Transcriptome analysis of low-dose ionizing radiation-impacted genes in CD4⁺ T-cells undergoing activation and regulation of their expression of select cytokines

References

• Asaithamby A, Chen D. 2009. Cellular responses to DNA double-strand breaks after low-dose γ-irradiation. Nucleic Acids Res. 37:3912–3923.
   PubMed Web of Science ®Google Scholar
• Cai L, Wang P. 1995. Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic γ-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their male offspring. Mutagenesis. 10:95–100.
   PubMed Web of Science ®Google Scholar
• Calabrese E, Bachmann K, Bailer A, Bolger P, Borak J, Cai L, Cedergreen N, Cherian M, Chiueh C, Clarkson T, et al. 2007. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol. 222:122–128.
   PubMed Web of Science ®Google Scholar
• Cheda A, Wrembel-Wargocka J, Lisiak E, Nowosielska E, Marciniak M, Janiak M. 2004. Single low doses of X rays inhibit the development of experimental tumor metastases and trigger the activities of NK cells in mice . Radiation Res. 161:335–340.
   PubMed Web of Science ®Google Scholar
• Cho S, Kang H, Kim M, Lee J, Kim S, Nam S, Kim J, Kim H, Pyo S, Yang K. 2016. Site-specific phosphorylation of Ikaros induced by low-dose ionizing radiation regulates cell cycle progression of B-lymphoblast through CK2 and AKT activation. Int J Radiation Oncol Biol Phys. 94:1207–1218.
   PubMed Web of Science ®Google Scholar
• Cohen B. 1994. Dose-response relationship for radiation carcinogenesis in the low-dose region. Int Arch Occup Environ Health. 66:71–75.
   PubMed Web of Science ®Google Scholar
• Dainiak N. 2002. Hematologic consequences of exposure to ionizing radiation. Exp Hematol. 30:513–528.
   PubMed Web of Science ®Google Scholar
• Feinendegen L. 2005. Evidence for beneficial low level radiation effects and radiation hormesis. Br J Radiol. 78:3–7.
   PubMed Web of Science ®Google Scholar
• Feinendegen L, Bond V, Sondhaus C, Muehlensiepen H. 1996. Radiation effects induced by low doses in complex tissue and their relation to cellular adaptive responses. Mutat Res. 358:199–205.
   PubMed Web of Science ®Google Scholar
• Gorelik L, Constant S, Flavell R. 2002. Mechanism of transforming growth factor of TGFβ-induced inhibition of T-helper Type I differentiation. J Exp Med. 195:1499–1505.
   PubMed Web of Science ®Google Scholar
• Gorelik L, Fields P, Flavell R. 2000. Cutting edge: TGFβ inhibits TH type 2 development through inhibition of GATA-3 expression. J Immunol. 165:4773–4777.
   PubMed Web of Science ®Google Scholar
• Gridley D, Pecaut M, Rizvi A, Coutrakon G, Luo-Owen X, Makinde A, Slater J. 2009. Low-dose, low-dose-rate proton radiation modulates CD4+ T-cell gene expression . Int J Radiat Biol. 85:250–261.
   PubMed Web of Science ®Google Scholar
• Gridley D, Rizvi A, Luo-Owen X, Makinde A, Pecaut M. 2009. Low-dose, low-dose rate photon radiation modifies leukocyte distribution and gene expression in CD4+ T-cells. J Radiation Res. 50:139–150.
   PubMed Web of Science ®Google Scholar
• Grudzenski S, Raths A, Conrad S, Rube C, Lobrich M. 2010. Inducible response required for repair of low-dose radiation damage in human fibroblasts. Proc Natl Acad Sci USA. 107:14205–14210.
   PubMed Web of Science ®Google Scholar
• Heath V, Murphy E, Crain C, Tomlinson M, O'Garra A. 2000. TGF-β1 down-regulates TH2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. Eur J Immunol. 30:2639–2649.
   PubMed Web of Science ®Google Scholar
• Jenkins M, Khoruts A, Ingulli E, Mueller D, McSorley S, Reinhardt R, Itano A, Pape K. 2001. In vivo activation of antigen-specific CD4 T-cells. Annu Rev Immunol. 19:23–45.
   PubMed Web of Science ®Google Scholar
• Livak K, Schmittgen T. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) Method. Methods. 25:402–408.
   PubMed Web of Science ®Google Scholar
• McFarland H, Puig M, Grajkowska L, Tsuji K, Lee J, Mason K, Verthelyi D, Rosenberg A. 2012. Regulatory T cells in γ-irradiation-induced immune suppression. PLoS One. 7:e39092
   PubMed Web of Science ®Google Scholar
• Mimaki M, Wang X, McKenzie M, Thorburn D, Ryan M. 2012. Understanding mitochondrial Complex I assembly in health and disease. Biochim Biophys Acta. 1817:851–862.
   PubMed Web of Science ®Google Scholar
• Nosel I, Vaurijoux A, Barquinero J, Gruel G. 2013. Characterization of gene expression profiles at low and very low doses of ionizing radiation. DNA Repair. 12:508–517.
   PubMed Web of Science ®Google Scholar
• Nowosielska E, Wrembel-Wargocka J, Cheda A, Lisiak E, Janiak M. 2006. Enhanced cytotoxic activity of macrophages and suppressed tumor metastases in mice irradiated with low doses of X-rays. J Radiation Res. 47:229–236.
   PubMed Web of Science ®Google Scholar
• Pandey R, Shankar B, Sharma D, Sainis K. 2005. Low-dose radiation induced immunomoculation: Effect on macrophages and CD8+ T-cells. Int J Radiat Biol. 81:801–812.
   PubMed Web of Science ®Google Scholar
• Parsons P. 2000. Hormesis: An adaptive expectation with emphasis on ionizing radiation. J Appl Toxicol. 20:103–112.
   PubMed Web of Science ®Google Scholar
• Rizvi A, Pecaut M, Gridley D. 2011. Low-dose γ-rays and simulated solar particle event protons modify splenocyte gene and cytokine expression patterns. J Radiation Res. 52:701–711.
   PubMed Web of Science ®Google Scholar
• Scott B. 2005. Stochastic thresholds: A novel explanation of non-linear dose-response relationships for stochastic radiobiological effects. Dose Response 3:547–567.
   Google Scholar
• Shin S, Lee K, Kang Y, Kim K, Kim C, Yang K, Jin Y, Kim C, Kim H. 2010. Alteration of cytokine profiles in mice exposed to chronic low-dose ionizing radiation. Biochem Biophys Res Commun. 397:644–649.
   PubMed Web of Science ®Google Scholar
• Song K, Kim M, Kang S, Jung S, Ahn J, Woo H, Nam S, Hwang S, Ryu S, Song J. 2015. Analysis of immune cell populations and cytokine profiles in murine splenocytes exposed to whole-body low-dose irradiation. Int J Radiation Biol. 91:795–803.
   Web of Science ®Google Scholar
• Subramanian A, Tamayo P, Mootha V, Mukherjee S, Ebert B, Gillette M, Paulovich A, Pomeroy S, Golub T, Lander E, et al. 2005. Gene set enrichment analysis: Knowledge-based approach to interpret genome-wide expression profiles. Proc Natl Acad. Sci USA 102:15545–15550.
   PubMed Web of Science ®Google Scholar
• Tran D. 2012. TGFβ: the sword, the wand, and the shield of FOXP3+ regulatory T-cells. J Mol Cell Biol. 4:29–37.
   PubMed Web of Science ®Google Scholar
• Vaiserman A. 2010. Radiation hormesis: Historical perspective and implications for low-dose cancer risk assessment. Dose Response 8:172–191.
   PubMed Web of Science ®Google Scholar
• Vinothkumar K, Zhu J, Hirst J. 2014. Architecture of mammalian respiratory complex I. Nature. 515:80–84.
   PubMed Web of Science ®Google Scholar
• Wrixon A. 2008. New ICRP recommendations. J Radiol Prot. 28:161–168.
   PubMed Web of Science ®Google Scholar
• Zhou X, Liao W, Liao J, Liao P, Lu H. 2015. Ribosomal proteins: Functions beyond the ribosome. J Mol Cell Biol. 7:92–104.
   PubMed Web of Science ®Google Scholar
• Zhu J, Yamane H, Paul W. 2010. Differentiation of effector CD4 T-cell populations. Annu Rev Immunol. 28:445–489.
   PubMed Web of Science ®Google Scholar