Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy

References

• Baker TG. A Quantitative and Cytological Study of Germ Cells in Human Ovaries. Proc R Soc Lond B Biol Sci 1963; 158:417-33
   PubMed Web of Science ®Google Scholar
• Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod 1992; 7:1342-6; PMID:1291557; https://doi.org/10.1093/oxfordjournals.humrep.a137570
   PubMed Web of Science ®Google Scholar
• Matsuda-Minehata F, Inoue N, Goto Y, Manabe N. The regulation of ovarian granulosa cell death by pro- and anti-apoptotic molecules. J Reprod Dev 2006; 52:695-705; PMID:16926526; https://doi.org/10.1262/jrd.18069
   PubMed Web of Science ®Google Scholar
• Tilly JL, Tilly KI, Kenton ML, Johnson AL. Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels. Endocrinology 1995; 136:232-41; PMID:7828536; https://doi.org/10.1210/endo.136.1.7828536
   PubMed Web of Science ®Google Scholar
• Duerrschmidt N, Zabirnyk O, Nowicki M, Ricken A, Hmeidan FA, Blumenauer V, Borlak J, Spanel-Borowski K. Lectin-like oxidized low-density lipoprotein receptor-1-mediated autophagy in human granulosa cells as an alternative of programmed cell death. Endocrinology 2006; 147:3851-60; PMID:16690797; https://doi.org/10.1210/en.2006-0088
   PubMed Web of Science ®Google Scholar
• Serke H, Vilser C, Nowicki M, Hmeidan FA, Blumenauer V, Hummitzsch K, Lösche A, Spanel-Borowski K. Granulosa cell subtypes respond by autophagy or cell death to oxLDL-dependent activation of the oxidized lipoprotein receptor 1 and toll-like 4 receptor. Autophagy 2009; 5:991-1003; PMID:19730000; https://doi.org/10.4161/auto.5.7.9507
   PubMed Web of Science ®Google Scholar
• Vilser C, Hueller H, Nowicki M, Hmeidan FA, Blumenauer V, Spanel-Borowski K. The variable expression of lectin-like oxidized low-density lipoprotein receptor (LOX-1) and signs of autophagy and apoptosis in freshly harvested human granulosa cells depend on gonadotropin dose, age, and body weight. Fertil Steril 2010; 93:2706-15; PMID:19342029; https://doi.org/10.1016/j.fertnstert.2009.02.038
   PubMed Web of Science ®Google Scholar
• D'Herde K, De Prest B, Roels F. Subtypes of active cell death in the granulosa of ovarian atretic follicles in the quail (Coturnix coturnix japonica). Reprod Nutr Dev 1996; 36:175-89; PMID:8663915; https://doi.org/10.1051/rnd:19960203
   PubMedGoogle Scholar
• Escobar ML, Echeverria OM, Ortiz R, Vazquez-Nin GH. Combined apoptosis and autophagy, the process that eliminates the oocytes of atretic follicles in immature rats. Apoptosis 2008; 13:1253-66; PMID:18690537; https://doi.org/10.1007/s10495-008-0248-z
   PubMed Web of Science ®Google Scholar
• Choi JY, Jo MW, Lee EY, Yoon BK, Choi DS. The role of autophagy in follicular development and atresia in rat granulosa cells. Fertil Steril 2010; 93:2532-7; PMID:20149359; https://doi.org/10.1016/j.fertnstert.2009.11.021
   PubMed Web of Science ®Google Scholar
• Choi J, Jo M, Lee E, Choi D. Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells. Fertil Steril 2011; 95:1482-6; PMID:20630503; https://doi.org/10.1016/j.fertnstert.2010.06.006
   PubMed Web of Science ®Google Scholar
• Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 2009; 7:65-74; PMID:19721819; https://doi.org/10.2174/157015909787602823
   PubMed Web of Science ®Google Scholar
• Stier A, Reichert S, Massemin S, Bize P, Criscuolo F. Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature. Front Zool 2012; 9:37; PMID:23268929; https://doi.org/10.1186/1742-9994-9-37
   PubMed Web of Science ®Google Scholar
• Murdoch WJ. Inhibition by oestradiol of oxidative stress-induced apoptosis in pig ovarian tissues. J Reprod Fertil 1998; 114:127-30; PMID:9875164; https://doi.org/10.1530/jrf.0.1140127
   PubMedGoogle Scholar
• Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol 2012; 10:49; PMID:22748101; https://doi.org/10.1186/1477-7827-10-49
   PubMed Web of Science ®Google Scholar
• Tilly JL, Tilly KI. Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles. Endocrinology 1995; 136:242-52; PMID:7828537; https://doi.org/10.1210/endo.136.1.7828537
   PubMed Web of Science ®Google Scholar
• Gupta RK, Miller KP, Babus JK, Flaws JA. Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative stress pathway. Toxicol Sci 2006; 93:382-9; PMID:16807286; https://doi.org/10.1093/toxsci/kfl052
   PubMed Web of Science ®Google Scholar
• Bras M, Queenan B, Susin SA. Programmed cell death via mitochondria: different modes of dying. Biochemistry (Mosc) 2005; 70:231-9; PMID:15807663; https://doi.org/10.1007/s10541-005-0105-4
   PubMed Web of Science ®Google Scholar
• Sinha K, Das J, Pal PB, Sil PC. Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol 2013; 87:1157-80; PMID:23543009; https://doi.org/10.1007/s00204-013-1034-4
   PubMed Web of Science ®Google Scholar
• Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J 2012; 441:523-40; PMID:22187934; https://doi.org/10.1042/BJ20111451
   PubMed Web of Science ®Google Scholar
• Dadakhujaev S, Jung EJ, Noh HS, Hah YS, Kim CJ, Kim DR. Interplay between autophagy and apoptosis in TrkA-induced cell death. Autophagy 2009; 5:103-5; PMID:19115484; https://doi.org/10.4161/auto.5.1.7276
   PubMed Web of Science ®Google Scholar
• Pan X, Liu D, Wang J, Zhang X, Yan M, Zhang D, Zhang J, Liu W. Peneciraistin C induces caspase-independent autophagic cell death through mitochondrial-derived reactive oxygen species production in lung cancer cells. Cancer Sci 2013; 104:1476-82; PMID:23952056; https://doi.org/10.1111/cas.12253
   PubMed Web of Science ®Google Scholar
• Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ 2008; 15:171-82; PMID:17917680; https://doi.org/10.1038/sj.cdd.4402233
   PubMed Web of Science ®Google Scholar
• Peluso JJ, Steger RW. Role of FSH in regulating granulosa cell division and follicular atresia in rats. J Reprod Fertil 1978; 54:275-8; PMID:722676; https://doi.org/10.1530/jrf.0.0540275
   PubMedGoogle Scholar
• Chun SY, Eisenhauer KM, Minami S, Billig H, Perlas E, Hsueh AJ. Hormonal regulation of apoptosis in early antral follicles: follicle-stimulating hormone as a major survival factor. Endocrinology 1996; 137:1447-56; PMID:8625923; https://doi.org/10.1210/endo.137.4.8625923
   PubMed Web of Science ®Google Scholar
• Shen M, Liu Z, Li B, Teng Y, Zhang J, Tang Y, Sun SC, Liu H. Involvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of apoptosis in mouse granulosa cells. Cell Death Dis 2014; 5:e1475; PMID:25321482; https://doi.org/10.1038/cddis.2014.400
   PubMed Web of Science ®Google Scholar
• Hunzicker-Dunn M, Maizels ET. FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A. Cell Signal 2006; 18:1351-9; PMID:16616457; https://doi.org/10.1016/j.cellsig.2006.02.011
   PubMed Web of Science ®Google Scholar
• Sasson R, Dantes A, Tajima K, Amsterdam A. Novel genes modulated by FSH in normal and immortalized FSH-responsive cells: new insights into the mechanism of FSH action. FASEB J 2003; 17:1256-66; PMID:12832290; https://doi.org/10.1096/fj.02-0740com
   PubMed Web of Science ®Google Scholar
• Grieshaber NA, Ko C, Grieshaber SS, Ji I, Ji TH. Follicle-stimulating hormone-responsive cytoskeletal genes in rat granulosa cells: class I beta-tubulin, tropomyosin-4, and kinesin heavy chain. Endocrinology 2003; 144:29-39; PMID:12488327
   PubMed Web of Science ®Google Scholar
• Jung CH, Ro SH, Cao J, Otto NM, Kim DH. mTOR regulation of autophagy. FEBS Lett 2010; 584:1287-95; PMID:20083114
   PubMed Web of Science ®Google Scholar
• Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18:1926-45; PMID:15314020
   PubMed Web of Science ®Google Scholar
• Reynolds THt, Bodine SC, Lawrence JC, Jr. Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J Biol Chem 2002; 277:17657-62; PMID:11884412
   PubMed Web of Science ®Google Scholar
• Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 2000; 60:3504-13; PMID:10910062
   PubMed Web of Science ®Google Scholar
• Codogno P, Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 2005; 12(Suppl 2):1509-18; PMID:16247498
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Stewart A, Kita H, Kato K, Duden R, Rubinsztein DC. Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet 2003; 12:985-94; PMID:12700167
   PubMed Web of Science ®Google Scholar
• Alam H, Maizels ET, Park Y, Ghaey S, Feiger ZJ, Chandel NS, Hunzicker-Dunn M. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation. J Biol Chem 2004; 279:19431-40; PMID:14982927
   PubMed Web of Science ®Google Scholar
• Hunzicker-Dunn ME, Lopez-Biladeau B, Law NC, Fiedler SE, Carr DW, Maizels ET. PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells. Proc Natl Acad Sci U S A 2012; 109:E2979-88; PMID:23045700
   PubMed Web of Science ®Google Scholar
• Choi J, Jo M, Lee E, Choi D. AKT is involved in granulosa cell autophagy regulation via mTOR signaling during rat follicular development and atresia. Reproduction 2014; 147:73-80; PMID:24131573; https://doi.org/10.1530/REP-13-0386
   PubMed Web of Science ®Google Scholar
• Nemoto S, Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 2002; 295:2450-2; PMID:11884717; https://doi.org/10.1126/science.1069004
   PubMed Web of Science ®Google Scholar
• Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004; 117:421-6; PMID:15137936; https://doi.org/10.1016/S0092-8674(04)00452-0
   PubMed Web of Science ®Google Scholar
• Barthel A, Schmoll D, Unterman TG. FoxO proteins in insulin action and metabolism. Trends Endocrinol Metab 2005; 16:183-9; PMID:15860415; https://doi.org/10.1016/j.tem.2005.03.010
   PubMed Web of Science ®Google Scholar
• Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005; 24:7410-25; PMID:16288288; https://doi.org/10.1038/sj.onc.1209086
   PubMed Web of Science ®Google Scholar
• Salih DA, Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 2008; 20:126-36; PMID:18394876; https://doi.org/10.1016/j.ceb.2008.02.005
   PubMed Web of Science ®Google Scholar
• Huang H, Tindall DJ. Dynamic FoxO transcription factors. J Cell Sci 2007; 120:2479-87; PMID:17646672; https://doi.org/10.1242/jcs.001222
   PubMed Web of Science ®Google Scholar
• Lam EWF, Shah K, Brosens JJ. The diversity of sex steroid action: the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer. Journal of Endocrinology 2012; 212:13-25; PMID:21382987; https://doi.org/10.1530/JOE-10-0480
   PubMed Web of Science ®Google Scholar
• Sengupta A, Molkentin JD, Yutzey KE. FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem 2009; 284:28319-31; PMID:19696026; https://doi.org/10.1074/jbc.M109.024406
   PubMed Web of Science ®Google Scholar
• Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res 2010; 107:1470-82; PMID:20947830; https://doi.org/10.1161/CIRCRESAHA.110.227371
   PubMed Web of Science ®Google Scholar
• Zhao Y, Yang J, Liao W, Liu X, Zhang H, Wang S, Wang D, Feng J, Yu L, Zhu WG. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol 2010; 12:665-75; PMID:20543840; https://doi.org/10.1038/ncb2069
   PubMed Web of Science ®Google Scholar
• Liu Z, Rudd MD, Hernandez-Gonzalez I, Gonzalez-Robayna I, Fan HY, Zeleznik AJ, Richards JS. FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Mol Endocrinol 2009; 23:649-61; PMID:19196834; https://doi.org/10.1210/me.2008-0412
   PubMed Web of Science ®Google Scholar
• Fan HY, O'Connor A, Shitanaka M, Shimada M, Liu Z, Richards JS. Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization. Mol Endocrinol 2010; 24:1529-42; PMID:20610534; https://doi.org/10.1210/me.2010-0141
   PubMed Web of Science ®Google Scholar
• Park Y, Maizels ET, Feiger ZJ, Alam H, Peters CA, Woodruff TK, Unterman TG, Lee EJ, Jameson JL, Hunzicker-Dunn M. Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad. J Biol Chem 2005; 280:9135-48; PMID:15613482; https://doi.org/10.1074/jbc.M409486200
   PubMed Web of Science ®Google Scholar
• Li X, Jiang Y, Wang Z, Liu G, Hutz RJ, Liu W, Xie Z, Shi F. Regulation of FoxO1 transcription factor by nitric oxide and cyclic GMP in cultured rat granulosa cells. Zoolog Sci 2005; 22:1339-46; PMID:16462106; https://doi.org/10.2108/zsj.22.1339
   PubMed Web of Science ®Google Scholar
• Shen M, Lin F, Zhang J, Tang Y, Chen WK, Liu H. Involvement of the up-regulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stress. J Biol Chem 2012; 287:25727-40; PMID:22669940; https://doi.org/10.1074/jbc.M112.349902
   PubMed Web of Science ®Google Scholar
• Liot G, Bossy B, Lubitz S, Kushnareva Y, Sejbuk N, Bossy-Wetzel E. Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway. Cell Death Differ 2009; 16:899-909; PMID:19300456; https://doi.org/10.1038/cdd.2009.22
   PubMed Web of Science ®Google Scholar
• Wang XN, Greenwald GS. Synergistic effects of steroids with FSH on folliculogenesis, steroidogenesis and FSH- and hCG-receptors in hypophysectomized mice. J Reprod Fertil 1993; 99:403-13; PMID:8107022; https://doi.org/10.1530/jrf.0.0990403
   PubMedGoogle Scholar
• Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, Domingo D, Yahalom J. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61:439-44; PMID:11212227
   PubMed Web of Science ®Google Scholar
• Shen M, Jiang Y, Guan Z, Cao Y, Sun SC, Liu H. FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy. Sci Rep 2016; 6:38090; PMID:27901103; https://doi.org/10.1038/srep38090
   PubMed Web of Science ®Google Scholar
• Marino G, Lopez-Otin C. Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell Mol Life Sci 2004; 61:1439-54; PMID:15197469; https://doi.org/10.1007/s00018-004-4012-4
   PubMed Web of Science ®Google Scholar
• Levine B, Yuan J. Autophagy in cell death: an innocent convict? J Clin Invest 2005; 115:2679-88; PMID:16200202; https://doi.org/10.1172/JCI26390
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016; 12:1-222; PMID:26799652; https://doi.org/10.1080/15548627.2015.1100356
   PubMed Web of Science ®Google Scholar
• Webb AE, Brunet A. FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci 2014; 39:159-69; PMID:24630600; https://doi.org/10.1016/j.tibs.2014.02.003
   PubMed Web of Science ®Google Scholar
• van der Vos KE, Coffer PJ. The Extending Network of FOXO Transcriptional Target Genes. Antioxid Redox Signal 2011; 14:579-92; https://doi.org/10.1089/ars.2010.3419
   PubMed Web of Science ®Google Scholar
• Sirotkin AV, Alexa R, Dekanová P, Kádasi A, Štochmalová A, Grossmann R, Alwasel SA, Harrath AH. The mTOR system can affect basic porcine ovarian cell functions and mediate the effect of ovarian hormonal regulators. Int J Pharmacol 2015; 11:570-578; https://doi.org/10.3923/ijp.2015.570.578
   Web of Science ®Google Scholar
• Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005; 3:28; PMID:16018814; https://doi.org/10.1186/1477-7827-3-28
   PubMed Web of Science ®Google Scholar
• Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42; PMID:18191218; https://doi.org/10.1016/j.cell.2007.12.018
   PubMed Web of Science ®Google Scholar
• Kroemer G, Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008; 9:1004-10; PMID:18971948; https://doi.org/10.1038/nrm2529
   PubMed Web of Science ®Google Scholar
• Tsai-Turton M, Luderer U. Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles. Endocrinology 2006; 147:1224-36; PMID:16339198; https://doi.org/10.1210/en.2005-1281
   PubMed Web of Science ®Google Scholar
• Corcelle E, Djerbi N, Mari M, Nebout M, Fiorini C, Fenichel P, Hofman P, Poujeol P, Mograbi B. Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogens. Autophagy 2007; 3:57-9; PMID:17102581; https://doi.org/10.4161/auto.3424
   PubMed Web of Science ®Google Scholar
• Shimizu S, Konishi A, Nishida Y, Mizuta T, Nishina H, Yamamoto A, Tsujimoto Y. Involvement of JNK in the regulation of autophagic cell death. Oncogene 2010; 29:2070-82; PMID:20101227; https://doi.org/10.1038/onc.2009.487
   PubMed Web of Science ®Google Scholar
• Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001; 410:37-40; PMID:11242034; https://doi.org/10.1038/35065000
   PubMed Web of Science ®Google Scholar
• Cottom J, Salvador LM, Maizels ET, Reierstad S, Park Y, Carr DW, Davare MA, Hell JW, Palmer SS, Dent P, et al. Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase. J Biol Chem 2003; 278:7167-79; PMID:12493768; https://doi.org/10.1074/jbc.M203901200
   PubMed Web of Science ®Google Scholar
• Li C, Liu H, Sun Y, Wang H, Guo F, Rao S, Deng J, Zhang Y, Miao Y, Guo C, et al. PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway. J Mol Cell Biol 2009; 1:37-45; PMID:19516051; https://doi.org/10.1093/jmcb/mjp002
   PubMed Web of Science ®Google Scholar
• Qin L, Wang Z, Tao L, Wang Y. ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy 2010; 6:239-47; PMID:20104019; https://doi.org/10.4161/auto.6.2.11062
   PubMed Web of Science ®Google Scholar
• Zha X, Hu Z, He S, Wang F, Shen H, Zhang H. TSC1/TSC2 inactivation inhibits AKT through mTORC1-dependent up-regulation of STAT3-PTEN cascade. Cancer Lett 2011; 313:211-7; PMID:22055460; https://doi.org/10.1016/j.canlet.2011.09.006
   PubMed Web of Science ®Google Scholar
• Han J, Pan XY, Xu Y, Xiao Y, An Y, Tie L, Pan Y, Li XJ. Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage. Autophagy 2012; 8:812-25; PMID:22622204; https://doi.org/10.4161/auto.19471
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang L, Yang J, Zhang P, Ma K, Zhou J, Liao W, Zhu WG. Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death. Autophagy 2010; 6:988-90; PMID:20798610; https://doi.org/10.4161/auto.6.7.13289
   PubMed Web of Science ®Google Scholar
• Medema RH, Jaattela M. Cytosolic FoxO1: alive and killing. Nat Cell Biol 2010; 12:642-3; PMID:20596046; https://doi.org/10.1038/ncb0710-642
   PubMed Web of Science ®Google Scholar
• Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96:857-68; PMID:10102273; https://doi.org/10.1016/S0092-8674(00)80595-4
   PubMed Web of Science ®Google Scholar
• Daitoku H, Sakamaki J, Fukamizu A. Regulation of FoxO transcription factors by acetylation and protein-protein interactions. Biochim Biophys Acta 2011; 1813:1954-60; PMID:21396404; https://doi.org/10.1016/j.bbamcr.2011.03.001
   PubMed Web of Science ®Google Scholar
• Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303:2011-5; PMID:14976264; https://doi.org/10.1126/science.1094637
   PubMed Web of Science ®Google Scholar
• Salminen A, Kaarniranta K, Kauppinen A. Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci 2013; 14:3834-59; PMID:23434668; https://doi.org/10.3390/ijms14023834
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y, Yoshimori T. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 2004; 117:2805-12; PMID:15169837; https://doi.org/10.1242/jcs.01131
   PubMed Web of Science ®Google Scholar
• Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003; 63:2103-8; PMID:12727826
   PubMed Web of Science ®Google Scholar