7,877
Views
39
CrossRef citations to date
0
Altmetric
Research Paper

VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle

, ORCID Icon, , , &
Pages 1082-1099 | Received 24 Jul 2018, Accepted 11 Jan 2019, Published online: 29 Jan 2019

References

  • Meyer H, Weihl CC. The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. J Cell Sci. 2014 Sep 15;127(Pt 18):3877–3883. PubMed PMID: 25146396; PubMed Central PMCID: PMCPMC4163641.
  • Lan B, Chai S, Wang P, et al. VCP/p97/Cdc48, a linking of protein homeostasis and cancer therapy. Curr Mol Med. 2018 Mar 7;17:608–618. PubMed PMID: 29521227.
  • Muller JM, Deinhardt K, Rosewell I, et al. Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality. Biochem Biophys Res Commun. 2007 Mar 9;354(2):459–465. PubMed PMID: 17239345.
  • Watts GD, Wymer J, Kovach MJ, et al. Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Nat Genet. 2004 Apr;36(4):377–381. PubMed PMID: 15034582.
  • Taylor JP. Multisystem proteinopathy: intersecting genetics in muscle, bone, and brain degeneration. Neurology. 2015 Aug 25;85(8):658–660. PubMed PMID: 26208960.
  • Weihl CC, Pestronk A, Kimonis VE. Valosin-containing protein disease: inclusion body myopathy with Paget’s disease of the bone and fronto-temporal dementia. Neuromuscul Disord. 2009 May;19(5):308–315. PubMed PMID: 19380227; PubMed Central PMCID: PMCPMC2859037.
  • Al-Obeidi E, Al-Tahan S, Surampalli A, et al. Genotype-phenotype study in patients with valosin-containing protein mutations associated with multisystem proteinopathy. Clin Genet. 2018 Jan;93(1):119–125. PubMed PMID: 28692196; PubMed Central PMCID: PMCPMC5739971.
  • Ju JS, Fuentealba RA, Miller SE, et al. Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol. 2009 Dec 14;187(6):875–888. PubMed PMID: 20008565; PubMed Central PMCID: PMCPMC2806317.
  • Papadopoulos C, Kirchner P, Bug M, et al. VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. Embo J. 2017 Jan 17;36(2):135–150. PubMed PMID: 27753622; PubMed Central PMCID: PMCPMC5242375.
  • Ritz D, Vuk M, Kirchner P, et al. Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations. Nat Cell Biol. 2011 Aug 7;13(9):1116–1123. PubMed PMID: 21822278; PubMed Central PMCID: PMCPMC3246400.
  • Weihl CC, Temiz P, Miller SE, et al. TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2008 Oct;79(10):1186–1189. PubMed PMID: 18796596; PubMed Central PMCID: PMCPMC2586594.
  • Piccirillo R, Goldberg AL. The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins. Embo J. 2012 Aug 1;31(15):3334–3350. PubMed PMID: 22773186; PubMed Central PMCID: PMCPMC3411080.
  • Zhang T, Mishra P, Hay BA, et al. Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants. Elife. 2017 Mar 21;6. DOI:10.7554/eLife.17834 PubMed PMID: 28322724; PubMed Central PMCID: PMCPMC5360448.
  • Johnson AE, Shu H, Hauswirth AG, et al. VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo. Elife. 2015 Jul 13;4. DOI:10.7554/eLife.07366 PubMed PMID: 26167652; PubMed Central PMCID: PMCPMC4574298.
  • Schutz AK, Rennella E, Kay LE. Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function. Proc Natl Acad Sci U S A. 2017 Jul 31;114:E6822–E6829. PubMed PMID: 28760999; PubMed Central PMCID: PMCPMC5565461.
  • Trusch F, Matena A, Vuk M, et al. The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97. J Biol Chem. 2015 Dec 4;290(49):29414–29427. PubMed PMID: 26475856; PubMed Central PMCID: PMCPMC4705944.
  • Papadopoulos C, Meyer H. Detection and clearance of damaged lysosomes by the endo-lysosomal damage response and lysophagy. Curr Biol. 2017 Dec 18;27(24):R1330–R1341. PubMed PMID: 29257971.
  • Komatsu M, Waguri S, Chiba T, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006 Jun 15;441(7095):880–884. PubMed PMID: 16625205.
  • Hara T, Nakamura K, Matsui M, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006 Jun 15;441(7095):885–889. PubMed PMID: 16625204.
  • Masiero E, Agatea L, Mammucari C, et al. Autophagy is required to maintain muscle mass. Cell Metab. 2009 Dec;10(6):507–515. PubMed PMID: 19945408.
  • Perera RM, Zoncu R. The lysosome as a regulatory hub. Annu Rev Cell Dev Biol. 2016 Oct 6;32:223–253. PubMed PMID: 27501449.
  • Ching JK, Elizabeth SV, Ju JS, et al. mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy. Hum Mol Genet. 2013 Mar 15;22(6):1167–1179. PubMed PMID: 23250913; PubMed Central PMCID: PMCPMC3657474.
  • Roczniak-Ferguson A, Petit CS, Froehlich F, et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal. 2012 Jun 12;5(228):ra42. PubMed PMID: 22692423; PubMed Central PMCID: PMCPMC3437338.
  • Napolitano G, Ballabio A. TFEB at a glance. J Cell Sci. 2016 Jul 1;129(13):2475–2481. PubMed PMID: 27252382; PubMed Central PMCID: PMCPMC4958300.
  • Chauhan S, Kumar S, Jain A, et al. TRIMs and galectins globally cooperate and TRIM16 and Galectin-3 co-direct autophagy in endomembrane damage homeostasis. Dev Cell. 2016 Oct 10;39(1):13–27. PubMed PMID: 27693506; PubMed Central PMCID: PMCPMC5104201.
  • Hao F, Kondo K, Itoh T, et al. Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site. J Cell Sci. 2018 Jan 29;131(3). DOI:10.1242/jcs.208017 PubMed PMID: 29222112.
  • Dobrynin G, Popp O, Romer T, et al. Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells. J Cell Sci. 2011 May 1;124(Pt 9):1571–1580. PubMed PMID: 21486945.
  • Nalbandian A, Llewellyn KJ, Badadani M, et al. A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse. Muscle Nerve. 2013 Feb;47(2):260–270. PubMed PMID: 23169451; PubMed Central PMCID: PMCPMC3556223.
  • Rebecca VW, Nicastri MC, McLaughlin N, et al. A unified approach to targeting the lysosome’s degradative and growth signaling roles. Cancer Discov. 2017 Nov;7(11):1266–1283. PubMed PMID: 28899863; PubMed Central PMCID: PMCPMC5833978.
  • Manifava M, Smith M, Rotondo S, et al. Dynamics of mTORC1 activation in response to amino acids. Elife. 2016 Oct 11;5. DOI:10.7554/eLife.19960 PubMed PMID: 27725083; PubMed Central PMCID: PMCPMC5059141.
  • Li Y, Xu M, Ding X, et al. Protein kinase C controls lysosome biogenesis independently of mTORC1. Nat Cell Biol. 2016 Oct;18(10):1065–1077. PubMed PMID: 27617930.
  • Medina DL, Di Paola S, Peluso I, et al. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol. 2015 Mar;17(3):288–299. PubMed PMID: 25720963; PubMed Central PMCID: PMCPMC4801004.
  • Skowyra ML, Schlesinger PH, Naismith TV, et al. Triggered recruitment of ESCRT machinery promotes endolysosomal repair. Science. 2018;360(6384):eaar5078.
  • Kustermann M, Manta L, Paone C, et al. Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. Autophagy. 2018 Jul 16;14:1911–1927. PubMed PMID: 30010465.
  • Tresse E, Salomons FA, Vesa J, et al. VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy. 2010 Feb;6(2):217–227. PubMed PMID: 20104022; PubMed Central PMCID: PMCPMC2929010.
  • Carlson CG, Rutter J, Bledsoe C, et al. A simple protocol for assessing inter-trial and inter-examiner reliability for two noninvasive measures of limb muscle strength. J Neurosci Methods. 2010 Feb 15;186(2):226–230. PubMed PMID: 19917311.
  • Carpenter AE, Jones TR, Lamprecht MR, et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 2006;7(10):R100. PubMed PMID: 17076895; PubMed Central PMCID: PMCPMC1794559.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.