Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels

References

• de Duve C. The lysosome turns fifty. Nat Cell Biol. 2005 Sep;7(9):847–849. PubMed PMID: 16136179.
   PubMed Web of Science ®Google Scholar
• Mony VK, Benjamin S, O’Rourke EJ. A lysosome-centered view of nutrient homeostasis. Autophagy. 2016;12(4):619–631. PubMed PMID: 27050453; PubMed Central PMCID: PMCPMC4836021. eng.
   PubMed Web of Science ®Google Scholar
• Colacurcio DJ, Nixon RA. Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Res Rev. 2016 Dec;32:75–88. PubMed PMID: 27197071; PubMed Central PMCID: PMCPMC5112157. eng.
   PubMed Web of Science ®Google Scholar
• Settembre C, Zoncu R, Medina DL, et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. Embo J. 2012 Mar 7;31(5):1095–1108. PubMed PMID: 22343943; PubMed Central PMCID: PMCPMC3298007.
   PubMed Web of Science ®Google Scholar
• Settembre C, De Cegli R, Mansueto G, et al. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol. 2013 Jun;15(6):647–658. PubMed PMID: 23604321; PubMed Central PMCID: PMCPMC3699877. eng.
   PubMed Web of Science ®Google Scholar
• Lodhi IJ, Semenkovich CF. Peroxisomes: a nexus for lipid metabolism and cellular signaling. Cell Metab. 2014 Mar 4;19(3):380–392. PubMed PMID: 24508507; PubMed Central PMCID: PMCPMC3951609.
   PubMed Web of Science ®Google Scholar
• Oda K, Nishimura Y, Ikehara Y, et al. Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes. Biochem Biophys Res Commun. 1991 Jul 15;178(1):369–377. PubMed PMID: 2069575.
   PubMed Web of Science ®Google Scholar
• Schrader M, Bonekamp NA, Islinger M. Fission and proliferation of peroxisomes. Biochim Biophys Acta. 2012 Sep;1822(9):1343–1357. PubMed PMID: 22240198.
   PubMed Web of Science ®Google Scholar
• Mandard S, Muller M, Kersten S. Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci. 2004 Feb;61(4):393–416. PubMed PMID: 14999402.
   PubMed Web of Science ®Google Scholar
• Rakhshandehroo M, Knoch B, Müller M, et al. Peroxisome proliferator-activated receptor alpha target genes. PPAR Res. 2010;2010:1–20. PubMed PMID: 20936127; PubMed Central PMCID: PMCPMC2948931.
   Web of Science ®Google Scholar
• Bagattin A, Hugendubler L, Mueller E. Transcriptional coactivator PGC-1alpha promotes peroxisomal remodeling and biogenesis. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20376–20381. PubMed PMID: 21059926; PubMed Central PMCID: PMCPMC2996647. eng.
   PubMed Web of Science ®Google Scholar
• Bowers WE. Christian de Duve and the discovery of lysosomes and peroxisomes. Trends Cell Biol. 1998 Aug;8(8):330–333. PubMed PMID: 9704410; eng.
   PubMed Web of Science ®Google Scholar
• Eckert JH, Erdmann R. Peroxisome biogenesis. Rev Physiol Biochem Pharmacol. 2003;147:75–121. PubMed PMID: 12687401.
   PubMed Web of Science ®Google Scholar
• Agrawal G, Fassas SN, Xia Z-J, et al. Distinct requirements for intra-ER sorting and budding of peroxisomal membrane proteins from the ER. J Cell Biol. 2016 Feb 1;212(3):335–348. PubMed PMID: 26833788; PubMed Central PMCID: PMCPMC4748575.
   PubMed Web of Science ®Google Scholar
• Koch J, Pranjic K, Huber A, et al. PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance. J Cell Sci. 2010 Oct 1;123(Pt 19):3389–3400. PubMed PMID: 20826455.
   PubMed Web of Science ®Google Scholar
• Rodrigues TA, Grou CP, Azevedo JE. Revisiting the intraperoxisomal pathway of mammalian PEX7. Sci Rep. 2015 Jul 3;5:11806. PubMed PMID: 26138649; PubMed Central PMCID: PMCPMC4490337.
   PubMed Web of Science ®Google Scholar
• Weller S, Cajigas I, Morrell J, et al. Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis. Am J Hum Genet. 2005 Jun;76(6):987–1007. PubMed PMID: 15858711; PubMed Central PMCID: PMCPMC1196456.
   PubMed Web of Science ®Google Scholar
• Kamijo K, Taketani S, Yokota S, et al. The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily. J Biol Chem. 1990 Mar 15;265(8):4534–4540. PubMed PMID: 1968461.
   PubMed Web of Science ®Google Scholar
• Beier K. Light microscopic morphometric analysis of peroxisomes by automatic image analysis: advantages of immunostaining over the alkaline DAB method. J Histochem Cytochem. 1992 Jan;40(1):115–121. PubMed PMID: 1370307.
   PubMed Web of Science ®Google Scholar
• Reddy JK, Hashimoto T. Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. Annu Rev Nutr. 2001;21:193–230. PubMed PMID: 11375435.
   PubMed Web of Science ®Google Scholar
• Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol. 2000 Mar;20(5):1868–1876. PubMed PMID: 10669761; PubMed Central PMCID: PMCPMC85369.
   PubMed Web of Science ®Google Scholar
• Fernandez-Marcos PJ, Auwerx J. Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr. 2011 Apr;93(4):884S–90. PubMed PMID: 21289221; PubMed Central PMCID: PMCPMC3057551.
   PubMed Web of Science ®Google Scholar
• Wang XJ, Yu J, Wong SH, et al. A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy. Autophagy. 2013 Oct;9(10):1500–1508. PubMed PMID: 23934082.
   PubMed Web of Science ®Google Scholar
• Honsho M, Yamashita S, Fujiki Y. Peroxisome homeostasis: mechanisms of division and selective degradation of peroxisomes in mammals. Biochim Biophys Acta. 2016 May;1863(5):984–991. PubMed PMID: 26434997.
   PubMed Web of Science ®Google Scholar
• Schedin S, Sindelar PJ, Pentchev P, et al. Peroxisomal impairment in Niemann-Pick type C disease. J Biol Chem. 1997 Mar 7;272(10):6245–6251. PubMed PMID: 9045641; eng.
   PubMed Web of Science ®Google Scholar
• Scott I, Webster BR, Chan CK, et al. GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy. J Biol Chem. 2014 Jan 31;289(5):2864–2872. PubMed PMID: 24356961; PubMed Central PMCID: PMCPMC3908418.
   PubMed Web of Science ®Google Scholar
• Sinha RA, Singh BK, Zhou J, et al. Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy. 2015;11(8):1341–1357. PubMed PMID: 26103054; PubMed Central PMCID: PMCPMC4590606.
   PubMed Web of Science ®Google Scholar
• Lesmana R, Sinha RA, Singh BK, et al. Thyroid hormone stimulation of autophagy is essential for mitochondrial biogenesis and activity in skeletal muscle. Endocrinology. 2016 Jan;157(1):23–38. PubMed PMID: 26562261.
   PubMed Web of Science ®Google Scholar
• Fredman P, Klinghardt GW, Nilsson O, et al. Lipid accumulation in liver, spleen, lungs and kidneys of miniature-pigs after chloroquine treatment. Biochem J. 1982 Mar 1;201(3):581–588. PubMed PMID: 7092813; PubMed Central PMCID: PMCPMC1163684.
   PubMed Web of Science ®Google Scholar
• Sinha RA, Singh BK, Yen PM. Reciprocal crosstalk between autophagic and endocrine signaling in metabolic homeostasis. Endocr Rev. 2017 Feb 1;38(1):69–102. PubMed PMID: 27901588.
   PubMed Web of Science ®Google Scholar