Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium

References

• Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010; 22:124-31; PMID:20034776; http://dx.doi.org/10.1016/j.ceb.2009.11.014
   PubMed Web of Science ®Google Scholar
• Yoshimori, T. Autophagy: a regulated bulk degradation process inside cells. Biochem Biophys Res Commun 2004; 313:453-8; PMID:14684184; http://dx.doi.org/10.1016/j.bbrc.2003.07.023
   PubMed Web of Science ®Google Scholar
• Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12:814-22; PMID:20811353; http://dx.doi.org/10.1038/ncb0910-814
   PubMed Web of Science ®Google Scholar
• Mizushima N. The pleiotropic role of autophagy: From protein metabolism to bactericide. Cell Death Differ 2005; 12:1535-41; PMID:16247501; http://dx.doi.org/10.1038/sj.cdd.4401728
   PubMed Web of Science ®Google Scholar
• Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 2004; 432:1032-6; PMID:15525940; http://dx.doi.org/10.1038/nature03029
   PubMed Web of Science ®Google Scholar
• Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169:425-34; PMID:15866887; http://dx.doi.org/10.1083/jcb.200412022
   PubMed Web of Science ®Google Scholar
• Boya P, González-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Métivier D, Meley D, Souquere S, Yoshimori T, et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25:1025-40; PMID:15657430; http://dx.doi.org/10.1128/MCB.25.3.1025-1040.2005
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010; 90:1383-435; PMID:20959619; http://dx.doi.org/10.1152/physrev.00030.2009
   PubMed Web of Science ®Google Scholar
• Linsenmeier RA, Padnick-Silver L. Metabolic dependence of photoreceptor on the choroid in the normal and detached retina. Invest Ophthalmol Vis Sci 2000; 41:3117-23; PMID:10967072
   PubMed Web of Science ®Google Scholar
• Wangsa-Wirawan ND, Linsenmeier RA. Retinal oxygen: fundamental and clinical aspects. Arch Ophthalmol 2003; 121:547-57; PMID:12695252; http://dx.doi.org/10.1001/archopht.121.4.547
   PubMed Web of Science ®Google Scholar
• Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda) 2010; 25:8-15; PMID:20134024; http://dx.doi.org/10.1152/physiol.00038.2009
   PubMed Web of Science ®Google Scholar
• Strauss O. The retinal pigment epithelium in visual function. Physiol Rev 2005; 85:845-81; PMID:15987797; http://dx.doi.org/10.1152/physrev.00021.2004
   PubMed Web of Science ®Google Scholar
• Young RW. The renewal of photoreceptor cell outer segments. J Cell Biol 1967; 33:61-72; PMID:6033942; http://dx.doi.org/10.1083/jcb.33.1.61
   PubMed Web of Science ®Google Scholar
• Young RW, Bok D. Participation of the retinal pigment epithelium in the rod outer segment renewal process. J Cell Biol 1969; 42:392-403; PMID:5792328; http://dx.doi.org/10.1083/jcb.42.2.392
   PubMed Web of Science ®Google Scholar
• LaVail MM. Legacy of the RCS rat: impact of a seminal study on retinal cell biology and retinal degenerative diseases. Prog Brain Res 2001; 131:617-27; PMID:11420975; http://dx.doi.org/10.1016/S0079-6123(01)31048-8
   PubMedGoogle Scholar
• van Lookeren Campagne M, LeCouter J, Yaspan BL, Ye W. Mechanisms of age related macular degeneration and therapeutic opportunities. J Pathol 2014; 232:151-64; PMID:24105633; http://dx.doi.org/10.1002/path.4266
   PubMed Web of Science ®Google Scholar
• Reme CE, Autophagy in visual cells and pigment epithelium. Invest. Ophthalmol Vis Sci 1977; 16:807-14; PMID:302253
   PubMed Web of Science ®Google Scholar
• Wang AL, Lukas TJ, Yuan M, Du N, Tso MO, Neufeld AH. Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS One 2009; 4:e4160; PMID:19129916; http://dx.doi.org/10.1371/journal.pone.0004160
   PubMed Web of Science ®Google Scholar
• Krohne TU, Stratmann NK, Kopitz J, Holz FG. Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells. Exp Eye Res 2010; 90:465-71; PMID:20059996; http://dx.doi.org/10.1016/j.exer.2009.12.011
   PubMed Web of Science ®Google Scholar
• Viiri J, Hyttinen JM, Ryhanen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A, Kaarniranta K. p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells. Mol Vis 2010; 16:1399-414; PMID:20680098
   PubMed Web of Science ®Google Scholar
• Mitter SK, Song C, Qi X, Mao H, Rao H, Akin DA, Lewin AS, Grant M, Dunn WA, Ding JD, et al. Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Autophagy 2014; 10(11):1989-2005; PMID:25484094.
   PubMedGoogle Scholar
• Mitter SK, Rao HV, Qi X, Cai J, Sugrue A, Dunn WA Jr, Grant MB, Boulton ME. Autophagy in the retina: a potential role in age-related macular degeneration. Adv Exp Med Biol 2012; 723:83-90; PMID:22183319; http://dx.doi.org/10.1007/978-1-4614-0631-0_12
   PubMed Web of Science ®Google Scholar
• Valapala M, Wilson C, Hose S, Bhutto IA, Grebe R, Dong A, Greenbaum S, Gu L, Sengupta S, Can M, et al. Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/bA3/A1-crystallin via V-ATPas-MTORC1 signaling. Autophagy 2014; 10:480-96; PMID:24468901; http://dx.doi.org/10.4161/auto.27292
   PubMed Web of Science ®Google Scholar
• Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, et al. Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS One 2013; 8:e69563; PMID:23922739; http://dx.doi.org/10.1371/journal.pone.0069563
   PubMed Web of Science ®Google Scholar
• Rodríguez-Muela N, Koga H, García-Ledo L, de la Villa P, de la Rosa EJ, Cuervo AM, Boya P. Balance between autophagic pathways preserves retinal homeostasis. Aging Cell 2013; 12:478-88; http://dx.doi.org/10.1111/acel.12072
   PubMed Web of Science ®Google Scholar
• Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 2009; 284:12297-305.
   PubMed Web of Science ®Google Scholar
• Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DJ. ULK-Atg13–FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20:1992-2003; PMID:19225151; http://dx.doi.org/10.1091/mbc.E08-12-1249
   PubMed Web of Science ®Google Scholar
• Gammoh N, Florey O, Overholtzer M, Jiang X. Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and-independent autophagy. Nat Struct Mol Biol 2013; 20:144-9; PMID:23262492; http://dx.doi.org/10.1038/nsmb.2475
   PubMed Web of Science ®Google Scholar
• Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N. FIP200 regulates targeting of Atg16L1 to the isolation membrane. EMBO Rep 2013; 14:284-91; PMID:23392225; http://dx.doi.org/10.1038/embor.2013.6
   PubMed Web of Science ®Google Scholar
• Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol 2008; 181:497-510; PMID:18443221; http://dx.doi.org/10.1083/jcb.200712064
   PubMed Web of Science ®Google Scholar
• Wang C, Liang CC, Bian ZC, Zhu Y, Guan JL. FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nat Neurosci 2013; 16:532-42; PMID:23542691; http://dx.doi.org/10.1038/nn.3365
   PubMed Web of Science ®Google Scholar
• Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 2011; 25:1510-27; PMID:21764854; http://dx.doi.org/10.1101/gad.2051011
   PubMed Web of Science ®Google Scholar
• Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan J-L. Role of FIP200 in cardiac and liver development and its regulation of TNF and TSC-mTOR signaling pathways. J Cell Biol 2006; 175:121-33; PMID:17015619; http://dx.doi.org/10.1083/jcb.200604129
   PubMed Web of Science ®Google Scholar
• Iacovelli J, Zhao C, Wolkow N, Veldman P, Gollomp K, Ojha P, Lukinova N, King A, Feiner L, Esumi N, et al. Generation of Cre transgenic mice with postnatal RPE-specific ocular expression. Invest Ophthalmol Vis Sci 2011; 52:1378-83; PMID:21212186; http://dx.doi.org/10.1167/iovs.10-6347
   PubMed Web of Science ®Google Scholar
• Kim JY, Zhao H, Martinez J, Doggett TA, Kolesnikov AV, Tang PH, Ablonczy Z, Chan CC, Zhou Z, Green DR, et al. Noncanonical autophagy promotes the visual cycle. Cell 2013; 154:365-76; PMID:23870125; http://dx.doi.org/10.1016/j.cell.2013.06.012
   PubMed Web of Science ®Google Scholar
• Yao J, Jia L, Shelby SJ, Ganios AM, Feathers K, Thompson DA, Zacks DN. Circadian and noncircadian modulation of autophagy in photoreceptors and retinal pigment epithelium. Invest Ophthalmol Vis Sci 2014; 55:3237-46; PMID:24781939; http://dx.doi.org/10.1167/iovs.13-13336
   PubMed Web of Science ®Google Scholar
• He L, Marioutina M, Dunaief JL, Marneros AG. Age- and gene-dosage-dependent cre-induced abnormalities in the retinal pigment epithelium. Am J Pathol 2014; 184:1660-7; PMID:24854863; http://dx.doi.org/10.1016/j.ajpath.2014.02.007
   PubMedGoogle Scholar
• Gan B, Guan JL. FIP200, a key signaling node to coordinately regulate various cellular processes. Cell Signal 2008; 20:787-94; PMID:18036779; http://dx.doi.org/10.1016/j.cellsig.2007.10.021
   PubMed Web of Science ®Google Scholar
• Chen L, Yang P, Kijlstra A. Distribution, markers and functions of retinal microglia. Ocul Immunol Inflamm 2002; 10:27-39; PMID:12461701; http://dx.doi.org/10.1076/ocii.10.1.27.10328
   PubMed Web of Science ®Google Scholar
• Langmann T. Microglia activation in retinal degeneration. J Leukoc Biol 2007; 81:1345-51; PMID:17405851; http://dx.doi.org/10.1189/jlb.0207114
   PubMed Web of Science ®Google Scholar
• Cuenca N, Fernandez-Sanchez L, Campello L, Maneu V, De al Villa P, Lax P, Pinilla I. Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases. Prog Retin Eye Res 2014; 43:17-75; PMID:25038518; http://dx.doi.org/10.1016/j.preteyeres.2014.07.001
   PubMed Web of Science ®Google Scholar
• Karlstetter M, Langmann T. Microglia in the aging retina. Adv Exp Med Biol 2014; 801:207-12; PMID:24664700; http://dx.doi.org/10.1007/978-1-4614-3209-8_27
   PubMedGoogle Scholar
• Rizzolo LJ. Basement membrane stimulates the polarized distribution of integrins but not the Na,K-ATPase in the retinal pigment epithelium. Cell Regul 1991; 2:939-49.; PMID:1667092
   PubMedGoogle Scholar
• Grossniklaus HE, Kang SJ, Berglin L. Animal models of choroidal and retinal neovascularization. Prog Retin Eye Res 2010; 29:500-19; PMID:20488255; http://dx.doi.org/10.1016/j.preteyeres.2010.05.003
   PubMed Web of Science ®Google Scholar
• Zacks DN, Ezra E, Terada Y, Michaud N, Connolly E, Gragoudas ES, Miller JW. Verteporfin photodynamic therapy in the rat model of choroidal neovascularization: angiographic and histologic characterization. Invest Ophthalmol Vis Sci 2002; 43:2384-91; PMID:12091441
   PubMed Web of Science ®Google Scholar
• Jiang A, Hu W, Meng H, Gao H, Qiao X. Loss of VLDL receptor activates retinal vascular endothelial cells and promotes angiogenesis. Invest Ophthalmol Vis Sci 2009; 50:844-50; PMID:18936153; http://dx.doi.org/10.1167/iovs.08-2447
   PubMedGoogle Scholar
• Lippai M, Low P. The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy. Biomed Res Int 2014; 2014:832704; PMID:25013806; http://dx.doi.org/10.1155/2014/832704
   PubMed Web of Science ®Google Scholar
• Ryhänen T, Hyttinen JM, Kopitz J, Rilla K, Kuusisto E, Mannermaa E, Viiri J, Holmberg CI, Immonen I, Meri S, et al. Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med 2009; 13:3616-31; http://dx.doi.org/10.1111/j.1582-4934.2008.00577.x
   PubMed Web of Science ®Google Scholar
• Ohno-Matsui K. Parallel findings in age-related macular degeneration and Alzheimer disease. Prog Retin Eye Res 2011; 30:217-38; PMID:21440663; http://dx.doi.org/10.1016/j.preteyeres.2011.02.004
   PubMed Web of Science ®Google Scholar
• Zhao Y, Bhattacharjee S, Jones BM, Hill JM, Clement C, Sambamurti K, Dua P, Lukiw WJ. Beta-amyloid precursor protein (bAAP) processing in Alzheimer disease (AD) and age-related macular degeneration (AMD). Mol Neurobiol 2014; Epub ahead of print.
   Web of Science ®Google Scholar
• Hyttinen JM, Amadio M, Viiri J, Pascale A, Salminen A, Kaarniranta K. Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases. Ageing Res Rev 2014:18C:16-28; http://dx.doi.org/10.1016/j.arr.2014.07.002
   Web of Science ®Google Scholar
• Mazzoni F, Safa H, Finnemann SC. Understanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture. Exp Eye Res 2014; 126:51-60; PMID:24780752
   PubMedGoogle Scholar
• Zheng W, Reem RE, Omarova S, Huang S, DiPatre PL, Charvet CD, Curcio CA, Pikuleva IA. Spatial distribution of the pathways of cholesterol homeostasis in human retina. PLoS One 2012; 7(5):e37926; PMID:22629470; http://dx.doi.org/10.1371/journal.pone.0037926
   PubMed Web of Science ®Google Scholar
• Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK. New insights into retinoid metabolism and cycling within the retina. Prog Retin Eye Res 2013; 32:48-63; PMID:23063666; http://dx.doi.org/10.1016/j.preteyeres.2012.09.002
   PubMed Web of Science ®Google Scholar
• Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Scaky K, Sadda SR, Beckman Initiative for Macular Research Classification Committee. Clinical classification of age-related macular degeneration. Ophthalmology 2013; 120:844-51; PMID:23332590; http://dx.doi.org/10.1016/j.ophtha.2012.10.036
   PubMed Web of Science ®Google Scholar
• Spaide RF, Curcio CA. Drusen characterization with multimodal imaging. Retina 2010; 30:1441-54; PMID:20924263; http://dx.doi.org/10.1097/IAE.0b013e3181ee5ce8
   PubMed Web of Science ®Google Scholar
• Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 2013; 9:973-84; PMID:23590900; http://dx.doi.org/10.4161/auto.24546
   PubMed Web of Science ®Google Scholar
• Machalinska A, Lubinski W, Klos P, Kawa M, Baumer B, Penkala K, Grzegrzolka R, Karczewicz D, Wiszniewska B, Machalinski B. Sodium iodate selectively injures the posterior pole of the retina in a dose-dependent manner: morphological and electrophysiological study. Neurochem Res 2010; 35:1819-27; PMID:20725778; http://dx.doi.org/10.1007/s11064-010-0248-6
   PubMed Web of Science ®Google Scholar
• Ramkumar HL, Zhang J, Chan CC. Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res 2010; 29:169-90; PMID:20206286; http://dx.doi.org/10.1016/j.preteyeres.2010.02.002
   PubMed Web of Science ®Google Scholar
• Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature 2011; 471:325-30; PMID:21297615; http://dx.doi.org/10.1038/nature09830
   PubMed Web of Science ®Google Scholar
• Tarallo V, Hiran Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, et al. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 2012:149; 847-59; PMID:22541070; http://dx.doi.org/10.1016/j.cell.2012.03.036
   PubMed Web of Science ®Google Scholar
• Gibbings D, Mostowy S, Voinnet O. Autophagy selectively regulates miRNA homeostasis. Autophagy 2013; 14:1314-21.
   Google Scholar
• Williams-Bey Y, Boularan C, Vural A, Huang NN, Hwang IY, Shan-Shi C, Kehri JH. Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-kB activation and enhancing autophagy. PLoS One 2014; 9(6):e97957; PMID:24911523; http://dx.doi.org/10.1371/journal.pone.0097957
   PubMed Web of Science ®Google Scholar
• Guo W, Sun Y, Liu W, Wu X, Guo L, Cai P, Wu X, Wu X, Shen Y, Shu Y, Gu Y, Xu Q. Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer. Autophagy 2014; 10:972-85; PMID:24879148; http://dx.doi.org/10.4161/auto.28374
   PubMed Web of Science ®Google Scholar
• Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C. Apolipoprotein E allele-dependent pathogenesis: a model for age-related macular degeneration. Proc Nat Acad Sci 2005; 102:11900-5; PMID:16079201; http://dx.doi.org/10.1073/pnas.0503015102
   PubMed Web of Science ®Google Scholar
• Curcio CA, Johnson M, Rudolf M, Huang JD. The oil spill in ageing Bruch membrane. Br J Ophthalmol 2011; 95:1638-45; PMID:21890786; http://dx.doi.org/10.1136/bjophthalmol-2011-300344
   PubMed Web of Science ®Google Scholar
• Pikuleva IA, Curcio CA. Cholesterol in the retina: the best is yet to come. Prog Retin Eye Res 2014; 41C:64-89; http://dx.doi.org/10.1016/j.preteyeres.2014.03.002
   Web of Science ®Google Scholar
• Liu K, Czaia MJ. Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ 2013; 20:3-11; PMID:22595754; http://dx.doi.org/10.1038/cdd.2012.63
   PubMed Web of Science ®Google Scholar
• Christian P, Sacco J, Adeli K. Autophagy: emerging roles in lipid homeostasis and metabolic control. Biochim Biophys Acta 2013; 1831:819-24; PMID:23274236; http://dx.doi.org/10.1016/j.bbalip.2012.12.009
   PubMed Web of Science ®Google Scholar
• Mattapallil MJ, Wawrousek EF, Chan CC, Zhao H, Roychoudhury J, Ferguson TA, Caspi RR. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 2012; 53:2921-7; PMID:22447858; http://dx.doi.org/10.1167/iovs.12-9662
   PubMed Web of Science ®Google Scholar
• Papermaster, DS. Preparation of retinal rod outer segments. Methods Enzymol 1982; 81:48-52; PMID:6212746; http://dx.doi.org/10.1016/S0076-6879(82)81010-0
   PubMed Web of Science ®Google Scholar
• Shelby SJ, Colwill K, Dhe-Paganon S, Pawson T, Thompson DA. MERTK interactions with SH2-domain proteins in the retinal pigment epithelium. PLoS One 2013; 8(2):e53964; PMID:23390493; http://dx.doi.org/10.1371/journal.pone.0053964
   PubMed Web of Science ®Google Scholar
• Sparrow JR, Boulton M. RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 2005; 80:595-606; PMID:15862166; http://dx.doi.org/10.1016/j.exer.2005.01.007
   PubMed Web of Science ®Google Scholar
• Hadziahmetovic M1, Song Y, Ponnuru P, Iacovelli J, Hunter A, Haddad N, Beard J, Connor JR, Vaulont S, Dunaief JL. Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci 2011; 52:109-18; PMID:20811044; http://dx.doi.org/10.1167/iovs.10-6113
   PubMed Web of Science ®Google Scholar
• Thompson DA, Khan NW, Othman MI, Chang B, Jia L, Grahek G, Wu Z, Hiriyanna S, Nellissery J, Li T, et al. Rd9 is a naturally occurring mouse model of a common form of retinitis pigmentosa caused by mutations in RPGR-ORF15. PLoS ONE 2012; 7(5):e35865; PMID:22563472; http://dx.doi.org/10.1371/journal.pone.0035865
   PubMed Web of Science ®Google Scholar
• Hemati N, Feathers KL, Chrispell JD, Reed DM, Carlson TJ, Thompson DA. RPE65 surface epitopes, protein interactions, and expression in rod- and cone-dominant species. Mol Vis 2005; 11:1151-65; PMID:16379027
   PubMed Web of Science ®Google Scholar