METTL3 and ALKBH5 oppositely regulate m⁶A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

References

• Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2016;12(1):1–222.
   PubMed Web of Science ®Google Scholar
• Yang ZJ, Chee CE, Huang S, et al. The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther. 2011;10(9):1533–1541.
   PubMed Web of Science ®Google Scholar
• Song H, Pu J, Wang L, et al. ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation. Autophagy. 2015;11(8):1308–1325.
   PubMed Web of Science ®Google Scholar
• Santarelli R, Granato M, Pentassuglia G, et al. KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression. Autophagy. 2016;12(12):2311–2325.
   PubMed Web of Science ®Google Scholar
• Pastore N, Brady OA, Diab HI, et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy. 2016;12(8):1240–1258.
   PubMed Web of Science ®Google Scholar
• Zhao E, Czaja MJ. Transcription factor EB: A central regulator of both the autophagosome and lysosome. Hepatology. 2012;55(5):1632–1634.
   PubMed Web of Science ®Google Scholar
• Parashar NC, Parashar G, Nayyar H, et al. N 6-adenine DNA methylation demystified in eukaryotic genome: from biology to pathology. Biochimie. 2018;144:56–62.
   Web of Science ®Google Scholar
• Brocard M, Ruggieri A, Locker N. m6A RNA methylation, a new hallmark in virus-host interactions. J Gen Virol. 2017;98(9):2207–2214.
   PubMed Web of Science ®Google Scholar
• Patil DP, Pickering BF, Jaffrey SR. Reading m 6 A in the transcriptome: m 6 A-binding proteins. Trends Cell Biol. 2018;28(2):113–127.
   Web of Science ®Google Scholar
• Wang X, Huang J, Zou T, et al. Human m6A writers: two subunits, 2 roles. RNA Biol. 2017;14(3):300–304.
   PubMed Web of Science ®Google Scholar
• Meyer K, Jaffrey SR. Rethinking m6A readers, writers, and erasers. Annu Rev Cell Dev Biol. 2017;33:319–342.
   Google Scholar
• Roignant J-Y, Soller M. m 6 A in mRNA: an ancient mechanism for fine-tuning gene expression. Trends Genet. 2017;33(6):380–390.
   Web of Science ®Google Scholar
• Guo M, Liu X, Zheng X, et al. m6A RNA modification determines cell fate by regulating mRNA degradation. Cell Reprogram. 2017;19(4):225–231.
   PubMed Web of Science ®Google Scholar
• Wei W, Ji X, Guo X, et al. Regulatory role of N6‐methyladenosine (m6A) methylation in RNA processing and human diseases. J Cell Biochem. 2017;118(9):2534–2543.
   Google Scholar
• Niu Y, Zhao X, Wu Y-S, et al. N 6-methyl-adenosine (m 6 A) in RNA: an old modification with a novel epigenetic function. Genomics Proteomics Bioinformatics. 2013;11(1):8–17.
   PubMedGoogle Scholar
• Schwartz S, Mumbach MR, Jovanovic M, et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites. Cell Rep. 2014;8(1):284–296.
   PubMed Web of Science ®Google Scholar
• Lexow J, Poggioli T, Sarathchandra P, et al. Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver. Dis Model Mech. 2013;6(6):1470–1476.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012;8(4):445–544.
   PubMed Web of Science ®Google Scholar
• Hale CM, Cheng Q, Ortuno D, et al. Identification of modulators of autophagic flux in an image-based high content siRNA screen. Autophagy. 2016;12(4):713–726.
   PubMed Web of Science ®Google Scholar
• Jeong K, Kwon HY, Jeong MS, et al. CNOT2 promotes degradation of p62/SQSTM1 as a negative regulator in ATG5 dependent autophagy. Oncotarget. 2017;8(28):46034.
   PubMedGoogle Scholar
• Chua JP, Reddy SL, Merry DE, et al. Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy. Hum Mol Genet. 2013;23(5):1376–1386.
   PubMed Web of Science ®Google Scholar
• Kudou K, Komatsu T, Nogami J, et al. The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation. Open Biol. 2017;7(9):170119.
   PubMed Web of Science ®Google Scholar
• Misquitta CM, Iyer VR, Werstiuk ES, et al. The role of 3′-untranslated region (3′-UTR) mediated mRNA stability in cardiovascular pathophysiology. Mol Cell Biochem. 2001;224(1–2):53–67.
   PubMed Web of Science ®Google Scholar
• Zhang S, Zhao BS, Zhou A, et al. m 6 A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell. 2017;31(4):591–606. e6.
   PubMed Web of Science ®Google Scholar
• Gratacós FM, Brewer G. The role of AUF1 in regulated mRNA decay. Wiley Interdiscip Rev RNA. 2010;1(3):457–473.
   PubMed Web of Science ®Google Scholar
• Wang X, He C. Dynamic RNA modifications in posttranscriptional regulation. Mol Cell. 2014;56(1):5–12.
   PubMed Web of Science ®Google Scholar
• Bartlett JJ, Trivedi PC, Yeung P, et al. Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy. Biochem J. 2016;473(21):3769–3789.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhao BS, Roundtree IA, et al. N 6-methyladenosine modulates messenger RNA translation efficiency. Cell. 2015;161(6):1388–1399.
   PubMed Web of Science ®Google Scholar
• Fu Y, Dominissini D, Rechavi G, et al. Gene expression regulation mediated through reversible m6A RNA methylation. Nat Rev Genet. 2014;15(5):293–306.
   PubMed Web of Science ®Google Scholar
• Lin S, Choe J, Du P, et al. The m 6 A methyltransferase METTL3 promotes translation in human cancer cells. Mol Cell. 2016;62(3):335–345.
   PubMed Web of Science ®Google Scholar
• Liu N, Zhou KI, Parisien M, et al. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res. 2017;45(10):6051–6063.
   PubMed Web of Science ®Google Scholar
• Fan Y, Lu H, Liang W, et al. Endothelial TFEB (Transcription Factor EB) positively regulates postischemic angiogenesis. Circ Res. 2018;122(7):945–957.
   PubMed Web of Science ®Google Scholar
• Ugolino J, Ji YJ, Conchina K, et al. Loss of C9orf72 enhances autophagic activity via deregulated mTOR and TFEB signaling. PLoS Genet. 2016;12(11):e1006443.
   PubMed Web of Science ®Google Scholar
• Zhou J, Wan J, Gao X, et al. Dynamic m6A mRNA methylation directs translational control of heat shock response. Nature. 2015;526(7574):591–594.
   PubMed Web of Science ®Google Scholar
• Val P, Lefrançois-Martinez A-M, Veyssière G, et al. SF-1 a key player in the development and differentiation of steroidogenic tissues. Nucl Recept. 2003;1(1):8.
   PubMedGoogle Scholar
• Hall ME, Smith G, Hall JE, et al. Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic mice. Am J Physiol Heart Circ Physiol. 2011;301(1):H253–H260.
   PubMed Web of Science ®Google Scholar
• McGaffin KR, Witham WG, Yester KA, et al. Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice. Cardiovasc Res. 2010;89(1):60–71.
   PubMed Web of Science ®Google Scholar
• Pu J, Yuan A, Shan P, et al. Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury. Eur Heart J. 2012;34(24):1834–1845.
   PubMed Web of Science ®Google Scholar
• Hong X, Song R, Song H, et al. PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis. Gut. 2014;63(10):1635–16347.
   Web of Science ®Google Scholar
• Moffat J, Grueneberg DA, Yang X, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 2006;124(6):1283–1298.
   PubMed Web of Science ®Google Scholar
• Dominissini D, Moshitch-Moshkovitz S, Salmon-Divon M, et al. Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing. Nat Protoc. 2013;8(1):176–189.
   PubMed Web of Science ®Google Scholar