Hormone Therapy in Adults: Suggested Revisions to the Sixth Version of the Standards of Care

REFERENCES

• Abbott , D. H. , Barnett , D. K. , Bruns , C. M. and Dumesic , D. A. 2005 . Androgen excess fetal programming of female reproduction: A developmental aetiology for polycystic ovary syndrome? . Human Reproduction Update , 11 : 357 – 374 .
   PubMed Web of Science ®Google Scholar
• American Academy of Family Physicians . 2005 . Definition of family medicine Retrieved August 10, 2009, from http://www.aafp.org/online/en/home/policy/policies/f/fammeddef.html
   Google Scholar
• American Diabetes Association . 2007 . Standards of medical care in diabetes—2007 . Diabetes Care , 30 : s4 – s41 .
   PubMedGoogle Scholar
• Amin , S. , Zhang , Y. , Sawin , C. T. , Evans , S. R. , Hannan , M. T. Kiel , D. P. 2000 . Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study . Annals of Internal Medicine. , 133 : 951 – 963 .
   PubMed Web of Science ®Google Scholar
• Asscheman , H. and Gooren , L. J. 1992 . Hormone treatment in transsexuals . Journal of Psychology & Human Sexuality , 5 ( 4 ) : 39 – 54 .
   Google Scholar
• Asscheman , H. , Gooren , L. J. , Assies , J. , Smits , J. P. and de Slegte , R. 1988 . Prolactin levels and pituitary enlargement in hormone-treated male-to-female transsexuals . Clinical Endocrinology. , 28 : 583 – 588 .
   PubMed Web of Science ®Google Scholar
• Asscheman , H. , Gooren , L. J. , Megens , J. A. , Nauta , J. , Kloosterboer , H. J. and Eikelboom , F. 1994 . Serum testosterone level is the major determinant of the male-female differences in serum levels of high-density lipoprotein (HDL) cholesterol and HDL2 cholesterol . Metabolism: Clinical and Experimental. , 43 : 935 – 939 .
   PubMedGoogle Scholar
• Baba , T. , Endo , T. , Honnma , H. , Kitajima , Y. , Hayashi , T. Ikeda , H. 2007 . Association between polycystic ovary syndrome and female-to-male transsexuality . Human Reproduction (Oxford, England). , 22 : 1011 – 1016 .
   PubMed Web of Science ®Google Scholar
• Balen , A. 2001 . Polycystic ovary syndrome and cancer . Human Reproduction Update. , 7 : 522 – 525 .
   PubMed Web of Science ®Google Scholar
• Balen , A. H. , Schachter , M. E. , Montgomery , D. , Reid , R. W. and Jacobs , H. S. 1993 . Polycystic ovaries are a common finding in untreated female to male transsexuals . Clinical Endocrinology. , 38 : 325 – 329 .
   PubMed Web of Science ®Google Scholar
• Basson , R. and Prior , J. C. 1998 . “ Hormonal therapy of gender dysphoria: The male-to-female transsexual ” . In Current concepts in transgender identity , Edited by: Denny , D. 277 – 296 . New York : Garland Publishing .
   Google Scholar
• Basson , R. and Pryor , J. 2001 . Towards optimal hormonal treatment of male to female gender identity disorder . Journal of Sexual and Reproductive Medicine , 1 ( 1 ) : 45 – 51 .
   Google Scholar
• Bell , J. I. , Bishop , M. C. and Britton , B. J. 1977 . Haemoperitoneum in a transsexual [Letter to the editor] . Lancet , 2 ( 8042 ) : 817
   Google Scholar
• Berra , M. , Armillotta , F. , D'Emidio , L. , Costantino , A. , Martorana , G. Pelusi , G. 2006 . Testosterone decreases adiponectin levels in female to male transsexuals . Asian Journal of Andrology. , 8 : 725 – 729 .
   PubMed Web of Science ®Google Scholar
• Bettocchi , C. , Palumbo , F. , Cormio , L. , Ditonno , P. , Battaglia , M. and Selvaggi , F. 2004 . The effects of androgen depletion on human erectile function: A prospective study in male-to-female transsexuals . International Journal of Impotence Research. , 16 : 544 – 546 .
   Google Scholar
• Bhasin , S. , Cunningham , G. R. , Hayes , F. J. , Matsumoto , A. M. , Snyder , P. J. Swerdloff , R. S. 2006 . Testosterone therapy in adult men with androgen deficiency syndromes: An endocrine society clinical practice guideline . Journal of Clinical Endocrinology & Metabolism. , 91 : 1995 – 2010 .
   PubMed Web of Science ®Google Scholar
• Bhasin , S. , Singh , A. B. , Mac , R. P. , Carter , B. , Lee , M. I. and Cunningham , G. R. 2003 . Managing the risks of prostate disease during testosterone replacement therapy in older men: Recommendations for a standardized monitoring plan . Journal of Andrology. , 24 : 299 – 311 .
   PubMed Web of Science ®Google Scholar
• Biller , J. and Saver , J. L. 1995 . Ischemic cerebrovascular disease and hormone therapy for infertility and transsexualism . Neurology , 45 : 1611 – 1613 .
   PubMedGoogle Scholar
• Bird , D. , Vowles , K. and Anthony , P. P. 1979 . Spontaneous rupture of a liver cell adenoma after long term methyltestosterone: Report of a case successfully treated by emergency right hepatic lobectomy . The British Journal of Surgery. , 66 : 212 – 213 .
   Google Scholar
• Blake , W. E. and Pitcher , M. E. 2003 . Estrogen-related pancreatitis in the setting of normal plasma lipids: Case report . Menopause. , 10 : 99 – 101 .
   Google Scholar
• Boice , J. D. Jr. , Friis , S. , McLaughlin , J. K. , Mellemkjaer , L. , Blot , W. J. Fraumeni , J. F. Jr. 1997 . Cancer following breast reduction surgery in Denmark . Cancer Causes & Control. , 8 : 253 – 258 .
   PubMed Web of Science ®Google Scholar
• Boice , J. D. Jr. , Persson , I. , Brinton , L. A. , Hober , M. , McLaughlin , J. K. Blot , W. J. 2000 . Breast cancer following breast reduction surgery in Sweden . Plastic and Reconstructive Surgery. , 106 : 755 – 762 .
   PubMed Web of Science ®Google Scholar
• Bolour , S. and Braunstein , G. 2005 . Testosterone therapy in women: A review . International Journal of Impotence Research: Official Journal of the International Society for Impotence Research. , 17 : 399 – 408 .
   PubMed Web of Science ®Google Scholar
• Bosinski , H. A. , Peter , M. , Bonatz , G. , Arndt , R. , Heidenreich , M. Sippell , W. G. 1997 . A higher rate of hyperandrogenic disorders in female-to-male transsexuals . Psychoneuroendocrinology. , 22 : 361 – 380 .
   PubMed Web of Science ®Google Scholar
• Bowman , C. and Goldberg , J. M. 2007 . Care of the patient undergoing sex reassignment surgery . International Journal of Transgenderism , 9 ( 3 ) : 135 – 165 .
   Google Scholar
• Bradley , S. J. , Oliver , G. D. , Chernick , A. B. and Zucker , K. J. 1998 . Experiment of nurture: Ablatio penis at 2 months, sex reassignment at 7 months, and a psychosexual follow-up in young adulthood . Pediatrics , 102 ( 1 ) : e9 Retrieved September 1, 2009, from http://pediatrics.aappublications.org/cgi/content/abstract/102/1/e9
   Google Scholar
• Brinton , L. A. , Persson , I. , Boice , J. D. Jr. , McLaughlin , J. K. and Fraumeni , J. F. Jr. 2001 . Breast cancer risk in relation to amount of tissue removed during breast reduction operations in Sweden . Cancer. , 91 : 478 – 483 .
   PubMedGoogle Scholar
• Bromham , D. 2005 . The pharmacological treatment of transsexuals Retrieved September 1, 2009, from http://tgmeds.org.uk/pharma.html
   Google Scholar
• Buffat , J. 2003 . Transsexuals: Clinical observations of cross-sex hormone substitution on psychological changes . Sexologies , 12 ( 45 ) : 53 – 55 .
   Google Scholar
• Burcombe , R. J. , Makris , A. , Pittam , M. and Finer , N. 2003 . Breast cancer after bilateral subcutaneous mastectomy in a female-to-male trans-sexual . Breast. , 12 : 290 – 293 .
   PubMed Web of Science ®Google Scholar
• Calof , O. M. , Singh , A. B. , Lee , M. L. , Kenny , A. M. , Urban , R. J. Tenover , J. L. 2005 . Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials . The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. , 60 : 1451 – 1457 .
   PubMed Web of Science ®Google Scholar
• Campion , J. M. and Maricic , M. J. 2003 . Osteoporosis in men . American Family Physician. , 67 : 1521 – 1526 .
   PubMed Web of Science ®Google Scholar
• Chasan-Taber , L. , Willett , W. C. , Stampfer , M. J. , Hunter , D. J. , Colditz , G. A. Spiegelman , D. 1997 . A prospective study of oral contraceptives and NIDDM among U.S. women . Diabetes Care , 20 : 330 – 335 .
   PubMed Web of Science ®Google Scholar
• Chobanian , A. V. , Bakris , G. L. , Black , H. R. , Cushman , W. C. , Green , L. A. Izzo , J. L. Jr. 2003 . Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure . Hypertension. , 42 : 1206 – 1252 .
   PubMed Web of Science ®Google Scholar
• Cibula , D. , Cifkova , R. , Fanta , M. , Poledne , R. , Zivny , J. and Skibova , J. 2000 . Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome . Human Reproduction (Oxford, England). , 15 : 785 – 789 .
   PubMed Web of Science ®Google Scholar
• Cirillo , D. J. , Wallace , R. B. , Rodabough , R. J. , Greenland , P. , LaCroix , A. Z. Limacher , M. C. 2005 . Effect of estrogen therapy on gallbladder disease . JAMA: The Journal of the American Medical Association. , 293 : 330 – 339 .
   PubMed Web of Science ®Google Scholar
• Clements , K. , Wilkinson , W. , Kitano , K. and Marx , R. 1999 . HIV prevention and health service needs of the transgender community in San Francisco . International Journal of Transgenderism , 3 ( 1 ) : 1 – 17 .
   Google Scholar
• Colditz , G. A. 2005 . Estrogen, estrogen plus progestin therapy, and risk of breast cancer . Clinical Cancer Research: An Official Journal of the American Association for Cancer Research , 11 ( 2 ) : 909s – 917s .
   Google Scholar
• Coombes , G. B. , Reiser , J. , Paradinas , F. J. and Burn , I. 1978 . An androgen-associated hepatic adenoma in a trans-sexual . The British Journal of Surgery. , 65 : 869 – 870 .
   Google Scholar
• Dahl , M. , Feldman , J. , Goldberg , J. and Jaberi , A. 2006 . Physical aspects of transgender endocrine therapy . International Journal of Transgenderism , 9 ( 3 ) : 111 – 134 .
   Google Scholar
• De Laet , C. E. , van Hout , B. A. , Burger , H. , Hofman , A. and Pols , H. A. 1997 . Bone density and risk of hip fracture in men and women: Cross sectional analysis . British Medical Journal (Clinical Research Ed) , 315 ( 7102 ) : 221 – 225 .
   PubMed Web of Science ®Google Scholar
• de Lignières , B. 1999 . Oral micronized progesterone . Clinical Therapeutics. , 21 : 41 – 60 .
   PubMed Web of Science ®Google Scholar
• Dean , C. E. 2000 . Prasterone (DHEA) and mania . The Annals of Pharmacotherapy. , 34 : 1419 – 1422 .
   PubMedGoogle Scholar
• Dimitrakakis , C. , Jones , R. A. , Liu , A. and Bondy , C. A. 2004 . Breast cancer incidence in postmenopausal women using testosterone in addition to usual hormone therapy . Menopause (New York, N.Y.). , 11 : 531 – 535 .
   PubMed Web of Science ®Google Scholar
• Dizon , D. S. , Tejada-Berges , T. , Koelliker , S. , Steinhoff , M. and Granai , C. O. 2006 . Ovarian cancer associated with testosterone supplementation in a female-to-male transsexual patient . Gynecologic and Obstetric Investigation. , 62 : 226 – 228 .
   PubMed Web of Science ®Google Scholar
• Dobs , A. S. , Meikle , A. W. , Arver , S. , Sanders , S. W. , Caramelli , K. E. and Mazer , N. A. 1999 . Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men . Journal of Clinical Endocrinology & Metabolism. , 84 : 3469 – 3478 .
   PubMed Web of Science ®Google Scholar
• Dubey , R. K. , Oparil , S. , Imthurn , B. and Jackson , E. K. 2002 . Sex hormones and hypertension . Cardiovascular Research. , 53 : 688 – 708 .
   PubMed Web of Science ®Google Scholar
• Ebell , M. H. , Siwek , J. , Weiss , B. D. , Woolf , S. H. , Susman , J. Ewigman , B. 2004 . Strength of recommendation taxonomy (SORT): A patient-centered approach to grading evidence in the medical literature . Journal of the American Board of Family Medicine. , 17 : 59 – 67 .
   Google Scholar
• Egan , R. A. and Kuyl , J. M. 2002 . Ischemic stroke in a man using estrogen . Journal of Stroke and Cerebrovascular Diseases. , 11 : 117 – 118 .
   Google Scholar
• Ehrmann , D. A. , Barnes , R. B. , Rosenfield , R. L. , Cavaghan , M. K. and Imperial , J. 1999 . Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome . Diabetes Care. , 22 : 141 – 146 .
   PubMed Web of Science ®Google Scholar
• Elbers , J. M. , Asscheman , H. , Seidell , J. C. and Gooren , L. J. 1999 . Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals . The American Journal of Physiology , 276 : E317 – E325 .
   PubMed Web of Science ®Google Scholar
• Elbers , J. M. , Asscheman , H. , Seidell , J. C. , Megens , J. A. and Gooren , L. J. 1997 . Long-term testosterone administration increases visceral fat in female to male transsexuals . Journal of Clinical Endocrinology & Metabolism. , 82 : 2044 – 2047 .
   PubMed Web of Science ®Google Scholar
• Elbers , J. M. , Giltay , E. J. , Teerlink , T. , Scheffer , P. G. , Asscheman , H. Seidell , J. C. 2003 . Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects . Clinical Endocrinology. , 58 : 562 – 571 .
   PubMed Web of Science ®Google Scholar
• Erenus , M. , Karakoc , B. and Gurler , A. 2001 . Comparison of effects of continuous combined transdermal with oral estrogen and oral progestogen replacement therapies on serum lipoproteins and compliance . Climacteric: The Journal of the International Menopause Society. , 4 : 228 – 234 .
   PubMedGoogle Scholar
• Eyler , A. E. 2007 . “ Primary medical care of the gender-variant patient ” . In Principles of transgender medicine and surgery , Edited by: Ettner , R. , Monstrey , S. and Eyler , E. 15 – 32 . Binghamton, NY : Routledge .
   Google Scholar
• Eyler , A. E. and Whittle , S. . FTM breast cancer: Community awareness and illustrative cases . 17th Biennial Symposium of the Harry Benjamin International Gender Dysphoria Association . Galveston, TX. Abstract retrieved January 1, 2005, from http://www.symposion.com/ijt/hbigda/2001/41_eyler.htm
   Google Scholar
• Factor , R. J. and Rothblum , E. 2008 . Exploring gender identity and community among three groups of transgender individuals in the United States: MTFs, FTMs, and gender queers . Health Sociology Review. , 17 : 235 – 253 .
   Web of Science ®Google Scholar
• Feldman , J. 2002 . New onset of type 2 diabetes mellitus with feminizing hormone therapy: Case series . International Journal of Transgenderism , 6 ( 2 ) Retrieved January 10, 2008, from http://www.symposion.com/ijt/ijtvo06no02_01.htm
   Google Scholar
• Feldman , J. . Masculinizing hormone therapy with testosterone 1% topical gel . Paper presented at the 19th Biennial Symposium of the Harry Benjamin International Gender Dysphoria Association . Bologna, Italy. April ,
   Google Scholar
• Feldman , J. 2007 . “ Preventive care of the transgendered patient ” . In Principles of transgender surgery and medicine , Edited by: Ettner , R. , Monstrey , S. and Eyler , A. E. 33 – 72 . New York : Haworth Press .
   Google Scholar
• Feldman , J. , Bockting , W. , Allen , S. and Brintell , D. . Smoking cessation among transgender persons receiving hormone therapy . Paper presented at the 18th Biennial Symposium of the Harry Benjamin International Gender Dysphoria Association . Gent, Belgium. September ,
   Google Scholar
• Feldman , J. and Goldberg , J. 2006 . Transgender primary medical care . International Journal of Transgenderism , 9 ( 3 ) : 3 – 34 .
   Google Scholar
• Fitzpatrick , L. A. , Pace , C. and Wiita , B. 2000 . Comparison of regimens containing oral micronized progesterone or medroxyprogesterone acetate on quality of life in postmenopausal women: A cross-sectional survey . Journal of Women's Health & Gender-Based Medicine. , 9 : 381 – 387 .
   PubMedGoogle Scholar
• Flaherty , C. , Franicevich , J. , Freeman , M. , Klein , P. , Kohler , L. Lusardi , C. 2001 . Protocols for hormonal reassignment of gender , San Francisco : San Francisco Department of Public Health . Retrieved January 1, 2005, from http://www.dph.sf.ca.us/chn/HlthCtrs/HlthCtrDocs/TransGendprotocols.pdf
   Google Scholar
• Fortin , C. J. , Klein , T. , Messmore , H. L. and O'Connell , J. B. 1984 . Myocardial infarction and severe thromboembolic complications. As seen in an estrogen-dependent transsexual . Archives of Internal Medicine , 144 : 1082 – 1083 .
   PubMedGoogle Scholar
• Futterweit , W. 1998 . Endocrine therapy of transsexualism and potential complications of long-term treatment . Archives of Sexual Behavior. , 27 : 209 – 226 .
   PubMed Web of Science ®Google Scholar
• Futterweit , W. and Deligdisch , L. 1986 . Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals . The Journal of Clinical Endocrinology & Metabolism. , 62 : 16 – 21 .
   PubMed Web of Science ®Google Scholar
• Futterweit , W. and Schwartz , I. 1988 . Histopathology of the breasts of 12 women receiving long-term exogenous androgen therapy . The Mount Sinai Journal of Medicine. , 55 : 309 – 312 .
   Google Scholar
• Ganly , I. and Taylor , E. W. 1995 . Breast cancer in a trans-sexual man receiving hormone replacement therapy . British Journal of Surgery , 82 ( 3 ) : 341
   PubMed Web of Science ®Google Scholar
• Gay and Lesbian Medical Association and LGBT health experts . 2001 . Healthy people 2010 companion document for lesbian, gay, bisexual and transgender (LGBT) health , San Francisco : Gay and Lesbian Medical Association . Retrieved September 1, 2009, from http://www.lgbthealth.net/downloads/hp2010doc.pdf
   Google Scholar
• Gharib , S. , Bigby , J. , Chapin , M. , Ginsburg , E. , Johnson , P. Manson , J. 2005 . Menopause: A guide to management , Boston : Brigham and Women's Hospital .
   Google Scholar
• Giltay , E. J. and Gooren , L. J. 2000 . Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females . Journal of Clinical Endocrinology & Metabolism. , 85 : 2913 – 2921 .
   PubMed Web of Science ®Google Scholar
• Giltay , E. J. , Lambert , J. , Gooren , L. J. , Elbers , J. M. , Steyn , M. and Stehouwer , C. D. 1999 . Sex steroids, insulin, and arterial stiffness in women and men . Hypertension. , 34 : 590 – 597 .
   Google Scholar
• Giltay , E. J. , Toorians , A. W. , Sarabdjitsingh , A. R. , de Vries , N. A. and Gooren , L. J. 2004 . Established risk factors for coronary heart disease are unrelated to androgen-induced baldness in female-to-male transsexuals . The Journal of Endocrinology. , 180 : 107 – 112 .
   PubMedGoogle Scholar
• Giorgi , A. , Weatherby , R. P. and Murphy , P. W. 1999 . Muscular strength, body composition and health responses to the use of testosterone enanthate: A double blind study . Journal of Science and Medicine in Sport/Sports Medicine Australia. , 2 : 341 – 355 .
   PubMedGoogle Scholar
• Girdler , S. S. , Hinderliter , A. L. , Wells , E. C. , Sherwood , A. , Grewen , K. M. and Light , K. C. 2004 . Transdermal versus oral estrogen therapy in postmenopausal smokers: Hemodynamic and endothelial effects . American Journal of Obstetrics and Gynecology. , 103 : 169 – 180 .
   Google Scholar
• Godsland , I. F. 2001 . Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: Analysis of studies published from 1974–2000 . Fertility and Sterility. , 75 : 898 – 915 .
   PubMed Web of Science ®Google Scholar
• Goh , H. H. , Loke , D. F. and Ratnam , S. S. 1995 . The impact of long-term testosterone replacement therapy on lipid and lipoprotein profiles in women . Maturitas. , 21 : 65 – 70 .
   PubMed Web of Science ®Google Scholar
• Goh , H. H. and Ratnam , S. S. 1997 . Effects of hormone deficiency, androgen therapy and calcium supplementation on bone mineral density in female transsexuals . Maturitas. , 26 : 45 – 52 .
   PubMed Web of Science ®Google Scholar
• Goldenberg , N. M. , Wang , P. and Glueck , C. J. 2003 . An observational study of severe hypertriglyceridemia, hypertriglyceridemic acute pancreatitis, and failure of triglyceride-lowering therapy when estrogens are given to women with and without familial hypertriglyceridemia . Clinica Chimica Acta: International Journal of Clinical Chemistry. , 332 : 11 – 19 .
   Google Scholar
• Gomes , M. P. and Deitcher , S. R. 2004 . Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: A clinical review . Archives of Internal Medicine. , 164 : 1965 – 1976 .
   PubMed Web of Science ®Google Scholar
• Gooren , L. J. 1999 . Hormonal sex reassignment . International Journal of Transgenderism , 3 ( 3 ) Retrieved January 1, 2005, from http://www.symposion.com/ijt/ijt990301.htm
   Google Scholar
• Gooren , L. J. 2005 . Hormone treatment of the adult transsexual patient . Hormone Research , 64 ( Suppl.2 ) : 31 – 36 .
   PubMed Web of Science ®Google Scholar
• Gooren , L. J. , Assies , J. , Asscheman , H. , de Slegte , R. and van Kessel , H. 1988 . Estrogen-induced prolactinoma in a man . Journal of Clinical Endocrinology & Metabolism. , 66 : 444 – 446 .
   PubMed Web of Science ®Google Scholar
• Gooren , L. J. and Bunck , M. C. 2004 . Androgen replacement therapy: Present and future . Drugs. , 64 : 1861 – 1891 .
   PubMed Web of Science ®Google Scholar
• Gooren , L. J. and Giltay , E. J. 2008 . Review of studies of androgen treatment of female-to-male transsexuals: Effects and risks of administration of androgens to females . Journal of Sexual Medicine. , 5 : 765 – 776 .
   PubMed Web of Science ®Google Scholar
• Gooren , L. J. , Giltay , E. J. and Bunck , M. C. 2008 . Long-term treatment of transsexuals with cross-sex hormones: Extensive personal experience . Journal of Clinical Endocrinology & Metabolism. , 93 : 19 – 25 .
   PubMed Web of Science ®Google Scholar
• Gordon , E. B. 1991 . Transsexual healing—Medicaid funding of sex reassignment surgery . Archives of Sexual Behavior. , 20 : 61 – 74 .
   PubMedGoogle Scholar
• Gorton , R. N. , Buth , J. and Spade , D. 2005 . Medical therapy and health maintenance for transgender men: A guide for health care providers , San Francisco : Lyon-Martin Women's Health Services .
   Google Scholar
• Grady , D. , Herrington , D. , Bittner , V. , Blumenthal , R. , Davidson , M. Hlatky , M. 2002 . Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and estrogen/progestin replacement study follow-up (HERS II) . JAMA: The Journal of the American Medical Association , 288 : 49 – 57 .
   PubMed Web of Science ®Google Scholar
• Graham , D. G. , Spano , M. S. , Stewart , T. V. , Staton , E. W. , Meers , A. and Pace , W. D. 2007 . Strategies for planning and launching PBRN research studies: A project of the Academy of Family Physicians National Research Network (AAFP NRN) . The Journal of the American Board of Family Medicine. , 20 : 220 – 228 .
   Google Scholar
• Green , L. A. and Hickner , J. 2006 . A short history of primary care practice-based research networks: From concept to essential research laboratories . Journal of the American Board of Family Medicine. , 19 : 1 – 10 .
   PubMed Web of Science ®Google Scholar
• Green , R. and Fleming , D. 1990 . Transsexual surgery follow-up: Status in the 1990s . Annual Review of Sex Research. , 1 : 163 – 174 .
   Google Scholar
• Green , R. , Newman , L. and Stoller , R. 1972 . Treatment of boyhood “transsexualism.” . Archives of General Psychiatry , 26 : 213 – 217 .
   PubMed Web of Science ®Google Scholar
• Greendale , G. A. , Edelstein , S. and Barrett-Connor , E. 1997 . Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo study . Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research. , 12 : 1833 – 1843 .
   PubMed Web of Science ®Google Scholar
• Grodstein , F. , Colditz , G. A. and Stampfer , M. J. 1994 . Postmenopausal hormone use and cholecystectomy in a large prospective study . American Journal of Obstetrics and Gynecology. , 83 : 5 – 11 .
   Google Scholar
• Grodstein , F. , Manson , J. E. and Stampfer , M. J. 2001 . Postmenopausal hormone use and secondary prevention of coronary events in the nurses' health study. A prospective, observational study . Annals of Internal Medicine , 135 : 1 – 8 .
   PubMed Web of Science ®Google Scholar
• Hachulla , E. , Rose , C. , Trillot , N. , Caulier-Leleu , M. T. and Pasturel-Michon , U. 2000 . What vascular events suggest a myeloproliferative disorder? . Journal des Maladies Vasculaires , 25 : 382 – 387 .
   Google Scholar
• Hage , J. J. , Dekker , J. J. , Karim , R. B. , Verheijen , R. H. and Bloemena , E. 2000 . Ovarian cancer in female-to-male transsexuals: Report of two cases . Gynecologic Oncology. , 76 : 413 – 415 .
   PubMed Web of Science ®Google Scholar
• Hajjar , R. R. , Kaiser , F. E. and Morley , J. E. 1997 . Outcomes of long-term testosterone replacement in older hypogonadal males: A retrospective analysis . Journal of Clinical Endocrinology Metabolism. , 82 : 3793 – 3796 .
   PubMed Web of Science ®Google Scholar
• Hak , A. E. , Witteman , J. C. M. , de Jong , F. H. , Geerlings , M. I. , Hofman , A. and Pols , H. A. P. 2002 . Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: The Rotterdam study . Journal of Clinical Endocrinology & Metabolism. , 87 : 3632 – 3639 .
   PubMed Web of Science ®Google Scholar
• Hall , R. C. and Hall , R. C. 2005 . Abuse of supraphysiologic doses of anabolic steroids . Southern Medical Journal , 98 ( 5 ) : 550 – 555 .
   Google Scholar
• Hannan , C. J. Jr. , Friedl , K. E. , Zold , A. , Kettler , T. M. and Plymate , S. R. 1991 . Psychological and serum homovanillic acid changes in men administered androgenic steroids . Psychoneuroendocrinology. , 16 : 335 – 343 .
   PubMedGoogle Scholar
• Haraldsen , I. R. , Haug , E. , Falch , J. , Egeland , T. and Opjordsmoen , S. 2007 . Cross-sex pattern of bone mineral density in early onset gender identity disorder . Hormones and Behavior. , 52 : 334 – 343 .
   Google Scholar
• Hardiman , P. , Pillay , O. C. and Atiomo , W. 2003 . Polycystic ovary syndrome and endometrial carcinoma . Lancet , 361 ( 9371 ) : 1810 – 1812 .
   PubMed Web of Science ®Google Scholar
• Heino , F. and Meyer-Bahlburg , H. 2005 . Gender identity outcome in female-raised 46, XY persons with penile agenesis, cloacal exstrophy of the bladder, or penile ablation . Archives of Sexual Behavior. , 34 : 423 – 438 .
   Google Scholar
• Hembree , W. C. , Cohen-Kettenis , P. , Delemarre-van de Waal , H. A. , Gooren , L. J. , Meyer , W. J. III Spack , N. P. 2009 . Endocrine treatment of transsexual persons: An endocrine society clinical practice guideline . Journal of Clinical Endocrinology & Metabolism. , 94 : 3132 – 3154 .
   PubMed Web of Science ®Google Scholar
• Hemelaar , M. , van der Mooren , M. J. , Mijatovic , V. , Bouman , A. A. , Schijf , C. Kroeks , M. V. A. M. 2003 . Oral, more than transdermal, estrogen therapy improves lipids and lipoprotein (a) in postmenopausal women: A randomized, placebo-controlled study . Menopause. , 10 : 550 – 558 .
   PubMed Web of Science ®Google Scholar
• Holte , J. , Gennarelli , G. , Wide , L. , Lithell , H. and Berne , C. 1998 . High prevalence of polycystic ovaries and associated clinical, endocrine, and metabolic features in women with previous gestational diabetes mellitus . The Journal of Clinical Endocrinology & Metabolism. , 83 : 1143 – 1150 .
   PubMed Web of Science ®Google Scholar
• Inoue , H. , Nishida , N. , Ikeda , N. , Tsuji , A. , Kudo , K. Hanagama , M. 2007 . The sudden and unexpected death of a female-to-male transsexual patient . Journal of Forensic and Legal Medicine. , 14 : 382 – 386 .
   PubMedGoogle Scholar
• Jacobeit , J. W. , Gooren , L. J. and Schulte , H. M. 2007 . Long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals . Journal of Sexual Medicine. , 4 : 1479 – 1484 .
   Google Scholar
• Jick , H. 2000 . Incidence of venous thromboembolism in users of combined oral contraceptives. Methods for identifying cases and estimating person time at risk must be detailed . British Medical Journal (Clinical Research Ed.) , 320 ( 7226 ) : 57 – 58 .
   Google Scholar
• Jockenhövel , F. 2004 . Testosterone therapy-what, when and to whom? . The Aging Male , 7 : 319 – 324 .
   PubMedGoogle Scholar
• Kapoor , D. , Goodwin , E. , Channer , K. S. and Jones , T. H. 2006 . Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes . European Journal of Endocrinology/European Federation of Endocrine Societies. , 154 : 899 – 906 .
   PubMed Web of Science ®Google Scholar
• Kirk , S. 1999 . Feminizing hormonal therapy for the transgendered , Pittsburgh, PA : Together Lifeworks .
   Google Scholar
• Koh-Banerjee , P. , Wang , Y. , Hu , F. B. , Spiegelman , D. , Willett , W. C. and Rimm , E. B. 2004 . Changes in body weight and body fat distribution as risk factors for clinical diabetes in US men . American Journal of Epidemiology. , 159 : 1150 – 1159 .
   PubMed Web of Science ®Google Scholar
• Kovacs , K. , Stefaneanu , L. , Ezzat , S. and Smyth , H. S. 1994 . Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study . Archives of Pathology & Laboratory Medicine , 118 : 562 – 565 .
   PubMed Web of Science ®Google Scholar
• Kruijver , F. P. M. , Zhou , J. N. , Pool , C. W. , Hofman , M. A. , Gooren , L. J. G. and Swaab , D. F. 2000 . Male-to-female transsexuals have female neuron numbers in a limbic nucleus . Journal of Clinical Endocrinology & Metabolism. , 85 : 2034 – 2041 .
   PubMed Web of Science ®Google Scholar
• Kwan , M. , Van Maasdam , J. and Davidson , J. M. 1985 . Effects of estrogen treatment on sexual behavior in male-to-female transsexuals: Experimental and clinical observations . Archives of Sexual Behavior. , 14 : 29 – 40 .
   PubMed Web of Science ®Google Scholar
• Lane , D. A. , Shah , S. and Beevers , D. G. 2007 . Low-dose spironolactone in the management of resistant hypertension: A surveillance study . Journal of Hypertension. , 25 : 891 – 894 .
   PubMed Web of Science ®Google Scholar
• Lawrence , A. A. , Shaffer , J. D. , Snow , W. R. , Chase , C. and Headlam , B. T. 1996 . Health care needs of transgendered patients [Letter to the editor] . JAMA: The Journal of the American Medical Association , 276 : 874
   Web of Science ®Google Scholar
• Legro , R. S. 2003 . Polycystic ovary syndrome and cardiovascular disease: A premature association? . Endocrine Reviews , 24 : 302 – 312 .
   PubMed Web of Science ®Google Scholar
• Levy , A. , Crown , A. and Reid , R. 2003 . Endocrine intervention for transsexuals . Clinical Endocrinology. , 59 : 409 – 418 .
   PubMed Web of Science ®Google Scholar
• Liao , D. J. and Dickson , R. B. 2002 . Roles of androgens in the development, growth, and carcinogenesis of the mammary gland . The Journal of Steroid Biochemistry and Molecular Biology. , 80 : 175 – 189 .
   PubMed Web of Science ®Google Scholar
• Liu , P. Y. , Death , A. K. and Handelsman , D. J. 2003 . Androgens and cardiovascular disease . Endocrine Reviews. , 24 : 313 – 340 .
   PubMed Web of Science ®Google Scholar
• Lombardi , E. 2001 . Enhancing transgender health care . American Journal of Public Health. , 91 : 869 – 872 .
   PubMed Web of Science ®Google Scholar
• Loverro , G. 2004 . Polycystic ovary syndrome and cardiovascular disease . Minerva Endocrinologica. , 29 : 129 – 138 .
   PubMedGoogle Scholar
• Lubbert , H. , Leo-Rossberg , I. and Hammerstein , J. 1992 . Effects of ethinyl estradiol on semen quality and various hormonal parameters in a eugonadal male . Fertility and Sterility. , 58 : 603 – 608 .
   PubMed Web of Science ®Google Scholar
• MacIndoe , J. H. 2003 . The challenges of testosterone deficiency. Uncovering the problem, evaluating the role of therapy . Postgraduate Medicine , 114 ( 4 ) : 51 – 58 . 61
   PubMed Web of Science ®Google Scholar
• Manjer , J. , Johansson , R. , Berglund , G. , Janzon , L. , Kaaks , R. Agren , A. 2003 . Postmenopausal breast cancer risk in relation to sex steroid hormones, prolactin and SHBG (Sweden) . Cancer Causes & Control: CCC. , 14 : 599 – 607 .
   PubMed Web of Science ®Google Scholar
• Manson , J. E. , Rimm , E. B. , Colditz , G. A. , Willett , W. C. , Nathan , D. M. Arky , R. A. 1992 . A prospective study of postmenopausal estrogen therapy and subsequent incidence of non-insulin-dependent diabetes mellitus . Annals of Epidemiology. , 2 : 665 – 673 .
   PubMedGoogle Scholar
• Markland , C. 1975 . Transexual surgery . Obstetrics and Gynecology Annual. , 4 : 309 – 330 .
   PubMedGoogle Scholar
• Markowitz , J. S. , Carson , W. H. and Jackson , C. W. 1999 . Possible dihydroepiandrosterone-induced mania . Biological Psychiatry. , 45 : 241 – 242 .
   PubMed Web of Science ®Google Scholar
• Marrazzo , J. M. , Koutsky , L. A. , Stine , K. L. , Kuypers , J. M. , Grubert , T. A. Galloway , D. A. 1998 . Genital human papillomavirus infection in women who have sex with women . The Journal of Infectious Diseases. , 178 : 1604 – 1609 .
   PubMed Web of Science ®Google Scholar
• McCredie , R. J. , McCrohon , J. A. , Turner , L. , Griffiths , K. A. , Handelsman , D. J. and Celermajer , D. S. 1998 . Vascular reactivity is impaired in genetic females taking high-dose androgens . Journal of the American College of Cardiology. , 32 : 1331 – 1335 .
   PubMedGoogle Scholar
• McPherson , K. , Steel , C. M. and Dixon , J. M. 2000 . ABC of breast diseases, breast cancer-epidemiology, risk factors, and genetics . British Medical Journal (Clinical Research Ed.) , 321 ( 7261 ) : 624 – 628 .
   PubMed Web of Science ®Google Scholar
• Melnikow , J. , Nuovo , J. , Willan , A. R. , Chan , B. K. and Howell , L. P. 1998 . Natural history of cervical squamous intraepithelial lesions: A meta-analysis . American Journal of Obstetrics and Gynecology. , 92 : 727 – 735 .
   Google Scholar
• Meyer , W. J. III , Bockting , W. O. , Cohen-Kettenis , P. , Coleman , E. , Di Ceglie , D. Devor , H. 2001 . The Standards of Care for Gender Identity Disorders , Minneapolis, MN : Harry Benjamin International Gender Dysphoria Association .
   Google Scholar
• Meyer , W. J. III , Walker , P. A. and Suplee , Z. R. 1981 . A survey of transsexual hormonal treatment in twenty gender-treatment centers . Journal of Sex Research. , 17 : 344 – 349 .
   Web of Science ®Google Scholar
• Meyer , W. J. III , Webb , A. , Stuart , C. A. , Finkelstein , J. W. , Lawrence , B. and Walker , P. A. 1986 . Physical and hormonal evaluation of transsexual patients: A longitudinal study . Archives of Sexual Behavior. , 15 : 121 – 138 .
   PubMed Web of Science ®Google Scholar
• Meyer-Bahlburg , H. , Migeon , C. , Berkovitz , G. , Gearhart , J. , Dolezal , C. and Wisniewski , A. 2004 . Attitudes of adult 46, XY intersex persons to clinical management policies . The Journal of Urology. , 171 : 1615 – 1619 .
   PubMed Web of Science ®Google Scholar
• Miller , N. , Bedard , Y. C. , Cooter , N. B. and Shaul , D. L. 1986 . Histological changes in the genital tract in transsexual women following androgen therapy . Histopathology. , 10 : 661 – 669 .
   PubMedGoogle Scholar
• Missmer , S. A. , Eliassen , A. H. , Barbieri , R. L. and Hankinson , S. E. 2004 . Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women . Journal of the National Cancer Institute. , 96 : 1856 – 1865 .
   PubMed Web of Science ®Google Scholar
• Money , J. 1994 . Sex errors of the body and related syndromes: A guide to counseling children, adolescents, and their families , Baltimore, MD : Paul H. Brookes Publishing .
   Google Scholar
• Monstrey , S. , Ceulemans , P. and Hoebke , P. 2007 . “ Surgery: Female-to-male patient ” . In Principles of transgender medicine and surgery , Edited by: Ettner , R. , Monstrey , S. and Eyler , A. E. 135 New York : Routledge .
   Google Scholar
• Moore , E. , Wisniewski , A. and Dobs , A. 2003 . Endocrine treatment of transsexual people: A review of treatment regimens, outcomes, and adverse effects . The Journal of Clinical Endocrinology & Metabolism. , 88 : 3467 – 3473 .
   PubMed Web of Science ®Google Scholar
• Mueller , A. , Kiesewetter , F. , Binder , H. , Beckmann , M. W. and Dittrich , R. 2007 . Long-term administration of testosterone undecanoate every 3 months for testosterone supplementation in female-to-male transsexuals . The Journal of Clinical Endocrinology & Metabolism. , 92 : 3470 – 3475 .
   PubMed Web of Science ®Google Scholar
• Mullins , G. , O'Sullivan , S. , Kinsella , J. , McEnroy , D. , Crimmins , D. Whyte , S. 2008 . Venous and arterial thrombo-embolic complications of hormonal treatment in a male-to-female transgender patient . Journal of Clinical Neuroscience. , 15 : 714 – 716 .
   Google Scholar
• Nelson , H. D. , Humphrey , L. L. , Nygren , P. , Teutsch , S. M. and Allan , J. D. 2002 . Postmenopausal hormone replacement therapy: Scientific review . JAMA: The Journal of the American Medical Association. , 288 : 872 – 881 .
   PubMed Web of Science ®Google Scholar
• Netscher , D. , Meade , R. A. , Friedman , J. D. , Malone , R. S. , Brady , J. R. and Thornby , J. 1999 . Mammography and reduction mammaplasty . Aesthetic Surgery Journal. , 19 : 445 – 451 .
   Google Scholar
• New , G. , Berry , K. L. , Cameron , J. D. , Harper , R. W. and Meredith , I. T. 2000 . Long-term oestrogen treatment does not alter systemic arterial compliance and haemodynamics in biological males . Coronary Artery Disease. , 11 : 253 – 259 .
   Google Scholar
• New , G. , Timmins , K. L. , Duffy , S. J. , Tran , B. T. , O'Brien , R. C. Harper , R. W. 1997 . Long-term estrogen therapy improves vascular function in male to female transsexuals . Journal of the American College of Cardiology. , 29 : 1437 – 1444 .
   PubMed Web of Science ®Google Scholar
• Nieschlag , E. and Behre , H. 1998 . “ Pharmacology and clinical uses of testosterone ” . In Testosterone: Action, deficiency, substitution , Edited by: Nieschlag , E. and Behre , H. 293 – 328 . Berlin, , Germany : Springer .
   Google Scholar
• Nieschlag , E. , Behre , H. , Bouchard , P. , Corrales , J. , Jones , T. Stalla , G. 2004 . Testosterone replacement therapy: Current trends and future directions . Human Reproduction Update. , 10 : 409 – 419 .
   PubMed Web of Science ®Google Scholar
• Norman , R. J. , Masters , L. , Milner , C. R. , Wang , J. X. and Davies , M. J. 2001 . Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome . Human Reproduction (Oxford, England). , 16 : 1995 – 1998 .
   PubMed Web of Science ®Google Scholar
• Oh , J. Y. , Barrett-Connor , E. , Wedick , N. M. and Wingard , D. L. 2002 . Endogenous sex hormones and the development of type 2 diabetes in older men and women: The Rancho Bernardo study . Diabetes Care. , 25 : 55 – 60 .
   PubMed Web of Science ®Google Scholar
• Oriel , K. A. 2000 . Medical care of transsexual patients . Journal of the Gay and Lesbian Medical Association. , 4 : 185 – 194 .
   Google Scholar
• Ouzan , J. , Catherine , P. , Lincoff , A. M. , Carr , E. and Mertes , M. 2002 . The role of spironolactone in the treatment of patients with refractory hypertension . American Journal of Hypertension. , 15 : 333 – 339 .
   PubMed Web of Science ®Google Scholar
• Pache , T. D. , Chadha , S. , Gooren , L. J. , Hop , W. C. , Jaarsma , K. W. Dommerholt , H. B. 1991 . Ovarian morphology in long-term androgen-treated female to male transsexuals. A human model for the study of polycystic ovarian syndrome? . Histopathology , 19 : 445 – 452 .
   PubMed Web of Science ®Google Scholar
• Paradinas , F. J. , Bull , T. B. , Westaby , D. and Murray-Lyon , I. M. 1977 . Hyperplasia and prolapse of hepatocytes into hepatic veins during long term methyltestosterone therapy: Possible relationships of these changes to the developement of peliosis hepatis and liver tumours . Histopathology. , 1 : 225 – 246 .
   PubMed Web of Science ®Google Scholar
• Parish , S. J. and Clayton , A. H. 2007 . Sexual medicine education: Review and commentary (CME) . Journal of Sexual Medicine. , 4 : 259 – 268 .
   PubMed Web of Science ®Google Scholar
• Parssinen , M. and Seppala , T. 2002 . Steroid use and long-term health risks in former athletes . Sports Medicine (Auckland, N.Z.). , 32 : 83 – 94 .
   PubMed Web of Science ®Google Scholar
• Pauly , I. B. 1974 . Female transsexualism: Part II . Archives of Sexual Behavior. , 3 : 509 – 526 .
   PubMed Web of Science ®Google Scholar
• Perego , E. , Scaini , A. , Romano , F. , Franciosi , C. and Uggeri , F. 2004 . Estrogen-induced severe acute pancreatitis in a male . Journal of the Pancreas. , 5 : 353 – 356 .
   Google Scholar
• Peverill , R. E. 2003 . Hormone therapy and venous thromboembolism . Bailliere's Best Practice & Research. Clinical Endocrinology & Metabolism. , 17 : 149 – 164 .
   PubMed Web of Science ®Google Scholar
• Pfäfflin , F. and Junge , A. 1998 . Sex reassignment: Thirty years of international follow-up studies SRS—A comprehensive review, 1961–1991 , Düsseldorf, , Germany : Symposion .
   Google Scholar
• Phornphutkul , C. , Fausto-Sterling , A. and Gruppuso , P. A. 2000 . Gender self-reassignment in an XY adolescent female born with ambiguous genitalia . Pediatrics. , 106 : 135 – 137 .
   PubMed Web of Science ®Google Scholar
• 2007 . Physicians' desk reference, , 61st ed. , Montavale, NJ : Thomson PDR .
   Google Scholar
• Pierpoint , T. , McKeigue , P. M. , Isaacs , A. J. , Wild , S. H. and Jacobs , H. S. 1998 . Mortality of women with polycystic ovary syndrome at long-term follow-up . Journal of Clinical Epidemiology. , 51 : 581 – 586 .
   PubMed Web of Science ®Google Scholar
• Pope , H. G. Jr. , Kouri , E. M. and Hudson , J. I. 2000 . Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: A randomized controlled trial . Archives of General Psychiatry. , 57 : 133 – 140 .
   PubMed Web of Science ®Google Scholar
• Prior , J. C. , Vigna , Y. M. and Watson , D. 1989 . Spironolactone with physiological female steroids for presurgical therapy of male-to-female transsexualism . Archives of Sexual Behavior. , 18 : 49 – 57 .
   PubMed Web of Science ®Google Scholar
• Prior , J. C. , Vigna , Y. M. , Watson , D. , Diewold , P. and Robinow , O. 1986 . Spironolactone in the presurgical therapy of male to female transsexuals: Philosophy and experience of the Vancouver Gender Dysphoria Clinic . Journal of Sex Information and Education Council of Canada. , 1 : 1 – 7 .
   Google Scholar
• Pritchard , T. J. , Pankowsky , D. A. , Crowe , J. P. and Abdul-Karim , F. W. 1988 . Breast cancer in a male-to-female transsexual. A case report . JAMA: The Journal of the American Medical Association , 259 : 2278 – 2280 .
   PubMed Web of Science ®Google Scholar
• Pryor , J. 2006 . The European Academy for Sexual Medicine (EASM): The challenge of developing European training standards in sexual medicine . Sexual and Relationship Therapy. , 21 : 273 – 279 .
   Google Scholar
• Quigley , C. , De Bellis , A. , Marschke , K. , El-Awady , M. , Wilson , E. and French , F. 1995 . Androgen receptor defects: Historical, clinical, and molecular perspectives . Endocrine Reviews. , 16 : 271 – 321 .
   PubMed Web of Science ®Google Scholar
• Reiner , W. G. and Gearhart , J. P. 2004 . Discordant sexual identity in some genetic males with cloacal exstrophy assigned to female sex at birth . New England Journal of Medicine. , 350 : 333 – 341 .
   PubMed Web of Science ®Google Scholar
• Resnick , H. E. , Valsania , P. , Halter , J. B. and Lin , X. 2000 . Relation of weight gain and weight loss on subsequent diabetes risk in overweight adults . Journal of Epidemiology & Community Health. , 54 : 596 – 602 .
   PubMed Web of Science ®Google Scholar
• Rhoden , E. L. and Morgentaler , A. 2004 . Risks of testosterone-replacement therapy and recommendations for monitoring . The New England Journal of Medicine. , 350 : 482 – 492 .
   PubMed Web of Science ®Google Scholar
• Riggs , B. L. , Khosla , S. and Melton , L. J. III . 1998 . A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men . Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research , 13 : 763 – 773 .
   PubMed Web of Science ®Google Scholar
• Rimm , E. B. , Manson , J. E. , Stampfer , M. J. , Colditz , G. A. , Willett , W. C. Rosner , B. 1992 . Oral contraceptive use and the risk of type 2 (non-insulin-dependent) diabetes mellitus in a large prospective study of women . Diabetologia. , 35 : 967 – 972 .
   PubMed Web of Science ®Google Scholar
• Rossouw , J. E. , Anderson , G. L. , Prentice , R. L. , LaCroix , A. Z. , Kooperberg , C. Stefanick , M. L. 2002 . Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the women's health initiative randomized controlled trial . JAMA: The Journal of the American Medical Association. , 288 : 321 – 333 .
   PubMed Web of Science ®Google Scholar
• Russell-Briefel , R. , Ezzati , T. M. , Perlman , J. A. and Murphy , R. S. 1987 . Impaired glucose tolerance in women using oral contraceptives: United States, 1976–1980 . Journal of Chronic Diseases. , 40 : 3 – 11 .
   PubMedGoogle Scholar
• Sader , M. A. , Griffiths , K. A. , Skilton , M. R. , Wishart , S. M. , Handelsman , D. J. and Celermajer , D. S. 2003 . Physiological testosterone replacement and arterial endothelial function in men . Clinical Endocrinology. , 59 : 62 – 67 .
   PubMed Web of Science ®Google Scholar
• Sanada , M. , Tsuda , M. , Kodama , I. , Sakashita , T. , Nakagawa , H. and Ohama , K. 2004 . Substitution of transdermal estradiol during oral estrogen-progestin therapy in postmenopausal women: Effects on hypertriglyceridemia . Menopause. , 11 : 331 – 336 .
   PubMed Web of Science ®Google Scholar
• Sarlis , N. J. , Weil , S. J. and Nelson , L. M. 1999 . Administration of metformin to a diabetic woman with extreme hyperandrogenemia of nontumoral origin: Management of infertility and prevention of inadvertent masculinization of a female fetus . The Journal of Clinical Endocrinology & Metabolism. , 84 : 1510 – 1512 .
   Google Scholar
• Scarabin , P. Y. , Oger , E. and Plu-Bureau , G. 2003 . Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk . Lancet , 362 ( 9382 ) : 428 – 432 .
   PubMed Web of Science ®Google Scholar
• Schairer , C. , Lubin , J. , Troisi , R. , Sturgeon , S. , Brinton , L. and Hoover , R. 2000 . Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk . JAMA: The Journal of the American Medical Association. , 283 : 485 – 491 .
   PubMed Web of Science ®Google Scholar
• Schildkraut , J. M. , Schwingl , P. J. , Bastos , E. , Evanoff , A. and Hughes , C. 1996 . Epithelial ovarian cancer risk among women with polycystic ovary syndrome . American Journal of Obstetrics and Gynecology. , 88 : 554 – 559 .
   Google Scholar
• Schlatterer , K. , von Werder , K. and Stalla , G. K. 1996 . Multistep treatment concept of transsexual patients . Experimental & Clinical Endocrinology & Diabetes. , 104 : 413 – 419 .
   PubMedGoogle Scholar
• Schlatterer , K. , Yassouridis , A. , von Werder , K. , Poland , D. , Kemper , J. and Stalla , G. K. 1998 . A follow-up study for estimating the effectiveness of a cross-gender hormone substitution therapy on transsexual patients . Archives of Sexual Behavior. , 27 : 475 – 492 .
   PubMed Web of Science ®Google Scholar
• Scholes , D. , LaCroix , A. Z. , Ichikawa , L. E. , Barlow , W. E. and Ott , S. M. 2005 . Change in bone mineral density among adolescent women using and discontinuing depot medroxyprogesterone acetate contraception . Archives of Pediatrics & Adolescent Medicine. , 159 : 139 – 144 .
   PubMed Web of Science ®Google Scholar
• Schulze , C. 1988 . Response of the human testis to long-term estrogen treatment: Morphology of sertoli cells, leydig cells and spermatogonial stem cells . Cell and Tissue Research. , 251 : 31 – 43 .
   PubMed Web of Science ®Google Scholar
• Serri , O. , Noiseux , D. , Robert , F. and Hardy , J. 1996 . Lactotroph hyperplasia in an estrogen treated male-to-female transsexual patient . Journal of Clinical Endocrinology and Metabolism. , 81 : 3177 – 3179 .
   Google Scholar
• Sherman , M. E. , Lorincz , A. T. , Scott , D. R. , Wacholder , S. , Castle , P. E. Glass , A. G. 2003 . Baseline cytology, human papilloma virus testing, and risk for cervical neoplasia: A 10-year cohort analysis . Journal of the National Cancer Institute. , 95 : 46 – 52 .
   PubMedGoogle Scholar
• Shortell , C. K. and Schwartz , S. I. 1991 . Hepatic adenoma and focal nodular hyperplasia . Surgery, Gynecology & Obstetrics. , 173 : 426 – 431 .
   PubMedGoogle Scholar
• Slabbekoorn , D. , Van Goozen , S. , Gooren , L. and Cohen-Kettenis , P. 2001 . Effects of cross-sex hormone treatment on emotionality in transsexuals . International Journal of Transgenderism , 5 ( 3 ) Retrieved January 10, 2009, from http://www.symposion.com/ijt/ijtvo05no03_02htm
   Google Scholar
• Smith , Y. L. S. , Van Goozen , S. H. M. , Kuiper , A. J. and Cohen-Kettenis , P. T. 2005 . Sex reassignment: Outcomes and predictors of treatment for adolescent and adult transsexuals . Psychological Medicine. , 35 : 89 – 99 .
   PubMed Web of Science ®Google Scholar
• Somboonporn , W. and Davis , S. R. 2004 . Testosterone effects on the breast: Implications for testosterone therapy for women . Endocrine Reviews. , 25 : 374 – 388 .
   PubMed Web of Science ®Google Scholar
• Spinder , T. , Spijkstra , J. J. , van den Tweel , J. G. , Burger , C. W. , van Kessel , H. Hompes , P. G. 1989 . The effects of long term testosterone administration on pulsatile luteinizing hormone secretion and on ovarian histology in eugonadal female to male transsexual subjects . The Journal of Clinical Endocrinology & Metabolism. , 69 : 151 – 157 .
   PubMed Web of Science ®Google Scholar
• Spritz , M. . Effects of cross gender hormonal therapy on prostates of 20 male-to-female postoperative patients . Paper presented at the 18th Biennial Symposium of the Harry Benjamin International Gender Dysphoria Association . Gent, Belgium. September ,
   Google Scholar
• Steinbeck , A. 1997 . Hormonal medication for transsexuals . Venereology. , 10 : 175 – 177 .
   Google Scholar
• Su , T. P. , Pagliaro , M. , Schmidt , P. J. , Pickar , D. , Wolkowitz , O. and Rubinow , D. R. 1993 . Neuropsychiatric effects of anabolic steroids in male normal volunteers . JAMA: The Journal of the American Medical Association. , 269 : 2760 – 2764 .
   PubMed Web of Science ®Google Scholar
• Symmers , W. S. 1968 . Carcinoma of breast in trans-sexual individuals after surgical and hormonal interference with the primary and secondary sex characteristics . British Medical Journal , 2 ( 597 ) : 82 – 85 .
   Google Scholar
• Tan , R. S. and Culberson , J. W. 2003 . An integrative review on current evidence of testosterone replacement therapy for the andropause . Maturitas. , 45 : 15 – 27 .
   PubMed Web of Science ®Google Scholar
• Tangpricha , V. , Ducharme , S. H. , Barber , T. W. and Chipkin , S. R. 2003 . Endocrinologic treatment of gender identity disorders . Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. , 9 : 12 – 21 .
   PubMedGoogle Scholar
• Tangpricha , V. , Turner , A. , Malabanan , A. and Holick , M. 2001 . Effects of testosterone therapy on bone mineral density in the FTM patient . International Journal of Transgenderism , 5 ( 4 ) Retrieved January 10, 2008, from http://symposion.com/ijt/hbigda/2001/39_tangpricha.htm
   Google Scholar
• Tangredi , J. F. and Buxton , I. L. 2001 . Hypertension as a complication of topical testosterone therapy . The Annals of Pharmacotherapy. , 35 : 1205 – 1207 .
   Google Scholar
• Teede , H. J. , Liang , Y. L. , Kotsopoulos , D. , Zoungas , S. , Craven , R. and McGrath , B. P. 2002 . Placebo-controlled trial of transdermal estrogen therapy alone in postmenopausal women: Effects on arterial compliance and endothelial function . Climacteric: The Journal of the International Menopause Society. , 5 : 160 – 169 .
   PubMedGoogle Scholar
• Thaler , C. 2007 . Putting transgender health care myths on trial Retrieved September 1, 2009, from http://www.lambdalegal.org/our-work/publications/page-32007335.html
   Google Scholar
• Third Expert Panel on the Management of Asthma . 2007 . Expert panel report 3: Guidelines for the diagnosis and management of asthma , Bethesda, MD : National Heart, Lung, and Blood Institute . (NIH Publication Number 08-5846)
   Google Scholar
• Thole , Z. , Manso , G. , Salgueiro , E. , Revuelta , P. and Hidalgo , A. 2004 . Hepatotoxicity induced by antiandrogens: A review of the literature . Urologia Internationalis , 73 : 289 – 295 .
   PubMed Web of Science ®Google Scholar
• Thompson , I. M. , Pauler , D. K. , Goodman , P. J. , Tangen , C. M. , Lucia , M. S. Parnes , H. L. 2004 . Prevalence of prostate cancer among men with a prostate-specific antigen level < or = 4.0 ng per milliliter . The New England Journal of Medicine , 350 : 2239 – 2246 .
   PubMed Web of Science ®Google Scholar
• Thurston , A. V. 1994 . Carcinoma of the prostate in a transsexual . British Journal of Urology , 73 : 217
   PubMedGoogle Scholar
• Toorians , A. W. , Gooren , L. J. and Asscheman , H. 2001 . Venous thromboembolism and (oral) estrogen use [Abstract] . International Journal of Transgenderism , 5 ( 4 ) Retrieved January 10, 2008, from http://www.symposion.com/ijt/hbigda/2001/43_toorians.htm
   Google Scholar
• Toorians , A. W. , Thomassen , M. C. , Zweegman , S. , Magdeleyns , E. J. , Tans , G. Gooren , L. J. 2003 . Venous thrombosis and changes of hemostatic variables during cross-sex hormone treatment in transsexual people . The Journal of Clinical Endocrinology and Metabolism. , 88 : 5723 – 5729 .
   PubMed Web of Science ®Google Scholar
• Transgender Health Action Coalition (THAC) . 1997 . Needs assessment survey project: Final report , Philadelphia : Philadelphia Foundation Legacy Fund .
   Google Scholar
• Turner , A. , Chen , T. C. , Barber , T. W. , Malabanan , A. O. , Holick , M. F. and Tangpricha , V. 2004 . Testosterone increases bone mineral density in female-to-male transsexuals: A case series of 15 subjects . Clinical Endocrinology. , 61 : 560 – 566 .
   PubMed Web of Science ®Google Scholar
• US Preventive Services Task Force . 2008 . Guide to clinical preventive services, 2008: Recommendations of the US Preventative Services Task Force , Rockville, MD : US Department of Health and Human Services, Agency for Healthcare Research and Quality . (AHRQ publication no. 08-05122)
   Google Scholar
• Vacheron-Trystram , M. N. , Cheref , S. , Gauillard , J. and Plas , J. 2002 . A case report of mania precipitated by use of DHEA . L'Encephale. , 28 : 563 – 566 .
   Google Scholar
• van Haarst , E. P. , Newling , D. W. , Gooren , L. J. , Asscheman , H. and Prenger , D. M. 1998 . Metastatic prostatic carcinoma in a male-to-female transsexual . British Journal of Urology , 81 : 776
   PubMedGoogle Scholar
• van Kesteren , P. J. , Asscheman , H. , Megens , J. A. and Gooren , L. J. 1997 . Mortality and morbidity in transsexual subjects treated with cross-sex hormones . Clinical Endocrinology. , 47 : 337 – 342 .
   PubMed Web of Science ®Google Scholar
• van Kesteren , P. J. , Gooren , L. J. and Megens , J. A. 1996 . An epidemiological and demographic study of transsexuals in The Netherlands . Archives of Sexual Behavior. , 25 : 589 – 600 .
   PubMed Web of Science ®Google Scholar
• van Kesteren , P. J. , Lips , P. , Gooren , L. J. , Asscheman , H. and Megens , J. 1998 . Long-term follow-up of bone mineral density and bone metabolism in transsexuals treated with cross-sex hormones . Clinical Endocrinology. , 48 : 347 – 354 .
   PubMed Web of Science ®Google Scholar
• Viallard , J. , Marit , G. , Mercie , P. , Leng , B. , Reiffers , J. and Pellegrin , J. 2000 . Polycythaemia as a complication of transdermal testosterone therapy [Letter to the editor] . British Journal of Haematology. , 110 : 237 – 238 .
   PubMed Web of Science ®Google Scholar
• Vongpatanasin , W. , Tuncel , M. , Wang , Z. , Arbique , D. , Mehrad , B. and Jialal , I. 2003 . Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women . Journal of the American College of Cardiology , 41 : 1358 – 1363 .
   PubMed Web of Science ®Google Scholar
• Wagner , G. 2005 . Sexual medicine in the medical curriculum . International Journal of Andrology. , 28 : 7 – 8 .
   Google Scholar
• Wald , M. , Meacham , R. B. , Ross , L. S. and Niederberger , C. S. 2006 . Testosterone replacement therapy for older men . Journal of Andrology. , 27 : 126 – 132 .
   PubMed Web of Science ®Google Scholar
• Wang , C. , Swerdloff , R. , Iranmanesh , A. and Dobs , A. 2000 . Testosterone gel study group, et al. transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men . Inpharma , 1 ( 1254 ) : 14 – 14 .
   Google Scholar
• Watanabe , S. , Yamasaki , S. , Tanae , A. , Hibi , I. and Honna , T. 1994 . Three cases of hepatocellular carcinoma among cyproterone users. Ad hoc committee on androcur users . Lancet , 344 ( 8936 ) : 1567 – 1568 .
   Google Scholar
• Weiss , E. L. , Bowers , M. B. Jr. and Mazure , C. M. 1999 . Testosterone-patch-induced psychotic mania [Letter to the editor] . The American Journal of Psychiatry. , 156 : 969 – 969 .
   Web of Science ®Google Scholar
• Whitsel , E. A. , Boyko , E. J. , Matsumoto , A. M. , Anawalt , B. D. and Siscovick , D. S. 2001 . Intramuscular testosterone esters and plasma lipids in hypogonadal men: A meta-analysis . The American Journal of Medicine. , 111 : 261 – 269 .
   PubMed Web of Science ®Google Scholar
• Wild , S. , Pierpoint , T. , Jacobs , H. and McKeigue , P. 2000 . Long-term consequences of polycystic ovary syndrome: Results of a 31 year follow-up study . Human Fertility. , 3 : 101 – 105 .
   PubMedGoogle Scholar
• World Health Organization . 2008 . The World Health Report 2008: Primary health care—now more than ever , Geneva, , Switzerland : World Health Organization .
   Google Scholar
• Xavier , J. 2000 . The Washington, D.C. transgender needs assessment survey: Final report for phase two , Washington, DC : Administration for HIV/AIDS of District of Columbia Government .
   Google Scholar
• Zitzmann , M. , Saad , F. and Nieschlag , E. . Long term experience of more than 8 years with a novel formulation of testosterone undecanoate (nebido) in substitution therapy of hypogonadal men [Abstract] . Paper presented at European Congress of Endocrinology . April 2006 , Glasgow, UK. Endocrine Abstracts, 11, P178
   Google Scholar