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Research Article

Effects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes

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Pages 1-16 | Received 18 Oct 2021, Accepted 02 Feb 2022, Published online: 22 Mar 2022

References

  • Arazi H, Taati B, Suzuki K. A review of the effects of leucine metabolite (β-hydroxy-β-methylbutyrate) supplementation and resistance training on inflammatory markers: a new approach to oxidative stress and cardiovascular risk factors. Antioxidants. 2018;7(10):148.
  • Cholewa JM, Newmire DE, and Rossi FE, et al. An Overview of Betaine Supplementation, Sports Performance, and Body Composition. In: Nutrition and Enhanced Sports Performance. 2nd ed. Edited by Debasis Bagchi, Sreejayan Nair, and Chandan K. Sen. USA: Elsevier; 2019. p. 691–706.
  • Ismaeel A. Effects of betaine supplementation on muscle strength and power: a systematic review. J Strength Cond Res. 2017;31(8):2338–2346.
  • Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004;80(3):539–549.
  • Zeisel SH, Mar M-H, Howe JC, et al. Concentrations of choline-containing compounds and betaine in common foods1. J Nutr. 2003;133(5):1302–1307.
  • Apicella JM, Lee EC, Bailey BL, et al. Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise. Eur J Appl Physiol. 2013;113(3):793–802.
  • Waldman HS, Bryant AR, McAllister MJ. Effects of Betaine Supplementation on Markers of Metabolic Flexibility, Body Composition, and Anaerobic Performance in Active College-Age Females. J Diet Suppl. 2021;1–17. DOI:10.1080/19390211.2021.1973644
  • Hoffman JR, Ratamess NA, Kang J, et al. Effect of betaine supplementation on power performance and fatigue. J Int Soc Sports Nutr. 2009;6(1):1.
  • Borsook ME, Billig HK, Golseth JG. Betaine and glycocyamine in the treatment of disability resulting from acute anterior poliomyelitis. Annals of Western Medicine and Surgery. 1952;6(7):423–427.
  • Nobari H, Kargarfard M, Minasian V, et al. The effects of 14-week betaine supplementation on endocrine markers, body composition and anthropometrics in professional youth soccer players: a double blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2021;18(1):1–10.
  • Maresh CM, Farrell MJ, Kraemer WJ, et al. The Effects of Betaine Supplementation on Strength and Power Performance. Med Sci Sports Exercise. 2007;39(5):S101.
  • Kraemer W, Bailey B, Clark J, et al. The influence of betaine supplementation on work performance and endocrine function in men. J Strength Cond Res. 2011;25:S100–S101.
  • Lee EC, Maresh CM, Kraemer WJ, et al. Ergogenic effects of betaine supplementation on strength and power performance. J Int Soc Sports Nutr. 2010;7(1):1.
  • Del Favero S, Roschel H, Artioli G, et al. Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance. Amino Acids. 2012;42(6):2299–2305.
  • Trepanowski JF, Farney TM, Mccarthy CG, et al. The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men. J Strength Cond Res. 2011;25(12):3461–3471.
  • Hoffman JR, Ratamess NA, Kang J, et al. Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise. J Strength Cond Res. 2011;25(8):2235–2241.
  • Cholewa JM, Wyszczelska-Rokiel M, Glowacki R, et al. Effects of betaine on body composition, performance, and homocysteine thiolactone. J Int Soc Sports Nutr. 2013;10(1):1.
  • Jackson AS, Pollock ML. Generalized equations for predicting body density of men. Br J Nutr. 1978;40(3):497–504.
  • Loenneke JP, Barnes JT, Wilson JM, et al. Reliability of field methods for estimating body fat. Clin Physiol Funct Imaging. 2013;33(5):405–408.
  • Baechle TR, and Earle RW. Essentials of strength training and conditioning. Illinois, UK: Human kinetics champaign; 2008.
  • Bakeman R. Recommended effect size statistics for repeated measures designs. Behav Res Methods. 2005;37(3):379–384.
  • Tomczak M, Tomczak E. The need to report effect size estimates revisited. An overview of some recommended measures of effect size. Trends in Sport Sciences. 2014. 21(1)
  • Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale NJ USA: Erlbaum; 1988.
  • Lakens D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol. 2013;4:863.
  • Cholewa JM, Guimaraes-Ferreira L, Zanchi NE. Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms. Amino Acids. 2014;46(8):1785–1793.
  • Temfemo A, Carling C, Ahmaidi S. Relationship between power output, lactate, skin temperature, and muscle activity during brief repeated exercises with increasing intensity. J Strength Cond Res. 2011;25(4):915–921.
  • Zagatto AM, Miyagi WE, Sousa FA, et al. Relationship between anaerobic capacity estimated using a single effort and 30-s tethered running outcomes. PloS One. 2017;12(2):e0172032.
  • Kempson SA, Zhou Y, Danbolt NC. The betaine/GABA transporter and betaine: roles in brain, kidney, and liver. Front Physiol. 2014;5:159.
  • Du Vigneaud V, Simmonds S, Chandler JP, et al. A further investigation of the role of betaine in transmethylation reactions in vivo. J Biol Chem. 1946;165(2):639–648.
  • Brenner M, Rankin JW, Sebolt D. The effect of creatine supplementation during resistance training in women. J Strength Cond Res. 2000;14(2):207–213.
  • Lee S, Hong G, Park W, et al. The effect of short-term creatine intake on blood lactic acid and muscle fatigue measured by accelerometer-based tremor response to acute resistance exercise. Physical Activity and Nutrition. 2020;24(1):29–36.
  • Oliver JM, Joubert DP, Martin SE, et al. Oral creatine supplementation’s decrease of blood lactate during exhaustive, incremental cycling. Int J Sport Nutr Exerc Metab. 2013;23(3):252–258.
  • Prevost MC, Nelson AG, Morris GS. Creatine supplementation enhances intermittent work performance. Res Q Exerc Sport. 1997;68(3):233–240.
  • Volek JS, Kraemer WJ, Bush JA, et al. Creatine supplementation enhances muscular performance during high-intensity resistance exercise. J Am Diet Assoc. 1997;97(7):765–770.
  • Eklund M, Bauer E, Wamatu J, et al. Potential nutritional and physiological functions of betaine in livestock. Nutr Res Rev. 2005;18(1):31–48.
  • Robinson TM, Sewell DA, Hultman E, et al. Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. J Appl Physiol. 1999;87(2):598–604.
  • Harris RC, Söderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci. 1992;83(3):367–374.
  • Brooks GA. The science and translation of lactate shuttle theory. Cell Metab. 2018;27(4):757–785.
  • Courtenay E, Capp M, Anderson C, et al. Vapor pressure osmometry studies of osmolyte− protein interactions: implications for the action of osmoprotectants in vivo and for the interpretation of “osmotic stress” experiments in vitro. Biochemistry. 2000;39(15):4455–4471.
  • Caldas T, Demont-Caulet N, Ghazi A, et al. Thermoprotection by glycine betaine and choline. Microbiology. 1999;145(9):2543–2548.
  • Lee I. Regulation of Cytochrome c Oxidase by Natural Compounds Resveratrol, (-)-Epicatechin, and Betaine. Cells. 2021;10(6). 10.3390/cells10061346
  • Lee I. Betaine is a positive regulator of mitochondrial respiration. Biochem Biophys Res Commun. 2015;456(2):621–625.
  • Zhang L, Qi Y, Z AL, et al. Betaine increases mitochondrial content and improves hepatic lipid metabolism. Food Funct. 2019;10(1):216–223.
  • Häkkinen K, Pakarinen A. Acute hormonal responses to two different fatiguing heavy-resistance protocols in male athletes. J Appl Physiol. 1993;74(2):882–887. 1985.
  • Riachy R, McKinney K, Tuvdendorj DR. Various Factors May Modulate the Effect of Exercise on Testosterone Levels in Men. J Funct Morphol Kinesiol. 2020;5(4):81.
  • Tremblay MS, Copeland JL, Van Helder W. Effect of training status and exercise mode on endogenous steroid hormones in men. J Appl Physiol. 2004;96(2):531–539. 1985.
  • Turner TT, Lysiak JJ. Oxidative stress: a common factor in testicular dysfunction. J Andrology. 2008;29(5):488–498.
  • Tazari M, Baghshani H, Moosavi Z. Effect of betaine versus arsenite-induced alterations of testicular oxidative stress and circulating androgenic indices in rats. Andrologia. 2018;50(10):e13091.
  • Mayo Clinic Laboratories. (2018). Testosterone, Total, Bioavailable, and Free, Serum. Retrieved from https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/83686 Accessed 16 9 2021
  • Stanojević A, Marković VM, Maćešić S, et al. Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress. Reaction Kinetics, Mechanisms and Catalysis. 2018;123(1):17–30
  • Huang QC, Xu ZR, Han XY, et al. Effect of betaine on growth hormone pulsatile secretion and serum metabolites in finishing pigs. Journal of Animal Physiology and Animal Nutrition (Berl). 2007;91(3–4):85–90.
  • Dar SA, Srivastava PP, Varghese T, et al. Expression of Growth and Hunger Related Genes and Physio-Biochemical Responses in Labeo rohita (Hamilton, 1822) Fed with Lysine and Betaine. Cell Physiol Biochem. 2019;53(5):851–864.