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Human m6A writers: Two subunits, 2 roles

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Pages 300-304 | Received 11 Oct 2016, Accepted 10 Jan 2017, Published online: 21 Feb 2017

References

  • Machnicka MA, Milanowska K, Osman Oglou O, Purta E, Kurkowska M, Olchowik A, Januszewski W, Kalinowski S, Dunin-Horkawicz S, Rother KM, et al. MODOMICS: a database of RNA modification pathways–2013 update. Nucleic Acids Res 2013; 41:D262-7; PMID:23118484; http://dx.doi.org/10.1093/nar/gks1007
  • Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell 2012; 149:1635-46; PMID:22608085; http://dx.doi.org/10.1016/j.cell.2012.05.003
  • Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 2012; 485:201-6; PMID:22575960; http://dx.doi.org/10.1038/nature11112
  • Dominissini D, Nachtergaele S, Moshitch-Moshkovitz S, Peer E, Kol N, Ben-Haim MS, Dai Q, Di Segni A, Salmon-Divon M, Clark WC, et al. The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA. Nature 2016; 530:441-6; PMID:26863196; http://dx.doi.org/10.1038/nature16998
  • Slotkin W, Nishikura K. Adenosine-to-inosine RNA editing and human disease. Genome Med 2013; 5:105; PMID:24289319; http://dx.doi.org/10.1186/gm508
  • Squires JE, Patel HR, Nousch M, Sibbritt T, Humphreys DT, Parker BJ, Suter CM, Preiss T. Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA. Nucleic Acids Res 2012; 40:5023-33; PMID:22344696; http://dx.doi.org/10.1093/nar/gks144
  • Schwartz S, Bernstein DA, Mumbach MR, Jovanovic M, Herbst RH, Leon-Ricardo BX, Engreitz JM, Guttman M, Satija R, Lander ES, et al. Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Cell 2014; 159:148-62; PMID:25219674; http://dx.doi.org/10.1016/j.cell.2014.08.028
  • Carlile TM, Rojas-Duran MF, Zinshteyn B, Shin H, Bartoli KM, Gilbert WV. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature 2014; 515:143-6; PMID:25192136; http://dx.doi.org/10.1038/nature13802
  • Beemon K, Keith J. Localization of N6-methyladenosine in the Rous sarcoma virus genome. J Mol Biol 1977; 113:165-79; PMID:196091; http://dx.doi.org/10.1016/0022-2836(77)90047-X
  • Lichinchi G, Gao S, Saletore Y, Gonzalez GM, Bansal V, Wang Y, Mason CE. Rana TM Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol 2016; 1:16011; PMID:27572442; http://dx.doi.org/10.1038/nmicrobiol.2016.11
  • Deng X, Chen K, Luo GZ, Weng X, Ji Q, Zhou T, He C. Widespread occurrence of N6-methyladenosine in bacterial mRNA. Nucleic Acids Res 2015; 43:6557-67; PMID:26068471; http://dx.doi.org/10.1093/nar/gkv596
  • Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, et al. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 2013; 155:1409-21; PMID:24269006; http://dx.doi.org/10.1016/j.cell.2013.10.047
  • Luo GZ, MacQueen A, Zheng G, Duan H, Dore LC, Lu Z, Liu J, Chen K, Jia G, Bergelson J, et al. Unique features of the m6A methylome in Arabidopsis thaliana. Nat Commun 2014; 5:5630; PMID:25430002; http://dx.doi.org/10.1038/ncomms6630
  • Meyer KD, Jaffrey SR. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol 2014; 15:313-26; PMID:24713629; http://dx.doi.org/10.1038/nrm3785
  • Fu Y, Dominissini D, Rechavi G, He C. Gene expression regulation mediated through reversible m(6)A RNA methylation. Nat Rev Genet 2014; 15:293-306; PMID:24662220; http://dx.doi.org/10.1038/nrg3724
  • Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Manor YS, et al. Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science 2015; 347:1002-6; PMID:25569111; http://dx.doi.org/10.1126/science.1261417
  • Chen T, Hao YJ, Zhang Y, Li MM, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, et al. m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 2015; 16:289-301; PMID:25683224; http://dx.doi.org/10.1016/j.stem.2015.01.016
  • Zhou J, Wan J, Gao X, Zhang X, Jaffrey SR, Qian SB. Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature 2015; 526:591-4; PMID:26458103; http://dx.doi.org/10.1038/nature15377
  • Xiao W, Adhikari S, Dahal U, Chen YS, Hao YJ, Sun BF, et al. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. Mol Cell 2016; 61:507-19; PMID:26876937; http://dx.doi.org/10.1016/j.molcel.2016.01.012
  • Adhikari S, Xiao W, Zhao YL, Yang YG. m(6)A: Signaling for mRNA splicing. RNA Biol 2016; 13:756-9; PMID:27351695; http://dx.doi.org/10.1080/15476286.2016.1201628
  • Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 2014; 505:117-20; PMID:24284625; http://dx.doi.org/10.1038/nature12730
  • Wang X, Zhao BS, Roundtree IA, Lu Z, Han D, Ma H, Weng X, Chen K, Shi H, He C. N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell 2015; 161:1388-99; PMID:26046440; http://dx.doi.org/10.1016/j.cell.2015.05.014
  • Meyer KD, Patil DP, Zhou J, Zinoviev A, Skabkin MA, Elemento O, Pestova TV, Qian SB, Jaffrey SR. 5′ UTR m(6)A Promotes Cap-Independent Translation. Cell 2015; 163:999-1010; PMID:26593424; http://dx.doi.org/10.1016/j.cell.2015.10.012
  • Bokar JA, Shambaugh ME, Polayes D, Matera AG, Rottman FM. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA 1997; 3:1233-47; PMID:9409616
  • Bujnicki JM, Feder M, Radlinska M, Blumenthal RM. Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. J Mol Evol 2002; 55:431-44; PMID:12355263; http://dx.doi.org/10.1007/s00239-002-2339-8
  • Hongay CF, Orr-Weaver TL. Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis. Proc Natl Acad Sci U S A 2011; 108:14855-60; PMID:21873203; http://dx.doi.org/10.1073/pnas.1111577108
  • Zhong S, Li H, Bodi Z, Button J, Vespa L, Herzog M, Fray RG. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. Plant Cell 2008; 20:1278-88; PMID:18505803; http://dx.doi.org/10.1105/tpc.108.058883
  • Clancy MJ, Shambaugh ME, Timpte CS, Bokar JA. Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA a potential mechanism for the activity of the IME4 gene. Nucleic Acids Res 2002; 30(20):4509-18; PMID:12384598; http://dx.doi.org/10.1093/nar/gkf573
  • Wang Y, Li Y, Toth JI, Petroski MD, Zhang Z, Zhao JC. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat Cell Biol 2014; 16:191-8; PMID:24394384; http://dx.doi.org/10.1038/ncb2902
  • Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites. Cell Rep 2014; 8:284-96; PMID:24981863; http://dx.doi.org/10.1016/j.celrep.2014.05.048
  • Ping XL, Sun BF, Wang L, Xiao W, Yang X, Wang WJ, Adhikari S, Shi Y, Lv Y, Chen YS, et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res 2014; 24:177-89; PMID:24407421; http://dx.doi.org/10.1038/cr.2014.3
  • Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol 2014; 10:93-5; PMID:24316715; http://dx.doi.org/10.1038/nchembio.1432
  • Iyer LM, Zhang D, Aravind L. Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification. BioEssays 2016; 38:27-40; PMID:26660621; http://dx.doi.org/10.1002/bies.201500104
  • Havugimana PC, Hart GT, Nepusz T, Yang H, Turinsky AL, Li Z, Wang PI, Boutz DR, Fong V, Phanse S, et al. A census of human soluble protein complexes. Cell 2012; 150:1068-81; PMID:22939629; http://dx.doi.org/10.1016/j.cell.2012.08.011
  • Wang X, Feng J, Xue Y, Guan Z, Zhang D, Liu Z, Gong Z, Wang Q, Huang J, Tang C, et al. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Nature 2016; 534:575-8; PMID:27281194; http://dx.doi.org/10.1038/nature18298
  • ledz´ PS, Jinek M. Structural insights into the molecular mechanism of the m6A writer complex. Elife 2016; 5:e18434; PMID:27627798; http://dx.doi.org/10.7554/eLife.18434
  • Wang P, Doxtader KA, Nam Y. Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. Mol Cell 2016; 63:306-17; PMID:27373337; http://dx.doi.org/10.1016/j.molcel.2016.05.041
  • Holm L, Rosenstrom P. Dali server: conservation mapping in 3D. Nucleic Acids Res 2010; 38:W545-9; PMID:20457744; http://dx.doi.org/10.1093/nar/gkq366
  • Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, et al. RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell 2013; 155:793-806; PMID:24209618; http://dx.doi.org/10.1016/j.cell.2013.10.026
  • Murn J, Teplova M, Zarnack K, Shi Y, Patel DJ. Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Nat Struct Mol Biol 2016; 23:16-23; PMID:26641712; http://dx.doi.org/10.1038/nsmb.3140
  • Hudson BP, Martinez-Yamout MA, Dyson HJ, Wright PE. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Nat Struct Mol Biol 2004; 11:257-64; PMID:14981510; http://dx.doi.org/10.1038/nsmb738
  • Shen L, Liang Z, Gu X, Chen Y, Teo ZW, Hou X, Cai WM, Dedon PC, Liu L, Yu H. N(6)-Methyladenosine RNA Modification Regulates Shoot Stem Cell Fate in Arabidopsis. Dev Cell 2016; 38:186-200; PMID:27396363; http://dx.doi.org/10.1016/j.devcel.2016.06.008
  • Liu N, Pan T. N6-methyladenosine-encoded epitranscriptomics. Nat Struct Mol Biol 2016; 23:98-102; PMID:26840897; http://dx.doi.org/10.1038/nsmb.3162
  • Tirumuru N, Zhao BS, Lu W, Lu Z, He C, Wu L. N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife 2016; 5:e15528; PMID:27371828; http://dx.doi.org/10.7554/eLife.15528
  • Lin S, Choe J, Du P, Triboulet R, Gregory RI. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell 2016; 62:335-45; PMID:27117702; http://dx.doi.org/10.1016/j.molcel.2016.03.021
  • Kennedy EM, Bogerd HP, Kornepati AV, Kang D, Ghoshal D, Marshall JB, Poling BC, Tsai K, Gokhale NS, Horner SM, et al. Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression. Cell Host Microbe 2016; 19:675-85; PMID:27117054; http://dx.doi.org/10.1016/j.chom.2016.04.002

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