Reference
- Ling S-C, Dastidar SG, Tokunaga S, et al. Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. Elife. 2019;8:602.
Commentary
Elevated FUS levels by overriding its autoregulation produce gain-of-toxicity properties that disrupt protein and RNA homeostasis
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Shuo-Chien LingDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore;Neurobiology/Ageing Programme, National University of Singapore, Singapore, Singapore;Program in Neuroscience and Behavior Disorders, Duke-NUS Medical School, Singapore, Republic of SingaporeCorrespondence[email protected];[email protected]
https://orcid.org/0000-0002-0300-8812View further author information
https://orcid.org/0000-0002-0300-8812View further author information