4,220
Views
33
CrossRef citations to date
0
Altmetric
Translational Research Paper

SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC

, , , , , , , , , , , , , ORCID Icon, , & show all
Pages 735-749 | Received 25 Jan 2019, Accepted 10 Jun 2019, Published online: 04 Jul 2019

References

  • Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017 May 06;67(3):177–193. PubMed PMID: 28248415.
  • Kesselring R, Glaesner J, Hiergeist A, et al. IRAK-M expression in tumor cells supports colorectal cancer progression through reduction of antimicrobial defense and stabilization of STAT3. Cancer Cell. 2016 May 9;29(5):684–696. PubMed PMID: 27150039.
  • Lieu C, Kopetz S. The SRC family of protein tyrosine kinases: a new and promising target for colorectal cancer therapy. Clin Colorectal Cancer. 2010 Apr;9(2):89–94. PubMed PMID: 20378502; PubMed Central PMCID: PMCPMC3091503
  • Chen J, Elfiky A, Han M, et al. The role of Src in colon cancer and its therapeutic implications. Clin Colorectal Cancer. 2014 Mar;13(1):5–13. PubMed PMID: 24361441.
  • Daigo Y, Furukawa Y, Kawasoe T, et al. Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients. Cancer Res. 1999 Sep 1;59(17):4222–4224. PubMed PMID: 10485460
  • Laghi L, Bianchi P, Orbetegli O, et al. Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients. Br J Cancer. 2001 Jan;84(2):196–198. PubMed PMID: 11161376; PubMed Central PMCID: PMCPMC2363715.
  • Bromberg JF, Horvath CM, Besser D, et al. Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol. 1998 May;18(5):2553–2558. PubMed PMID: 9566875; PubMed Central PMCID: PMCPMC110635
  • Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer. 2005 Nov;41(16):2502–2512. PubMed PMID: 16199153
  • Talbot JJ, Song X, Wang X, et al. The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation. J Am Soc Nephrol. 2014 Aug;25(8):1737–1748. PubMed PMID: 24578126; PubMed Central PMCID: PMCPMC4116067.
  • Benham-Pyle BW, Sim JY, Hart KC, et al. Increasing beta-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. Elife. 2016 Oct 26;5. DOI:10.7554/eLife.19799 PubMed PMID: 27782880; PubMed Central PMCID: PMCPMC5104517.
  • Gayrard C, Bernaudin C, Dejardin T, et al. Src- and confinement-dependent FAK activation causes E-cadherin relaxation and beta-catenin activity. J Cell Biol. 2018 Mar 5;217(3):1063–1077. PubMed PMID: 29311227; PubMed Central PMCID: PMCPMC5839785.
  • Whitehead J, Vignjevic D, Futterer C, et al. Mechanical factors activate beta-catenin-dependent oncogene expression in APC mouse colon. Hfsp J. 2008 Oct;2(5):286–294. PubMed PMID: 19404440; PubMed Central PMCID: PMCPMC2639941.
  • Cullen PJ, Korswagen HC. Sorting nexins provide diversity for retromer-dependent trafficking events. Nat Cell Biol. 2011 Dec 22;14(1):29–37. PubMed PMID: 22193161; PubMed Central PMCID: PMCPMC3613977.
  • Chen Y, Wu B, Xu L, et al. A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell Res. 2012 Feb;22(2):333–345. PubMed PMID: 21844891; PubMed Central PMCID: PMCPMC3271581.
  • You Y, Zhou C, Li D, et al. Sorting nexin 10 acting as a novel regulator of macrophage polarization mediates inflammatory response in experimental mouse colitis. Sci Rep. 2016 Feb;09(6):20630. PubMed PMID: 26856241; PubMed Central PMCID: PMCPMC4746623.
  • Zhou C, You Y, Shen W, et al. Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation. Ann Rheum Dis. 2016 Jun;75(6):1211–1218. PubMed PMID: 26141367.
  • Zhang S, Hu B, You Y, et al. Sorting nexin 10 acts as a tumor suppressor in tumorigenesis and progression of colorectal cancer through regulating chaperone mediated autophagy degradation of p21(Cip1/WAF1). Cancer Lett. 2018 Apr;10(419):116–127. PubMed PMID: 29355659.
  • Liu X, Wei W, Li X, et al. BMI1 and MEL18 promote colitis-associated cancer in mice via REG3B and STAT3. Gastroenterology. 2017 Dec;153(6):1607–1620. PubMed PMID: 28780076.
  • Herrmann A, Vogt M, Monnigmann M, et al. Nucleocytoplasmic shuttling of persistently activated STAT3. J Cell Sci. 2007 Sep 15;120(Pt 18):3249–3261. PubMed PMID: 17726064.
  • Chen D, Fan W, Lu Y, et al. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol Cell. 2012 Mar 09;45(5):629–641. PubMed PMID: 22342342; PubMed Central PMCID: PMCPMC3299828.
  • Eskelinen EL. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Aspects Med. 2006 Oct–Dec;27(5–6):495–502. PubMed PMID: 16973206
  • Xu T, Xu J, Ye Y, et al. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins. 2014 Dec;82(12):3483–3489. PubMed PMID: 25212774.
  • Su K, Xu T, Yu Z, et al. Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain. FEBS Lett. 2017 Jul;591(13):2011–2018. PubMed PMID: 28542875.
  • Harris KF, Shoji I, Cooper EM, et al. Ubiquitin-mediated degradation of active Src tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13738–13743. PubMed PMID: 10570142; PubMed Central PMCID: PMCPMC24134
  • Sandilands E, Serrels B, McEwan DG, et al. Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol. 2011 Dec 4;14(1):51–60. PubMed PMID: 22138575.
  • Yeatman TJ. A renaissance for SRC. Nat Rev Cancer. 2004 Jun;4(6):470–480. PubMed PMID: 15170449
  • Santos CI, Costa-Pereira AP. Signal transducers and activators of transcription-from cytokine signalling to cancer biology. Biochim Biophys Acta. 2011 Aug;1816(1):38–49. PubMed PMID: 21447371
  • Grivennikov S, Karin E, Terzic J, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009 Feb 3;15(2):103–113. PubMed PMID: 19185845; PubMed Central PMCID: PMCPMC2667107.
  • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006 Nov 3;127(3):469–480. PubMed PMID: 17081971.
  • Lilien J, Balsamo J. The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Curr Opin Cell Biol. 2005 Oct;17(5):459–465. PubMed PMID: 16099633
  • van Veelen W, Le NH, Helvensteijn W, et al. beta-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis. Gut. 2011 Sep;60(9):1204–1212. PubMed PMID: 21307168; PubMed Central PMCID: PMCPMC3152867.
  • Mokarram P, Albokashy M, Zarghooni M, et al. New frontiers in the treatment of colorectal cancer: autophagy and the unfolded protein response as promising targets. Autophagy. 2017 May 4;13(5):781–819. PubMed PMID: 28358273; PubMed Central PMCID: PMCPMC5446063.
  • Cuervo AM, Wong E. Chaperone-mediated autophagy: roles in disease and aging. Cell Res. 2014 Jan;24(1):92–104. PubMed PMID: 24281265; PubMed Central PMCID: PMCPMC3879702
  • Kaushik S, Cuervo AM. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 2012 Aug;22(8):407–417. PubMed PMID: 22748206; PubMed Central PMCID: PMCPMC3408550
  • Kon M, Kiffin R, Koga H, et al. Chaperone-mediated autophagy is required for tumor growth. Sci Transl Med. 2011 Nov 16;3(109):109ra117. PubMed PMID: 22089453; PubMed Central PMCID: PMCPMC4000261.
  • Nassour J, Radford R, Correia A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019 Jan;565(7741):659–663. PubMed PMID: 30675059.
  • Mizushima N, Noda T, Yoshimori T, et al. A protein conjugation system essential for autophagy. Nature. 1998 Sep 24;395(6700):395–398. PubMed PMID: 9759731.
  • Park JM, Huang S, Wu TT, et al. Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy. Cancer Biol Ther. 2013 Feb;14(2):100–107. PubMed PMID: 23192274; PubMed Central PMCID: PMCPMC3571991.
  • Ren F, Shu G, Liu G, et al. Knockdown of p62/sequestosome 1 attenuates autophagy and inhibits colorectal cancer cell growth. Mol Cell Biochem. 2014 Jan;385(1–2):95–102. PubMed PMID: 24065390.
  • Neufert C, Becker C, Neurath MF. An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat Protoc. 2007;2(8):1998–2004. PubMed PMID: 17703211
  • Fu MM, Nirschl JJ, Holzbaur ELF. LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes. Dev Cell. 2014 Jun 9;29(5):577–590. PubMed PMID: 24914561; PubMed Central PMCID: PMCPMC4109720.
  • Stromhaug PE, Berg TO, Fengsrud M, et al. Purification and characterization of autophagosomes from rat hepatocytes. Biochem J. 1998 Oct 15;335(Pt 2):217–224. PubMed PMID: 9761717; PubMed Central PMCID: PMCPMC1219772

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.