References
- Dawson JE, Anderson BE, Fishbein DB, Sanchez JL, Goldsmith CS, Wilson KH, Duntley CW. Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis. J Clin Microbiol 1991; 29:2741–5; PMID:1757540
- Anderson BE, Dawson JE, Jones DC, Wilson KH. Ehrlichia chaffeensis, a new species associated with human ehrlichiosis. J Clin Microbiol 1991; 29:2838–42; PMID:1757557
- Maeda K, Markowitz N, Hawley RC, Ristic M, Cox D, McDade JE. Human infection with Ehrlichia canis, a leukocytic rickettsia. N Engl J Med 1987; 316:853–6; PMID:3029590; http://dx.doi.org/10.1056/NEJM198704023161406
- Paddock CD, Childs JE. Ehrlichia chaffeensis: a prototypical emerging pathogen. Clin Microbiol Rev 2003; 16:37–64; PMID:12525424; http://dx.doi.org/10.1128/CMR.16.1.37-64.2003
- Walker DH, Ismail N, Olano JP, McBride JW, Yu XJ, Feng HM. Ehrlichia chaffeensis: a prevalent, life-threatening, emerging pathogen. Trans Am Clin Climatol Assoc 2004; 115:375–82; discussion 82-4; PMID:17060980
- Abu Kwaik Y, Bumann D. Microbial quest for food in vivo: 'nutritional virulence' as an emerging paradigm. Cell Microbiol 2013; 15:882–90; PMID:23490329; http://dx.doi.org/10.1111/cmi.12138
- Rikihisa Y. Molecular pathogenesis of Ehrlichia chaffeensis infection. Annu Rev Microbiol 2015; 69:283–304; PMID:26488275; http://dx.doi.org/10.1146/annurev-micro-091014-104411
- Barnewall RE, Rikihisa Y, Lee EH. Ehrlichia chaffeensis inclusions are early endosomes which selectively accumulate transferrin receptor. Infect Immun 1997; 65:1455–61; PMID:9119487
- Mott J, Barnewall RE, Rikihisa Y. Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells. Infect Immun 1999; 67:1368–78; PMID:10024584
- Lin M, Rikihisa Y. Degradation of p22phox and inhibition of superoxide generation by Ehrlichia chaffeensis in human monocytes. Cell Microbiol 2007; 9:861–74; PMID:17087735; http://dx.doi.org/10.1111/j.1462-5822.2006.00835.x
- Hotopp JC, Lin M, Madupu R, Crabtree J, Angiuoli SV, Eisen JA, Seshadri R, Ren Q, Wu M, Utterback TR, et al. Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet 2006; 2:e21; PMID:16482227; http://dx.doi.org/10.1371/journal.pgen.0020021
- De Duve C, Wattiaux R. Functions of lysosomes. Annu Rev Physiol 1966; 28:435–92; PMID:5322983; http://dx.doi.org/10.1146/annurev.ph.28.030166.002251
- Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat?Cell Biol 2010; 12:814–22; PMID:20811353; http://dx.doi.org/10.1038/ncb0910-814
- Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011; 147:728–41; PMID:22078875; http://dx.doi.org/10.1016/j.cell.2011.10.026
- Lamb CA, Yoshimori T, Tooze SA. The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol 2013; 14:759–74; PMID:24201109; http://dx.doi.org/10.1038/nrm3696
- Mizushima N, Yoshimori T, Ohsumi Y. The role of atg proteins in autophagosome formation. Annu Rev Cell Dev Biol 2011; 27:107–32; PMID:21801009; http://dx.doi.org/10.1146/annurev-cellbio-092910-154005
- Itakura E, Kishi C, Inoue K, Mizushima N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 2008; 19:5360–72; PMID:18843052; http://dx.doi.org/10.1091/mbc.E08-01-0080
- Mizushima N, Sugita H, Yoshimori T, Ohsumi Y. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem 1998; 273:33889–92; PMID:9852036; http://dx.doi.org/10.1074/jbc.273.51.33889
- Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720–8; PMID:11060023; http://dx.doi.org/10.1093/emboj/19.21.5720
- Dunn WA, Jr. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J Cell Biol 1990; 110:1923–33; PMID:2351689; http://dx.doi.org/10.1083/jcb.110.6.1923
- Berg TO, Fengsrud M, Stromhaug PE, Berg T, Seglen PO. Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes. J Biol Chem 1998; 273:21883–92; PMID:9705327; http://dx.doi.org/10.1074/jbc.273.34.21883
- Liou W, Geuze HJ, Geelen MJ, Slot JW. The autophagic and endocytic pathways converge at the nascent autophagic vacuoles. J Cell Biol 1997; 136:61–70; PMID:9008703; http://dx.doi.org/10.1083/jcb.136.1.61
- Ahlberg J, Marzella L, Glaumann H. Uptake and degradation of proteins by isolated rat liver lysosomes. Suggestion of a microautophagic pathway of proteolysis. Lab Invest 1982; 47:523–32; PMID:6755063
- Morvan J, Kochl R, Watson R, Collinson LM, Jefferies HB, Tooze?SA. In vitro reconstitution of fusion between immature ?autophagosomes and endosomes. Autophagy 2009; 5:676–89; PMID:19337031; http://dx.doi.org/10.4161/auto.5.5.8378
- Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007; 9:1102–9; PMID:17909521; http://dx.doi.org/10.1038/ncb1007-1102
- Klionsky DJ, Eskelinen EL, Deretic V. Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes … wait, I'm confused. Autophagy 2014; 10:549–51; PMID:24657946; http://dx.doi.org/10.4161/auto.28448
- Thurston TL, Ryzhakov G, Bloor S, von Muhlinen N, Randow F. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol 2009; 10:1215–21; PMID:19820708; http://dx.doi.org/10.1038/ni.1800
- Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, et al. Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol 2009; 11:1233–40; PMID:19749745; http://dx.doi.org/10.1038/ncb1967
- Dupont N, Lacas-Gervais S, Bertout J, Paz I, Freche B, Van Nhieu GT, Van Der Goot FG, Sansonetti PJ, Lafont F. Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 2009; 6:137–49; PMID:19683680; http://dx.doi.org/10.1016/j.chom.2009.07.005
- Zheng YT, Shahnazari S, Brech A, Lamark T, Johansen T, Brumell JH. The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol 2009; 183:5909–16; PMID:19812211; http://dx.doi.org/10.4049/jimmunol.0900441
- Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004; 119:753–66; PMID:15607973; http://dx.doi.org/10.1016/j.cell.2004.11.038
- Gutierrez MG, Vazquez CL, Munafo DB, Zoppino FC, Beron W, Rabinovitch M, Colombo MI. Autophagy induction favours the generation and maturation of the Coxiella-replicative vacuoles. Cell Microbiol 2005; 7:981–93; PMID:15953030; http://dx.doi.org/10.1111/j.1462-5822.2005.00527.x
- Starr T, Child R, Wehrly TD, Hansen B, Hwang S, Lopez-Otin C, Virgin HW, Celli J. Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. Cell Host Microbe 2012; 11:33–45; PMID:22264511; http://dx.doi.org/10.1016/j.chom.2011.12.002
- Steele S, Brunton J, Ziehr B, Taft-Benz S, Moorman N, Kawula T. Francisella tularensis harvests nutrients derived via ATG5-independent autophagy to support intracellular growth. PLoS Pathog 2013; 9:e1003562; PMID:23966861; http://dx.doi.org/10.1371/journal.ppat.1003562
- Niu H, Yamaguchi M, Rikihisa Y. Subversion of cellular autophagy by Anaplasma phagocytophilum. Cell Microbiol 2008; 10:593–605; PMID:17979984; http://dx.doi.org/10.1111/j.1462-5822.2007.01068.x
- Niu H, Rikihisa Y. Ats-1: a novel bacterial molecule that links ?autophagy to bacterial nutrition. Autophagy 2013; 9:787–8; PMID:23388398; http://dx.doi.org/10.4161/auto.23693
- Niu H, Xiong Q, Yamamoto A, Hayashi-Nishino M, Rikihisa Y. Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection. Proc Natl Acad Sci U S A 2012; 109:20800–7; PMID:23197835; http://dx.doi.org/10.1073/pnas.1218674109
- Ohashi N, Zhi N, Lin Q, Rikihisa Y. Characterization and transcriptional analysis of gene clusters for a type IV secretion machinery in human granulocytic and monocytic ehrlichiosis agents. Infect Immun 2002; 70:2128–38; PMID:11895979; http://dx.doi.org/10.1128/IAI.70.4.2128-2138.2002
- Cheng Z, Wang X, Rikihisa Y. Regulation of type IV secretion apparatus genes during Ehrlichia chaffeensis intracellular development by a previously unidentified protein. J Bacteriol 2008; 190:2096–105; PMID:18192398; http://dx.doi.org/10.1128/JB.01813-07
- Bao W, Kumagai Y, Niu H, Yamaguchi M, Miura K, Rikihisa Y. Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles. J Bacteriol 2009; 191:278–86; PMID:18952796; http://dx.doi.org/10.1128/JB.01031-08
- Rikihisa Y, Lin M. Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins. Curr Opin Microbiol 2010; 13:59–66; PMID:20053580; http://dx.doi.org/10.1016/j.mib.2009.12.008
- Backert S, Meyer TF. Type IV secretion systems and their effectors in bacterial pathogenesis. Curr Opin Microbiol 2006; 9:207–17; PMID:16529981; http://dx.doi.org/10.1016/j.mib.2006.02.008
- Liu H, Bao W, Lin M, Niu H, Rikihisa Y. Ehrlichia type IV secretion effector ECH0825 is translocated to mitochondria and curbs ROS and apoptosis by upregulating host MnSOD. Cell Microbiol 2012; 14:1037–50; PMID:22348527; http://dx.doi.org/10.1111/j.1462-5822.2012.01775.x
- Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, Gaullier JM, Parton RG, Stenmark H. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J 2000; 19:4577–88; PMID:10970851; http://dx.doi.org/10.1093/emboj/19.17.4577
- Schnatwinkel C, Christoforidis S, Lindsay MR, Uttenweiler-Joseph S, Wilm M, Parton RG, Zerial M. The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. PLoS Biol 2004; 2:E261; PMID:15328530; http://dx.doi.org/10.1371/journal.pbio.0020261
- Patki V, Virbasius J, Lane WS, Toh BH, Shpetner HS, Corvera S. Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 1997; 94:7326–30; PMID:9207090; http://dx.doi.org/10.1073/pnas.94.14.7326
- Simonsen A, Lippe R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 1998; 394:494–8; PMID:9697774; http://dx.doi.org/10.1038/28879
- Backer JM. The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem J 2008; 410:1–17; PMID:18215151; http://dx.doi.org/10.1042/BJ20071427
- Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000; 275:992–8; PMID:10625637; http://dx.doi.org/10.1074/jbc.275.2.992
- Seglen PO, Gordon PB. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 1982; 79:1889–92; PMID:6952238; http://dx.doi.org/10.1073/pnas.79.6.1889
- Lindmo K, Stenmark H. Regulation of membrane traffic by ?phosphoinositide 3-kinases. J Cell Sci 2006; 119:605–14; PMID:16467569; http://dx.doi.org/10.1242/jcs.02855
- Ohashi N, Zhi N, Zhang Y, Rikihisa Y. Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family. Infect Immun 1998; 66:132–9; PMID:9423849
- Cheng Z, Lin M, Rikihisa Y. Ehrlichia chaffeensis proliferation begins with NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by Proline and Glutamine Uptake. MBio 2014; 5:e02141; PMID:25425236; http://dx.doi.org/10.1128/mBio.02141-14
- Mohan Kumar D, Yamaguchi M, Miura K, Lin M, Los M, Coy JF, Rikihisa Y. Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells. PLoS Pathog 2013; 9:e1003666; PMID:24098122; http://dx.doi.org/10.1371/journal.ppat.1003666
- Jaber N, Dou Z, Chen JS, Catanzaro J, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin RZ, Zhang J, et al. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci U S A 2012; 109:2003–8; PMID:22308354; http://dx.doi.org/10.1073/pnas.1112848109
- Vieira OV, Bucci C, Harrison RE, Trimble WS, Lanzetti L, Gruenberg J, Schreiber AD, Stahl PD, Grinstein S. Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Mol Cell Biol 2003; 23:2501–14; PMID:12640132; http://dx.doi.org/10.1128/MCB.23.7.2501-2514.2003
- Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2001; 2:330–5; PMID:11306555; http://dx.doi.org/10.1093/embo-reports/kve061
- Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 2011; 147:223–34; PMID:21962518; http://dx.doi.org/10.1016/j.cell.2011.08.037
- Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991; 253:905–9; PMID:1715094; http://dx.doi.org/10.1126/science.1715094
- Homer CR, Richmond AL, Rebert NA, Achkar JP, McDonald C. ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology 2010; 139;1630–41, 41 e1-2; PMID:20637199; http://dx.doi.org/10.1053/j.gastro.2010.07.006
- Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, Tokuhisa T, Ohsumi Y, Yoshimori T. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001; 152:657–68; PMID:11266458; http://dx.doi.org/10.1083/jcb.152.4.657
- Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 2004; 432:1032–6; PMID:15525940; http://dx.doi.org/10.1038/nature03029
- Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885–9; PMID:16625204; http://dx.doi.org/10.1038/nature04724
- Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, et al. Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 2008; 4:458–69; PMID:18996346; http://dx.doi.org/10.1016/j.chom.2008.10.003
- Cross M, Mangelsdorf I, Wedel A, Renkawitz R. Mouse lysozyme M gene: isolation, characterization, and expression studies. Proc Natl Acad Sci U S A 1988; 85:6232–6; PMID:3413093; http://dx.doi.org/10.1073/pnas.85.17.6232
- Zhao Z, Thackray LB, Miller BC, Lynn TM, Becker MM, Ward E, Mizushima NN, Denison MR, Virgin HW, 4th. Coronavirus replication does not require the autophagy gene ATG5. Autophagy 2007; 3:581–5; PMID:17700057; http://dx.doi.org/10.4161/auto.4782
- George MD, Baba M, Scott SV, Mizushima N, Garrison BS, Ohsumi Y, Klionsky DJ. Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways. Mol Biol Cell 2000; 11:969–82; PMID:10712513; http://dx.doi.org/10.1091/mbc.11.3.969
- Chen R, Zou Y, Mao D, Sun D, Gao G, Shi J, Liu X, Zhu C, Yang M, Ye W, et al. The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation. J Cell Biol 2014; 206:173–82; PMID:25049270; http://dx.doi.org/10.1083/jcb.201403009
- Cocuron JC, Anderson B, Boyd A, Alonso AP. Targeted metabolomics of Physaria fendleri, an industrial crop producing hydroxy fatty acids. Plant Cell Physiol 2014; 55:620–33; PMID:24443498; http://dx.doi.org/10.1093/pcp/pcu011
- Sneve ML, Overbye A, Fengsrud M, Seglen PO. Comigration of two autophagosome-associated dehydrogenases on two-dimensional polyacrylamide gels. Autophagy 2005; 1:157–62; PMID:16874067; http://dx.doi.org/10.4161/auto.1.3.2037
- Ge Y, Rikihisa Y. Surface-exposed proteins of Ehrlichia chaffeensis. Infect Immun 2007; 75:3833–41; PMID:17517859; http://dx.doi.org/10.1128/IAI.00188-07
- Kumagai Y, Matsuo J, Hayakawa Y, Rikihisa Y. Cyclic di-GMP signaling regulates invasion of Ehrlichia chaffeensis into human monocytes. J Bacteriol 2010; 192:4122–33; PMID:20562302; http://dx.doi.org/10.1128/JB.00132-10
- Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. U.K. induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 2013; 15:741–50; PMID:23685627; http://dx.doi.org/10.1038/ncb2757
- Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13:132–41; PMID:21258367; http://dx.doi.org/10.1038/ncb2152
- Ferrari S, Bandi HR, Hofsteenge J, Bussian BM, Thomas G. Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites. J Biol Chem 1991; 266:22770–5; PMID:1939282
- Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DG. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem 1996; 271:27879–87; PMID:8910387; http://dx.doi.org/10.1074/jbc.271.44.27879
- Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009; 284:8023–32; PMID:19150980; http://dx.doi.org/10.1074/jbc.M900301200
- Kim PK, Hailey DW, Mullen RT, Lippincott-Schwartz J. Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc Natl Acad Sci U S A 2008; 105:20567–74; PMID:19074260; http://dx.doi.org/10.1073/pnas.0810611105
- Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131–45; PMID:17580304; http://dx.doi.org/10.1074/jbc.M702824200
- Ichimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, Kominami E, Yamane T, Tanaka K, Komatsu M. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem 2008; 283:22847–57; PMID:18524774; http://dx.doi.org/10.1074/jbc.M802182200
- Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, ?Umemoto T, Saitoh T, Nakatogawa H, Kobayashi S, et al. ?Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol 2013; 203:115–28; PMID:24100292; http://dx.doi.org/10.1083/jcb.201304188
- Alonso S, Pethe K, Russell DG, Purdy GE. Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy. Proc Natl Acad Sci U S A 2007; 104:6031–6; PMID:17389386; http://dx.doi.org/10.1073/pnas.0700036104
- Purdy GE, Russell DG. Ubiquitin trafficking to the lysosome: keeping the house tidy and getting rid of unwanted guests. Autophagy 2007; 3:399–401; PMID:17457035; http://dx.doi.org/10.4161/auto.4272
- Barnett TC, Liebl D, Seymour LM, Gillen CM, Lim JY, Larock CN, Davies MR, Schulz BL, Nizet V, Teasdale RD, et al. The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication. Cell Host Microbe 2013; 14:675–82; PMID:24331465; http://dx.doi.org/10.1016/j.chom.2013.11.003
- Khweek AA, Caution K, Akhter A, Abdulrahman BA, Tazi M, ?Hassan H, Majumdar N, Doran A, Guirado E, Schlesinger LS, et al. A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy. Eur J Immunol 2013; 43:1333–44; PMID:23420491; http://dx.doi.org/10.1002/eji.201242835
- Campbell AM, Kessler PD, Fambrough DM. The alternative carboxyl termini of avian cardiac and brain sarcoplasmic reticulum/endoplasmic reticulum Ca(2+)-ATPases are on opposite sides of the membrane. J Biol Chem 1992; 267:9321–5; PMID:1533629
- Bhakdi S, Tranum-Jensen J, Sziegoleit A. Mechanism of membrane damage by streptolysin-O. Infect Immun 1985; 47:52–60; PMID:3880730
- Venkatraman P, Wetzel R, Tanaka M, Nukina N, Goldberg AL. Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol Cell 2004; 14:95–104; PMID:15068806; http://dx.doi.org/10.1016/S1097-2765(04)00151-0
- Raspe M, Gillis J, Krol H, Krom S, Bosch K, van Veen H, Reits E. Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity. J Cell Sci 2009; 122:3262–71; PMID:19690053; http://dx.doi.org/10.1242/jcs.045567
- Bhutani N, Venkatraman P, Goldberg AL. Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation. EMBO J 2007; 26:1385–96; PMID:17318184; http://dx.doi.org/10.1038/sj.emboj.7601592
- Menzies FM, Hourez R, Imarisio S, Raspe M, Sadiq O, Chandraratna D, O'Kane C, Rock KL, Reits E, Goldberg AL, et al. Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. Hum Mol Genet 2010; 19:4573–86; PMID:20829225; http://dx.doi.org/10.1093/hmg/ddq385
- Harding TM, Morano KA, Scott SV, Klionsky DJ. Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway. J Cell Biol 1995; 131:591–602; PMID:7593182; http://dx.doi.org/10.1083/jcb.131.3.591
- Komoda M, Kakuta H, Takahashi H, Fujimoto Y, Kadoya S, Kato F, Hashimoto Y. Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study. Bioorg Med Chem 2001; 9:121–31; PMID:11197332; http://dx.doi.org/10.1016/S0968–0896(00)00231–5
- Kakuta H, Koiso Y, Nagasawa K, Hashimoto Y. Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. Bioorg Med Chem Lett 2003; 13:83–6; PMID:12467622; http://dx.doi.org/10.1016/S0960–894X(02)00845–4
- Dou Z, Pan JA, Dbouk HA, Ballou LM, DeLeon JL, Fan Y, Chen JS, Liang Z, Li G, Backer JM, et al. Class IA PI3K p110beta subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Mol Cell 2013; 50:29–42; PMID:23434372; http://dx.doi.org/10.1016/j.molcel.2013.01.022
- Su WC, Chao TC, Huang YL, Weng SC, Jeng KS, Lai MM. Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. J Virol 2011; 85:10561–71; PMID:21835792; http://dx.doi.org/10.1128/JVI.00173–11
- Ravikumar B, Imarisio S, Sarkar S, O'Kane CJ, Rubinsztein DC. Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. J Cell Sci 2008; 121:1649–60; PMID:18430781; http://dx.doi.org/10.1242/jcs.025726
- Bucci C, Lutcke A, Steele-Mortimer O, Olkkonen VM, Dupree P, Chiariello M, Bruni CB, Simons K, Zerial M. Co-operative regulation of endocytosis by three Rab5 isoforms. FEBS Lett 1995; 366:65–71; PMID:7789520; http://dx.doi.org/10.1016/0014–5793(95)00477-Q
- Huang F, Khvorova A, Marshall W, Sorkin A. Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem 2004; 279:16657–61; PMID:14985334; http://dx.doi.org/10.1074/jbc.C400046200
- Su X, Lodhi IJ, Saltiel AR, Stahl PD. Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5. J Biol Chem 2006; 281:27982–90; PMID:16880210; http://dx.doi.org/10.1074/jbc.M602873200
- Christoforidis S, Miaczynska M, Ashman K, Wilm M, Zhao L, Yip SC, Waterfield MD, Backer JM, Zerial M. Phosphatidylinositol-3-OH kinases are Rab5 effectors. Nature cell biology 1999; 1:249–52; PMID:10559924; http://dx.doi.org/10.1038/12075
- Pfeffer SR. GTP-binding proteins in intracellular transport. Trends Cell Biol 1992; 2:41–6; PMID:14731525; http://dx.doi.org/10.1016/0962-8924(92)90161-F
- Bourne HR. Do GTPases direct membrane traffic in secretion? Cell 1988; 53:669–71; PMID:2836065; http://dx.doi.org/10.1016/0092-8674(88)90081-5
- Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 2009; 10:513–25; PMID:19603039; http://dx.doi.org/10.1038/nrm2728
- Haas AK, Fuchs E, Kopajtich R, Barr FA. A GTPase-activating protein controls Rab5 function in endocytic trafficking. Nat Cell Biol 2005; 7:887–93; PMID:16086013; http://dx.doi.org/10.1038/ncb1290
- Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469:323–35; PMID:21248839; http://dx.doi.org/10.1038/nature09782
- Deretic V. Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol Rev 2011; 240:92–104; PMID:21349088; http://dx.doi.org/10.1111/j.1600-065X.2010.00995.x
- Lin TC, Chen YR, Kensicki E, Li AY, Kong M, Li Y, Mohney RP, Shen HM, Stiles B, Mizushima N, et al. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy 2012; 8:1477–93; PMID:22906967; http://dx.doi.org/10.4161/auto.21228
- Fratti RA, Chua J, Vergne I, Deretic V. Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest. Proc Natl Acad Sci U S A 2003; 100:5437–42; PMID:12702770; http://dx.doi.org/10.1073/pnas.0737613100
- Puri RV, Reddy PV, Tyagi AK. Secreted acid phosphatase (SapM) of Mycobacterium tuberculosis is indispensable for arresting phagosomal maturation and growth of the pathogen in guinea pig tissues. PLoS One 2013; 8:e70514; PMID:23923000; http://dx.doi.org/10.1371/journal.pone.0070514
- Alvarez-Dominguez C, Madrazo-Toca F, Fernandez-Prieto L, ?Vandekerckhove J, Pareja E, Tobes R, Gomez-Lopez MT, Del Cerro-Vadillo E, Fresno M, Leyva-Cobián F, et al. Characterization of a Listeria monocytogenes protein interfering with Rab5a. Traffic 2008; 9:325–37; PMID:18088303; http://dx.doi.org/10.1111/j.1600-0854.2007.00683.x
- Pal A, Severin F, Lommer B, Shevchenko A, Zerial M. Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. J Cell Biol 2006; 172:605–18; PMID:16476778; http://dx.doi.org/10.1083/jcb.200509091
- Tooze J, Hollinshead M, Ludwig T, Howell K, Hoflack B, Kern H. In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome. J Cell Biol 1990; 111:329–45; PMID:2166050; http://dx.doi.org/10.1083/jcb.111.2.329
- Eskelinen EL. Maturation of autophagic vacuoles in Mammalian cells. Autophagy 2005; 1:1–10; PMID:16874026; http://dx.doi.org/10.4161/auto.1.1.1270
- Fader CM, Colombo MI. Autophagy and multivesicular bodies: two closely related partners. Cell Death Differ 2009; 16:70–8; PMID:19008921; http://dx.doi.org/10.1038/cdd.2008.168
- Shin HW, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, et al. An enzymatic cascade of Rab5 effectors regulates ?phosphoinositide turnover in the endocytic pathway. J Cell Biol 2005; 170:607–18; PMID:16103228; http://dx.doi.org/10.1083/jcb.200505128
- Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, ?Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol 2001; 155:19–25; PMID:11581283; http://dx.doi.org/10.1083/jcb.200107069
- Kobayashi T, Stang E, Fang KS, de Moerloose P, Parton RG, ?Gruenberg J. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function. Nature 1998; 392:193–7; PMID:9515966; http://dx.doi.org/10.1038/32440
- Petiot A, Faure J, Stenmark H, Gruenberg J. PI3P signaling regulates receptor sorting but not transport in the endosomal pathway. J Cell Biol 2003; 162:971–9; PMID:12975344; http://dx.doi.org/10.1083/jcb.200303018
- Fernandez-Borja M, Wubbolts R, Calafat J, Janssen H, Divecha N, Dusseljee S, Neefjes J. Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity. Curr Biol 1999; 9:55–8; PMID:9889123; http://dx.doi.org/10.1016/S0960-9822(99)80048-7
- Zhang J, Reiling C, Reinecke JB, Prislan I, Marky LA, Sorgen PL, Naslavsky N, Caplan S. Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. Traffic 2012; 13:745–57; PMID:22284051; http://dx.doi.org/10.1111/j.1600-0854.2012.01334.x
- Barnewall RE, Rikihisa Y. Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin. Infect Immun 1994; 62:4804–10; PMID:7927758
- Rikihisa Y, Zhi N, Wormser GP, Wen B, Horowitz HW, Hechemy KE. Ultrastructural and antigenic characterization of a granulocytic ehrlichiosis agent directly isolated and stably cultivated from a patient in New York state. J Infect Dis 1997; 175:210–3; PMID:8985223; http://dx.doi.org/10.1093/infdis/175.1.210
- Kim HY, Rikihisa Y. Characterization of monoclonal antibodies to the 44-kgdalton major outer membrane protein of the human granulocytic ehrlichiosis agent. J Clin Microbiol 1998; 36:3278–84; PMID:9774579
- Cavalli V, Vilbois F, Corti M, Marcote MJ, Tamura K, Karin M, Arkinstall S, Gruenberg J. The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex. Mol Cell 2001; 7:421–32; PMID:11239470; http://dx.doi.org/10.1016/S1097-2765(01)00189-7
- Dunn KW, Kamocka MM, McDonald JH. A practical guide to evaluating colocalization in biological microscopy. Am J Physiol Cell Physiol 2011; 300:C723–42; PMID:21209361; http://dx.doi.org/10.1152/ajpcell.00462.2010
- Cheng Z, Kumagai Y, Lin M, Zhang C, Rikihisa Y. Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cell Microbiol 2006; 8:1241–52; PMID:16882029; http://dx.doi.org/10.1111/j.1462-5822.2006.00704.x
- Hatch TP. Competition between Chlamydia psittaci and L cells for host isoleucine pools: a limiting factor in chlamydial multiplication. Infect Immun 1975; 12:211–20; PMID:1095493
- Chen PI, Kong C, Su X, Stahl PD. Rab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptors. J Biol Chem 2009; 284:30328–38; PMID:19723633; http://dx.doi.org/10.1074/jbc.M109.034546
- Miura K, Rikihisa Y. Liver transcriptome profiles associated with strain-specific Ehrlichia chaffeensis-induced hepatitis in SCID mice. Infect Immun 2009; 77:245–54; PMID:19001077; http://dx.doi.org/10.1128/IAI.00979-08
- Nougayrede JP, Foster GH, Donnenberg MS. Enteropathogenic Escherichia coli effector EspF interacts with host protein Abcf2. Cell Microbiol 2007; 9:680–93; PMID:17064289; http://dx.doi.org/10.1111/j.1462-5822.2006.00820.x
- Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, ?Yoshimori T, Yamamoto A. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol 2009; 11:1433–7; PMID:19898463; http://dx.doi.org/10.1038/ncb1991