Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function

References

• Brundin P, Melki R, Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 2010; 11:301-7; PMID:20308987; http://dx.doi.org/10.1038/nrm2873
   PubMed Web of Science ®Google Scholar
• Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol 2010; 6:702-6; PMID:21045796; http://dx.doi.org/10.1038/nrneurol.2010.145
   PubMed Web of Science ®Google Scholar
• Jucker M, Walker LC. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature 2013; 501:45-51; PMID:24005412; http://dx.doi.org/10.1038/nature12481
   PubMed Web of Science ®Google Scholar
• Bae EJ, Lee HJ, Rockenstein E, Ho DH, Park EB, Yang NY, Desplats P, Masliah E, Lee SJ. Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. J Neurosci 2012; 32:13454-69; PMID:23015436; http://dx.doi.org/10.1523/JNEUROSCI.1292-12.2012
   PubMed Web of Science ®Google Scholar
• Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM. Alpha-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration. Cell Rep 2014; 7:2054-65; PMID:24931606; http://dx.doi.org/10.1016/j.celrep.2014.05.033
   PubMed Web of Science ®Google Scholar
• Lee HJ, Bae EJ, Lee SJ. Extracellular α–synuclein-a novel and crucial factor in Lewy body diseases. Nat Rev Neurol 2014; 10:92-8; PMID:24468877; http://dx.doi.org/10.1038/nrneurol.2013.275
   PubMed Web of Science ®Google Scholar
• Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Formation of toxic oligomeric α-synuclein species in living cells. PLoS One 2008; 3:e1867; PMID:18382657; http://dx.doi.org/10.1371/journal.pone.0001867
   PubMed Web of Science ®Google Scholar
• McKay JP, Raizen DM, Gottschalk A, Schafer WR, Avery L. eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx. Genetics 2004; 166:161-9; PMID:15020415; http://dx.doi.org/10.1534/genetics.166.1.161
   PubMed Web of Science ®Google Scholar
• Rogers C, Reale V, Kim K, Chatwin H, Li C, Evans P, de Bono M. Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. Nat Neurosci 2003; 6:1178-85; PMID:14555955; http://dx.doi.org/10.1038/nn1140
   PubMed Web of Science ®Google Scholar
• Lee HJ, Bae EJ, Jang A, Ho DH, Cho ED, Suk JE, Yun YM, Lee SJ. Enzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificities. J Neurosci Methods 2011; 199:249-57; PMID:21658411; http://dx.doi.org/10.1016/j.jneumeth.2011.05.020
   PubMed Web of Science ®Google Scholar
• Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 1993; 366:461-4; PMID:8247153; http://dx.doi.org/10.1038/366461a0
   PubMed Web of Science ®Google Scholar
• Denzel MS, Storm NJ, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, Sommer T, Hoppe T, Antebi A. Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell 2014; 156:1167-78; PMID:24630720; http://dx.doi.org/10.1016/j.cell.2014.01.061
   PubMed Web of Science ®Google Scholar
• Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van Dam E, van de Berg WD, Forrest SL, Parkkinen L, Gai WP, Hattori N, et al. Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology. Neurobiol Dis 2015; 79:81-99; PMID:25937088; http://dx.doi.org/10.1016/j.nbd.2015.04.009
   PubMed Web of Science ®Google Scholar
• Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, et al. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun 2013; 4:2267; PMID:23925298
   PubMed Web of Science ®Google Scholar
• Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, Rodrigues AP, Manning G, Dillin A. RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature 2012; 489:263-8; PMID:22922647; http://dx.doi.org/10.1038/nature11315
   PubMed Web of Science ®Google Scholar
• Hansen C, Angot E, Bergstrom AL, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, et al. α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest 2011; 121:715-25; PMID:21245577; http://dx.doi.org/10.1172/JCI43366
   PubMed Web of Science ®Google Scholar
• Bae EJ, Yang NY, Song M, Lee CS, Lee JS, Jung BC, Lee HJ, Kim S, Masliah E, Sardi SP, et al. Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein. Nat Commun 2014; 5:4755; PMID:25156829; http://dx.doi.org/10.1038/ncomms5755
   PubMed Web of Science ®Google Scholar
• Lee HJ, Suk JE, Bae EJ, Lee JH, Paik SR, Lee SJ. Assembly-dependent endocytosis and clearance of extracellular α-synuclein. Int J Biochem Cell Biol 2008; 40:1835-49; PMID:18291704; http://dx.doi.org/10.1016/j.biocel.2008.01.017
   PubMed Web of Science ®Google Scholar
• Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein. Proc Natl Acad Sci U S A 2009; 106:13010-5; PMID:19651612; http://dx.doi.org/10.1073/pnas.0903691106
   PubMed Web of Science ®Google Scholar
• Clark SG, Shurland DL, Meyerowitz EM, Bargmann CI, van der Bliek AM. A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans. Proc Natl Acad Sci U S A 1997; 94:10438-43; PMID:9294229; http://dx.doi.org/10.1073/pnas.94.19.10438
   PubMed Web of Science ®Google Scholar
• Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ. Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp Mol Med 2013; 45:e22; PMID:23661100; http://dx.doi.org/10.1038/emm.2013.45
   PubMed Web of Science ®Google Scholar
• Syntichaki P, Xu K, Driscoll M, Tavernarakis N. Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature 2002; 419:939-44; PMID:12410314; http://dx.doi.org/10.1038/nature01108
   PubMed Web of Science ®Google Scholar
• Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, Di Malta C, Donaudy F, Embrione V, Polishchuk RS, et al. A gene network regulating lysosomal biogenesis and function. Science 2009; 325:473-7; PMID:19556463
   PubMed Web of Science ®Google Scholar
• Grove CA, De Masi F, Barrasa MI, Newburger DE, Alkema MJ, Bulyk ML, Walhout AJ. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 2009; 138:314-27; PMID:19632181; http://dx.doi.org/10.1016/j.cell.2009.04.058
   PubMed Web of Science ®Google Scholar
• Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlotzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, et al. Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy 2012; 8:754-66; PMID:22647715; http://dx.doi.org/10.4161/auto.19371
   PubMed Web of Science ®Google Scholar
• Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE. Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric α-synuclein. Am J Pathol 2009; 175:736-47; PMID:19628769; http://dx.doi.org/10.2353/ajpath.2009.080928
   PubMed Web of Science ®Google Scholar
• Kilpatrick K, Zeng Y, Hancock T, Segatori L. Genetic and chemical activation of TFEB mediates clearance of aggregated α-synuclein. PloS one 2015; 10:e0120819; PMID:25790376; http://dx.doi.org/10.1371/journal.pone.0120819
   PubMed Web of Science ®Google Scholar
• Lee HJ, Khoshaghideh F, Patel S, Lee SJ. Clearance of α-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci 2004; 24:1888-96; PMID:14985429; http://dx.doi.org/10.1523/JNEUROSCI.3809-03.2004
   PubMed Web of Science ®Google Scholar
• Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974; 77:71-94; PMID:4366476
   PubMed Web of Science ®Google Scholar
• Gengyo-Ando K, Yoshina S, Inoue H, Mitani S. An efficient transgenic system by TA cloning vectors and RNAi for C. elegans. Biochem Biophys Res Commun 2006; 349:1345-50; PMID:16979594; http://dx.doi.org/10.1016/j.bbrc.2006.08.183
   PubMed Web of Science ®Google Scholar
• Lee LW, Lo HW, Lo SJ. Vectors for co-expression of two genes in Caenorhabditis elegans. Gene 2010; 455:16-21; PMID:20149852; http://dx.doi.org/10.1016/j.gene.2010.02.001
   PubMed Web of Science ®Google Scholar
• Hobert O. PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans. BioTechniques 2002; 32:728-30; PMID:11962590
   PubMed Web of Science ®Google Scholar
• Mello CC, Kramer JM, Stinchcomb D, Ambros V. Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 1991; 10:3959-70; PMID:1935914
   PubMed Web of Science ®Google Scholar
• Frokjaer-Jensen C, Davis MW, Hopkins CE, Newman BJ, Thummel JM, Olesen SP, Grunnet M, Jorgensen EM. Single-copy insertion of transgenes in Caenorhabditis elegans. Nat Genet 2008; 40:1375-83; PMID:18953339; http://dx.doi.org/10.1038/ng.248
   PubMed Web of Science ®Google Scholar
• Yang JS, Nam HJ, Seo M, Han SK, Choi Y, Nam HG, Lee SJ, Kim S. OASIS: online application for the survival analysis of lifespan assays performed in aging research. PloS one 2011; 6:e23525; PMID:21858155; http://dx.doi.org/10.1371/journal.pone.0023525
   PubMed Web of Science ®Google Scholar