References
- Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30.
- Pawlik TM, Sondak VK. Malignant melanoma: current state of primary and adjuvant treatment. Crit Rev Oncol Hematol. 2003;45(3):245–264.
- Lugowski A, Nicholson B, Rissland OS. Determining mRNA half-lives on a transcriptome-wide scale. Methods. 2018;137:90–98.
- Mitra M, Lee HN, Coller HA. Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts. J Vis Exp. 2018;131. DOI:10.3791/56423
- Narsai R, Howell KA, Millar AH, et al. Genome-wide analysis of mRNA decay rates and their determinants in Arabidopsis thaliana. Plant Cell. 2007;19(11):3418–3436.
- Yang E, van Nimwegen E, Zavolan M, et al. Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res. 2003;13(8):1863–1872.
- Benjamin D, Moroni C. mRNA stability and cancer: an emerging link? Expert Opin Biol Ther. 2007;7(10):1515–1529.
- Singer RH, Penman S. Stability of HeLa cell mRNA in actinomycin. Nature. 1972;240(5376):100–102.
- Alkallas R, Fish L, Goodarzi H, et al. Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease. Nat Commun. 2017;8(1):909.
- Tani H, Mizutani R, Salam KA, et al. Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals. Genome Res. 2012;22(5):947–956.
- Bensaude O. Inhibiting eukaryotic transcription: which compound to choose? How to evaluate its activity? Transcription. 2011;2(3):103–108.
- Imamachi N, Tani H, Mizutani R, et al. BRIC-seq: a genome-wide approach for determining RNA stability in mammalian cells. Methods. 2014;67(1):55–63.
- Diermeier-Daucher S, Clarke ST, Hill D, et al. Cell type specific applicability of 5-ethynyl-2ʹ-deoxyuridine (EdU) for dynamic proliferation assessment in flow cytometry. Cytometry A. 2009;75(6):535–546.
- Imamachi N, Salam KA, Suzuki Y, et al. A GC-rich sequence feature in the 3ʹ UTR directs UPF1-dependent mRNA decay in mammalian cells. Genome Res. 2017;27(3):407–418.
- Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 2014;15(8):509–524.
- Alberti C, Cochella L. A framework for understanding the roles of miRNAs in animal development. Development. 2017;144(14):2548–2559.
- Peng Y, Croce CM. The role of MicroRNAs in human cancer. Signal Transduct Target Ther. 2016;1:15004.
- Kawamata T, Tomari Y. Making RISC. Trends Biochem Sci. 2010;35(7):368–376.
- Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014;20(8):460–469.
- Khabar KS. Hallmarks of cancer and AU-rich elements. Wiley Interdiscip Rev RNA. 2017;8:1.
- Mazar J, DeYoung K, Khaitan D, et al. The regulation of miRNA-211 expression and its role in melanoma cell invasiveness. PLoS One. 2010;5(11):e13779.
- Mazar J, Qi F, Lee B, et al. MicroRNA 211 Functions as a Metabolic Switch in Human Melanoma Cells. Mol Cell Biol. 2016;36(7):1090–1108.
- Clark MB, Johnston RL, Inostroza-Ponta M, et al. Genome-wide analysis of long noncoding RNA stability. Genome Res. 2012;22(5):885–898.
- Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–15550.
- Katerinaki E, Evans GS, Lorigan PC, et al. TNF-alpha increases human melanoma cell invasion and migration in vitro: the role of proteolytic enzymes. Br J Cancer. 2003;89(6):1123–1129.
- Gray-Schopfer VC, Karasarides M, Hayward R, et al. Tumor necrosis factor-alpha blocks apoptosis in melanoma cells when BRAF signaling is inhibited. Cancer Res. 2007;67(1):122–129.
- Box NF, Vukmer TO, Terzian T. Targeting p53 in melanoma. Pigment Cell Melanoma Res. 2014;27(1):8–10.
- Busse A, Keilholz U. Role of TGF-beta in melanoma. Curr Pharm Biotechnol. 2011;12(12):2165–2175.
- Perrot CY, Javelaud D, Mauviel A. Insights into the Transforming Growth Factor-beta Signaling Pathway in Cutaneous Melanoma. Ann Dermatol. 2013;25(2):135–144.
- Giles N, Pavey S, Pinder A, et al. Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin. Br J Dermatol. 2012;166(2):362–371.
- Frederick DT, Piris A, Cogdill AP, et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res. 2013;19(5):1225–1231.
- Ji Z, Flaherty KT, Tsao H. Targeting the RAS pathway in melanoma. Trends Mol Med. 2012;18(1):27–35.
- Xu Y, Brenn T, Brown ER, et al. Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors. Br J Cancer. 2012;106(3):553–561.
- Guda MR, Asuthkar S, Labak CM, et al. Targeting PDK4 inhibits breast cancer metabolism. Am J Cancer Res. 2018;8(9):1725–1738.
- Sahoo A, Sahoo SK, Joshi P, et al. MicroRNA-211 Loss Promotes Metabolic Vulnerability and BRAF Inhibitor Sensitivity in Melanoma. J Invest Dermatol. 2019;139(1):167–176.
- Sahoo A, Lee B, Boniface K, et al. MicroRNA-211 Regulates Oxidative Phosphorylation and Energy Metabolism in Human Vitiligo. J Invest Dermatol. 2017;137(9):1965–1974.
- Barbato S, Marrocco E, Intartaglia D, et al. MiR-211 is essential for adult cone photoreceptor maintenance and visual function. Sci Rep. 2017;7(1):17004.
- Asuthkar S, Velpula KK, Chetty C, et al. Epigenetic regulation of miRNA-211 by MMP-9 governs glioma cell apoptosis, chemosensitivity and radiosensitivity. Oncotarget. 2012;3(11):1439–1454.
- Song GQ, Zhao Y. MicroRNA-211, a direct negative regulator of CDC25B expression, inhibits triple-negative breast cancer cells’ growth and migration. Tumour Biol. 2015;36(7):5001–5009.
- Xia B, Yang S, Liu T, et al. miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6. Mol Cancer. 2015;14:57.
- Bu Y, Yoshida A, Chitnis N, et al. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018;20(1):104–115.
- Chu TH, Yang CC, Liu CJ, et al. miR-211 promotes the progression of head and neck carcinomas by targeting TGFbetaRII. Cancer Lett. 2013;337(1):115–124.
- Bell RE, Khaled M, Netanely D, et al. Transcription factor/microRNA axis blocks melanoma invasion program by miR-211 targeting NUAK1. J Invest Dermatol. 2014;134(2):441–451.
- Chang Z, Cai C, Han D, et al. Anoctamin5 regulates cell migration and invasion in thyroid cancer. Int J Oncol. 2017;51(4):1311–1319.
- Hodgkinson K, Forrest LA, Vuong N, et al. GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer. Oncogene. 2018;37(44):5873–5886.
- Ghosh MG, Thompson DA, Weigel RJ. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Cancer Res. 2000;60(22):6367–6375.
- Rae JM, Johnson MD, Cordero KE, et al. GREB1 is a novel androgen-regulated gene required for prostate cancer growth. Prostate. 2006;66(8):886–894.
- Wang L, Chen Q, Chen Z, et al. EFEMP2 is upregulated in gliomas and promotes glioma cell proliferation and invasion. Int J Clin Exp Pathol. 2015;8(9):10385–10393.
- Yao L, Lao W, Zhang Y, et al. Identification of EFEMP2 as a serum biomarker for the early detection of colorectal cancer with lectin affinity capture assisted secretome analysis of cultured fresh tissues. J Proteome Res. 2012;11(6):3281–3294.
- Margue C, Philippidou D, Reinsbach SE, et al. New target genes of MITF-induced microRNA-211 contribute to melanoma cell invasion. PLoS One. 2013;8(9):e73473.
- Boyle GM, Woods SL, Bonazzi VF, et al. Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell Melanoma Res. 2011;24(3):525–537.
- Ishibashi T, Bottaro DP, Chan A, et al. Expression cloning of a human dual-specificity phosphatase. Proc Natl Acad Sci U S A. 1992;89(24):12170–12174.
- Henkens R, Delvenne P, Arafa M, et al. Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR. BMC Cancer. 2008;8:147.
- Arnoldussen YJ, Lorenzo PI, Pretorius ME, et al. The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer. Cancer Res. 2008;68(22):9255–9264.
- Hao L, ElShamy WM. BRCA1-IRIS activates cyclin D1 expression in breast cancer cells by downregulating the JNK phosphatase DUSP3/VHR. Int J Cancer. 2007;121(1):39–46.
- Rahmouni S, Cerignoli F, Alonso A, et al. Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence. Nat Cell Biol. 2006;8(5):524–531.
- Chen YR, Chou HC, Yang CH, et al. Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene. 2017;36(47):6509–6517.
- Amand M, Erpicum C, Bajou K, et al. DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase. Mol Cancer. 2014;13:108.
- Huang CY, Tan TH. DUSPs, to MAP kinases and beyond. Cell Biosci. 2012;2(1):24.
- Tambe MB, Narvi E, Kallio M. Reduced levels of Dusp3/Vhr phosphatase impair normal spindle bipolarity in an Erk1/2 activity-dependent manner. FEBS Lett. 2016;590(16):2757–2767.
- Hemmings BA, Restuccia DF. PI3K-PKB/Akt pathway. Cold Spring Harb Perspect Biol. 2012;4(9):a011189.
- Robitaille H, Simard-Bisson C, Larouche D, et al. The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression. J Invest Dermatol. 2010;130(1):74–85.
- Rane MJ, Pan Y, Singh S, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003;278(30):27828–27835.
- Deng W, Zhang Y, Gu L, et al. Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cells. Cancer Cell Int. 2016;16:5.
- Hu X, Chen P, Wu Y, et al. MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016;34(7):1846–1858.
- Davies MA. The role of the PI3K-AKT pathway in melanoma. Cancer J. 2012;18(2):142–147.
- Zhuang D, Mannava S, Grachtchouk V, et al. C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells. Oncogene. 2008;27(52):6623–6634.
- Lin X, Sun R, Zhao X, et al. C-myc overexpression drives melanoma metastasis by promoting vasculogenic mimicry via c-myc/snail/Bax signaling. J Mol Med (Berl). 2017;95(1):53–67.
- Corazao-Rozas P, Guerreschi P, Andre F, et al. Mitochondrial oxidative phosphorylation controls cancer cell’s life and death decisions upon exposure to MAPK inhibitors. Oncotarget. 2016;7(26):39473–39485.
- Das S, Das J, Samadder A, et al. Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria. Exp Biol Med (Maywood). 2012;237(12):1433–1448.
- Lin K, Baritaki S, Militello L, et al. The Role of B-RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF-kappaB/Snail/RKIP/PTEN Circuit. Genes Cancer. 2010;1(5):409–420.
- Meier J, Hovestadt V, Zapatka M, et al. Genome-wide identification of translationally inhibited and degraded miR-155 targets using RNA-interacting protein-IP. RNA Biol. 2013;10(6):1018–1029.
- Kutsche LK, Gysi DM, Fallmann J, et al. Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis. Cell Syst. 2018;7(4):438–52.e8.
- Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.