Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression

References

• Koochekpour S. Androgen receptor signaling and mutations in prostate cancer. Asian J Androl 2010; 12:639-57; PMID:20711217; http://dx.doi.org/10.1038/aja.2010.89
   PubMed Web of Science ®Google Scholar
• Heinlein CA, Chang C. Androgen receptor (AR) coregulators: an overview. Endocr Rev 2002; 23:175-200; PMID:11943742; http://dx.doi.org/10.1210/edrv.23.2.0460
   PubMed Web of Science ®Google Scholar
• Knudsen KE, Scher HI. Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer. Clin Cancer Res 2009; 15:4792-8; PMID:19638458; http://dx.doi.org/10.1158/1078-0432.CCR-08-2660
   PubMed Web of Science ®Google Scholar
• Shen MM, Abate-Shen C. Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev 2010; 24:1967-2000; PMID:20844012; http://dx.doi.org/10.1101/gad.1965810
   PubMed Web of Science ®Google Scholar
• Society AC. Cancer Facts & Figures 2015. Atlanta: American Cancer Society, 2015.
   Google Scholar
• Augello MA, Den RB, Knudsen KE. AR function in promoting metastatic prostate cancer. Cancer Metastasis Rev 2014; 33:399-411; PMID:24425228; http://dx.doi.org/10.1007/s10555-013-9471-3
   PubMed Web of Science ®Google Scholar
• He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43:67-93; PMID:19653858; http://dx.doi.org/10.1146/annurev-genet-102808-114910
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010; 90:1383-435; PMID:20959619; http://dx.doi.org/10.1152/physrev.00030.2009
   PubMed Web of Science ®Google Scholar
• Jin S, White E. Role of autophagy in cancer: management of metabolic stress. Autophagy 2007; 3:28-31; PMID:16969128; http://dx.doi.org/10.4161/auto.3269
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, et al. Autophagy in malignant transformation and cancer progression. EMBO J 2015; 34:856-80; PMID:25712477; http://dx.doi.org/10.15252/embj.201490784
   PubMed Web of Science ®Google Scholar
• Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, et al. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov 2014; 4:914-27; PMID:24875857; http://dx.doi.org/10.1158/2159-8290.CD-14-0363
   PubMed Web of Science ®Google Scholar
• Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726-34; PMID:16148885; http://dx.doi.org/10.1038/nrc1692
   PubMed Web of Science ®Google Scholar
• Levy JM, Thompson JC, Griesinger AM, Amani V, Donson AM, Birks DK, Morgan MJ, Mirsky DM, Handler MH, Foreman NK, et al. Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors. Cancer Discov 2014; 4:773-80; PMID:24823863; http://dx.doi.org/10.1158/2159-8290.CD-14-0049
   PubMed Web of Science ®Google Scholar
• Mathew R, Karantza-Wadsworth V, White E. Role of autophagy in cancer. Nat Rev Cancer 2007; 7:961-7; PMID:17972889; http://dx.doi.org/10.1038/nrc2254
   PubMed Web of Science ®Google Scholar
• Thorburn A, Thamm DH, Gustafson DL. Autophagy and cancer therapy. Mol Pharmacol 2014; 85:830-8; PMID:24574520; http://dx.doi.org/10.1124/mol.114.091850
   PubMed Web of Science ®Google Scholar
• White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009; 15:5308-16; PMID:19706824; http://dx.doi.org/10.1158/1078-0432.CCR-07-5023
   PubMed Web of Science ®Google Scholar
• Hippert MM, O'Toole PS, Thorburn A. Autophagy in cancer: good, bad, or both? Cancer Res 2006; 66:9349-51; PMID:17018585; http://dx.doi.org/10.1158/0008-5472.CAN-06-1597
   PubMed Web of Science ®Google Scholar
• Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 2011; 17:654-66; PMID:21325294; http://dx.doi.org/10.1158/1078-0432.CCR-10-2634
   PubMed Web of Science ®Google Scholar
• Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, Howe MK, McDonnell DP, Frigo DE. Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol 2013; 27:280-95; PMID:23250485; http://dx.doi.org/10.1210/me.2012-1260
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Codogno P, Cuervo AM, Deretic V, Elazar Z, Fueyo-Margareto J, Gewirtz DA, Kroemer G, Levine B, Mizushima N, et al. A comprehensive glossary of autophagy-related molecules and processes. Autophagy 2010; 6:438-48; PMID:20484971; http://dx.doi.org/10.4161/auto.6.4.12244
   PubMed Web of Science ®Google Scholar
• Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 2013; 15:741-50; PMID:23685627; http://dx.doi.org/10.1038/ncb2757
   PubMed Web of Science ®Google Scholar
• Geng J, Klionsky DJ. The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein modifications: beyond the usual suspects’ review series. EMBO Rep 2008; 9:859-64; PMID:18704115; http://dx.doi.org/10.1038/embor.2008.163
   PubMed Web of Science ®Google Scholar
• Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, et al. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell 2006; 10:321-30; PMID:17010675; http://dx.doi.org/10.1016/j.ccr.2006.09.005
   PubMed Web of Science ®Google Scholar
• Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 2010; 18:11-22; PMID:20579941; http://dx.doi.org/10.1016/j.ccr.2010.05.026
   PubMed Web of Science ®Google Scholar
• Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP. Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. Mol Endocrinol 2009; 23:1385-96; PMID:19460858; http://dx.doi.org/10.1210/me.2009-0010
   PubMed Web of Science ®Google Scholar
• Chng KR, Chang CW, Tan SK, Yang C, Hong SZ, Sng NY, Cheung E. A transcriptional repressor co-regulatory network governing androgen response in prostate cancers. Embo j 2012; 31:2810-23; PMID:22531786; http://dx.doi.org/10.1038/emboj.2012.112
   PubMed Web of Science ®Google Scholar
• Tan PY, Chang CW, Chng KR, Wansa KD, Sung WK, Cheung E. Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival. Mol Cell Biol 2012; 32:399-414; PMID:22083957; http://dx.doi.org/10.1128/MCB.05958-11
   PubMed Web of Science ®Google Scholar
• Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 2005; 122:33-43; PMID:16009131; http://dx.doi.org/10.1016/j.cell.2005.05.008
   PubMed Web of Science ®Google Scholar
• Liu MH, Cheung E. Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer. Mol Cell Endocrinol 2014; 382:624-32; PMID:24071518; http://dx.doi.org/10.1016/j.mce.2013.09.019
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016; 12:1-222; PMID:26799652; http://dx.doi.org/10.1080/15548627.2015.1100356
   PubMed Web of Science ®Google Scholar
• Johansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011; 7:279-96; PMID:21189453; http://dx.doi.org/10.4161/auto.7.3.14487
   PubMed Web of Science ®Google Scholar
• Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, et al. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nat Neurosci 2014; 17:1180-9; PMID:25108912; http://dx.doi.org/10.1038/nn.3787
   PubMed Web of Science ®Google Scholar
• Blessing AM, Ganesan S, Rajapakshe K, Ying Sung Y, Bollu LR, Shi Y, Cheung E, Coarfa C, Chang JT, McDonnell DP, et al. Identification of a novel coregulator, SH3YL1, that interacts with the androgen receptor N-terminus. Mol Endocrinol 2015; 29(10):1426-39: me20151079
   PubMed Web of Science ®Google Scholar
• Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum Mol Genet 2011; 20:3852-66; PMID:21752829; http://dx.doi.org/10.1093/hmg/ddr306
   PubMed Web of Science ®Google Scholar
• Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, et al. TFEB links autophagy to lysosomal biogenesis. Science 2011; 332:1429-33; PMID:21617040; http://dx.doi.org/10.1126/science.1204592
   PubMed Web of Science ®Google Scholar
• Kimura S, Fujita N, Noda T, Yoshimori T. Monitoring autophagy in mammalian cultured cells through the dynamics of LC3. Methods Enzymol 2009; 452:1-12; PMID:19200872; http://dx.doi.org/10.1016/S0076-6879(08)03601-X
   PubMed Web of Science ®Google Scholar
• Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3:452-60; PMID:17534139; http://dx.doi.org/10.4161/auto.4451
   PubMed Web of Science ®Google Scholar
• Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal 2012; 5:ra42; PMID:22692423; http://dx.doi.org/10.1126/scisignal.2002790
   PubMed Web of Science ®Google Scholar
• Nelson PS, Clegg N, Arnold H, Ferguson C, Bonham M, White J, Hood L, Lin B. The program of androgen-responsive genes in neoplastic prostate epithelium. Proc Natl Acad Sci U S A 2002; 99:11890-5; PMID:12185249; http://dx.doi.org/10.1073/pnas.182376299
   PubMed Web of Science ®Google Scholar
• Grasso CS, Wu YM, Robinson DR, Cao X, Dhanasekaran SM, Khan AP, Quist MJ, Jing X, Lonigro RJ, Brenner JC, et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 2012; 487:239-43; PMID:22722839; http://dx.doi.org/10.1038/nature11125
   PubMed Web of Science ®Google Scholar
• Varambally S, Yu J, Laxman B, Rhodes DR, Mehra R, Tomlins SA, Shah RB, Chandran U, Monzon FA, Becich MJ, et al. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell 2005; 8:393-406; PMID:16286247; http://dx.doi.org/10.1016/j.ccr.2005.10.001
   PubMed Web of Science ®Google Scholar
• Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, Magee MS, Frigo DE, Wilder-Romans K, Shilkrut M, Han S, et al. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. J Clin Invest 2013; 123:493-508; PMID:23257359; http://dx.doi.org/10.1172/JCI64750
   PubMed Web of Science ®Google Scholar
• Kimura T, Takabatake Y, Takahashi A, Isaka Y. Chloroquine in cancer therapy: a double-edged sword of autophagy. Cancer Res 2013; 73:3-7; PMID:23288916; http://dx.doi.org/10.1158/0008-5472.CAN-12-2464
   PubMed Web of Science ®Google Scholar
• Liu B, Miyake H, Nishikawa M, Tei H, Fujisawa M. Expression Profile of Autophagy-related Markers in Localized Prostate Cancer: Correlation With Biochemical Recurrence After Radical Prostatectomy. Urology 2015; 85:1424-30; PMID:25881865; http://dx.doi.org/10.1016/j.urology.2015.03.006
   PubMed Web of Science ®Google Scholar
• Martinet W, Schrijvers DM, Timmermans JP, Bult H, De Meyer GR. Immunohistochemical analysis of macroautophagy: recommendations and limitations. Autophagy 2013; 9:386-402; PMID:23242143; http://dx.doi.org/10.4161/auto.22968
   PubMed Web of Science ®Google Scholar
• Akin D, Wang SK, Habibzadegah-Tari P, Law B, Ostrov D, Li M, Yin XM, Kim JS, Horenstein N, Dunn WA, Jr. A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors. Autophagy 2014; 10:2021-35; PMID:25483883; http://dx.doi.org/10.4161/auto.32229
   PubMed Web of Science ®Google Scholar
• Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, et al. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Mol Cell 2015; 59:285-97; PMID:26118643; http://dx.doi.org/10.1016/j.molcel.2015.05.031
   PubMed Web of Science ®Google Scholar
• Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev 2013; 27:1447-61; PMID:23824538; http://dx.doi.org/10.1101/gad.219642.113
   PubMed Web of Science ®Google Scholar
• Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature 2013; 504:296-300; PMID:24305049; http://dx.doi.org/10.1038/nature12865
   PubMed Web of Science ®Google Scholar
• Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 2011; 25:1510-27; PMID:21764854; http://dx.doi.org/10.1101/gad.2051011
   PubMed Web of Science ®Google Scholar
• Xie X, Koh JY, Price S, White E, Mehnert JM. Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. Cancer Discov 2015; 5:410-23; PMID:25673642; http://dx.doi.org/10.1158/2159-8290.CD-14-1473
   PubMed Web of Science ®Google Scholar
• Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC, Von Hoff DD, Maitra A, Kimmelman AC. Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov 2014; 4:905-13; PMID:24875860; http://dx.doi.org/10.1158/2159-8290.CD-14-0362
   PubMed Web of Science ®Google Scholar
• Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev 2011; 25:717-29; PMID:21406549; http://dx.doi.org/10.1101/gad.2016111
   PubMed Web of Science ®Google Scholar
• Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov 2013; 3:1272-85; PMID:23965987; http://dx.doi.org/10.1158/2159-8290.CD-13-0397
   PubMed Web of Science ®Google Scholar
• White E, Mehnert JM, Chan CS. Autophagy, Metabolism, and Cancer. Clin Cancer Res 2015; 21:5037-46; PMID:26567363; http://dx.doi.org/10.1158/1078-0432.CCR-15-0490
   PubMed Web of Science ®Google Scholar
• Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP. CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. Cancer Res 2011; 71:528-37; PMID:21098087; http://dx.doi.org/10.1158/0008-5472.CAN-10-2581
   PubMed Web of Science ®Google Scholar
• Frigo DE, McDonnell DP. Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation. Mol Cancer Ther 2008; 7:659-69; PMID:18347151; http://dx.doi.org/10.1158/1535-7163.MCT-07-0480
   PubMed Web of Science ®Google Scholar
• Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D, et al. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res 2008; 68:7475-83; PMID:18794135; http://dx.doi.org/10.1158/0008-5472.CAN-08-1047
   PubMed Web of Science ®Google Scholar
• Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, Zhang A, Xia X, Ilkayeva OR, Xin L, et al. Androgens regulate prostate cancer cell growth via an AMPK-PGC-1alpha-mediated metabolic switch. Oncogene 2014; 33:5251-61; PMID:24186207; http://dx.doi.org/10.1038/onc.2013.463
   PubMed Web of Science ®Google Scholar
• Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20:1992-2003; PMID:19225151; http://dx.doi.org/10.1091/mbc.E08-12-1249
   PubMed Web of Science ®Google Scholar
• Blessing A, Xu L, Gao G, Bollu LR, Ren J, Li H, Wu X, Su F, Huang WC, Hung MC, et al. Sodium/Glucose Co-transporter 1 expression increases in human diseased prostate. Cancer Science and Therapy 2012; 4:306-12.
   Google Scholar
• Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2012; 2:401-4; PMID:22588877; http://dx.doi.org/10.1158/2159-8290.CD-12-0095
   PubMed Web of Science ®Google Scholar
• Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013; 6:l1; PMID:23550210; http://dx.doi.org/10.1126/scisignal.2004088
   PubMed Web of Science ®Google Scholar
• Bollu LR, Katreddy RR, Blessing AM, Pham N, Zheng B, Wu X, Weihua Z. Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation. Oncotarget 2015; 6(33):34992-5003; PMID:26378037
   PubMed Web of Science ®Google Scholar
• Gaur S, Wen Y, Song JH, Parikh NU, Mangala LS, Blessing AM, Ivan C, Wu SY, Varkaris A, Shi Y, et al. Chitosan nanoparticle-mediated delivery of MiRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy. 2015; 6(30):29161-77
   Google Scholar
• Sternberg SR. Biomedical Image-Processing. Computer 1983; 16:22-34; http://dx.doi.org/10.1109/MC.1983.1654163
   Web of Science ®Google Scholar
• Kapur JN, Sahoo PK, Wong AKC. A new method for gray-level picture thresholding using the entropy of the histogram. Computer Vision Graphics and Image Processing 1985; 29:273-85; http://dx.doi.org/10.1016/0734-189X(85)90125-2
   Google Scholar
• Vincent L, Soille P. Watersheds in digital spaces - an efficient algorithm based on immersion simulations. Ieee Transactions on Pattern Analysis and Machine Intelligence 1991; 13:583-98; http://dx.doi.org/10.1109/34.87344
   Web of Science ®Google Scholar
• Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, Di Malta C, Donaudy F, Embrione V, Polishchuk RS, et al. A gene network regulating lysosomal biogenesis and function. Science 2009; 325:473-7; PMID:19556463
   PubMed Web of Science ®Google Scholar