Immunologic Effector Mechanisms in Animal Models of Occupational Asthma

References

• Abe, M., Shibata, K., Akatsu, H., Shimizu, N., Sakata, N., Katsuragi, T., and Okada, H. 2001. Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats. J. Immunol. 167:4651–4660.
   PubMed Web of Science ®Google Scholar
• Abraham, W. M. 2003. Of Mice and Men. Am. J. Resp. Cell Mol. Biol. 28: 1-4.Andersson, P. 1980. Antigen-induced bronchial anaphylaxis in actively sensitized guinea pigs: Anti-anaphylactic effects of sodium cromoglycate and aminophylline. Br. J. Pharmacol. 69:467–472.
   Google Scholar
• Andersson, P. 1982. Effects of inhibitors of anaphylactic mediators in two models of bronchial anaphylaxis in anesthetized guinea pigs. Br. J. Pharmacol. 77:301–307.
   PubMed Web of Science ®Google Scholar
• Andersson, P., and Brattsand, R. 1982. Protective effects of the glucocorticoid, budesonide, on lung anaphylaxis in actively sensitized guinea pigs: Inhibition of IgE-but not of IgG-mediated anaphylaxis. Br. J. Pharmacol. 76: 139-147.Andius, P., Arakawa, H., Molne, J., Pullerits, T., Skoogh, B. E., and Lotvall, J. 1996. Inflammatory responses in skin and airways after allergen challenge in Brown Norway rats sensitized to trimellitic anhydride. Allergy 51: 556-562.Arakawa, H., Kawikova, I., Skoogh, B., Hayes, J., Morikawa, A., Lofdahl, C., and Lotvall, J. 1993a. Role of arachidonic acid metabolites in airway responses induced by trimellitic anhydride in actively sensitized guinea pigs. Am. Rev. Respir. Dis. 147:1116–1121.
   Google Scholar
• Arakawa, H., Lotvall, J., Kawikova, I., Tee, R., Hayes, J., Lofdahl, C. G., Taylor, A. J. N., and Skoogh, B. E. 1993b. Airway allergy to trimellitic anhydride in guinea pigs: Different time courses of IgG1 titer and airway responses to allergen challenge. J. Allergy Clin. Immunol. 92:425–434.
   PubMed Web of Science ®Google Scholar
• Arakawa, H., Andius, P., Kawikova, I., Skoogh, B. E., Lofdahl, C. G., and Lotvall, J. 1994. Treatment with cyclosporin A during sensitization with trimellitic anhydride attenuates the airway response to allergen challenge three weeks later. Eur. J. Pharmacol. 252:313–319.
   PubMed Web of Science ®Google Scholar
• Arakawa, H., Lotvall, J., Kawikova, I., Morikawa, A., Lofdahl, C. G., and Skoogh, B. E. 1995. Airway responses following intradermal sensitization to different types of allergens: Ovalbumin, trimellitic anhydride and Dermatophagoides farinae. Int. Arch. Allergy Immunol. 108:274–280.
   PubMed Web of Science ®Google Scholar
• Arts, J. H. E., Bloksma, N., Muis, T. L., and Kuper, C. F. 2003. Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats. Toxicol. Appl. Pharmacol. 187:38–49.
   PubMed Web of Science ®Google Scholar
• Arts, J. H. E., and Kuper, C. F. 2003. Approaches to induce and elicit respiratory allergy: Impact of route and intensity of exposure. Toxicol. Lett. 140-141:213–222.
   Google Scholar
• Bernstein, I. L., Bernstein, D. I., Chan-Yeung, M., and Malo, J. L. 1999. Definition and Classification of Asthma. In Asthma in the Workplace, 2nd Edition (I. L Bernstein, M. Chan-Yeung, J. L. Malo, and D. I. Bernstein, Eds.), pp. 1-3, Marcel Dekker, Inc., New York.
   Google Scholar
• Blyth, D. I., Pedrick, M. S., Savage, T. J., Hessel, E. M., and Fattah, D. 1996. Lung inflammation and epithelial changes in a murine model of atopic asthma. Am. J. Respir. Cell Mol. Biol. 14:425–438.
   PubMed Web of Science ®Google Scholar
• Boeniger, M. F., Lummus, Z. L., Biagini, R. E., Bernstein, D. I., Swanson, M. C., Reed, C., and Massoudi, M. 2001. Exposure to protein aeroallergens in egg processing facilities. Appl. Occup. Environ. Health 16:660–670.
   PubMedGoogle Scholar
• Botham, P. A., Hext, P. M., Rattray, N. J., Walsh, S. T., and Woodcock, D. R. 1988. Sensitization of guinea pigs by inhalation exposure to low molecular weight chemicals. Toxicol. Lett. 41:159–173.
   PubMed Web of Science ®Google Scholar
• Botham, P. A., Rattray, N. J., Woodcock, D. R., Walsh, S. T., and Hext, P. M. 1989. The induction of respiratory allergy in guinea-pigs following intradermal injection of trimellitic anhydride: Comparison with the response to 2, 4-dinitrochlorobenzene. Toxicol. Lett. 47:25–39.
   PubMed Web of Science ®Google Scholar
• Brewer, J. P., Kisselgof, A. B., and Martin, T. R. 1999. Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice. Am. J. Respir. Crit. Care Med. 160:1150–1156.
   PubMed Web of Science ®Google Scholar
• Chan-Yeung, M., and Lam, S. 1986. Occupational Asthma. Am. Rev. Respir. Dis. 133:666–703.
   Google Scholar
• Correy, D. B., Fokesson, H. G., Warnock, M. L., Erle, D. J., Matthay, M. A., Wiener-Kronish, J. P., and Locksley, R. M. 1996. Interleukin 4, but not interleukin 5 or eosinophils is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109–117.
   PubMed Web of Science ®Google Scholar
• Cui, Z. H., Sjostrand, M., Pullerits, T., Andius, P., Skoogh, B. E., and Lotvall, J. 1997. Bronchial hyperresponsiveness, epithelial damage, and airway eosinophilia after single and repeated allergen exposure in a rat model of anhydride-induced asthma. Allergy 52:739–746.
   PubMed Web of Science ®Google Scholar
• Cui, Z. H., Skoogh, B. E., Pullerits, T., and Lotvall, J. 1999. Bronchial hyper-responsiveness and airway wall remodeling induced by exposure to allergen for 9 weeks. Allergy 54:1074–1082.
   PubMed Web of Science ®Google Scholar
• Dearman, R. J., Hegarty, J. M., and Kimber, I. 1991. Inhalation exposure of mice to trimellitic anhydride induces both IgG and IgE anti-hapten antibody. Int. Arch. Allergy Appl. Immunol. 95:70–76.
   PubMedGoogle Scholar
• Dearman, R. J., Basketter, D. A., and Kimber, I. 1996. Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice. Toxicol. Appl. Pharmacol. 138:308–316.
   PubMed Web of Science ®Google Scholar
• Dearman, R. J., Betts, C. J., Humphreys, N., Flanagan, B. F., Gilmour, N. J., Basketter, D. A., and Kimber, I. 2003. Chemical allergy: Considerations for the practical application of cytokine profiling. Toxicol. Sci. 71:137–145.
   Google Scholar
• Eapen, S. S., and Busse, W. W. 2002. Asthma. J. Allergy Clin. Immunol. 16:325–353.
   Google Scholar
• Escudero. C., Quirce. S., Fernandez-Nieto, M., de Miguel, J., Cuesta, J., and Sastre, J. 2003. Egg white proteins as inhalant allergens associated with baker’s asthma. Allergy 58:616–620.
   PubMed Web of Science ®Google Scholar
• Eum, S. Y., Maghni, K., Hamid, Q., Campbell, H., Eidelman, D. H., and Martin, J. G. 2003. Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse. Am. J. Resp. Cell Mol. Biol. 28:25–32.
   PubMed Web of Science ®Google Scholar
• Evans, T. W., Rogers, D. F., Aursudkij, B., Chung, K. F., and Barnes, P. J. 1988. Inflammatory mediators involved in antigen-induced airway microvascular leakage in guinea pigs. Am. Rev. Resp. Dis. 138:395–399.
   PubMed Web of Science ®Google Scholar
• Foster, A., and Chan, C. C. 1991. Peptide leukotriene involvement in pulmonary eosinophil migration upon antigen challenge in the actively sensitized guinea pig. Int. Arch. Allergy Appl. Immunol. 96:279–284.
   PubMedGoogle Scholar
• Foster, P. S., Hogan, S. P., Ramsay, A. J., Matthei, A. K., and Young, I. G. 1996. IL-5 deficiency abolishes eosinophilia, airways hyperreactivity and lung damage in a mouse asthma model. J. Exp. Med. 183:195–201.
   PubMed Web of Science ®Google Scholar
• Fraser, D. G., Regal, J. F., and Arndt, M. L. 1995. Trimellitic anhydride-induced allergic response in the lung: Role of the complement system in cellular changes. J. Pharmacol Exp. Ther. 273:793–801.
   PubMed Web of Science ®Google Scholar
• Fraser, D. G., Graziano, F. M., Larsen, C. P., and Regal, J. F. 1998. The role of IgG1 and IgG2 in trimellitic anhydride-induced allergic response in the guinea pig lung. Toxicol. Appl. Pharmacol. 150:218–227.
   PubMed Web of Science ®Google Scholar
• Gerard, C., and Rollins, B. J. 2001. Chemokines and Disease. Nature Immunol. 2:108–115.
   PubMed Web of Science ®Google Scholar
• Gulbenkian, A. R., Egan, R. W., Fernandez, X., Jones, H., Kreutner, W., Kung, T., Payvandi, F., Sullivan, L., Zurcher, J. A., and Watnick, A. S. 1992. Interleukin-5 modulates eosinophil accumulation in allergic guinea pig lung. Am. Rev. Respir. Dis. 146:263–265.
   PubMed Web of Science ®Google Scholar
• Hamelmann, E., Oshiba, A., Loader, J., Larsen, G. L., Gleich, G., Lee, J., and Gelfand, E. W. 1997a. Anti-interleukin 5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization. Am. J. Respir. Crit. Care Med. 155:819–825.
   PubMed Web of Science ®Google Scholar
• Hamelmann, E., Oshiba, A., Schwarze, J., Bradley, K., Loader, J., Larsen, G. L., and Gelfand, E. W. 1997b. Allergen specific IgE and IL5 are essential for the development of airway hyperresponsiveness. Am. J. Respir. Cell Mol. Biol. 16:674–682.
   PubMed Web of Science ®Google Scholar
• Hamelmann, E., Takeda, K., Schwarze, J., Vella, A. T., Irvin, C. G., and Gelfand, E. W. 1999. Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or Blymphocytes. Am. J. Respir. Cell Mol. Biol. 21:480–489.
   PubMed Web of Science ®Google Scholar
• Hamelmann, E., Vella, A. T., Oshiba, A., Marrack, P., Kappler, J. W., and Gelfand, E. W. 1997c. Allergic airway sensitization induces T-cell activation but not airway hyperresponsiveness in B-cell deficient mice. Proc. Natl. Acad. Sci USA 94:1350–1355.
   PubMed Web of Science ®Google Scholar
• Hayes, J. P., Barnes, P. J., Newman Taylor, A. J., and Chung, K. F. 1993. Effect of a topical corticosteroid on airway hyperresponsiveness and eosinophilic inflammation induced by trimellitic anhydride exposure in sensitized guinea pigs. J. Allergy Clin. Immunol. 92:450–456.
   PubMed Web of Science ®Google Scholar
• Hayes, J. P., Daniel, R., Tee, R. D., Barnes, P. J., Chung, K. F., and Taylor, A. J. N. 1992a. Specific immunological and bronchopulmonary responses following intradermal sensitization to free trimellitic anhydride in guinea pigs. Clin. Exp. Allergy 22:694–700.
   PubMed Web of Science ®Google Scholar
• Hayes, J. P., Daniel, R., Tee, R. D., Barnes, P. J., Taylor, A. J. N., and Chung, K. F. 1992b. Bronchial hyperreactivity after inhalation of trimellitic anhydride dust in guinea pigs after intradermal sensitization to free hapten. Am. Rev. Respir. Dis. 146:1311–1314.
   PubMed Web of Science ®Google Scholar
• Hayes, J. P., Kuo, H. P., Rohde, J. A. L., Newman Taylor, A. J., Barnes, P. J., Chung, K. F., and Rogers, D. F. 1995. Neurogenic goblet cell secretion and bronchoconstriction in guinea pigs sensitized to trimellitic anhydride. Eur. J. Pharmacol. 292:127–134.
   PubMed Web of Science ®Google Scholar
• Hayes, J. P., Lotvall, J. O., Baraniuk, J., Daniel, R., Barnes, P. J., Newman Taylor, A. J., and Chung, K. F. 1992c. Bronchoconstriction and airway microvascular leakage in guinea pigs sensitized with trimellitic anhydride. Am. Rev. Respir. Dis. 146:1306–1310.
   PubMed Web of Science ®Google Scholar
• Hayes, J. P., Lotvall, J. O., Barnes, P. J., Newman Taylor, A. J., and Chung, K. F. 1992d. Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea-pigs. Br. J. Pharmacol. 106:828–832.
   PubMed Web of Science ®Google Scholar
• Hogan, S. P., Matthaei, K. I., Young, J. M., Koskinen, A., Young, I. G., and Foster, P. S. 1998. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J. Immunol. 161:1501–1509.
   PubMed Web of Science ®Google Scholar
• Humbles, A. A., Conroy, D. M., Marleau, S., Rankin, S. M., Palframan, R. T., Proudfoot, A. E., Wells, T. N., Li, D., Jeffery, P. K., Griffiths-Johnson, D. A., Williams, T. J., and Jose, P. J. 1997. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: Analysis in a guinea pig model in vivo. J. Exp. Med. 186:601–612.
   Google Scholar
• Humbles, A. A., Lu, B., Nilsson, C. A., Lilly, C., Israel, E., Fujiwara, Y., Gerard, N. P., and Gerard, C. 2000. A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature 406:998–1001.
   PubMed Web of Science ®Google Scholar
• Ishida, K., Kelly, L. J., Thomson, R. J., Beattie, L. L., and Schellenberg, R. R. 1989. Repeated antigen challenge induces airway hyperresponsiveness with tissue eosinophilia in guinea pigs. J. Appl. Physiol. 67:1133–1139.
   PubMed Web of Science ®Google Scholar
• Ishida, K., Thomson, R. J., Beattie, L. L., Wiggs, B., and Schellenberg, R. R. 1990. Inhibition of antigen-induced airway hyperresponsiveness, but not acute hypoxia nor airway eosinophilia, by an antagonist of platelet-activating factor. J. Immunol. 144:3907–3911.
   PubMed Web of Science ®Google Scholar
• Kagoshima, M., Tomomatsu, N., Aratani, H., and Terasawa, M. 1991. Effect of Y-20811, a long lasting thromboxane A2 synthetase inhibitor, on antigen-induced airway hyperresponsiveness in guinea pigs. Int. Arch. Allergy Appl. Immunol. 96:238–243.
   PubMedGoogle Scholar
• Karp, C. L., Grupe, A., Schadt, E., Ewart, S. L., Keane-Moore, M., Cuomo, P. J., Kohrl, J., Wahl, L., Kuperman, D., Germer, S., Aud, D., Peltz, G., Wills-Karp, M. 2000. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nature Immunol. 1:221–226.
   PubMed Web of Science ®Google Scholar
• Larsen, C. P., and Regal, J. F. 2002a. Trimellitic anhydride-induced cellular infiltration into guinea pig lung varies with age but not gender. Int. Arch. Allergy Appl. Immunol.127:63–72.
   Google Scholar
• Larsen, C. P., and Regal, J. F. 2002b. Trimellitic anhydride (TMA) dust induces airway obstruction and eosinophilia in non-sensitized guinea pigs. Toxicology 178:89–99.
   PubMed Web of Science ®Google Scholar
• Larsen, C. P., Regal, R. R., and Regal, J. F. 2001. Trimellitic anhydride-induced allergic response in the guinea pig lung involves antibody-dependent and -independent complement system activation. J. Pharmacol. Exp. Ther. 296:284–292.
   PubMed Web of Science ®Google Scholar
• Leach, C. L., Hatoum, N. S., Ratajczak, H. V., Zeiss, C. R., and Garvin, P. J. 1988. Evidence of immunologic control of lung injury induced by trimellitic anhydride. Am. Rev. Respir. Dis. 137:186–191.
   PubMed Web of Science ®Google Scholar
• Leach, C. L., Hatoum, N. S., Ratajczak, H. V., Zeiss, C. R., Roger, J. C., and Garvin, P. J. 1987. The pathologic and immunologic response to inhaled trimellitic anhydride in rats. Toxicol. Appl. Pharmacol. 87:67–80.
   PubMed Web of Science ®Google Scholar
• Leach, C. L., Hatoum, N. S., Zeiss, C. R., and Garvin, P. J. 1989. Immuno-logic tolerance in rats during 13 weeks of inhalation exposure to trimellitic anhydride. Fundam. Appl. Toxicol. 12:519–529.
   PubMedGoogle Scholar
• Leong, K. P., and Huston, D. P. 2001. Understanding the pathogenesis of allergic asthma using mouse models. Ann. Allergy Asthma Immunol. 87:96–110.
   PubMed Web of Science ®Google Scholar
• Li, Y., Martin, L. D., Minnicozzi, M., Greenfeder, S., Fine, J., Pettersen, C. A., Chorley, B., and Adler, K.B. 2001. Enhanced expression of mucin genes in a guinea pig model of allergic asthma. Am. J. Respir. Cell Mol. Biol. 25:644–651.
   PubMed Web of Science ®Google Scholar
• Mehlhop, P. D., Van de Rijn, M., Goldberg, A. B., Brewer, J. P., Kurup, V. P., Martin, T. R., and Oettgen, H. C. 1997. Allergen-induced bronchial hyperre-activity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc. Natl. Acad. Sci. USA 94:1344–1349.
   PubMed Web of Science ®Google Scholar
• Meurs, H., McKay, S., Maarsingh, H., Hamer, M. A. M., Macic, L., Molendijk, N., and Zaagsma, J. 2002. Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness. Br. J. Pharmacol. 136:391–398.
   PubMed Web of Science ®Google Scholar
• Meurs, H., Maarsingh, H., and Zaagsma, J. 2003. Arginase and asthma: Novel insights into nitric oxide homeostasis and airway hyperresponsiveness. Trends Pharmacol. Sci. 24:450–455.
   Google Scholar
• Nabe, T., Yamashita, K., Miura, M., Kawai, T., and Kohno, S. 2002. Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs. Clin. Exp. Allergy 32:633–640.
   PubMed Web of Science ®Google Scholar
• Nag, S., Lamkhloued, B., and Renzi, P. M. 2002. Interleukin-2-induced increased airway responsiveness and lung TH2 cytokine expression occur after antigen challenge through the leukotriene pathway. Am. J. Respir. Crit. Care Med. 165:1540–1545.
   PubMed Web of Science ®Google Scholar
• National Asthma Education and Prevention Program, Expert Panel Report 2. Guidelines for the Diagnosis and Management of Asthma. National Heart Lung and Blood Institute, NIH Publication 97-4051, July, 1997. NIOSH Current Intelligence Bulletin 21. 1978. Trimellitic anhydride (TMA). U.S. Dept. of Health Education and Welfare (NIOSH). Publication No. 78–121.
   Google Scholar
• Obata, H., Tao, Y., Kido, M., Nagata, N., Tanaka, I. and Kuroiwa, A. 1992. Guinea pig model of immunologic asthma induced by inhalation of trimellitic anhydride. Am. Rev. Respir. Dis. 146:1553–1558.
   PubMed Web of Science ®Google Scholar
• Oettgen, H. C., Martin, T. R., Wynshaw, B. A., Deng, G., Drazen, J. M., and Leder, P. 1994. Active anaphylaxis in IgE-deficient mice. Nature 370:367–370.
   PubMed Web of Science ®Google Scholar
• Oshiba, A., Hamelmann, E., Takeda, K., Bradley, K. L., Loader, J. E., Larsen, G. L., and Gelfand, E. W. 1996. Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice. J. Clin. Invest. 97:1398–1408.
   PubMed Web of Science ®Google Scholar
• Pauluhn, J. 1994. Assessment of chemicals for their potential to induce respiratory allergy in guinea pigs: A comparison of different routes of induction and confounding effects due to pulmonary hyperreactivity. Toxicol. In Vitro 8:981–985.
   Google Scholar
• Pauluhn, J., and Eben, A. 1991. Validation of a non-invasive technique to assess immediate or delayed-onset of airway hypersensitivity in guinea-pigs. J. Appl. Toxicol. 11:423–431.
   PubMed Web of Science ®Google Scholar
• Pauluhn, J., Eidmann, P., Freyberger. A., Wasinska-Kempka, G., and Vohr, H. W. 2002. Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: A comparison of endpoints. J. Appl. Toxicol. 22:89–97.
   PubMed Web of Science ®Google Scholar
• Plitnick, L. M., Loveless, S. E., Ladics, G. S., Holsapple, M. P., Selgrade, M. J., Sailstad, D. M., and Smialowicz, R. J. 2002. Cytokine profiling for chemical sensitizers: Application of the ribonuclease protection assay and effect of dose. Toxicol. Appl. Pharmacol. 179:145–154.
   PubMed Web of Science ®Google Scholar
• Regal, J. F. 1989. Mechanism of IgG-and IgE-Mediated Contraction of Airway Smooth Muscle. In Focus on Pulmonary Pharmacology and Toxicology, Vol. 1 (M. A. Hollinger, Ed.), pp. 73-90, CRC Press, Inc., Boca Raton. Regal, J. F., and Fraser, D. G. 1996. Systemic complement system depletion does not inhibit cellular accumulation in antihistamine pretreated allergic guinea pig lung. Int. Arch. Allergy Appl. Immunol. 109:150–160.
   Google Scholar
• Regal, J. F., Mohrman, M. E., and Sailstad, D. M. 2001. Trimellitic anhydride-induced eosinophilia in a mouse model of occupational asthma. Toxicol. Appl. Pharmacol. 175:234–242.
   PubMed Web of Science ®Google Scholar
• Richerson, H. B. 1972. Acute experimental hypersensitivity pneumonitis in the guinea pig. J. Lab. Clin. Med. 79:745–757.
   PubMed Web of Science ®Google Scholar
• Roska, A. K., Garancis, J. C., Moore, V. L., and Abramoff, P. 1977. Immune-complex disease in guinea pig lungs: I. Elicitation by aerosol challenge, suppression with cobra venom factor, and passive transfer with serum. Clin. Immunol. Immunopathol. 8:213–224.
   PubMedGoogle Scholar
• Rothenberg, M. E. 1999. Eotaxin: An essential mediator of eosinophil trafficking into mucosal tissues. Am. J. Respir. Cell Mol. Biol. 21:291–295.
   Google Scholar
• Sakai, K., Yokoyama, A., Kohno, N., and Hiwada, K. 1999. Effect of different sensitizing doses of antigen in a murine model of atopic asthma. Clin. Exp. Immunol. 118:9–15.
   PubMed Web of Science ®Google Scholar
• Schaper, M., and Brost, M. A. 1991. Respiratory effects of trimellitic anhydride aerosols in mice. Arch. Toxicol. 65:671–677.
   PubMed Web of Science ®Google Scholar
• Schuiling, M., Zuidhof, A. B., Bonouvrie, M. A., Venema, N., Zaagsma, J., and Meurs, H. 1998. Role of nitric oxide in the development and partial reversal of allergen-induced airway hyperreactivity in conscious, unrestrained guinea-pigs. Br. J. Pharmacol. 123:1450–1456.
   PubMed Web of Science ®Google Scholar
• Smith, A. B., Bernstein, D. I., London, M. A., Gallagher, J., Ornella, G. A., Gelletly, S. K., Wallingford, K., and Newman, M. A. 1990. Evaluation of occupational asthma from airborne egg protein exposure in multiple settings. Chest 98:398–404.
   PubMed Web of Science ®Google Scholar
• Tao, Y., Sugiura, T., Nakamura, H., Kido, M., Danaka, I., and Kuroiwa, A. 1991. Experimental lung injury induced by trimellitic anhydride inhalation in guinea pigs. Int. Arch. Allergy Appl. Immunol. 96:119–127.
   PubMedGoogle Scholar
• Tomkinson, A., Cieslewicz, G., Duez, C., Larson, K. A., Lee, J. J., and Gelfand, E. W. 2001. Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice. Am. J Respir. Crit. Care Med. 163:721–730.
   PubMed Web of Science ®Google Scholar
• Tumas, D. B., Chan, B., Werther, W., Wrin, T., Vennari, J., Desjardin, N., Shields, R. L., and Jardieu, P. 2001. Anti-IgE efficacy in murine asthma models is dependent on the method of allergen sensitization. J. Allergy Clin. Immunol. 107:1025–1033.
   PubMed Web of Science ®Google Scholar
• Van Kampen, V., Merget, R., and Baur, X. 2000. Occupational airway sensitizers: An overview on the respective literature. Am. J. Ind. Med. 38:164–218.
   PubMed Web of Science ®Google Scholar
• Vento, K. L., Dearman, R. J., Kimber, I., Basketter, D. A., and Coleman, J. W. 1996. Selectivity of IgE responses, mast cell sensitization, and cytokine expression in the immune response of Brown Norway rats to chemical allergens. Cell. Immunol. 172:246–253.
   PubMed Web of Science ®Google Scholar
• Warbrick, E. V., Dearman, R. J., and Kimber, I. 2002. IgG and IgE antibody responses following exposure of Brown Norway rats to trimellitic anhydride: Comparison of inhalation and topical exposure. Toxicology 172:157–168.
   Google Scholar
• Wills-Karp, M. 2000. Murine models of asthma in understanding immune dys-regulation in human asthma. Immunopharmacology 48: 263-268.Wolyniec, W. W., LaPlante, A. M., Kontny, M., Lazer, E. S., Letts, L. G., and Wegner, C. D. 1991. BI-L-239, a 5-lipoxygenase inhibitor, blocks inhaled antigen-induced airway hyperresponsiveness in conscious guinea pigs. Agents Action 34:73–76.
   Google Scholar
• Yan, Z. Q., Hansson, G. K., Skoogh, B. E., and Lotvall, J. O. 1995. Induction of nitric oxide synthase in a model of allergic occupational asthma. Allergy 50:760–764.
   PubMed Web of Science ®Google Scholar
• Zeiss, C. R., Hatoum, N. S., Ferguson, J., Trout, J., Levitz, D., Siddiqui, F., Henderson, A. A., Yermakoff, J., and Patterson, R. 1992. Localization of inhaled trimellitic anhydride to lung with a respiratory lymph node antibody secreting cell response. J. Allergy Clin. Immunol. 90:944–952.
   PubMed Web of Science ®Google Scholar
• Zeiss, C. R., Leach, C. L., Levitz, D., Hatoum, N. S., Garvin, P. J., and Patterson, R. 1989. Lung injury induced by short term intermittent trimellitic anhydride inhalation. J. Allergy Clin. Immunol. 84:219–223.
   PubMed Web of Science ®Google Scholar
• Zeiss, C. R., Leach, C. L., Smith, L. J., Levitz, D., Hatoum, N. S., Garvin, P. J., and Patterson, R. 1988. A serial immunologic and histopathologic study of lung injury induced by trimellitic anhydride. Am. Rev. Respir. Dis. 137:191–196.
   PubMed Web of Science ®Google Scholar
• Zeiss, C. R., Mitchell, J. H., Peenen, V., Harris, J., and Levitz, D. 1990. A twelve year clinical and immunologic evaluation of workers involved in the manufacture of trimellitic anhydride (TMA). Allergy Proc. 11:71–77.
   PubMedGoogle Scholar
• Zeiss, C. R., Patterson, R., Pruzansky, J. J., Miller M. M., Rosenberg, M., and Levitz, D. 1977. Trimellitic anhydride-induced airway syndromes: Clinical and immunologic studies. J. Allergy Clin. Immunol. 60:96–103.
   PubMed Web of Science ®Google Scholar
• Zhang. X. D., Murray, D. K., Lewis, D. M., and Siegel, P. D. 2002b. Dose-response and time course of specific IgE and IgG after single and repeated topical skin exposure to dry trimellitic anhydride powder in a Brown Norway rat model. Allergy 57:620–625.
   PubMed Web of Science ®Google Scholar
• Zhang, X. D., Siegel, P., and Lewis, D. M. 2002a. Immunotoxicology of organic acid anhydrides (OAAs). Intl. Immunopharmacol. 2:239–248.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Lamm, W. J., Albert, R. K., Chi, E. Y., Henderson, W. R., and Lewis, D. B. 1997. Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response. Am. J. Respir. Crit. Care Med. 155:661–669.
   PubMed Web of Science ®Google Scholar
• Zimmermann, N., King, N. E., Laporte, J., Yang, M., Mishra, A., Pope, S. M., Muntel, E. E., Witte, D. P., Pegg, A. A., Foster, P. S., Hamid, Q., and Rothenberg, M. E. 2003. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J. Clin Invest. 111:1863–1874.
   PubMed Web of Science ®Google Scholar