesenchymal stem cell-derived exosomes. Tissue Eng Regen Med. 2022;19(5):1013–31. doi:10.1007/s13770-022-00450-8.
  • Chulpanova DS, Gilazieva ZE, Akhmetzyanova ER, Kletukhina SK, Rizvanov AA, Solovyeva VV. Cytochalasin B-induced membrane vesicles from human mesenchymal stem cells overexpressing TRAIL, PTEN and IFN-beta1 can kill carcinoma cancer cells. Tissue Cell. 2021;73:101664. doi:10.1016/j.tice.2021.101664.
  • Gao H, Gong XC, Chen ZD, Xu XS, Zhang Q, Xu XM. Induction of apoptosis in hormone-resistant human prostate cancer PC3 cells by inactivated Sendai virus. Biomed Environ Sci. 2014;27(7):506–14. doi:10.3967/bes2014.082.
  • Yi BR, Hwang KA, Kim YB, Kim SU, Choi KC. Effects of genetically engineered stem cells expressing cytosine deaminase and interferon-beta or carboxyl esterase on the growth of LNCaP rrostate cancer cells. Int J Mol Sci. 2012;13(10):12519–32. doi:10.3390/ijms131012519.
  • Alblewi FF, Okasha RM, Eskandrani AA, Afifi TH, Mohamed HM, Halawa AH, Fouda AM, Al-Dies AM, Mora A, El-Agrody AM. Design and synthesis of novel heterocyclic-based 4H-benzo[h]chromene moieties: targeting antitumor caspase 3/7 activities and cell cycle analysis. Molecules. 2019;24(6):1060. doi:10.3390/molecules24061060.
  • Moirangthem DS, Laishram S, Borah JC, Kalita MC, Talukdar NC. Cephalotaxus griffithii Hook.F. needle extract induces cell cycle arrest, apoptosis and suppression of hTERT and hTR expression on human breast cancer cells. BMC Complement Altern Med. 2014;14(1):305. doi:10.1186/1472-6882-14-305.
  • Kotawong K, Chaijaroenkul W, Roytrakul S, Phaonakrop N, Na-Bangchang K. Screening of molecular targets of action of atractylodin in cholangiocarcinoma by applying proteomic and metabolomic approaches. Metabolites. 2019;9(11):260. doi:10.3390/metabo9110260.
  • Ahn J, Lee H, Seo K, Kang S, Ra J, Youn H, Rutteman GR. Anti-tumor effect of adipose tissue derived-mesenchymal stem cells expressing interferon-β and treatment with cisplatin in a xenograft mouse model for canine melanoma. PLoS One. 2013;8(9):e74897. doi:10.1371/journal.pone.0074897.
  • Dicitore A, Grassi ES, Borghi MO, Gelmini G, Cantone MC, Gaudenzi G, Persani L, Caraglia M, Vitale G. Antitumor activity of interferon-beta1a in hormone refractory prostate cancer with neuroendocrine differentiation. J Endocrinol Invest. 2017;40(7):761–70. doi:10.1007/s40618-017-0631-0.
  • Shi X, Sun J, Li H, Lin H, Xie W, Li J, Tan W. Antitumor efficacy of interferon-gamma-modified exosomal vaccine in prostate cancer. The Prostate. 2020;80(11):811–23. doi:10.1002/pros.23996.
  • Deng H, Sun C, Sun Y, Li H, Yang L, Wu D, Gao Q, Jiang X. Lipid, protein, and MicroRNA composition within mesenchymal stem cell-derived exosomes. Cell Reprogram. 2018;20(3):178–86. doi:10.1089/cell.2017.0047.
  • Toh WS, Lai RC, Zhang B, Lim SK. MSC exosome works through a protein-based mechanism of action. Biochem Soc Trans. 2018;46(4):843–53. doi:10.1042/BST20180079.
  • Chen J, Li Z, Yue C, Ma J, Cao L, Lin J, Zhu D, An R, Lai J, Guo Y, et al. Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis. Apoptosis. 2023;28(3–4):549–65. doi:10.1007/s10495-022-01798-x.
  • Ling MY, Yang XC, Yu N, Song YP, Zheng YJ, Tang CM, Ding WJ, Sun Y, Yan R, Wang SP, et al. Exosomes from human umbilical cord mesenchymal stem cells protect aortas in Db/db mice characterized by combination of metabolomics and proteomics. Arch Biochem Biophys. 2022;731:109430. doi:10.1016/j.abb.2022.109430.
  • Wu X, Zeng Z, Peng K, Ren D, Zhang L. Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis. Tissue Cell. 2023;82:102078. doi:10.1016/j.tice.2023.102078.