PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5

References

• Kiffin R, Bandyopadhyay U, Cuervo AM. Oxidative stress and autophagy. Antioxid Redox Signal. 2006 Jan–Feb;8(1–2):152–162. PubMed PMID: 16487049.
   PubMed Web of Science ®Google Scholar
• Scherz-Shouval R, Shvets E, Fass E, et al. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007 Apr 04;26(7):1749–1760. PubMed PMID: 17347651; PubMed Central PMCID: PMCPMC1847657.
   PubMed Web of Science ®Google Scholar
• Chen Y, Azad MB, Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ. 2009 Jul;16(7):1040–1052. PubMed PMID: 19407826.
   PubMed Web of Science ®Google Scholar
• Filomeni G, De Zio D, Cecconi F. Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ. 2015 Mar;22(3):377–388. PubMed PMID: 25257172; PubMed Central PMCID: PMCPMC4326572.
   PubMed Web of Science ®Google Scholar
• Chance B, Boveris A, Oschino N, and Loschen, G. The nature of the catalase intermediate in its biological function. In: King TE, Mason HS, Morrison M, editors. Oxidases and related redox systems.  Baltimore: University Park Press; 1973. p. 350–353.
   Google Scholar
• Dodson M, Darley-Usmar V, Zhang J. Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radic Biol Med. 2013 Oct;63:207–221. PubMed PMID: 23702245; PubMed Central PMCID: PMCPMC3729625.
   PubMed Web of Science ®Google Scholar
• Altman BJ, Rathmell JC. Metabolic stress in autophagy and cell death pathways. Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a008763. PubMed PMID: 22952396; PubMed Central PMCID: PMCPMC3428762.
   PubMed Web of Science ®Google Scholar
• Hatsugai N, Perez Koldenkova V, Imamura H, et al. Changes in cytosolic ATP levels and intracellular morphology during bacteria-induced hypersensitive cell death as revealed by real-time fluorescence microscopy imaging. Plant Cell Physiol. 2012 Oct;53(10):1768–1775. PubMed PMID: 22942251.
   PubMed Web of Science ®Google Scholar
• Sano R, Reed JC. ER stress-induced cell death mechanisms. Biochim Biophys Acta. 2013 Dec;1833(12):3460–3470. PubMed PMID: 23850759; PubMed Central PMCID: PMCPMC3834229.
   PubMed Web of Science ®Google Scholar
• Wang M, Kaufman RJ. Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature. 2016 Jan 21;529(7586):326–335. PubMed PMID: 26791723.
   PubMed Web of Science ®Google Scholar
• Ciechanover A. The unravelling of the ubiquitin system. Nat Rev Mol Cell Biol. 2015 May;16(5):322–324. PubMed PMID: 25907614.
   PubMed Web of Science ®Google Scholar
• Ciechanover A, Kwon YT. Protein Quality Control by Molecular Chaperones in Neurodegeneration. Front Neurosci. 2017;11:185. PubMed PMID: 28428740; PubMed Central PMCID: PMCPMC5382173.
   PubMed Web of Science ®Google Scholar
• Kwon YT, Ciechanover A. The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy. Trends Biochem Sci. 2017 Nov;42(11):873–886. PubMed PMID: 28947091.
   PubMed Web of Science ®Google Scholar
• Ciechanover A. Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Bioorg Med Chem. 2013 Jun 15;21(12):3400–3410. PubMed PMID: 23485445.
   PubMed Web of Science ®Google Scholar
• Bachmair A, Finley D, Varshavsky A. In vivo half-life of a protein is a function of its amino-terminal residue. Science. 1986 Oct 10;234(4773):179–186. PubMed PMID: 3018930.
   PubMed Web of Science ®Google Scholar
• Sriram SM, Kim BY, Kwon YT. The N-end rule pathway: emerging functions and molecular principles of substrate recognition. Nat Rev Mol Cell Biol. 2011 Oct 21;12(11):735–747. PubMed PMID: 22016057.
   PubMed Web of Science ®Google Scholar
• Tasaki T, Sriram SM, Park KS, et al. The N-end rule pathway. Annu Rev Biochem. 2012;81:261–289. PubMed PMID: 22524314; PubMed Central PMCID: PMCPMC3610525.
   PubMed Web of Science ®Google Scholar
• Kwon YT, Reiss Y, Fried VA, et al. The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7898–7903. PubMed PMID: 9653112; PubMed Central PMCID: PMCPMC20901.
   PubMed Web of Science ®Google Scholar
• Kwon YT, Xia Z, Davydov IV, et al. Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. Mol Cell Biol. 2001 Dec;21(23):8007–8021. PubMed PMID: 11689692; PubMed Central PMCID: PMCPMC99968.
   PubMed Web of Science ®Google Scholar
• Tasaki T, Mulder LCF, Iwamatsu A, et al. A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. Mol Cell Biol. 2005 Aug;25(16):7120–7136. PubMed PMID: 16055722; PubMed Central PMCID: PMCPMC1190250.
   PubMed Web of Science ®Google Scholar
• Kwon YT, Xia Z, An JY, et al. Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol Cell Biol. 2003 Nov;23(22):8255–8271. PubMed PMID: 14585983; PubMed Central PMCID: PMCPMC262401.
   PubMed Web of Science ®Google Scholar
• Kwon YT, Kashina AS, Varshavsky A. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. Mol Cell Biol. 1999 Jan;19(1):182–193. PubMed PMID: 9858543; PubMed Central PMCID: PMCPMC83877.
   PubMed Web of Science ®Google Scholar
• Kwon YT, Kashina AS, Davydov IV, et al. An essential role of N-terminal arginylation in cardiovascular development. Science. 2002 Jul 05;297(5578):96–99. PubMed PMID: 12098698.
   PubMed Web of Science ®Google Scholar
• Lee MJ, Tasaki T, Moroi K, et al. RGS4 and RGS5 are in vivo substrates of the N-end rule pathway. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15030–15035. PubMed PMID: 16217033; PubMed Central PMCID: PMCPMC1257735.
   PubMed Web of Science ®Google Scholar
• Lee MJ, Pal K, Tasaki T, et al. Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):100–105. PubMed PMID: 18162545; PubMed Central PMCID: PMCPMC2224166.
   PubMed Web of Science ®Google Scholar
• Lee MJ, Kim DE, Zakrzewska A, et al. Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes. J Biol Chem. 2012 Jul 6;287(28):24043–24052. PubMed PMID: 22577142; PubMed Central PMCID: PMCPMC3390678.
   PubMed Web of Science ®Google Scholar
• Sriram SM, Banerjee R, Kane RS, et al. Multivalency-assisted control of intracellular signaling pathways: application for ubiquitin- dependent N-end rule pathway. Chem Biol. 2009 Feb 27;16(2):121–131. PubMed PMID: 19246002; PubMed Central PMCID: PMCPMC2665046.
   PubMedGoogle Scholar
• Sriram SM, Kwon YT. The molecular principles of N-end rule recognition. Nat Struct Mol Biol. 2010 Oct;17(10):1164–1165. PubMed PMID: 20924402.
   PubMed Web of Science ®Google Scholar
• Lopez Sambrooks C, Carpio MA, Hallak ME. Arginylated calreticulin at plasma membrane increases susceptibility of cells to apoptosis. J Biol Chem. 2012 Jun 22;287(26):22043–22054. PubMed PMID: 22577148; PubMed Central PMCID: PMCPMC3381163.
   PubMed Web of Science ®Google Scholar
• Cha-Molstad H, Sung KS, Hwang J, et al. Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding. Nat Cell Biol. 2015 Jul;17(7):917–929. PubMed PMID: 26075355; PubMed Central PMCID: PMCPMC4490096.
   PubMed Web of Science ®Google Scholar
• Cha-Molstad H, Yu JE, Feng Z, et al. p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis. Nat Commun. 2017 Jul 24;8(1):102. PubMed PMID: 28740232; PubMed Central PMCID: PMCPMC5524641.
   PubMedGoogle Scholar
• Shim SM, Choi HR, Sung KW, et al. The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation. Sci Signal. 2018 Jan 2;11(511):eaan0630. PubMed PMID: 29295953.
   PubMed Web of Science ®Google Scholar
• Hayashi T, Ishimori C, Takahashi-Niki K, et al. DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem Biophys Res Commun. 2009 Dec 18;390(3):667–672. PubMed PMID: 19822128.
   PubMed Web of Science ®Google Scholar
• Kim JM, Shin HI, Cha SS, et al. DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling. Nat Commun. 2012;3:1296. PubMed PMID: 23250426.
   PubMed Web of Science ®Google Scholar
• Won KJ, Jung SH, Lee CK, et al. DJ-1/park7 protects against neointimal formation via the inhibition of vascular smooth muscle cell growth. Cardiovasc Res. 2013 Mar 01;97(3):553–561. PubMed PMID: 23230227.
   PubMed Web of Science ®Google Scholar
• Lev N, Ickowicz D, Barhum Y, et al. DJ-1 protects against dopamine toxicity. J Neural Transm (Vienna). 2009 Feb;116(2):151–160. PubMed PMID: 18974921.
   PubMed Web of Science ®Google Scholar
• Cao J, Lou S, Ying M, et al. DJ-1 as a human oncogene and potential therapeutic target. Biochem Pharmacol. 2015 Feb 01;93(3):241–250. PubMed PMID: 25498803.
   PubMed Web of Science ®Google Scholar
• Olzmann JA, Brown K, Wilkinson KD, et al. Familial Parkinson’s disease-associated L166P mutation disrupts DJ-1 protein folding and function. J Biol Chem. 2004 Feb 27;279(9):8506–8515. PubMed PMID: 14665635.
   PubMed Web of Science ®Google Scholar
• Shendelman S, Jonason A, Martinat C, et al. DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol. 2004 Nov;2(11):e362. PubMed PMID: 15502874; PubMed Central PMCID: PMCPMC521177.
   PubMed Web of Science ®Google Scholar
• Jeong HJ, Kim DW, Woo SJ, et al. Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model. Mol Cells. 2012 May;33(5):471–478. PubMed PMID: 22526393; PubMed Central PMCID: PMCPMC3887734.
   PubMed Web of Science ®Google Scholar
• Yamaguchi S, Yamane T, Takahashi-Niki K, et al. Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. PLoS One. 2012;7(5):e38144. PubMed PMID: 22666465; PubMed Central PMCID: PMCPMC3364227.
   PubMed Web of Science ®Google Scholar
• Ariga H, Takahashi-Niki K, Kato I, et al. Neuroprotective function of DJ-1 in Parkinson’s disease. Oxid Med Cell Longev. 2013;2013:683920. PubMed PMID: 23766857; PubMed Central PMCID: PMCPMC3671546.
   PubMed Web of Science ®Google Scholar
• Mitsumoto A, Nakagawa Y, Takeuchi A, et al. Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat. Free Radic Res. 2001 Sep;35(3):301–310. PubMed PMID: 11697128.
   PubMed Web of Science ®Google Scholar
• Bonifati V, Rizzu P, van Baren MJ, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2003 Jan 10;299(5604):256–259. PubMed PMID: 12446870.
   PubMed Web of Science ®Google Scholar
• Taira T, Saito Y, Niki T, et al. DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep. 2004 Feb;5(2):213–218. PubMed PMID: 14749723; PubMed Central PMCID: PMCPMC1298985.
   PubMed Web of Science ®Google Scholar
• Zhou W, Zhu M, Wilson MA, et al. The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J Mol Biol. 2006 Mar 03;356(4):1036–1048. PubMed PMID: 16403519.
   PubMed Web of Science ®Google Scholar
• Andres-Mateos E, Perier C, Zhang L, et al. DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14807–14812. PubMed PMID: 17766438; PubMed Central PMCID: PMCPMC1976193.
   PubMed Web of Science ®Google Scholar
• Im JY, Lee KW, Junn E, et al. DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex. Neurosci Res. 2010 Jul;67(3):203–208. PubMed PMID: 20385180; PubMed Central PMCID: PMCPMC2883683.
   PubMed Web of Science ®Google Scholar
• Wilson MA. The role of cysteine oxidation in DJ-1 function and dysfunction. Antioxid Redox Signal. 2011 Jul 01;15(1):111–122. PubMed PMID: 20812780; PubMed Central PMCID: PMCPMC3110098.
   PubMed Web of Science ®Google Scholar
• Saito Y. Oxidized DJ-1 as a possible biomarker of Parkinson’s disease. J Clin Biochem Nutr. 2014 May;54(3):138–144. PubMed PMID: 24894116; PubMed Central PMCID: PMCPMC4042152.
   PubMed Web of Science ®Google Scholar
• Canet-Aviles RM, Wilson MA, Miller DW, et al. The Parkinson’s disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9103–9108. PubMed PMID: 15181200; PubMed Central PMCID: PMCPMC428480.
   PubMed Web of Science ®Google Scholar
• Kim RH, Smith PD, Aleyasin H, et al. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A. 2005 Apr 05;102(14):5215–5220. PubMed PMID: 15784737; PubMed Central PMCID: PMCPMC555037.
   PubMed Web of Science ®Google Scholar
• Park J, Kim SY, Cha GH, et al. Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene. 2005 Nov;21(361):133–139. PubMed PMID: 16203113.
   PubMed Web of Science ®Google Scholar
• Meulener MC, Xu K, Thomson L, et al. Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12517–12522. PubMed PMID: 16894167; PubMed Central PMCID: PMCPMC1533799.
   PubMed Web of Science ®Google Scholar
• Kahle PJ, Waak J, Gasser T. DJ-1 and prevention of oxidative stress in Parkinson’s disease and other age-related disorders. Free Radic Biol Med. 2009 Nov 15;47(10):1354–1361. PubMed PMID: 19686841.
   PubMed Web of Science ®Google Scholar
• Li HM, Niki T, Taira T, et al. Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. Free Radic Res. 2005 Oct;39(10):1091–1099. PubMed PMID: 16298734.
   PubMed Web of Science ®Google Scholar
• Wang B, Cai Z, Tao K, et al. Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7. Autophagy. 2016 Aug 2;12(8):1215–1228. PubMed PMID: 27171370; PubMed Central PMCID: PMCPMC4968227.
   PubMed Web of Science ®Google Scholar
• Xu CY, Kang WY, Chen YM, et al. DJ-1 inhibits alpha-synuclein aggregation by regulating chaperone-mediated autophagy. Front Aging Neurosci. 2017;9:308. PubMed PMID: 29021755; PubMed Central PMCID: PMCPMC5623690.
   PubMed Web of Science ®Google Scholar
• Inoue T, Suzuki-Karasaki Y. Mitochondrial superoxide mediates mitochondrial and endoplasmic reticulum dysfunctions in TRAIL-induced apoptosis in Jurkat cells. Free Radic Biol Med. 2013 Aug;61:273–284. PubMed PMID: 23608466.
   PubMed Web of Science ®Google Scholar
• Suzuki-Karasaki M, Ochiai T, Suzuki-Karasaki Y. Crosstalk between mitochondrial ROS and depolarization in the potentiation of TRAIL-induced apoptosis in human tumor cells. Int J Oncol. 2014 Feb;44(2):616–628. PubMed PMID: 24337174.
   PubMed Web of Science ®Google Scholar
• Dickinson BC, Srikun D, Chang CJ. Mitochondrial-targeted fluorescent probes for reactive oxygen species. Curr Opin Chem Biol. 2010 Feb;14(1):50–56. PubMed PMID: 19910238; PubMed Central PMCID: PMCPMC2830890.
   PubMed Web of Science ®Google Scholar
• Ling LU, Tan KB, Lin H, et al. The role of reactive oxygen species and autophagy in safingol-induced cell death. Cell Death Dis. 2011 Mar;10(2):e129. PubMed PMID: 21390063; PubMed Central PMCID: PMCPMC3101809.
   PubMed Web of Science ®Google Scholar
• Nakatani Y, Ogryzko V. Immunoaffinity purification of mammalian protein complexes. Methods Enzymol. 2003;370:430–444. PubMed PMID: 14712665.
   PubMed Web of Science ®Google Scholar
• Moore DJ, Zhang L, Troncoso J, et al. Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Hum Mol Genet. 2005 Jan 1;14(1):71–84. PubMed PMID: 15525661.
   PubMed Web of Science ®Google Scholar
• Moscat J, Diaz-Meco MT. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell. 2009 Jun 12;137(6):1001–1004. PubMed PMID: 19524504; PubMed Central PMCID: PMCPMC3971861.
   PubMed Web of Science ®Google Scholar
• Lu K, Psakhye I, Jentsch S. Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family. Cell. 2014 Jul 31;158(3):549–563. PubMed PMID: 25042851.
   PubMed Web of Science ®Google Scholar
• Huber LA, Teis D. Lysosomal signaling in control of degradation pathways. Curr Opin Cell Biol. 2016 Apr;39:8–14. PubMed PMID: 26827287.
   PubMed Web of Science ®Google Scholar
• Marwaha R, Arya SB, Jagga D, et al. The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes. J Cell Biol. 2017 Apr 03;216(4):1051–1070. PubMed PMID: 28325809; PubMed Central PMCID: PMCPMC5379943.
   PubMed Web of Science ®Google Scholar
• McEwan DG, Popovic D, Gubas A, et al. PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. Mol Cell. 2015 Jan 08;57(1):39–54. PubMed PMID: 25498145.
   PubMed Web of Science ®Google Scholar
• Komatsu M, Kurokawa H, Waguri S, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 2010 Mar;12(3):213–223. PubMed PMID: 20173742.
   PubMed Web of Science ®Google Scholar
• Ichimura Y, Waguri S, Sou YS, et al. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell. 2013 Sep 12;51(5):618–631. PubMed PMID: 24011591.
   PubMed Web of Science ®Google Scholar
• Katsuragi Y, Ichimura Y, Komatsu M. p62/SQSTM1 functions as a signaling hub and an autophagy adaptor. FEBS J. 2015 Dec;282(24):4672–4678. PubMed PMID: 26432171.
   PubMed Web of Science ®Google Scholar
• Lim J, Lachenmayer ML, Wu S, et al. Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet. 2015;11(2):e1004987. PubMed PMID: 25723488; PubMed Central PMCID: PMCPMC4344198.
   PubMed Web of Science ®Google Scholar
• Milan E, Perini T, Resnati M, et al. A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy. 2015;11(7):1161–1178. PubMed PMID: 26043024; PubMed Central PMCID: PMCPMC4590585.
   PubMed Web of Science ®Google Scholar
• Watanabe Y, Tsujimura A, Taguchi K, et al. HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy. 2017 Jan 2;13(1):133–148. PubMed PMID: 27846364; PubMed Central PMCID: PMCPMC5240838.
   PubMed Web of Science ®Google Scholar
• Wang S, El-Deiry WS. TRAIL and apoptosis induction by TNF-family death receptors. Oncogene. 2003 Nov 24;22(53):8628–8633. PubMed PMID: 14634624.
   PubMed Web of Science ®Google Scholar
• Ziauddin MF, Guo ZS, Me O, et al. TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer. Gene Ther. 2010 Apr;17(4):550–559. PubMed PMID: 20182517; PubMed Central PMCID: PMCPMC3250063.
   PubMed Web of Science ®Google Scholar
• Dai Y, Dent P, Grant S. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL. Mol Pharmacol. 2003 Dec;64(6):1402–1409. PubMed PMID: 14645670.
   PubMed Web of Science ®Google Scholar
• LeBlanc HN, Ashkenazi A. Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ. 2003 Jan;10(1):66–75. PubMed PMID: 12655296.
   PubMed Web of Science ®Google Scholar
• Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal. 2014 Jul 20;21(3):396–413. PubMed PMID: 24702237; PubMed Central PMCID: PMCPMC4076992.
   PubMed Web of Science ®Google Scholar
• Fu K, Ren H, Wang Y, et al. DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene. 2012 Mar 08;31(10):1311–1322. PubMed PMID: 21785459.
   PubMed Web of Science ®Google Scholar
• Girotto S, Sturlese M, Bellanda M, et al. Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53. J Biol Chem. 2012 May 25;287(22):18738–18749. PubMed PMID: 22431735; PubMed Central PMCID: PMCPMC3365698.
   PubMed Web of Science ®Google Scholar
• Martinat C, Shendelman S, Jonason A, et al. Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism. PLoS Biol. 2004 Nov;2(11):e327. PubMed PMID: 15502868; PubMed Central PMCID: PMCPMC521171.
   PubMed Web of Science ®Google Scholar
• Shevchenko A, Tomas H, Havlis J, et al. In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc. 2006;1(6):2856–2860. PubMed PMID: 17406544.
   PubMed Web of Science ®Google Scholar
• Wieckowski MR, Giorgi C, Lebiedzinska M, et al. Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat Protoc. 2009;4(11):1582–1590. PubMed PMID: 19816421.
   PubMed Web of Science ®Google Scholar
• Lee DH, Sung KS, Bartlett DL, et al. HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. Cell Signal. 2015 Feb;27(2):293–305. PubMed PMID: 25446253; PubMed Central PMCID: PMCPMC4276460.
   PubMed Web of Science ®Google Scholar