19,179
Views
204
CrossRef citations to date
0
Altmetric
Research Paper

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

, , , , , , , , , , , & show all
Pages 1860-1881 | Received 09 Mar 2018, Accepted 21 Feb 2019, Published online: 09 Apr 2019

References

  • Goldberg EL, Dixit VD. Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev. 2015;265:63–74. PMID:25879284.
  • Poewe W, Seppi K, Tanner CM, et al. Parkinson disease. Nat Rev Dis Primers. 2017;3:17013. PMID:28332488.
  • Block ML, Zecca L, Hong J. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 2007;8:57–69. PMID: 17180163.
  • Pedersen M, Bruunsgaard H, Weis N, et al. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev. 2003;124:495–502. PMID:12714258.
  • Ferrucci L, Corsi A, Lauretani F, et al. The origins of age-related proinflammatory state. Blood. 2005;105:2294–2299. PMID:15572589.
  • Wang L, Zhai Y, Xu L, et al. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Exp Neurol. 2014;251:22–29. PMID: 24220636.
  • Zhang G, Li J, Purkayastha S, et al. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature. 2013;497:211–216. PMID: 23636330.
  • Zhang Y, Kim MS, Jia B, et al. Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature. 2017;548:52–57. PMID: 28746310.
  • Blaylock RL. Parkinson‘s disease: microglial/macrophage-induced immunoexcitotoxicity as a central mechanism of neurodegeneration. Surg Neurol Int. 2017;8:65. PMID:28540131.
  • Calabrese V, Santoro A, Monti D, et al. Aging and Parkinson‘s Disease: inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis. Free Radic Biol Med. 2017;115:80–91. PMID:29080843.
  • Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21:677–687. PMID:26121197.
  • Athauda D, Foltynie T. The ongoing pursuit of neuroprotective therapies in Parkinson disease. Nat Rev Neurol. 2015;11:25–40. PMID:25447485.
  • Rider P, Carmi Y, Cohen I. Biologics for targeting inflammatory cytokines, clinical uses, and limitations. Int J Cell Biol. 2016;2016:1–11. PMID: 28083070.
  • Rees K, Stowe R, Patel S, et al. Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson‘s disease: evidence from observational studies. Cochrane Database Syst Rev. 2011:D8454. PMID:22071848. DOI:10.1002/14651858.CD008454.pub2.
  • Driver JA, Logroscino G, Lu L, et al. Use of non-steroidal anti-inflammatory drugs and risk of Parkinson‘s disease: nested case-control study. BMJ. 2011;342:d198. PMID:21252104.
  • Bassani TB, Vital MA, Rauh LK. Neuroinflammation in the pathophysiology of Parkinson‘s disease and therapeutic evidence of anti-inflammatory drugs. Arq Neuropsiquiatr. 2015;73:616–623. PMID:26200058.
  • Lamkanfi M, Dixit VM. Mechanisms and functions of inflammasomes. Cell. 2014;157:1013–1022. PMID:24855941.
  • Patel MN, Carroll RG, Galván-Peña S, et al. Inflammasome priming in sterile inflammatory disease. Trends Mol Med. 2017;23:165–180. PMID: 28109721.
  • Youm YH, Grant RW, McCabe LR, et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013;18:519–532. PMID:24093676.
  • Lu A, Magupalli VG, Ruan J, et al. Unified polymerization mechanism for the assembly of PYCARD-dependent inflammasomes. Cell. 2014;156:1193–1206. PMID:24630722.
  • Guo C, Xie S, Chi Z, et al. Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome. Immunity. 2016;45:802–816. PMID: 27692610.
  • Guo W, Sun Y, Liu W, et al. Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer. Autophagy. 2014;10:972–985. PMID: 24879148.
  • Afonina IS, Zhong Z, Karin M, et al. Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome. Nat Immunol. 2017;18:861–869. PMID: 28722711.
  • Yan Y, Jiang W, Liu L, et al. Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome. Cell. 2015;160:62–73. PMID: 25594175.
  • Py BF, Kim MS, Vakifahmetoglu-Norberg H, et al. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell. 2013;49:331–338. PMID:23246432.
  • Manach C, Scalbert A, Morand C, et al. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79:727–747. PMID:15113710.
  • Morales-Ibanez O, Affò S, Rodrigo-Torres D, et al. Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis. Gut. 2016;65:840–851. PMID: 25652085. .
  • Da-Silva WS, Harney JW, Kim BW, et al. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes. 2007;56:767–776. PMID: 17327447.
  • Nabavi SF, Sureda A, Dehpour AR, et al. Regulation of autophagy by polyphenols: paving the road for treatment of neurodegeneration. Biotechnol Adv. 2017. PMID: 29221764. DOI:10.1016/j.biotechadv.2017.12.001.
  • Park SE, Sapkota K, Kim S, et al. Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells. Brit J Pharmacol. 2011;164:1008–1025. PMID: 21449918.
  • Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl 1):S4–9. PMID:24833586.
  • Zhou Y, Lu M, Du RH, et al. MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson‘s disease. Mol Neurodegener. 2016;11:28. PMID:27084336.
  • Kigerl KA, de Rivero Vaccari JP, Dietrich WD, et al. Pattern recognition receptors and central nervous system repair. Exp Neurol. 2014;258:5–16. PMID: 25017883. .
  • Gao HM, Zhang F, Zhou H, et al. Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson‘s disease. Environ Health Perspect. 2011;119:807–814. PMID:21245015.
  • Wong YC, Krainc D. SNCA toxicity in neurodegeneration: mechanism and therapeutic strategies. Nat Med. 2017;23:1–13. PMID: 28170377. .
  • Codolo G, Plotegher N, Pozzobon T, et al. Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies. PLoS One. 2013;8:e55375. PMID:23383169.
  • Koprich JB, Kalia LV, Brotchie JM. Animal models of SNCAopathy for Parkinson disease drug development. Nat Rev Neurosci. 2017;18:515–529. PMID: 28747776.
  • Di Virgilio F, Dal Ben D, Sarti AC, et al. The P2X7 Receptor in Infection and Inflammation. Immunity. 2017;47:15–31. PMID:28723547.
  • Baker PJ, De Nardo D, Moghaddas F, et al. Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition. Physiol Rev. 2017;97:1165–1209. PMID: 28615462. .
  • Klionsky DJ, Cuervo AM, Seglen PO. Methods for monitoring autophagy from yeast to human. Autophagy. 2007;3:181–206. PMID:17224625;PMID: 17224625.
  • Cha-Molstad H, Lee SH, Kim JG, et al. Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway. Autophagy. 2017:1–6. PMID:29261001. DOI:10.1080/15548627.2017.1415190.
  • Cha-Molstad H, Yu JE, Feng Z, et al. p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis. Nat Commun. 2017;8:102. PMID:28740232.
  • Demishtein A, Fraiberg M, Berko D, et al. SQSTM1/p62-mediated autophagy compensates for loss of proteasome polyubiquitin recruiting capacity. Autophagy. 2017;13:1697–1708. PMID:28792301.
  • Lee JA, Gao FB. Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia. J Neurosci. 2009;29:8506–8511. PMID:19571141.
  • Mamik MK, Power C. Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts. Brain. 2017;140:2273–2285. PMID: 29050380.
  • Reeve A, Simcox E, Turnbull D. Ageing and Parkinson‘s disease: why is advancing age the biggest risk factor? Ageing Res Rev. 2014;14:19–30. PMID: 24503004. .
  • Prattichizzo F, De Nigris V, Spiga R, et al. Inflammageing and metaflammation: the yin and yang of type 2 diabetes. Ageing Res Rev. 2018;41:1–17. PMID: 29081381.
  • Zou YM, Liu J, Tian ZY, et al. Systematic review of the prevalence and incidence of Parkinson‘s disease in the People‘s Republic of China. Neuropsychiatr Dis Treat. 2015;11:1467–1472. PMID:26109861.
  • PYCARDherio A, Schwarzschild MA. The epidemiology of Parkinson‘s disease: risk factors and prevention. Lancet Neurol. 2016;15:1257–1272. PMID:27751556.
  • Shao W, Zhang SZ, Tang M, et al. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via alphaB-crystallin. Nature. 2013;494:90–94. PMID:23242137.
  • Zhong Z, Umemura A, Sanchez-Lopez E, et al. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016;164:896–910. PMID: 26919428.
  • Goldbach-Mansky R, Dailey NJ, Canna SW, et al. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med. 2006;355:581–592. PMID:16899778.
  • Qiao C, Yin N, Gu HY, et al. Atp13a2 Deficiency Aggravates Astrocyte-Mediated Neuroinflammation via NLRP3 Inflammasome Activation. Cns Neurosci Ther. 2016;22:451–460. PMID:26848562.
  • Komatsu M, Kageyama S, Ichimura Y. p62/SQSTM1/A170: physiology and pathology. Pharmacol Res. 2012;66:457–462. PMID:22841931.
  • Song H, Liu B, Huai W, et al. The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3. Nat Commun. 2016;7:13727. PMID: 27929086. .
  • Labzin LI, Heneka MT, Latz E. Innate Immunity and Neurodegeneration. Annu Rev Med. 2018;69:437–449. PMID:29106805.
  • Colonna M, Butovsky O. Microglia Function in the Central Nervous System During Health and Neurodegeneration. Annu Rev Immunol. 2017;35:441–468. PMID:28226226.
  • Chung HY, Cesari M, Anton S, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009;8:18–30. PMID:18692159.
  • Brichta L, Shin W, Jackson-Lewis V, et al. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nat Neurosci. 2015;18:1325–1333. PMID:26214373.
  • Lu M, Sun X, Qiao C, et al. Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation. Neurobiol Aging. 2014;35:421–430. PMID: 2404197.
  • Huang R, Zhang Y, Han B, et al. Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Autophagy. 2017. PMID: 28786753. DOI:10.1080/15548627.2017.1356975.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.