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Autophagy Volume 15, 2019 - Issue 4
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Editor’s Corner

Spatially distinct pools of TORC1 balance protein homeostasis

Vikramjit LahiriLife Sciences Institute, and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USAView further author information
&
Daniel J. KlionskyLife Sciences Institute, and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-7828-8118View further author information
ORCID Icon
Pages 561-564 | Received 22 Jan 2019, Accepted 22 Jan 2019, Published online: 06 Feb 2019

References

  • Bar-Peled L, Sabatini DM. Regulation of mTORC1 by amino acids. Trends Cell Biol. 2014 Jul;24(7):400–406. PubMed PMID: 24698685; PubMed Central PMCID: PMCPMC4074565.
  • Gonzalez A, Hall MN. Nutrient sensing and TOR signaling in yeast and mammals. Embo J. 2017 Feb 15;36(4):397–408. PubMed PMID: 28096180; PubMed Central PMCID: PMCPMC5694944.
  • Shimobayashi M, Hall MN. Multiple amino acid sensing inputs to mTORC1. Cell Res. 2016 Jan;26(1):7–20. PubMed PMID: 26658722; PubMed Central PMCID: PMCPMC4816134.
  • Gaubitz C, Prouteau M, Kusmider B, et al. TORC2 Structure and Function. Trends Biochem Sci. 2016 Jun;41(6):532–545. PubMed PMID: 27161823.
  • Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017 Mar 9;168(6):960–976. PubMed PMID: 28283069; PubMed Central PMCID: PMCPMC5394987.
  • Sancak Y, Peterson TR, Shaul YD, et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13;320(5882):1496–1501. PubMed PMID: 18497260; PubMed Central PMCID: PMCPMC2475333.
  • Chantranupong L, Scaria SM, Saxton RA, et al. The CASTOR proteins are arginine sensors for the mTORC1 pathway. Cell. 2016 Mar 24;165(1):153–164. PubMed PMID: 26972053; PubMed Central PMCID: PMCPMC4808398.
  • Parmigiani A, Nourbakhsh A, Ding B, et al. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep. 2014 Nov 20;9(4):1281–1291. PubMed PMID: 25457612; PubMed Central PMCID: PMCPMC4303546.
  • Jewell JL, Kim YC, Russell RC, et al. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science. 2015 Jan 9;347(6218):194–198. PubMed PMID: 25567907; PubMed Central PMCID: PMCPMC4384888.
  • Wyant GA, Abu-Remaileh M, Wolfson RL, et al. mTORC1 activator slc38a9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient. Cell. 2017 Oct 19;171(3):642–654 e12. PubMed PMID: 29053970; PubMed Central PMCID: PMCPMC5704964.
  • Menon S, Dibble CC, Talbott G, et al. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 2014 Feb 13;156(4):771–785. PubMed PMID: 24529379; PubMed Central PMCID: PMCPMC4030681.
  • Demetriades C, Doumpas N, Teleman AA. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell. 2014 Feb 13;156(4):786–799. PubMed PMID: 24529380; PubMed Central PMCID: PMCPMC4346203.
  • Jin N, Mao K, Jin Y, et al. Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell. 2014 Apr;25(7):1171–1185. PubMed PMID: 24478451; PubMed Central PMCID: PMCPMC3967979.
  • Kamada Y, Yoshino K, Kondo C, et al. Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol. 2010 Feb;30(4):1049–1058. PubMed PMID: 19995911; PubMed Central PMCID: PMCPMC2815578.
  • Betz C, Hall MN. Where is mTOR and what is it doing there? J Cell Biol. 2013 Nov 25;203(4):563–574. PubMed PMID: 24385483; PubMed Central PMCID: PMCPMC3840941.
  • Hatakeyama R, Peli-Gulli MP, Hu Z, et al. Spatially distinct pools of TORC1 balance protein homeostasis. Mol Cell. 2018 Nov 19. PubMed PMID: 30527664. DOI:10.1016/j.molcel.2018.10.040.
  • Binda M, Peli-Gulli MP, Bonfils G, et al. The Vam6 GEF controls TORC1 by activating the EGO complex. Mol Cell. 2009 Sep 11;35(5):563–573. PubMed PMID: 19748353.
  • Cowles CR, Odorizzi G, Payne GS, et al. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell. 1997 Oct 3;91(1):109–118. PubMed PMID: 9335339.
  • Bowers K, Stevens TH. Protein transport from the late Golgi to the vacuole in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2005 Jul 10;1744(3):438–454. PubMed PMID: 15913810.
  • Hinners I, Tooze SA. Changing directions: clathrin-mediated transport between the Golgi and endosomes. J Cell Sci. 2003 Mar 1;116(Pt 5):763–771. PubMed PMID: 12571274.
  • Sturgill TW, Cohen A, Diefenbacher M, et al. TOR1 and TOR2 have distinct locations in live cells. Eukaryot Cell. 2008 Oct;7(10):1819–1830. PubMed PMID: 18723607; PubMed Central PMCID: PMCPMC2568074.
  • Henne WM, Buchkovich NJ, Emr SD. The ESCRT pathway. Dev Cell. 2011 Jul 19;21(1):77–91. PubMed PMID: 21763610.

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