MIR210HG regulates glycolysis, cell proliferation, and metastasis of pancreatic cancer cells through miR-125b-5p/HK2/PKM2 axis

References

• Siegel RL, Miller KD, Jemal A. CA: a cancer journal for clinicians. Cancer Statistics. 2019;69(1).
   Google Scholar
• Neoptolemos JP, Kleeff J, Michl P, et al. Therapeutic developments in pancreatic cancer: current and future perspectives. Nat Rev Gastroenterol Hepatol. 2018;15(6):333–348.
   PubMed Web of Science ®Google Scholar
• Dunne RF, Hezel AF. Genetics and biology of pancreatic ductal adenocarcinoma. Hematol Oncol Clin North Am. 2015;29(4):595–608.
   PubMed Web of Science ®Google Scholar
• Ying H, Dey P, Yao W, et al. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 2016;30(4):355–385.
   PubMed Web of Science ®Google Scholar
• Icard P, Shulman S, Farhat D, et al. How the Warburg effect supports aggressiveness and drug resistance of cancer cells? Drug Resist Updat. 2018;38:1–11.
   PubMed Web of Science ®Google Scholar
• Liberti MV, Locasale JW. The Warburg effect: how does it benefit cancer cells? Trends Biochem Sci. 2016;41(3):211–218.
   PubMed Web of Science ®Google Scholar
• Ganapathy-Kanniappan S. Molecular intricacies of aerobic glycolysis in cancer: current insights into the classic metabolic phenotype. Crit Rev Biochem Mol Biol. 2018;53(6):667–682.
   PubMed Web of Science ®Google Scholar
• Buscail L, Bournet B, Dufresne M, et al. [Advance in the biology of pancreatic of cancer]. Bull Cancer. 2015;102(6 Suppl 1):S53–61.
   PubMed Web of Science ®Google Scholar
• Halbrook CJ, Lyssiotis CA. Employing metabolism to improve the diagnosis and treatment of pancreatic cancer. Cancer Cell. 2017;31(1):5–19.
   PubMed Web of Science ®Google Scholar
• Lu H, Forbes RA, Verma A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem. 2002;277(26):23111–23115.
   PubMed Web of Science ®Google Scholar
• Jin X, Dai L, Ma Y, et al. Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer. Cancer Cell Int. 2020;20:273.
   PubMed Web of Science ®Google Scholar
• Yang J, Ren B, Yang G, et al. The enhancement of glycolysis regulates pancreatic cancer metastasis. Cell Mol Life Sci. 2020;77(2):305–321.
   PubMed Web of Science ®Google Scholar
• Golias T, Kery M, Radenkovic S, et al. Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase. Int J Cancer. 2019;144(4):674–686.
   PubMed Web of Science ®Google Scholar
• Mota Reyes C, Yurteri Ü, Friess H, et al. Future directions of neoadjuvant therapy in pancreatic cancer. Oncoscience. 2020;7(7–8):44–46.
   PubMedGoogle Scholar
• Anastasiadou E, Jacob LS, Slack FJ. Non-coding RNA networks in cancer. Nat Rev Cancer. 2018;18(1).
   PubMed Web of Science ®Google Scholar
• Saw PE, et al., Non-coding RNAs: the new central dogma of cancer biology. Science China. Life sciences, 2020.
   Google Scholar
• Slack FJ, Chinnaiyan AM. The role of non-coding RNAs in oncology. Cell. 2019;179(5):1033–1055.
   PubMed Web of Science ®Google Scholar
• Lv Y, Huang S. Role of non-coding RNA in pancreatic cancer. Oncol Lett. 2019;18(4):3963–3973.
   PubMed Web of Science ®Google Scholar
• Chandra Gupta S, Nandan Tripathi Y. Potential of long non-coding RNAs in cancer patients: from biomarkers to therapeutic targets. Int J Cancer. 2017;140(9):1955–1967.
   PubMed Web of Science ®Google Scholar
• Capula M, Mantini G, Funel N, et al. New avenues in pancreatic cancer: exploiting microRNAs as predictive biomarkers and new approaches to target aberrant metabolism. Expert Rev Clin Pharmacol. 2019;12(12):1081–1090.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhao X, Zhou Y, et al. The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer. J Transl Med. 2015;13(1):84.
   PubMed Web of Science ®Google Scholar
• You L, Chang D, Du H-Z, et al. Genome-wide screen identifies PVT1 as a regulator of Gemcitabine sensitivity in human pancreatic cancer cells. Biochem Biophys Res Commun. 2011;407(1):1–6.
   PubMed Web of Science ®Google Scholar
• Jiao F, et al. Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer. Oncol Rep. 2014;32(6):2485–2492.
   PubMed Web of Science ®Google Scholar
• Li D, Qian X, Xu P, et al. Identification of lncRNAs and their functional network associated with chemoresistance in SW1990/GZ pancreatic cancer cells by RNA sequencing. DNA Cell Biol. 2018;37(10):839–849.
   PubMed Web of Science ®Google Scholar
• Li X-Y, Zhou L-Y, Luo H, et al. The long noncoding RNA MIR210HG promotes tumor metastasis by acting as a ceRNA of miR-1226-3p to regulate mucin-1c expression in invasive breast cancer. Aging (Albany NY). 2019;11(15):5646–5665.
   PubMedGoogle Scholar
• Kang X, Kong F, Huang K, et al. <p>LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1. Onco Targets Ther. 2019;12:3779–3790.
   PubMed Web of Science ®Google Scholar
• Wang A-H, Jin C-H, Cui G-Y, et al. MIR210HG promotes cell proliferation and invasion by regulating miR-503-5p/TRAF4 axis in cervical cancer. Aging (Albany NY). 2020;12(4):3205–3217.
   PubMedGoogle Scholar
• Li J, Wu Q-M, Wang X-Q, et al. Long Noncoding RNA miR210HG Sponges miR-503 to facilitate osteosarcoma cell invasion and metastasis. DNA Cell Biol. 2017;36(12):1117–1125.
   PubMed Web of Science ®Google Scholar
• Ata-Abadi NS, Mowla SJ, Aboutalebi F, et al. Hypoxia-related long noncoding RNAs are associated with varicocele-related male infertility. PloS One. 2020;15(4):e0232357.
   PubMed Web of Science ®Google Scholar
• Du Y, Wei N, Ma R, et al. Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer. Front Oncol. 2020;10:580176.
   PubMed Web of Science ®Google Scholar
• Jeggari A, Marks DS, Larsson E. miRcode: a map of putative microRNA target sites in the long non-coding transcriptome. Bioinformatics. 2012;28(15):2062–2063.
   PubMed Web of Science ®Google Scholar
• Sticht C, De La Torre C, Parveen A, et al. miRWalk: an online resource for prediction of microRNA binding sites. PLoS One. 2018;13(10):e0206239.
   PubMed Web of Science ®Google Scholar
• Das MK, Andreassen R, Haugen TB, et al. Identification of endogenous controls for use in miRNA quantification in human cancer cell lines. Cancer Genomics Proteomics. 2016;13(1):63–68.
   PubMed Web of Science ®Google Scholar
• Bu X-N, Qiu C, Wang C, et al. Inhibition of DACH1 activity by short hairpin RNA represses cell proliferation and tumor invasion in pancreatic cancer. Oncol Rep. 2016;36(2):745–754.
   PubMed Web of Science ®Google Scholar
• Yan L, et al. Glucose metabolism in pancreatic cancer. 2019; 11(10)
   Google Scholar
• Yamamura S, Imai-Sumida M, Tanaka Y, et al. Interaction and cross-talk between non-coding RNAs. Cell Mol Life Sci. 2018;75(3):467–484.
   PubMed Web of Science ®Google Scholar
• Weng W, Zhang Z, Huang W, et al. Identification of a competing endogenous RNA network associated with prognosis of pancreatic adenocarcinoma. Cancer Cell Int. 2020;20(1):231.
   PubMed Web of Science ®Google Scholar
• Jiang J, Bi Y, Liu X-P, et al. To construct a ceRNA regulatory network as prognostic biomarkers for bladder cancer. J Cell Mol Med. 2020;24(9):5375–5386.
   PubMed Web of Science ®Google Scholar
• Ni J, Zhou S, Yuan W, et al. Mechanism of miR-210 involved in epithelial-mesenchymal transition of pancreatic cancer cells under hypoxia. J Recept Signal Transduct Res. 2019;39(5–6):399–406.
   PubMed Web of Science ®Google Scholar
• Counihan JL, Grossman EA, Nomura DK. Cancer metabolism: current understanding and therapies. Chem Rev. 2018;118(14):6893–6923.
   PubMed Web of Science ®Google Scholar
• An M-X, Li S, Yao H-B, et al. BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells. J Cell Biol. 2017;216(12):4091–4105.
   PubMed Web of Science ®Google Scholar
• Li C, Zhao Z, Zhou Z, et al. PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma. Dig Dis Sci. 2016;61(3):767–773.
   PubMed Web of Science ®Google Scholar
• Zhou M, Diao Z, Yue X, et al. Construction and analysis of dysregulated lncRNA-associated ceRNA network identified novel lncRNA biomarkers for early diagnosis of human pancreatic cancer. Oncotarget. 2016;7(35):56383–56394.
   PubMed Web of Science ®Google Scholar
• Wang W, et al. A novel mRNA-miRNA-lncRNA competing endogenous RNA triple sub-network associated with prognosis of pancreatic cancer. Aging (Albany NY). 2019;11(9):2610–2627.
   PubMedGoogle Scholar
• He Z, et al. Identification of LINC01234 and MIR210HG as novel prognostic signature for colorectal adenocarcinoma. J Cell Physiol. 2019;234(5):6769–6777.
   PubMed Web of Science ®Google Scholar
• Zhou X, et al. Plasma miRNAs in diagnosis and prognosis of pancreatic cancer: a miRNA expression analysis. Gene. 2018;673:181–193.
   PubMed Web of Science ®Google Scholar
• Yang D, et al. miR-125b-5p enhances chemotherapy sensitivity to cisplatin by down-regulating Bcl2 in gallbladder cancer. Sci Rep. 2017;7:43109.
   PubMed Web of Science ®Google Scholar
• Li Y, et al. miR-125b-5p inhibits breast cancer cell proliferation, migration and invasion by targeting KIAA1522. Biochem Biophys Res Commun. 2018;504(1):277–282.
   PubMed Web of Science ®Google Scholar
• Liu S, Chen Q, Wang Y. MiR-125b-5p suppresses the bladder cancer progression via targeting HK2 and suppressing PI3K/AKT pathway. Hum Cell. 2020;33(1):185–194.
   PubMed Web of Science ®Google Scholar