Progress and application of epitranscriptomic m⁶A modification in gastric cancer

References

• Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012;150(1):12–27.
   PubMed Web of Science ®Google Scholar
• Boccaletto P, Machnicka MA, Purta E, et al. MODOMICS: a database of RNA modification pathways 2017 update. Nucleic Acids Res. 2018;46(D1):D303–D307.
   PubMed Web of Science ®Google Scholar
• Saletore Y, Meyer K, Korlach J, et al. The birth of the Epitranscriptome: deciphering the function of RNA modifications. Genome Biol. 2012;13(10):175.
   PubMed Web of Science ®Google Scholar
• Wei CM, Gershowitz A, Moss B. Methylated nucleotides block 5’ terminus of HeLa cell messenger RNA. Cell. 1975;4(4):379–386.
   PubMed Web of Science ®Google Scholar
• Dominissini D, Moshitch-Moshkovitz S, Schwartz S, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012;485(7397):201–206.
   PubMed Web of Science ®Google Scholar
• Schwartz S, Mumbach MR, Jovanovic M, et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5’ sites. Cell Rep. 2014;8(1):284–296.
   PubMed Web of Science ®Google Scholar
• Thüring K, Schmid K, Keller P, et al. LC-MS analysis of methylated RNA. Methods Mol Biol. 2017;1562:3–18.
   PubMedGoogle Scholar
• Meyer KD, Saletore Y, Zumbo P, et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons. Cell. 2012;149(7):1635–1646.
   PubMed Web of Science ®Google Scholar
• Molinie B, Wang J, Lim KS, et al. m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome. Nat Methods. 2016;13(8):692–698.
   PubMed Web of Science ®Google Scholar
• Linder B, Grozhik AV, Olarerin-George AO, et al. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nat Methods. 2015;12(8):767–772.
   PubMed Web of Science ®Google Scholar
• Garcia-Campos MA, Edelheit S, Toth U, et al. Deciphering the “m6A Code” via Antibody-Independent quantitative profiling. Cell. 2019;178(3):731–747.e16.
   PubMed Web of Science ®Google Scholar
• Zaccara S, Ries RJ, Jaffrey SR. Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol. 2019;20(10):608–624.
   PubMed Web of Science ®Google Scholar
• Jia G, Fu Y, Zhao X, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 2011;7(12):885–887.
   PubMed Web of Science ®Google Scholar
• Zheng G, Dahl JA, Niu Y, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013;49(1):18–29.
   PubMed Web of Science ®Google Scholar
• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249.
   PubMed Web of Science ®Google Scholar
• Jaffrey SR, Kharas MG. Emerging links between m6A and misregulated mRNA methylation in cancer. Genome Med. 2017;9(1):2.
   PubMedGoogle Scholar
• Bokar JA, Rath-Shambaugh ME, Ludwiczak R, et al. Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex. J Biol Chem. 1994;269(26):17697–17704.
   PubMed Web of Science ®Google Scholar
• Rottman FM, Bokar JA, Narayan P, et al. N6-adenosine methylation in mRNA: substrate specificity and enzyme complexity. Biochimie. 1994;76(12):1109–1114.
   PubMed Web of Science ®Google Scholar
• Bokar JA, Shambaugh ME, Polayes D, et al. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA. 1997;3(11):1233–1247.
   PubMed Web of Science ®Google Scholar
• Bujnicki JM, Feder M, Radlinska M, et al. Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA: m(6)Amethyltransferase. J Mol Evol. 2002;55(4):431–444.
   PubMed Web of Science ®Google Scholar
• Liu J, Yue Y, Han D, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 2014;10(2):93–95.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li Y, Toth JI, et al. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat Cell Biol. 2014;16(2):191–198.
   PubMed Web of Science ®Google Scholar
• Śledź P, Jinek M. Structural insights into the molecular mechanism of the m(6)A writer complex. Elife. 2016;5:e18434.
   PubMed Web of Science ®Google Scholar
• Ortega A, Niksic M, Bachi A, et al. Biochemical function of female-lethal (2)D/Wilms’ tumor suppressor-1-associated proteins in alternative pre-mRNA splicing. J Biol Chem. 2003;278(5):3040–3047.
   PubMed Web of Science ®Google Scholar
• Zhong S, Li H, Bodi Z, et al. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. Plant Cell. 2008;20(5):1278–1288.
   PubMed Web of Science ®Google Scholar
• Agarwala SD, Blitzblau HG, Hochwagen A, et al. RNA methylation by the MIS complex regulates a cell fate decision in yeast. PLoS Genet. 2012;8(6):e1002732.
   PubMed Web of Science ®Google Scholar
• XL P, BF S, Wang L, et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 2014;24(2):177–189.
   PubMed Web of Science ®Google Scholar
• Yue Y, Liu J, Cui X, et al. VIRMA mediates preferential m6A mRNA methylation in 3ʹUTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018;4(1):10.
   PubMed Web of Science ®Google Scholar
• Lence T, Akhtar J, Bayer M, et al. m6A modulates neuronal functions and sex determination in drosophila. Nature. 2016;540(7632):242–247.
   PubMed Web of Science ®Google Scholar
• Knuckles P, Lence T, Haussmann IU, et al. Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d. Genes Dev. 2018;32(5–6):415–429.
   PubMed Web of Science ®Google Scholar
• Růžička K, Zhang M, Campilho A, et al. Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI. New Phytol. 2017;215(1):157–172.
   PubMed Web of Science ®Google Scholar
• Wang Z, Pan Z, Adhikari S, et al. m6A deposition is regulated by PRMT1-mediated arginine methylation of METTL14 in its disordered C-terminal region. EMBO J. 2021;40(5):e106309.
   PubMed Web of Science ®Google Scholar
• Oerum S, Meynier V, Catala M, et al. A comprehensive review of m6A/m6Am RNA methyltransferase structures. Nucleic Acids Res. 2021;49(13):7239–7255.
   PubMed Web of Science ®Google Scholar
• Sergiev PV, Serebryakova MV, Bogdanov AA, et al. The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. J Mol Biol. 2008;375(1):291–300.
   PubMed Web of Science ®Google Scholar
• Pendleton KE, Chen B, Liu K, et al. The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention. Cell. 2017;169(5):824–835.e14.
   PubMed Web of Science ®Google Scholar
• Warda AS, Kretschmer J, Hackert P, et al. Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 2017;18(11):2004–2014.
   PubMed Web of Science ®Google Scholar
• Dai YZ, Liu YD, Li J, et al. METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m6A-dependent manner. Cell Mol Biol Lett. 2022;27(1):41.
   PubMed Web of Science ®Google Scholar
• Ma H, Wang X, Cai J, et al. N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nat Chem Biol. 2019;15(1):88–94.
   PubMed Web of Science ®Google Scholar
• van Tran N, Ernst FGM, Hawley BR, et al. The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res. 2019;47(15):7719–7733.
   PubMed Web of Science ®Google Scholar
• Du H, Zhao Y, He J, et al. YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex. Nat Commun. 2016;7(1):12626.
   PubMedGoogle Scholar
• Wang X, Zhao BS, Roundtree IA, et al. N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell. 2015;161(6):1388–1399.
   PubMed Web of Science ®Google Scholar
• Shi H, Wang X, Lu Z, et al. YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. Cell Res. 2017;27(3):315–328.
   PubMed Web of Science ®Google Scholar
• Li A, YS C, XL P, et al. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation. Cell Res. 2017;27(3):444–447.
   PubMed Web of Science ®Google Scholar
• Yang Y, Fan X, Mao M, et al. Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res. 2017;27(5):626–641.
   PubMed Web of Science ®Google Scholar
• Zaccara S, Jaffrey SR. A unified model for the function of YTHDF proteins in regulating m6A-Modified mRNA. Cell. 2020;181(7):1582–1595.e18.
   PubMed Web of Science ®Google Scholar
• Roundtree IA, Luo GZ, Zhang Z, et al. YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs. Elife. 2017;6:e31311.
   PubMed Web of Science ®Google Scholar
• Xiao W, Adhikari S, Dahal U, et al. Nuclear m(6)A reader YTHDC1 regulates mRNA splicing. Mol Cell. 2016;61(4):507–519.
   PubMed Web of Science ®Google Scholar
• Patil DP, Chen CK, Pickering BF, et al. m(6)A RNA methylation promotes XIST-mediated transcriptional repression. Nature. 2016;537(7620):369–373.
   PubMed Web of Science ®Google Scholar
• Liu N, Dai Q, Zheng G, et al. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015;518(7540):560–564.
   PubMed Web of Science ®Google Scholar
• Liu N, Zhou KI, Parisien M, et al. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res. 2017;45(10):6051–6063.
   PubMed Web of Science ®Google Scholar
• Huang H, Weng H, Sun W, et al. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018;20(3):285–295.
   PubMed Web of Science ®Google Scholar
• Kretschmer J, Rao H, Hackert P, et al. The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5’-3’ exoribonuclease XRN1. RNA. 2018;24(10):1339–1350.
   PubMed Web of Science ®Google Scholar
• Zhao BS, Roundtree IA, He C. Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol. 2017;18(1):31–42.
   PubMed Web of Science ®Google Scholar
• Jia G, Yang CG, Yang S, et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 2008;582(23–24):3313–3319.
   PubMed Web of Science ®Google Scholar
• Fu Y, Jia G, Pang X, et al. FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nat Commun. 2013;4(1):1798.
   PubMedGoogle Scholar
• Ueda Y, Ooshio I, Fusamae Y, et al. AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells. Sci Rep. 2017;7(1):42271.
   PubMedGoogle Scholar
• Li H, Zhang Y, Guo Y, et al. ALKBH1 promotes lung cancer by regulating m6A RNA demethylation. Biochem Pharmacol. 2021;189:114284.
   PubMed Web of Science ®Google Scholar
• Mauer J, Luo X, Blanjoie A, et al. Reversible methylation of m6Am in the 5’ cap controls mRNA stability. Nature. 2017;541(7637):371–375.
   PubMed Web of Science ®Google Scholar
• Zhang X, Wei LH, Wang Y, et al. Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates. Proc Natl Acad Sci U S A. 2019;116(8):2919–2924.
   PubMed Web of Science ®Google Scholar
• Song H , Wang Y, Wang R, et al. SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference. Cell Chem Biol. 2020;27(3):283–291.
   PubMed Web of Science ®Google Scholar
• He L, Li H, Wu A, et al. Functions of N6-methyladenosine and its role in cancer. Mol Cancer. 2019;18(1):176.
   PubMed Web of Science ®Google Scholar
• Yue B, Song C, Yang L, et al. METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer. Mol Cancer. 2019;18(1):142.
   PubMed Web of Science ®Google Scholar
• Liu T, Yang S, Sui J, et al. Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer. J Cell Physiol. 2020;235(1):548–562.
   PubMed Web of Science ®Google Scholar
• Yang Z, Jiang X, Li D, et al. HBXIP promotes gastric cancer via METTL3-mediated MYC mRNA m6A modification. Aging (Albany NY). 2020;12(24):24967–24982.
   PubMedGoogle Scholar
• Wang Q, Chen C, Ding Q, et al. METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. Gut. 2020;69(7):1193–1205.
   PubMed Web of Science ®Google Scholar
• Li H, Su Q, Li B, et al. High expression of WTAP leads to poor prognosis of gastric cancer by influencing tumour-associated T lymphocyte infiltration. J Cell Mol Med. 2020;24(8):4452–4465.
   PubMed Web of Science ®Google Scholar
• Su Y, Huang J, Hu J. m6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gastric cancer. Front Oncol. 2019;9:1038.
   PubMed Web of Science ®Google Scholar
• Liu X, Xiao M, Zhang L, et al. The m6A methyltransferase METTL14 inhibits the proliferation, migration, and invasion of gastric cancer by regulating the PI3K/AKT/mTOR signaling pathway. J Clin Lab Anal. 2021;35(3):e23655.
   PubMed Web of Science ®Google Scholar
• Zhang C, Zhang M, Ge S, et al. Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer. Cancer Med. 2019;8(10):4766–4781.
   PubMed Web of Science ®Google Scholar
• Wang Z, Liu J, Yang Y, et al. Expression and prognostic potential of ribosome 18S RNA m6A methyltransferase METTL5 in gastric cancer. Cancer Cell Int. 2021;21(1):569.
   PubMed Web of Science ®Google Scholar
• Xu D, Shao W, Jiang Y, et al. FTO expression is associated with the occurrence of gastric cancer and prognosis. Oncol Rep. 2017;38(4):2285–2292.
   PubMed Web of Science ®Google Scholar
• Li Y, Zheng D, Wang F, et al. Expression of demethylase genes, FTO and ALKBH1, Is associated with prognosis of gastric cancer. Dig Dis Sci. 2019;64(6):1503–1513.
   PubMed Web of Science ®Google Scholar
• Shimura T, Kandimalla R, Okugawa Y, et al. Novel evidence for m6A methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer. Br J Cancer. 2022;126(2):228–237.
   PubMed Web of Science ®Google Scholar
• Hu Y, Gong C, Li Z, et al. Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification. Mol Cancer. 2022;21(1):34.
   PubMed Web of Science ®Google Scholar
• Jing JJ, Zhao X, Li H, et al. Expression profiles and prognostic roles of m6A writers, erasers and readers in gastric cancer. Future Oncol. 2021;17(20):2605–2620.
   PubMed Web of Science ®Google Scholar
• Zhang J, Guo S, Piao HY, et al. ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1. J Physiol Biochem. 2019;75(3):379–389.
   PubMed Web of Science ®Google Scholar
• Guan K, Liu X, Li J, et al. Expression status and prognostic value of M6A-associated genes in gastric cancer. J Cancer. 2020;11(10):3027–3040.
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Ohsugi M, Sasako T, et al. The RNA methyltransferase Complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in Adipogenesis. Mol Cell Biol. 2018;38(16):e00116–18.
   PubMed Web of Science ®Google Scholar
• De Souza CR, Leal MF, Calcagno DQ, et al. MYC deregulation in gastric cancer and its clinicopathological implications. PLoS One. 2013;8(5):e64420.
   PubMed Web of Science ®Google Scholar
• Yang Z, Jiang X, Zhang Z, et al. HDAC3-dependent transcriptional repression of FOXA2 regulates FTO/m6A/MYC signaling to contribute to the development of gastric cancer. Cancer Gene Ther. 2021;28(1–2):141–155.
   PubMed Web of Science ®Google Scholar
• Deng X, Su R, Weng H, et al. RNA N6-methyladenosine modification in cancers: current status and perspectives. Cell Res. 2018;28(5):507–517.
   PubMed Web of Science ®Google Scholar
• Xie JW, Huang XB, Chen QY, et al. m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling. Mol Cancer. 2020;19(1):114.
   PubMed Web of Science ®Google Scholar
• Pi J, Wang W, Ji M, et al. YTHDF1 promotes gastric carcinogenesis by controlling translation of FZD7. Cancer Res. 2021;81(10):2651–2665.
   PubMed Web of Science ®Google Scholar
• He X, Shu Y. RNA N6-methyladenosine modification participates in miR-660/E2F3 axis-mediated inhibition of cell proliferation in gastric cancer. Pathol Res Pract. 2019;215(6):152393.
   PubMed Web of Science ®Google Scholar
• Xie S, Chang Y, Jin H, et al. Non-coding RNAs in gastric cancer. Cancer Lett. 2020;493:55–70.
   PubMed Web of Science ®Google Scholar
• Luo Z, Rong Z, Zhang J, et al. Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression. Mol Cancer. 2020;19(1):86.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Rong Z, Luo Z, et al. Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis. Mol Cancer. 2019;18(1):126.
   PubMed Web of Science ®Google Scholar
• Coker H, Wei G, Brockdorff N. m6A modification of non-coding RNA and the control of mammalian gene expression. Biochim Biophys Acta Gene Regul Mech. 2019;1862(3):310–318.
   PubMed Web of Science ®Google Scholar
• Hu N, Ji H. N6-methyladenosine (m6A)-mediated up-regulation of long noncoding RNA LINC01320 promotes the proliferation, migration, and invasion of gastric cancer via miR495-5p/RAB19 axis. Bioengineered. 2021;12(1):4081–4091.
   PubMed Web of Science ®Google Scholar
• Liu D, Xia AD, Wu LP, et al. IGF2BP2 promotes gastric cancer progression by regulating the IGF1R-RhoA-ROCK signaling pathway. Cell Signal. 2022;94:110313.
   PubMed Web of Science ®Google Scholar
• Zhou W, Xian Q, Wang Q, et al. m6A methyltransferase 3 promotes the proliferation and migration of gastric cancer cells through the m6A modification of YAP1. J Oncol. 2021;2021:8875424.
   PubMed Web of Science ®Google Scholar
• Chen XY, Liang R, Yi YC, et al. The m6A reader YTHDF1 facilitates the tumorigenesis and metastasis of gastric cancer via USP14 translation in an m6A-Dependent manner. Front Cell Dev Biol. 2021;9:647702.
   PubMed Web of Science ®Google Scholar
• Huo FC, Zhu ZM, Zhu WT, et al. METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2. Oncogene. 2021;40(16):2968–2981.
   PubMed Web of Science ®Google Scholar
• Yu H, Zhao K, Zeng H, et al. N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability. Biomed Pharmacother. 2021;133:111075.
   PubMed Web of Science ®Google Scholar
• Miao R, Dai CC, Mei L, et al. KIAA1429 regulates cell proliferation by targeting c-Jun messenger RNA directly in gastric cancer. J Cell Physiol. 2020;235(10):7420–7432.
   PubMed Web of Science ®Google Scholar
• Wang XK, Zhang YW, Wang CM, et al. METTL16 promotes cell proliferation by up-regulating cyclin D1 expression in gastric cancer. J Cell Mol Med. 2021;25(14):6602–6617.
   PubMed Web of Science ®Google Scholar
• Sun Y, Li S, Yu W, et al. N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer. Cell Death Dis. 2020;11(10):836.
   PubMed Web of Science ®Google Scholar
• Zhang C, Wang J, Geng X, et al. Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach. Epigenomics. 2020;12(12):1027–1040.
   PubMed Web of Science ®Google Scholar
• Lu Y, Li Z, Lin C, et al. Translation role of circRNAs in cancers. J Clin Lab Anal. 2021;35(7):e23866.
   PubMed Web of Science ®Google Scholar
• Fan HN, Chen ZY, Chen XY, et al. METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis. Mol Cancer. 2022;21(1):51.
   PubMed Web of Science ®Google Scholar
• Yao ZT, Yang YM, Sun MM, et al. New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer. Cancer Commun. 2022;42(2):117–140.
   Web of Science ®Google Scholar
• Zhu L, Zhu Y, Han S, et al. Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer. Cell Death Dis. 2019;10(6):383.
   PubMed Web of Science ®Google Scholar
• Yan J, Huang X, Zhang X, et al. LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells. Biochem Biophys Res Commun. 2020;521(4):887–893.
   PubMed Web of Science ®Google Scholar
• Wang S, Wang Y, Zhang Z, et al. Long Non-Coding RNA NRON promotes tumor proliferation by regulating ALKBH5 and nanog in gastric cancer. J Cancer. 2021;12(22):6861–6872.
   PubMed Web of Science ®Google Scholar
• Zhang F, Yan Y, Cao X, et al. Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer. Aging (Albany NY). 2021;13(8):12224–12238.
   PubMedGoogle Scholar
• He H, Wu W, Sun Z, et al. MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of SEC62. Biochem Biophys Res Commun. 2019;517(4):581–587.
   PubMed Web of Science ®Google Scholar
• Zhang B, Wu Q, Li B, et al. m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer. Mol Cancer. 2020;19(1):53.
   PubMed Web of Science ®Google Scholar
• Ge L, Zhang N, Chen Z, et al. Level of N6-Methyladenosine in peripheral blood RNA: a novel predictive biomarker for gastric cancer. Clin Chem. 2020;66(2):342–351.
   PubMed Web of Science ®Google Scholar
• Zhang B, Chen Z, Tao B, et al. m6A target microRNAs in serum for cancer detection. Mol Cancer. 2021;20(1):170.
   PubMed Web of Science ®Google Scholar
• Liu T, Yang S, Cheng YP, et al. The N6-Methyladenosine (m6A) methylation gene YTHDF1 reveals a potential diagnostic role for gastric cancer. Cancer Manag Res. 2020;12:11953–11964.
   PubMed Web of Science ®Google Scholar
• Wang X, Guan D, Wang D, et al. Genetic variants in m6A regulators are associated with gastric cancer risk. Arch Toxicol. 2021;95(3):1081–1088.
   PubMed Web of Science ®Google Scholar
• Li J, Zuo Z, Lai S, et al. Differential analysis of RNA methylation regulators in gastric cancer based on TCGA data set and construction of a prognostic model. J Gastrointest Oncol. 2021;12(4):1384–1397.
   PubMed Web of Science ®Google Scholar
• Feng S, Qiu G, Yang L, et al. Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation. Biosci Rep. 2021;41(1):BSR20200842.
   PubMed Web of Science ®Google Scholar
• Yang H, Wen Y, Zhang M, et al. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Autophagy. 2020;16(2):271–288.
   PubMed Web of Science ®Google Scholar