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Research Paper

Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation

, , , , , , , ORCID Icon, , , , , & ORCID Icon show all
Pages 1495-1505 | Received 11 Jun 2018, Accepted 13 Feb 2019, Published online: 19 Mar 2019

References

  • Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol. 2010;12:823–830. PMID: 20811354.
  • Mizushima N. Autophagy in protein and organelle turnover. Cold Spring Harb Symp Quant Biol. 2011;76:397–402. PMID:21813637.
  • Li Q, Liu Y, Sun M. Autophagy and Alzheimer’s Disease. Cell Mol Neurobiol. 2016;37:377–388. PMID: 27260250.
  • Jiang P, Mizushima N. Autophagy and human diseases. Cell Res. 2014;24:69–79. PMID:24323045.
  • Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol. 2007;8:931–937. PMID:17712358.
  • Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Patho. 2010;221:3–12. PMID:20225336.
  • Itakura E, Mizushima N. Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy. 2010;6:764–776. PMID: 20639694.
  • Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo J. 2000;19:5720–5728. PMID:11060023.
  • Mizushima N, Yoshimori T, Ohsumi Y. Role of the Apg12 conjugation system in mammalian autophagy. Int J Biochem Cell Biol. 2003;35:553–561. PMID:12672448.
  • Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12:1–222. PMID:26799652.
  • Shin HJ, Kim H, Oh S, et al. AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy. Nature. 2016;534:553–557. PMID:27309807.
  • Füllgrabe J, Ghislat G, Cho DH, et al. Transcriptional regulation of mammalian autophagy at a glance. J Cell Sci. 2016;16:3059–3066. PMID:27528206.
  • Xie Y, Kang R, Sun X, et al. Posttranslational modification of autophagy-related proteins in macroautophagy. Autophagy. 2015;11:28–45. PMID:25484070.
  • Lipinski MM, Hoffman G, Ng A, et al. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell. 2010;18:1041–1052. PMID:20627085.
  • Orvedahl A, Sumpter R Jr, Xiao G, et al. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature. 2011;480:113–117. PMID:22020285.
  • Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol. 2007;9:1102–1109. PMID:17909521.
  • Bremser M, Nickel W, Schweikert M, et al. Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. Cell. 1999;96:495–506. PMID:10052452.
  • Gommel DU, Memon AR, Heiss A, et al. Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23. Embo J. 2001;20:6751–6760. PMID:11726511.
  • Liu S, Zhang S, Bromley-Brits K, et al. Transcriptional regulation of TMP21 by NFAT. Mol Neurodegener. 2011;6:21–32. PMID:21375783.
  • Liu S, Bromley-Brits K, Xia K, et al. TMP21 degradation is mediated by the ubiquitin-proteasome pathway. Eur J Neurosci. 2008;28:1980–1988. PMID:19046380.
  • Xie J, Yang Y, Li J, et al. Expression of tmp21 in normal adult human tissues. Int J Clin Exp Med. 2014;7:2976–2983. PMID:25356171.
  • Chen F, Hasegawa H, Schmitt-Ulms G, et al. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature. 2006;440:1208–1212. PMID:16641999.
  • Hu CD, Grinberg AV, Kerppola TK. Visualization of protein interactions in living cells using bimolecular fluorescence complementation (BiFC) analysis. Curr Protoc Protein Sci. 2005. Chapter19, Unit19.10. PMID:18429278. DOI: 10.1002/0471140864.ps1910s41
  • Huang T, Kim CK, Alvarea AA, et al. MST4 phosprylation of ATG4B regulates autophagy acitivity, tumorigenecity, and radirsistance in glioblastoma. Cancer Cell. 2017;32:840–855. PMID: 29232556.
  • Yang Z, Wilkie-Grantham RP, Yanagi T, et al. ATG4B (autophagin-1) phosphorylation modulates autophagy. J Biol Chem. 2015;290:26549–26561. PMID: 26378241.
  • Ketteler R, Seed B. Quantitation of autophagy by luciferase release assay. Autophagy. 2008;4:801–806. PMID:18641457.
  • Vetrivel KS, Kodam A, Gong P, et al. Localization and regional distribution of p23/TMP21 in the brain. Neurobiol Dis. 2008;32:37–49. PMID: 18652896.
  • Kathiria AS, Butcher LD, Feagins LA, et al. Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. PLoS One. 2012;7:e31231. PMID:22363587.
  • Hasegawa J, Iwamoto R, Otomo T, et al. Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome. Embo J. 2016;35:1853–1867. PMID:27340123.
  • Li Z, Schulze RJ, Weller SG, et al. A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Sci Adv. 2016;2:e1601470. PMID: 28028537.
  • Yue X, Zhao P, Wu K, et al. GRIM-19 inhibition induced autophagy through activation of ERK and HIF-1α not STAT3 in Hela cells. Tumour Biol. 2016;37:9789–9796. PMID:26810068.
  • Wang H, Xiao L, Kazanietz MG. p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function. J Biol Chem. 2011;286:15821–15831. PMID:21454541.
  • Xu X, Gao H, Qin J, et al. TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy through activation of the AMPK/mTOR pathway. Int J Clin Exp Pathol. 2015;8:10824–10831. PMID:26617795.
  • Mariño G, Uría JA, Puente XS, et al. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem. 2003;278:3671–3678. PMID:12446702.
  • Satoo K, Noda NN, Kumeta H, et al. The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. Embo J. 2009;28:1341–1350. PMID:19322194.
  • Tanida I, Sou YS, Ezaki J, et al. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem. 2004;279:36268–36276. PMID:15187094.
  • Muppirala M, Gupta V, Syntaxin SG. 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi. Biol Cell. 2011;103:333–350. PMID:21545355.
  • Diao J, Liu R, Rong Y, et al. ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature. 2015;7548:563–566. PMID:25686604.
  • Itakura E, Kishi-Itakura C, Mizushima N. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell. 2012;151:1256–1269. PMID:23217709.
  • Blum R, Lepier A. The luminal domain of p23 (Tmp21) plays a critical role in p23 cell surface trafficking. Traffic. 2008;9:1530–1550. PMID:18627576.
  • Jo YK, Park NY, Park SJ, et al. O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity. Oncotarget. 2016;7:57186–57196. PMID:27527864.
  • Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med. 2013;19:983–997. PMID:23921753.
  • Glenner GG, Wong CW. Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 1984;120:885–890. PMID:6375662.
  • Grundke-Iqbal I, Iqbal K, Tung YC, et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A. 1986;83:4913–4917. PMID:3088567.
  • Lipinski MM, Zheng B, Lu T, et al. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease. Proc Natl Acad Sci U S A. 2010;107:14164–14169. PMID: 20660724.
  • Zheng X, Xie Z, Zhu Z, et al. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. PLoS One. 2014;9:e111536. PMID: 25360664.
  • Pickford F, Masliah E, Britschgi M, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest. 2008;118:2190–2199. PMID:18497889.
  • Lee JH, Yu WH, Kumar A, et al. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell. 2010;141:1146–1158. PMID: 20541250.
  • Nixon RA. Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci. 2007;120:4081–4091. PMID: 18032783.
  • Colacurcio DJ, Pensalfini A, Jiang Y, et al. Dysfunction of autophagy and endosomal-lysosomal pathways: roles in pathogenesis of down syndrome and Alzheimer’s disease. Free Radic Biol Med. 2018;114:40–51. PMID: 28988799.
  • Zhang X, Wu Y, Cai F, et al. A novel Alzheimer-associated SNP in Tmp21 increases amyloidogenesis. Mol Neurobiol. 2018;55:1862–1870. PMID: 28233271.
  • The National Institute on Aging and Reagan Institute Working Groupon Diagnostic Criteria for the Neuropathological Assessmen to fAlzheimer’s Disease, NIARI. Consensus recommendations for the postmortem diagnosis of Alzheimer’s disease. Neurobiol Aging. 1997;18:S1–S2.
  • Jo DG, Arumugam TV, Woo HN, et al. Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer’s disease. Neurobiol Aging. 2010;31:917–925. PMID: 18687504.

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