A role for ABCG2 beyond drug transport: Regulation of autophagy

References

• Dean M, Rzhetsky A, Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 2001; 11:1156-66; PMID:11435397; http://dx.doi.org/10.1101/gr.GR-1649R
   PubMed Web of Science ®Google Scholar
• Scotto KW. Transcriptional regulation of ABC drug transporters. Oncogene 2003; 22:7496-511; PMID:14576854; http://dx.doi.org/10.1038/sj.onc.1206950
   PubMed Web of Science ®Google Scholar
• Diestra JE, Scheffer GL, Catala I, Maliepaard M, Schellens JH, Scheper RJ, Germa-Lluch JR, Izquierdo MA. Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material. J Pathol 2002; 198:213-9; PMID:12237881; http://dx.doi.org/10.1002/path.1203
   PubMed Web of Science ®Google Scholar
• Turner JG, Gump JL, Zhang C, Cook JM, Marchion D, Hazlehurst L, Munster P, Schell MJ, Dalton WS, Sullivan DM. ABCG2 expression, function, and promoter methylation in human multiple myeloma. Blood 2006; 108:3881-9; PMID:16917002; http://dx.doi.org/10.1182/blood-2005-10-009084
   PubMed Web of Science ®Google Scholar
• Britton KM, Eyre R, Harvey IJ, Stemke-Hale K, Browell D, Lennard TWJ, Meeson AP. Breast cancer, side population cells and ABCG2 expression. Cancer Lett 2012; 323:97-105; PMID:22521545; http://dx.doi.org/10.1016/j.canlet.2012.03.041
   PubMed Web of Science ®Google Scholar
• Haraguchi N, Utsunomiya T, Inoue H, Tanaka F, Mimori K, Barnard GF, Mori M. Characterization of a side population of cancer cells from human gastrointestinal system. Stem cells (Dayton, Ohio) 2006; 24:506-13; PMID:16239320; http://dx.doi.org/10.1634/stemcells.2005-0282
   PubMed Web of Science ®Google Scholar
• Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005; 5:275-84; PMID:15803154; http://dx.doi.org/10.1038/nrc1590
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Das A, Mallya K, Ahmad I. Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling. J Cell Sci 2007; 120:2652-62; PMID:17635990; http://dx.doi.org/10.1242/jcs.008417
   PubMed Web of Science ®Google Scholar
• Evseenko DA, Murthi P, Paxton JW, Reid G, Emerald BS, `Mohankumar KM, Lobie PE, Brennecke SP, Kalionis B, Keelan JA. The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction. Faseb J 2007; 21:3592-605; PMID:17595345; http://dx.doi.org/10.1096/fj.07-8688com
   PubMed Web of Science ®Google Scholar
• Evseenko DA, Paxton JW, Keelan JA. The xenobiotic transporter ABCG2 plays a novel role in differentiation of trophoblast-like BeWo cells. Placenta 2007; 28(Suppl A):S116-20; PMID:17275084; http://dx.doi.org/10.1016/j.placenta.2006.12.003
   PubMed Web of Science ®Google Scholar
• Erdei Z, Sarkadi B, Brozik A, Szebenyi K, Varady G, Mako V, Pentek A, Orban TI, Apati A. Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response. Eur Biophys J 2013; 42:169-79; PMID:22851001; http://dx.doi.org/10.1007/s00249-012-0838-0
   PubMed Web of Science ®Google Scholar
• Shien K, Toyooka S, Ichimura K, Soh J, Furukawa M, Maki Y, Muraoka T, Tanaka N, Ueno T, Asano H, et al. Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy. Lung cancer 2012; 77:162-7; PMID:22387005; http://dx.doi.org/10.1016/j.lungcan.2012.02.006
   PubMed Web of Science ®Google Scholar
• Ingram WJ, Crowther LM, Little EB, Freeman R, Harliwong I, Veleva D, Hassall TE, Remke M, Taylor MD, Hallahan AR. ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma. Exp Hematol Oncol 2013; 2:26; PMID:24219920; http://dx.doi.org/10.1186/2162-3619-2-26
   PubMedGoogle Scholar
• He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43:67-93; PMID:19653858; http://dx.doi.org/10.1146/annurev-genet-102808-114910
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069-75; PMID:18305538; http://dx.doi.org/10.1038/nature06639
   PubMed Web of Science ®Google Scholar
• White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12:401-10; PMID:22534666; http://dx.doi.org/10.1038/nrc3262
   PubMed Web of Science ®Google Scholar
• Robey RW, Medina-Perez WY, Nishiyama K, Lahusen T, Miyake K, Litman T, Senderowicz AM, Ross DD, Bates SE. Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells. Clin Cancer Res 2001; 7:145-52; PMID:11205902
   PubMed Web of Science ®Google Scholar
• Ding R, Shi J, Pabon K, Scotto KW. Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance. Mol Pharmacol 2012; 81:328-37; PMID:22113078; http://dx.doi.org/10.1124/mol.111.075556
   PubMed Web of Science ®Google Scholar
• Rusten TE, Stenmark H. p62, an autophagy hero or culprit? Nat Cell Biol 2010; 12:207-9; PMID:20190829; http://dx.doi.org/10.1038/ncb0310-207
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445-544; PMID:22966490; http://dx.doi.org/10.4161/auto.19496
   PubMed Web of Science ®Google Scholar
• Menzies FM, Moreau K, Puri C, Renna M, Rubinsztein DC. Measurement of autophagic activity in mammalian cells. Curr Protoc Cell Biol 2012; Chapter 15:Unit 15 6; PMID:22422474
   PubMedGoogle Scholar
• Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, Kruh GD. Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res 2003; 63:4048-54; PMID:12874005
   PubMed Web of Science ®Google Scholar
• Ifergan I, Shafran A, Jansen G, Hooijberg JH, Scheffer GL, Assaraf YG. Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis. J Biol Chem 2004; 279:25527-34; PMID:15047700; http://dx.doi.org/10.1074/jbc.M401725200
   PubMed Web of Science ®Google Scholar
• Breedveld P, Pluim D, Cipriani G, Dahlhaus F, van Eijndhoven MA, de Wolf CJ, Kuil A, Beijnen JH, Scheffer GL, Jansen G, et al. The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol 2007; 71:240-9; PMID:17032904; http://dx.doi.org/10.1124/mol.106.028167
   PubMed Web of Science ®Google Scholar
• van Herwaarden AE, Wagenaar E, Merino G, Jonker JW, Rosing H, Beijnen JH, Schinkel AH. Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. Mol Cel Biol 2007; 27:1247-53; PMID:17145775; http://dx.doi.org/10.1128/MCB.01621-06
   PubMed Web of Science ®Google Scholar
• Shukla S, Wu CP, Nandigama K, Ambudkar SV. The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2. Mol Cancer Ther 2007; 6:3279-86; PMID:18065489; http://dx.doi.org/10.1158/1535-7163.MCT-07-0564
   PubMed Web of Science ®Google Scholar
• Jonker JW, Buitelaar M, Wagenaar E, Van Der Valk MA, Scheffer GL, Scheper RJ, Plosch T, Kuipers F, Elferink RP, Rosing H, et al. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci U S A 2002; 99:15649-54; PMID:12429862; http://dx.doi.org/10.1073/pnas.202607599
   PubMed Web of Science ®Google Scholar
• Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP, Schuetz JD. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 2004; 279:24218-25; PMID:15044468; http://dx.doi.org/10.1074/jbc.M313599200
   PubMed Web of Science ®Google Scholar
• Woodward OM, Kottgen A, Coresh J, Boerwinkle E, Guggino WB, Kottgen M. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A 2009; 106:10338-42; PMID:19506252; http://dx.doi.org/10.1073/pnas.0901249106
   PubMed Web of Science ®Google Scholar
• Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem 2007; 282:37298-302; PMID:17986448; http://dx.doi.org/10.1074/jbc.C700195200
   PubMed Web of Science ®Google Scholar
• Tanida I, Yamasaki M, Komatsu M, Ueno T. The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation. Autophagy 2012; 8:88-97; PMID:22170151; http://dx.doi.org/10.4161/auto.8.1.18339
   PubMed Web of Science ®Google Scholar
• Ito H, Daido S, Kanzawa T, Kondo S, Kondo Y. Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. International journal of oncology 2005; 26:1401-10; PMID:15809734
   PubMed Web of Science ®Google Scholar
• Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008; 68:1485-94; PMID:18316613; http://dx.doi.org/10.1158/0008-5472.CAN-07-0562
   PubMed Web of Science ®Google Scholar
• Johnstone RW, Cretney E, Smyth MJ. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood 1999; 93:1075-85; PMID:9920858
   PubMed Web of Science ®Google Scholar
• Smyth MJ, Krasovskis E, Sutton VR, Johnstone RW. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc Natl Acad Sci U S A 1998; 95:7024-9; PMID:9618532; http://dx.doi.org/10.1073/pnas.95.12.7024
   PubMed Web of Science ®Google Scholar
• Li F, Zeng H, Ying K. The combination of stem cell markers CD133 and ABCG2 predicts relapse in stage I non-small cell lung carcinomas. Med Oncol 2011; 28:1458-62; PMID:20717756; http://dx.doi.org/10.1007/s12032-010-9646-5
   PubMed Web of Science ®Google Scholar
• Omran OM. The prognostic value of breast cancer resistance protein (BCRB/ABCG2) expression in breast carcinomas. J Environ Pathol Toxicol Oncol 2012; 31:367-76; PMID:23394449; http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2013006767
   PubMed Web of Science ®Google Scholar
• Tsunoda S, Okumura T, Ito T, Kondo K, Ortiz C, Tanaka E, Watanabe G, Itami A, Sakai Y, Shimada Y. ABCG2 expression is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma. Oncology 2006; 71:251-8; PMID:17671398; http://dx.doi.org/10.1159/000106787
   PubMed Web of Science ®Google Scholar
• Brechbuhl HM, Gould N, Kachadourian R, Riekhof WR, Voelker DR, Day BJ. Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2. J Biol Chem 2010; 285:16582-7; PMID:20332504; http://dx.doi.org/10.1074/jbc.M109.090506
   PubMed Web of Science ®Google Scholar
• Gauthier C, Ozvegy-Laczka C, Szakacs G, Sarkadi B, Di Pietro A. ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity. Front Pharmacol 2013; 4:138; PMID:24312054; http://dx.doi.org/10.3389/fphar.2013.00138
   PubMed Web of Science ®Google Scholar
• Shimizu S, Yoshida T, Tsujioka M, Arakawa S. Autophagic cell death and cancer. Int J Mol Sci 2014; 15:3145-53; PMID:24566140; http://dx.doi.org/10.3390/ijms15023145
   PubMed Web of Science ®Google Scholar
• Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137:1062-75; PMID:19524509; http://dx.doi.org/10.1016/j.cell.2009.03.048
   PubMed Web of Science ®Google Scholar
• Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E, et al. Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov 2013; 3:894-907; PMID:23650262; http://dx.doi.org/10.1158/2159-8290.CD-13-0011
   PubMed Web of Science ®Google Scholar
• Gewirtz DA. The four faces of autophagy: implications for cancer therapy. Cancer Res 2014; 74:647-51; PMID:24459182; http://dx.doi.org/10.1158/0008-5472.CAN-13-2966
   PubMed Web of Science ®Google Scholar
• Carew JS, Kelly KR, Nawrocki ST. Autophagy as a target for cancer therapy: new developments. Cancer Manag Res 2012; 4:357-65; PMID:23091399
   PubMedGoogle Scholar
• Marki-Zay J, Tauberne Jakab K, Szeremy P, Krajcsi P. MDR-ABC transporters: biomarkers in rheumatoid arthritis. Clin Exp Rheumatol 2013; 31:779-87; PMID:23711386
   PubMed Web of Science ®Google Scholar
• Desideri E, Filomeni G, Ciriolo MR. Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells. Autophagy 2012; 8:1769-81; PMID:22964495; http://dx.doi.org/10.4161/auto.22037
   PubMed Web of Science ®Google Scholar
• Mazzanti R, Platini F, Bottini C, Fantappie O, Solazzo M, Tessitore L. Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line. Biochem Pharmacol 2009; 78:21-32; PMID:19447220; http://dx.doi.org/10.1016/j.bcp.2009.03.013
   PubMed Web of Science ®Google Scholar
• Fletcher JI, Haber M, Henderson MJ, Norris MD. ABC transporters in cancer: more than just drug efflux pumps. Nat Rev Cancer 2010; 10:147-56; PMID:20075923; http://dx.doi.org/10.1038/nrc2789
   PubMed Web of Science ®Google Scholar
• Li F, Tiede B, Massague J, Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 2007; 17:3-14; PMID:17179981; http://dx.doi.org/10.1038/sj.cr.7310118
   PubMed Web of Science ®Google Scholar
• Honjo Y, Hrycyna CA, Yan QW, Medina-Perez WY, Robey RW, van de Laar A, Litman T, Dean M, Bates SE. Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells. Cancer Res 2001; 61:6635-9; PMID:11559526.
   PubMed Web of Science ®Google Scholar
• Ee PL, He X, Ross DD, Beck WT. Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference. Mol Cancer Ther 2004; 3:1577-83; PMID:15634651.
   PubMed Web of Science ®Google Scholar