References
- Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem. 1996; 271: 8144-51; PMID:8626503; http://dx.doi.org/10.1074/jbc.271.14.8144
- Levine TD, Gao F, King PH, Andrews LG, Keene JD. Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. Mol Cell Biol 1993; 13: 3494-504; PMID:8497264
- Wang W, Caldwell MC, Lin S, Furneaux H, Gorospe M. HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J 2000; 19: 2340-50; PMID:10811625; http://dx.doi.org/10.1093/emboj/19.10.2340
- Wang W, Yang X, Cristofalo VJ, Holbrook NJ, Gorospe M. Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Mol Cell Biol 2001; 21: 5889-98; PMID:11486028; http://dx.doi.org/10.1128/MCB.21.17.5889-5898.2001
- Gallouzi IE, Brennan CM, Stenberg MG, Swanson MS, Eversole A, Maizels N, Steitz, JA. HuR binding to cytoplasmic mRNA is perturbed by heat shock. Proc Natl Acad Sci USA 2000; 97: 3073-78.
- Wang W, Furneaux H, Cheng H, Caldwell MC, Hutter D, Liu Y, Holbrook N, Gorospe M. HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol 2000; 20: 760-769; PMID:10629032; http://dx.doi.org/10.1128/MCB.20.3.760-769.2000
- Gallouzi IE, Brennan CM, Steitz JA. Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock. RNA 2001; 7: 1348-61; PMID:11565755; http://dx.doi.org/10.1017/S1355838201016089
- Mazan-Mamczarz K, Galban S, Lopez de Silanes I, Martindale JL, Atasoy U, Keene JD, Gorospe M. RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci USA 2003; 100: 8354-59; PMID:12821781; http://dx.doi.org/10.1073/pnas.1432104100
- Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, et al. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell 2007; 25: 543-57; PMID:17317627; http://dx.doi.org/10.1016/j.molcel.2007.01.011
- Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle 2007; 6: 1288-92; PMID:17534146; http://dx.doi.org/10.4161/cc.6.11.4299
- Mazroui R, Di Marco S, Clair E, von Roretz C, Tenenbaum SA, Keene JD, Saleh M, Gallouzi, I.E. Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. J Cell Biol 2008; 180: 113-27; PMID:18180367; http://dx.doi.org/10.1083/jcb.200709030
- von Roretz C, Jin Lian X, Macri, AM, Punjani N, Clair E, Drouin O, Dormoy-Raclet V, Ma JF, Gallouzi IE. Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis. Cell Death Differ 2013; 20: 154-68; PMID:22955946; http://dx.doi.org/10.1038/cdd.2012.111
- Tran H, Maurer F, Nagamine Y. Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. Mol Cell Biol 2003; 23: 7177-88; PMID:14517288; http://dx.doi.org/10.1128/MCB.23.20.7177-7188.2003
- Figueroa A, Cuadrado A, Fan J, Atasoy U, Muscat GE, Munoz-Canoves P, Gorospe M, Munoz A. Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol 2003; 23: 4991-5004; PMID:12832484; http://dx.doi.org/10.1128/MCB.23.14.4991-5004.2003
- Cherry J, Karschner V, Jones H, Pekala PH. HuR, an RNA-binding protein, involved in the control of cellular differentiation. In Vivo 2006; 20: 17-23; PMID:16433023
- Yi J, Chang N, Liu X, Guo G, Xue L, Tong T, Gorospe M, Wang W. Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence. Nucleic Acids Res 2009; 38: 1547-58; PMID:20007147; http://dx.doi.org/10.1093/nar/gkp1114
- Katsanou V, Papadaki O, Milatos S, Blackshear PJ, Anderson P, Kollias G, Kontoyiannis DL. HuR as a negative posttranscriptional modulator in inflammation. Mol Cell 2005; 19: 777-89; PMID:16168373; http://dx.doi.org/10.1016/j.molcel.2005.08.007
- Atasoy U, Watson J, Patel D, Keene JD. ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. J Cell Sci 1998; 111: 3145-56; PMID:9763509
- Atasoy U, Curry SL, Lopez de Silanes I, Shyu AB, Casolaro V, Gorospe M, Stellato C. Regulation of eotaxin gene expression by TNF-α and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. J Immunol 2003; 171: 4369-78; PMID:14530362; http://dx.doi.org/10.4049/jimmunol.171.8.4369
- McMullen MR, Cocuzzi E, Hatzoglou M, Nagy LE. Chronic ethanol exposure increases the binding of HuR to the TNFalpha 3'-untranslated region in macrophages. J Biol Chem 2003; 278: 38333-41; PMID:12876290; http://dx.doi.org/10.1074/jbc.M304566200
- Srikantan S, Gorospe M. HuR function in disease. Front Biosci 2012; 17: 189-205; http://dx.doi.org/10.2741/3921
- Adam SA, Nakagawa T, Swanson MS, Woodruff TK, Dreyfuss G. mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence. Mol Cell Biol 1986; 6: 2932-43; PMID:3537727
- Sachs AB, Bond MW, Kornberg RD. A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: domain structure and expression. Cell 1986; 45: 827-35; PMID:3518950; http://dx.doi.org/10.1016/0092-8674(86)90557-X
- Maris C, Dominguez C, Allain FH. The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression. FEBS J 2005; 272: 2118-2131; PMID:15853797; http://dx.doi.org/10.1111/j.1742-4658.2005.04653.x
- Good PJ. A conserved family of elav-like genes in vertebrates. Proc Natl Acad Sci USA 1995; 92: 4557-61; PMID:7753842; http://dx.doi.org/10.1073/pnas.92.10.4557
- Wang H, Zeng F, Liu Q, Liu Z, Niu L, Teng M, Li X. The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding. Acta Crystallogr B Biol Crystallogr 2013; 69: 373-80; http://dx.doi.org/10.1107/S0907444912047828
- Díaz-Moreno I, Hollingworth D, Kelly G, Martin S, García-Mayoral M, Briata P, Gherzi R, Ramos A. Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets. Nucleic Acids Res 2010; 38: 5193-205; http://dx.doi.org/10.1093/nar/gkq216
- Fan XC, Steitz JA. HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc Natl Acad Sci USA 1998; 95: 15293-98; PMID:9860962; http://dx.doi.org/10.1073/pnas.95.26.15293
- Brennan CM, Gallouzi IE, Steitz, JA. Protein ligands to HuR modulate its interaction with target mRNAs in vivo. J Cell Biol 2000; 151: 1-14; PMID:11018049; http://dx.doi.org/10.1083/jcb.151.1.1
- Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC, Rosenberg S, et al. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science 2003; 299: 223-26; PMID:12522243; http://dx.doi.org/10.1126/science.1076807
- Rebane A, Aab A, Steitz JA. Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. RNA 2004; 10: 590-99; PMID:15037768; http://dx.doi.org/10.1261/rna.5224304
- Wang W, Yang X, Kawai T, López de Silanes I, Mazan-Mamczarz K, Chen P, Chook YM, Quensel C, Köhler M, Gorospe M. AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem 2004; 279: 48376-88; PMID:15342649; http://dx.doi.org/10.1074/jbc.M409014200
- van der Giessen K, Gallouzi IE. Involvement of transportin 2-mediated HuR import in muscle cell differentiation. Mol Biol Cell 2007; 18: 2619-29; PMID:17475777; http://dx.doi.org/10.1091/mbc.E07-02-0167
- Fialcowitz-White EJ, Brewer BY, Ballin JD, Willis CD, Toth EA, Wilson GM. Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences. J Biol Chem 2007; 282: 20948-59; PMID:17517897; http://dx.doi.org/10.1074/jbc.M701751200
- Park S, Myszka DG, Yu M, Littler SJ, Laird-Offringa IA. HuD RNA Recognition Motifs Play Distinct Roles in the Formation of a Stable Complex with AU-Rich RNA. Mol Cell Biol 2000; 20: 4765-72; PMID:10848602; http://dx.doi.org/10.1128/MCB.20.13.4765-4772.2000
- Doller A, Pfeilschifter J, Eberhardt W. Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR. Cell Signal 2008; 20: 2165-73; PMID:18585896; http://dx.doi.org/10.1016/j.cellsig.2008.05.007
- Eberhardt W, Doller A, Pfeilschifter J. Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation. Curr Protein Pept Sci 2012; 13: 380-90; PMID:22708484; http://dx.doi.org/10.2174/138920312801619439
- Kim HH, Abdelmohsen K, Lal A, Pullmann RJ, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, et al. Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev 2008; 22: 1804-15; PMID:18593881; http://dx.doi.org/10.1101/gad.1645808
- Kim HH, Yang X, Kuwano Y, Gorospe M. Modification at HuR (S242) alters HuR localization and proliferative influence. Cell Cycle 2008; 7: 3371-77; PMID:18948743; http://dx.doi.org/10.4161/cc.7.21.6895
- Doller A, Huwiler A, Muller R, Radeke HH, Pfeilschifter J, Eberhardt W. Protein kinase C α-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Mol Biol Cell 2007; 18: 2137-48; PMID:17392515; http://dx.doi.org/10.1091/mbc.E06-09-0850
- Doller A, Akool elS, Huwiler A, Muller R, Radeke HH, Pfeilschifter J, Eberhardt W. Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. Mol Cell Biol 2008; 28: 2608-25; PMID:18285462; http://dx.doi.org/10.1128/MCB.01530-07
- Li H, Park S, Kilburn B, Jelinek MA, Henschen-Edman A, Aswad DW, Stallcup MR, Laird-Offringa IA. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. J Biol Chem 2002; 277: 44623-30; PMID:12237300; http://dx.doi.org/10.1074/jbc.M206187200
- Embade N, Fernandez-Ramos D, Varela-Rey M, Beraza N, Sini M, de Juan VG, Woodhoo A, Martinez-Lopez N, Rodriguez-Iruretagoyena B, Bustamante FJ, et al. Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology 2012; 55: 1237-48; PMID:22095636; http://dx.doi.org/10.1002/hep.24795
- Chung S, Jiang L, Cheng S, Furneaux H. Purification and properties of HuD, a neuronal RNA-binding protein. J Biol Chem 1996; 271: 11518-24; PMID:8626712; http://dx.doi.org/10.1074/jbc.271.19.11518
- Yeap BB, Voon DC, Vivian JP, McCulloch RK, Thomson AM, Giles KM, Czyzyk-Krzeska MF, Furneaux H, Wilce MC, Wilce JA, et al. Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA. J Biol Chem 2002; 277: 27183-92; PMID:12011088; http://dx.doi.org/10.1074/jbc.M202883200
- Barker A, Epis MR, Porter CJ, Hopkins BR, Wilce MC, Wilce JA, Giles KM, Leedman PJ. Sequence requirements for RNA binding by HuR and AUF1. J Biochem 2012; 151: 423-37; PMID:22368252; http://dx.doi.org/10.1093/jb/mvs010
- Abe R, Sakashita E, Yamamoto K, Sakamoto H. Two Different RNA Binding Activities for the AU-Rich Element and the Poly(A) Sequence of the Mouse Neuronal Protein mHuC. Nucleic Acids Res 1996; 24: 4895-901; PMID:9016658; http://dx.doi.org/10.1093/nar/24.24.4895
- Ma WJ, Chung S, Furneaux H. The Elav-like proteins bind to AU-rich elements and to the poly (A) tail of mRNA. Nucleic Acids Res 1997; 25: 3564-69; PMID:9278474; http://dx.doi.org/10.1093/nar/25.18.3564
- Anderson KD, Morin MA, Beckel-Mitchener A, Mobarak CD, Neve RL, Furneaux HM, Burry R, Perrone-Bizzozero NI. Overexpression of HuD, but not of its truncated form HuD I+II, promotes GAP-43 gene expression and neurite outgrowth in PC12 cells in the absence of nerve growth factor. J Neurochem 2000; 75: 1103-14; PMID:10936192; http://dx.doi.org/10.1046/j.1471-4159.2000.0751103.x
- Meisner NC, Hintersteiner M, Seifert JM, Bauer R, Benoit RM, Widmer A, Schindler T, Uhl V, Lang M, Gstach H, et al. Terminal adenosyl transferase activity of posttranscriptional regulator HuR revealed by confocal on-bead screening. J Mol Biol 2009; 386: 435-50; PMID:19109971; http://dx.doi.org/10.1016/j.jmb.2008.12.020
- Toba G, White K. The third RNA recognition motif of Drosophila ELAV protein has a role in multimerization. Nucleic Acids Res 2008; 36: 1390-99; PMID:18203745; http://dx.doi.org/10.1093/nar/gkm1168
- Samson ML, Lisbin MJ, White K. Two distinct temperature-sensitive alleles at the elav locus of Drosophila are suppressed nonsense mutations of the same tryptophan codon. Genetics 1995; 141: 1101-11; PMID:8582616
- Díaz-Moreno I, Hollingworth D, Frenkiel TA, Kelly G, Martin S, Howell S, García-Mayoral M, Gherzi R, Briata P, Ramos, A. Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding. Nat Struct Mol Biol 2009; 16: 238-46; http://dx.doi.org/10.1038/nsmb.1558
- Scheiba RM, Aroca A, Díaz-Moreno I. HuR thermal stability is dependent on domain binding and upon phosphorylation. Eur Biophys J 2012; 41: 597-605; PMID:22706953; http://dx.doi.org/10.1007/s00249-012-0827-3
- Wishart DS, Arndt D, Berjanskii M, Tang P, Zhou J, Lin G. CS23D: a web server for rapid protein structure generation using NMR chemical shifts and sequence data. Nucleic Acids Res 2008; 36: W496-W502; PMID:18515350; http://dx.doi.org/10.1093/nar/gkn305
- Benoit RM, Meisner NC, Kallen J, Graff P, Hemmig R, Cebe R, Ostermeier C, Widmer, H, Auer M. The x-ray crystal structure of the first RNA recognition motif and site-directed mutagenesis suggest a possible HuR redox sensing mechanism. J Mol Biol 2010; 397: 1231-44; PMID:20219472; http://dx.doi.org/10.1016/j.jmb.2010.02.043
- Query CC, Bentley RC, Keene JD. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell 1989; 57: 89-101; PMID:2467746; http://dx.doi.org/10.1016/0092-8674(89)90175-X
- Shamoo Y, Krueger U, Rice LM, Williams KR, Steitz TA. Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution. Nat Struct Biol 1997; 4: 215-222; PMID:9164463; http://dx.doi.org/10.1038/nsb0397-215
- Gao FB, Keene JD. Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. Journal of Cell Science 1996; 109: 579-89; PMID:8907704
- Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, et al. Structure of PTB bound to RNA: specific binding and implications for splicing regulation. Science 2005; 309: 2054-57; PMID:16179478; http://dx.doi.org/10.1126/science.1114066
- Crichlow GV, Zhou H, Hsiao HH, Frederick KB, Debrosse M, Yang Y, Folta-Stogniew EJ, Chung HJ, Fan C, De la Cruz EM, et al. Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition. EMBO J 2008; 27: 277-89; PMID:18059478; http://dx.doi.org/10.1038/sj.emboj.7601936
- Cukier CD, Hollingworth D, Martin SR, Kelly G, Díaz-Moreno I, Ramos A. Molecular basis of FIR-mediated c-myc transcriptional control. Nat Struct Mol Biol 2010; 17: 1058-64; PMID:20711187; http://dx.doi.org/10.1038/nsmb.1883
- Handa N, Kukimoto-Niino M, Akasaka R, Kishishita S, Murayama K, Terada T, Inoue M, Kigawa T, Kose S, Imamoto N, et al. The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain. J Mol Biol 2006; 363: 114-24; PMID:16962612; http://dx.doi.org/10.1016/j.jmb.2006.07.089
- Corsini L, Hothorn M, Stier G, Rybin V, Scheffzek K, Gibson, TJ, Sattler M. Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60. J Biol Chem 2008; 284: 630-39; PMID:18974054; http://dx.doi.org/10.1074/jbc.M805395200
- David PS, Tanveer R, Port JD. FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1. RNA 2007; 13: 1453-68; PMID:17626845; http://dx.doi.org/10.1261/rna.501707
- Daubner GM, Clery A, Allain FH. RRM-RNA recognition: NMR or crystallography…and new findings. Curr Opin Struct Biol 2013; 23: 100-8; PMID:23253355; http://dx.doi.org/10.1016/j.sbi.2012.11.006
- Sokolowski M, Schwartz S. Heterogeneous nuclear ribonucleoprotein C binds exclusively to the functionally important UUUUU-motifs in the human papillomavirus type-1 AU-rich inhibitory element. Virus Res 2001; 73: 163-75; PMID:11172920; http://dx.doi.org/10.1016/S0168-1702(00)00238-0
- Sokolowski M, Furneaux H, Schwartz S. The inhibitory activity of the AU-rich RNA element in the human papillomavirus type 1 late 3' untranslated region correlates with its affinity for the elav-like HuR protein. J Virol 1999; 73: 1080-91; PMID:9882309
- Lopez de Silanes I, Zhan M, Lal A, Yang X, Gorospe M. Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci USA 2004; 101: 2987-92; PMID:14981256; http://dx.doi.org/10.1073/pnas.0400352101
- Doller A, Winkler C, Azrilian I, Schulz S, Hartmann S, Pfeilschifter J, Eberhardt W. High constitutive HuR phosphorylation at Ser 318 by PKCd propagates tumor relevant functions in colon carcinoma cells. Carcinogenesis 2011; 32: 676-85; PMID:21310943; http://dx.doi.org/10.1093/carcin/bgr024
- Schulz S, Doller A, Pendini NR, Wilce JA, Pfeilschifter J, Eberhardt W. Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR. Cell Signal 2013; 25: 2485-95; PMID:23978401; http://dx.doi.org/10.1016/j.cellsig.2013.08.003
- Marley J, Lu M, Bracken C. A method for efficient isotopic labeling of recombinant proteins. J Biomol NMR 2001; 20: 71-75; PMID:11430757; http://dx.doi.org/10.1023/A:1011254402785
- Jung YS, Zweckstetter M. Mars - robust automatic backbone assignment of proteins. J Biomol NMR 2004; 30: 11-23; PMID:15452431; http://dx.doi.org/10.1023/B:JNMR.0000042954.99056.ad
- Cole J, Lary J. 2009. HeteroAnalysis, Analytical Ultracentrifugation Facility, Bioservices Center, University of Connecticut.
- Schuck P. Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. Biophys J 2000; 78: 1606-19; PMID:10692345; http://dx.doi.org/10.1016/S0006-3495(00)76713-0
- Laue TM, Shah BD, Ridgeway TM, Pelletier SL. Computer-aided interpretation of analytical sedimentation data for proteins. In Analytical Ultracentrifugation in Biochemistry and Polymer Science (eds. SE Harding, AJ Rowe, JC Horton), 1992; pp. 90−125. Royal Society of Chemistry, Cambridge.
- Cruz-Gallardo I, Aroca A, Persson C, Karlsson BG, Díaz-Moreno I. RNA Binding of T-cell Intracellular Antigen-1 (TIA-1) C-terminal RNA Recognition Motif Is Modified by pH.Conditions. J. Biol. Chem. 2013; 288: 25986-94; PMID:23902765; http://dx.doi.org/10.1074/jbc.M113.489070
- Case DA, Darden TA, Cheatham TE, Simmerling CLIII, Wang J, Duke RE, Luo R, Merz KM, Pearlman DA, Crowley M, et al. 2006. AMBER 9 University of California, San Francisco.
- Duan Y, Wu C, Chowdhury S, Lee MC, Xiong G, Zhang W, Rong Y, Cieplak P, Luo R, Lee T, et al. A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations. J. Comput. Chem 2003; 24: 1999-2012.
- Andersen HC. Molecular dynamics simulations at constant pressure and/or temperature. J Chem Phys 1980; 72: 2384-93; http://dx.doi.org/10.1063/1.439486
- Ryckaert JP, Ciccoti G, Berendsen HJC. Numerical integration of the Cartesian equations of motion of a system with constraints: Molecular dynamics of n-alkanes. J. Computational Phys 1977; 23: 327-41; http://dx.doi.org/10.1016/0021-9991(77)90098-5
- Pettersen EFG, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. UCSF Chimera - A Visualization System for Exploratory Research and Analysis. J Comput Chem 2004; 25: 1605-12; PMID:15264254; http://dx.doi.org/10.1002/jcc.20084