References
- Court DL, Gan J, Liang Y-H, et al. RNase III: genetics and function; structure and mechanism. Annu Rev Genet. 2013;47:405–431.
- Chong MMW, Zhang G, Cheloufi S, et al. Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev. 2010 Sept 1;24(17):1951–1960.
- Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature. 2003 Sept 25;425(6956):415–419.
- Bartel DP. Metazoan MicroRNAs. Cell. 2018 Mar 22;173(1):20–51.
- Denli AM, Tops BBJ, Plasterk RHA, et al. Processing of primary microRNAs by the Microprocessor complex. Nature. 2004 Nov 11;432(7014):231–235.
- Gregory RI, Yan K-P, Amuthan G, et al. The Microprocessor complex mediates the genesis of microRNAs. Nature. 2004 Nov 11;432(7014):235–240.
- Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 2014 Aug;15(8):509–524.
- Triboulet R, Chang H-M, Lapierre RJ, et al. Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA. 2009 June;15(6):1005–1011.
- Karginov FV, Cheloufi S, Chong MMW, et al. Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases. Mol Cell. 2010 June 25;38(6):781–788.
- Lin Y-T, Sullivan CS. Expanding the role of Drosha to the regulation of viral gene expression. Proc Natl Acad Sci USA. 2011 July 5;108(27):11229–11234.
- Han J, Pedersen JS, Kwon SC, et al. Posttranscriptional crossregulation between Drosha and DGCR8. Cell. 2009 Jan 9;136(1):75–84.
- Sun K, Lai EC. Adult-specific functions of animal microRNAs. Nat Rev Genet. 2013 Aug;14(8):535–548.
- Lin S, Gregory RI. MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015 June;15(6):321–333.
- Peng Y, Croce CM. The role of MicroRNAs in human cancer. Signal Transduct Target Ther. 2016 Jan 28;1:15004.
- Iorio MV, Ferracin M, Liu C-G, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005 Aug 15;65(16):7065–7070.
- Thomson JM, Newman M, Parker JS, et al. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006 Aug 15;20(16):2202–2207.
- Merritt WM, Lin YG, Han LY, et al. Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med. 2008 Dec 18;359(25):2641–2650.
- Volinia S, Calin GA, Liu C-G, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA. 2006 Feb 14;103(7):2257–2261.
- Han J, Lee Y, Yeom K-H, et al. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 2004 Dec 15;18(24):3016–3027.
- Nguyen TA, Jo MH, Choi Y-G, et al. Functional anatomy of the human microprocessor. Cell. 2015 June 4;161(6):1374–1387.
- Kwon SC, Nguyen TA, Choi Y-G, et al. Structure of human DROSHA. Cell. 2016 Jan 14;164(1–2):81–90.
- Dai L, Chen K, Youngren B, et al. Cytoplasmic Drosha activity generated by alternative splicing. Nucleic Acids Res. 2016 Dec 1;44(21):10454–10466.
- Link S, Grund SE, Diederichs S. Alternative splicing affects the subcellular localization of Drosha. Nucleic Acids Res. 2016 June 20;44(11):5330–5343.
- Grund SE, Polycarpou-Schwarz M, Luo C, et al. Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells. Neoplasia. 2012 Mar;14(3):238–248.
- Kent WJ, Sugnet CW, Furey TS, et al. The human genome browser at UCSC. Genome Res. 2002 June;12(6):996–1006.
- Xie M, Li M, Vilborg A, et al. Mammalian 5ʹ-capped microRNA precursors that generate a single microRNA. Cell. 2013 Dec 19;155(7):1568–1580.
- Zamudio JR, Kelly TJ, Sharp PA. Argonaute-bound small RNAs from promoter-proximal RNA polymerase II. Cell. 2014 Feb 27;156(5):920–934.
- Allegra D, Bilan V, Garding A, et al. Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia. Leukemia. 2014 Jan;28(1):98–107.
- Pfeffer SR, Yang CH, Pfeffer LM. The Role of miR-21 in Cancer. Drug Dev Res. 2015 Sept;76(6):270–277.
- Roush S, Slack FJ. The let-7 family of microRNAs. Trends Cell Biol. 2008 Oct;18(10):505–516.
- Treiber T, Treiber N, Meister G. Regulation of microRNA biogenesis and its crosstalk with other cellular pathways. Nat Rev Mol Cell Biol. 2019;20(1):5–20.
- Kumar MS, Pester RE, Chen CY, et al. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 2009 Dec 1;23(23):2700–2704.
- Lambertz I, Nittner D, Mestdagh P, et al. Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Cell Death Differ. 2010 Apr;17(4):633–641.
- Lau JW, Lehnert E, Sethi A, et al. The cancer genomics cloud: collaborative, reproducible, and democratized-a new paradigm in large-scale computational research. Cancer Res. 2017 Nov 1;77(21):e3–6.
- Bofill-De Ros X, Chen K, Chen S, et al. QuagmiR: a cloud-based application for isomiR big data analytics. Bioinformatics. 2019 May 1;35(9):1576–1578.