Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance

References

• Schwartz MW, Woods SC, Porte D Jr. et al. Central nervous system control of food intake. Nature. 2000 Apr 06;404(6778):661–671. PubMed PMID: 10766253.
   PubMed Web of Science ®Google Scholar
• Waterson MJ, Horvath TL. Neuronal regulation of energy homeostasis: beyond the hypothalamus and feeding. Cell Metab. 2015 Dec 1;22(6):962–970. PubMed PMID: 26603190.
   PubMed Web of Science ®Google Scholar
• Garcia-Caceres C, Fuente-Martin E, Argente J, et al. Emerging role of glial cells in the control of body weight. Mol Metab. 2012;1(1–2):37–46. PubMed PMID: 24024117; PubMed Central PMCID: PMC3757650.
   PubMed Web of Science ®Google Scholar
• Buckman LB, Ellacott KL. The contribution of hypothalamic macroglia to the regulation of energy homeostasis. Front Syst Neurosci. 2014;8:212. PubMed PMID: 25374514; PubMed Central PMCID: PMC4206078.
   PubMedGoogle Scholar
• Ebling FJP, Lewis JE. Tanycytes and hypothalamic control of energy metabolism. Glia. 2018 Jun;66(6):1176–1184. PubMed PMID: 29411421.
   PubMed Web of Science ®Google Scholar
• Bolborea M, Dale N. Hypothalamic tanycytes: potential roles in the control of feeding and energy balance. Trends Neurosci. 2013 Feb;36(2):91–100. PubMed PMID: 23332797; PubMed Central PMCID: PMCPMC3605593.
   PubMed Web of Science ®Google Scholar
• Elizondo-Vega R, Cortes-Campos C, Barahona MJ, et al. The role of tanycytes in hypothalamic glucosensing. J Cell Mol Med. 2015 Jul;19(7):1471–1482. PubMed PMID: 26081217; PubMed Central PMCID: PMCPMC4511346.
   PubMed Web of Science ®Google Scholar
• Lazutkaite G, Solda A, Lossow K, et al. Amino acid sensing in hypothalamic tanycytes via umami taste receptors. Mol Metab. 2017 Nov;6(11):1480–1492. PubMed PMID: 29107294; PubMed Central PMCID: PMCPMC5681271.
   PubMed Web of Science ®Google Scholar
• Balland E, Dam J, Langlet F, et al. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab. 2014 Feb 4;19(2):293–301. PubMed PMID: 24506870; PubMed Central PMCID: PMCPMC3936883.
   PubMed Web of Science ®Google Scholar
• Gao Y, Tschop MH, Luquet S. Hypothalamic tanycytes: gatekeepers to metabolic control. Cell Metab. 2014 Feb 4;19(2):173–175. PubMed PMID: 24506860.
   PubMed Web of Science ®Google Scholar
• Cortes-Campos C, Elizondo R, Llanos P, et al. MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction. PloS One. 2011 Jan 28;6(1):e16411. PubMed PMID: 21297988; PubMed Central PMCID: PMC3030577.
   PubMed Web of Science ®Google Scholar
• Langlet F, Levin BE, Luquet S, et al. Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metab. 2013 Apr 2;17(4):607–617. PubMed PMID: 23562080; PubMed Central PMCID: PMCPMC3695242.
   PubMed Web of Science ®Google Scholar
• Braestrup C, Squires RF. Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding. Proc Natl Acad Sci U S A. 1977 Sep;74(9):3805–3809. PubMed PMID: 20632; PubMed Central PMCID: PMCPMC431738.
   PubMed Web of Science ®Google Scholar
• Falchi AM, Battetta B, Sanna F, et al. Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands. Neuropharmacology. 2007 Aug;53(2):318–329. PubMed PMID: 17631921.
   PubMed Web of Science ®Google Scholar
• Fan J, Campioli E, Midzak A, et al. Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7261–7266. PubMed PMID: 26039990; PubMed Central PMCID: PMCPMC4466704.
   PubMed Web of Science ®Google Scholar
• Papadopoulos V, Mukhin AG, Costa E, et al. The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biol Chem. 1990 Mar 5;265(7):3772–3779. PubMed PMID: 2154488.
   PubMed Web of Science ®Google Scholar
• Azarashvili T, Grachev D, Krestinina O, et al. The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria. Cell Calcium. 2007 Jul;42(1):27–39. PubMed PMID: 17174393.
   PubMed Web of Science ®Google Scholar
• Sileikyte J, Petronilli V, Zulian A, et al. Regulation of the inner membrane mitochondrial permeability transition by the outer membrane translocator protein (peripheral benzodiazepine receptor). J Biol Chem. 2011 Jan 14;286(2):1046–1053. PubMed PMID: 21062740; PubMed Central PMCID: PMCPMC3020711.
   PubMed Web of Science ®Google Scholar
• Veenman L, Shandalov Y, Gavish M. VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis. J Bioenerg Biomembr. 2008 Jun;40(3):199–205. PubMed PMID: 18670869.
   PubMed Web of Science ®Google Scholar
• Lee JW, Kim LE, Shim HJ, et al. A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation. Biochem Biophys Res Commun. 2016 Jun 3;474(3):587–593. PubMed PMID: 27103438.
   PubMed Web of Science ®Google Scholar
• Bae KR, Shim HJ, Balu D, et al. Translocator protein 18 kDa negatively regulates inflammation in microglia. J Neuroimmune Pharmacol. 2014 Jun;9(3):424–437. PubMed PMID: 24687172.
   PubMed Web of Science ®Google Scholar
• Chen MK, Guilarte TR. Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacol Ther. 2008 Apr;118(1):1–17. PubMed PMID: 18374421; PubMed Central PMCID: PMCPMC2453598.
   PubMed Web of Science ®Google Scholar
• Batarseh A, Papadopoulos V. Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol. 2010 Oct 7;327(1–2):1–12. PubMed PMID: 20600583; PubMed Central PMCID: PMCPMC2922062.
   PubMed Web of Science ®Google Scholar
• Gavish M, Bachman I, Shoukrun R, et al. Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev. 1999 Dec;51(4):629–650. PubMed PMID: 10581326.
   PubMed Web of Science ®Google Scholar
• Tu LN, Zhao AH, Hussein M, et al. Translocator protein (TSPO) affects mitochondrial fatty acid oxidation in steroidogenic cells. Endocrinology. 2016 Mar;157(3):1110–1121. PubMed PMID: 26741196; PubMed Central PMCID: PMCPMC4769361.
   PubMed Web of Science ®Google Scholar
• Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004 Apr;6(4):463–477. PubMed PMID: 15068787.
   PubMed Web of Science ®Google Scholar
• Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature. 2009 Apr 30;458(7242):1131–1135. PubMed PMID: 19339967; PubMed Central PMCID: PMCPMC2676208.
   PubMed Web of Science ®Google Scholar
• Schulze RJ, Sathyanarayan A, Mashek DG. Breaking fat: The regulation and mechanisms of lipophagy. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1178–1187. PubMed PMID: 28642194; PubMed Central PMCID: PMCPMC5595645.
   PubMed Web of Science ®Google Scholar
• Singh R, Cuervo AM. Lipophagy: connecting autophagy and lipid metabolism. Int J Cell Biol. 2012;2012:282041. PubMed PMID: 22536247; PubMed Central PMCID: PMCPMC3320019.
   PubMedGoogle Scholar
• Liu K, Czaja MJ. Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ. 2013 Jan;20(1):3–11. PubMed PMID: 22595754; PubMed Central PMCID: PMCPMC3524634.
   PubMed Web of Science ®Google Scholar
• Dong H, Czaja MJ. Regulation of lipid droplets by autophagy. Trends Endocrinol Metab. 2011 Jun;22(6):234–240. PubMed PMID: 21419642; PubMed Central PMCID: PMCPMC3118855.
   PubMed Web of Science ®Google Scholar
• Khaldoun SA, Emond-Boisjoly MA, Chateau D, et al. Autophagosomes contribute to intracellular lipid distribution in enterocytes. Mol Biol Cell. 2014 Jan;25(1):118–132. PubMed PMID: 24173715; PubMed Central PMCID: PMCPMC3873883.
   PubMed Web of Science ®Google Scholar
• Tatsumi T, Takayama K, Ishii S, et al. Forced lipophagy reveals that lipid droplets are required for early embryonic development in mouse. Development. 2018 Feb 23; 145(4). PubMed PMID: 29475974
   PubMed Web of Science ®Google Scholar
• Riffelmacher T, Clarke A, Richter FC, et al. Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation. Immunity. 2017 Sep 19;47(3):466–480 e5. PubMed PMID: 28916263; PubMed Central PMCID: PMCPMC5610174.
   PubMed Web of Science ®Google Scholar
• Ouimet M, Franklin V, Mak E, et al. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 2011 Jun 8;13(6):655–667. PubMed PMID: 21641547; PubMed Central PMCID: PMCPMC3257518.
   PubMed Web of Science ®Google Scholar
• Sathyanarayan A, Mashek MT, Mashek DG. ATGL promotes autophagy/lipophagy via SIRT1 to control hepatic lipid droplet catabolism. Cell Rep. 2017 Apr 4;19(1):1–9. PubMed PMID: 28380348; PubMed Central PMCID: PMCPMC5396179.
   PubMed Web of Science ®Google Scholar
• Minami S, Yamamoto T, Takabatake Y, et al. Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation. Autophagy. 2017 Oct 3;13(10):1629–1647. PubMed PMID: 28813167; PubMed Central PMCID: PMCPMC5640178.
   PubMed Web of Science ®Google Scholar
• Kaushik S, Rodriguez-Navarro JA, Arias E, et al. Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. Cell Metab. 2011 Aug 3;14(2):173–183. PubMed PMID: 21803288; PubMed Central PMCID: PMCPMC3148494.
   PubMed Web of Science ®Google Scholar
• Zubiete-Franco I, Garcia-Rodriguez JL, Martinez-Una M, et al. Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis. J Hepatol. 2016 Feb;64(2):409–418. PubMed PMID: 26394163; PubMed Central PMCID: PMCPMC4718902.
   PubMed Web of Science ®Google Scholar
• Lin YC, Chang PF, Lin HF, et al. Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy. J Hepatol. 2016 Dec;65(6):1209–1216. PubMed PMID: 27417217.
   PubMed Web of Science ®Google Scholar
• Rodriguez EM, Blazquez JL, Pastor FE, et al. Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int Rev Cytol. 2005;247:89–164. PubMed PMID: 16344112.
   PubMedGoogle Scholar
• Mayer CM, Fick LJ, Gingerich S, et al. Hypothalamic cell lines to investigate neuroendocrine control mechanisms. Front Neuroendocrinol. 2009 Aug;30(3):405–423. PubMed PMID: 19341762.
   PubMed Web of Science ®Google Scholar
• Miranda-Angulo AL, Byerly MS, Mesa J, et al. Rax regulates hypothalamic tanycyte differentiation and barrier function in mice. J Comp Neurol. 2014 Mar;522(4):876–899. PubMed PMID: 23939786; PubMed Central PMCID: PMCPMC3947139.
   PubMed Web of Science ®Google Scholar
• Chen R, Wu X, Jiang L, et al. Single-cell RNA-SEQ reveals hypothalamic cell diversity. Cell Rep. 2017 Mar 28;18(13):3227–3241. PubMed PMID: 28355573; PubMed Central PMCID: PMCPMC5782816.
   PubMed Web of Science ®Google Scholar
• Hardie DG. AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond). 2008 Sep;32(Suppl 4):S7–12. PubMed PMID: 18719601.
   PubMed Web of Science ®Google Scholar
• Srivastava P, Kaul A, Ojha H, et al. Design, synthesis and biological evaluation of methyl-2-(2-(5-bromo benzoxazolone)acetamido)3-(1H-indol-3-yl)propanoate: TSPO ligand for SPECT. RSC Adv. 2016;6(115):114491–114499. PubMed PMID: WOS:000391457400072; English.
   Web of Science ®Google Scholar
• Totis M, Kremers P, Batt AM, et al. Induction of liver microsomal cytochrome P-450 isozymes by 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide. Xenobiotica. 1989 Aug;19(8):857–866. PubMed PMID: 2815828.
   PubMed Web of Science ®Google Scholar
• Woods A, Dickerson K, Heath R, et al. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2005 Jul;2(1):21–33. PubMed PMID: 16054096.
   PubMed Web of Science ®Google Scholar
• Hoyer-Hansen M, Bastholm L, Szyniarowski P, et al. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell. 2007 Jan 26;25(2):193–205. PubMed PMID: 17244528.
   PubMed Web of Science ®Google Scholar
• Oh TS, Cho H, Cho JH, et al. Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression. Autophagy. 2016 Nov;12(11):2009–2025. PubMed PMID: 27533078; PubMed Central PMCID: PMCPMC5103348.
   PubMed Web of Science ®Google Scholar
• Hardie DG. AMPK and autophagy get connected. Embo J. 2011 Feb 16;30(4):634–635. PubMed PMID: 21326174; PubMed Central PMCID: PMCPMC3041958.
   PubMed Web of Science ®Google Scholar
• Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011 Jan 28;331(6016):456–461. PubMed PMID: 21205641; PubMed Central PMCID: PMCPMC3030664.
   PubMed Web of Science ®Google Scholar
• Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol. 2004 Dec;36(12):2503–2518. PubMed PMID: 15325588.
   PubMed Web of Science ®Google Scholar
• Bjorkoy G, Lamark T, Pankiv S, et al. Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol. 2009;452:181–197. PubMed PMID: 19200883.
   PubMed Web of Science ®Google Scholar
• Nazarko VY, Zhong Q. ULK1 targets Beclin-1 in autophagy. Nat Cell Biol. 2013 Jul;15(7):727–728. PubMed PMID: 23817237; PubMed Central PMCID: PMCPMC4442023.
   PubMed Web of Science ®Google Scholar
• Kletsas D, Li W, Han Z, et al. Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways. Biochem Pharmacol. 2004 May 15;67(10):1927–1932. PubMed PMID: 15130769.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Polo RA, Carvalho G, Braun T, et al. PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor. Oncogene. 2005 Nov 17;24(51):7503–7513. PubMed PMID: 16091749.
   PubMed Web of Science ®Google Scholar
• Hans G, Wislet-Gendebien S, Lallemend F, et al. Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression. Biochem Pharmacol. 2005 Mar 1;69(5):819–830. PubMed PMID: 15710359.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1–222. PubMed PMID: 26799652; PubMed Central PMCID: PMCPMC4835977.
   PubMed Web of Science ®Google Scholar
• Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy. 2007 Sep-Oct;3(5):452–460. PubMed PMID: 17534139.
   PubMed Web of Science ®Google Scholar
• Zhou J, Tan SH, Nicolas V, et al. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res. 2013 Apr;23(4):508–523. PubMed PMID: 23337583; PubMed Central PMCID: PMCPMC3616426.
   PubMed Web of Science ®Google Scholar
• Granatiero V, Giorgio V, Cali T, et al. Reduced mitochondrial Ca(2+) transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase. Cell Death Differ. 2016 Feb;23(2):231–241. PubMed PMID: 26206091; PubMed Central PMCID: PMCPMC4716301.
   PubMed Web of Science ®Google Scholar
• Narendra D, Tanaka A, Suen DF, et al. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol. 2008 Dec 1;183(5):795–803. PubMed PMID: 19029340; PubMed Central PMCID: PMCPMC2592826.
   PubMed Web of Science ®Google Scholar
• Akmayev IG, Popov AP. Morphological aspects of the hypothalamic-hypophyseal system. VII. The tanycytes: Their relation to the hypophyseal adrenocorticotrophic function. An ultrastructural study. Cell Tissue Res. 1977 May 16;180(2):263–282. PubMed PMID: 194701.
   PubMed Web of Science ®Google Scholar
• Pak T, Yoo S, Miranda-Angulo AL, et al. Rax-CreERT2 knock-in mice: a tool for selective and conditional gene deletion in progenitor cells and radial glia of the retina and hypothalamus. PloS One. 2014;9(4):e90381. PubMed PMID: 24699247; PubMed Central PMCID: PMCPMC3974648.
   PubMed Web of Science ®Google Scholar
• Hofmann K, Lamberz C, Piotrowitz K, et al. Tanycytes and a differential fatty acid metabolism in the hypothalamus. Glia. 2017 Feb;65(2):231–249. PubMed PMID: 27726181.
   PubMed Web of Science ®Google Scholar
• Gao Q, Goodman JM. The lipid droplet-a well-connected organelle. Front Cell Dev Biol. 2015;3:49. PubMed PMID: 26322308; PubMed Central PMCID: PMCPMC4533013.
   PubMed Web of Science ®Google Scholar
• Weidberg H, Shvets E, Elazar Z. Lipophagy: selective catabolism designed for lipids. Dev Cell. 2009 May;16(5):628–630. PubMed PMID: 19460339.
   PubMed Web of Science ®Google Scholar
• Da Pozzo E, Giacomelli C, Barresi E, et al. Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection. Biochem Soc Trans. 2015 Aug;43(4):559–565. PubMed PMID: 26551693.
   PubMedGoogle Scholar
• Gatliff J, East D, Crosby J, et al. TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy. 2014;10(12):2279–2296. PubMed PMID: 25470454; PubMed Central PMCID: PMCPMC4502750.
   PubMed Web of Science ®Google Scholar
• Owen DR, Matthews PM. Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands. Int Rev Neurobiol. 2011;101:19–39. PubMed PMID: 22050847.
   PubMed Web of Science ®Google Scholar
• Lacapere JJ, Delavoie F, Li H, et al. Structural and functional study of reconstituted peripheral benzodiazepine receptor. Biochem Biophys Res Commun. 2001 Jun 8;284(2):536–541. PubMed PMID: 11394915.
   PubMed Web of Science ®Google Scholar
• Campanella M, Szabadkai G, Rizzuto R. Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195. Biochem Pharmacol. 2008 Dec 1;76(11):1628–1636. PubMed PMID: 18929543; PubMed Central PMCID: PMCPMC2844953.
   PubMed Web of Science ®Google Scholar
• Green AC, Dowdall MJ, Richardson CM. ATP acting on P2Y receptors triggers calcium mobilization in Schwann cells at the neuroelectrocyte junction in skate. Neuroscience. 1997 Sep;80(2):635–651. PubMed PMID: 9284364.
   PubMed Web of Science ®Google Scholar
• Troadec JD, Thirion S, Petturiti D, et al. ATP acting on P2Y receptors triggers calcium mobilization in primary cultures of rat neurohypophysial astrocytes (pituicytes). Pflugers Arch. 1999 Apr;437(5):745–753. PubMed PMID: 10087153.
   PubMed Web of Science ®Google Scholar
• James G, Butt AM. P2X and P2Y purinoreceptors mediate ATP-evoked calcium signalling in optic nerve glia in situ. Cell Calcium. 2001 Oct;30(4):251–259. PubMed PMID: 11587549.
   PubMed Web of Science ®Google Scholar
• Layhadi JA, Turner J, Crossman D, et al. ATP Evokes Ca(2+) responses and CXCL5 secretion via P2X4 receptor activation in human monocyte-derived macrophages. J Immunol. 2018 Feb 1;200(3):1159–1168. PubMed PMID: 29255078; PubMed Central PMCID: PMCPMC5784824.
   PubMed Web of Science ®Google Scholar
• Ostuni MA, Ducroc R, Peranzi G, et al. Translocator protein (18 kDa) ligand PK 11195 induces transient mitochondrial Ca2+ release leading to transepithelial Cl- secretion in HT-29 human colon cancer cells. Biol Cell. 2007 Nov;99(11):639–647. PubMed PMID: 17561806.
   PubMed Web of Science ®Google Scholar
• Tamse C, Lu X, Mortel E. et al. The peripheral benzodiazepine receptor modulates ca2+ transport through the vdac in rat heart mitochondria. Int J Clin Basic Cardiol. 2008;11(1):24–29.
   Google Scholar
• Gatliff J, East DA, Singh A, et al. A role for TSPO in mitochondrial Ca(2+) homeostasis and redox stress signaling. Cell Death Dis. 2017 Jun 22;8(6):e2896. PubMed PMID: 28640253; PubMed Central PMCID: PMCPMC5520880.
   PubMed Web of Science ®Google Scholar
• Joo HK, Lee YR, Lim SY, et al. Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1. FEBS Lett. 2012 May 7;586(9):1349–1355. PubMed PMID: 22616995.
   PubMed Web of Science ®Google Scholar
• Joo HK, Lee YR, Kang G, et al. The 18-kDa translocator protein inhibits vascular cell adhesion molecule-1 expression via inhibition of mitochondrial reactive oxygen species. Mol Cells. 2015 Dec;38(12):1064–1070. PubMed PMID: 26608360; PubMed Central PMCID: PMCPMC4696997.
   PubMed Web of Science ®Google Scholar
• Gut P, Baeza-Raja B, Andersson O, et al. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol. 2013 Feb;9(2):97–104. PubMed PMID: 23201900; PubMed Central PMCID: PMCPMC3552031.
   PubMed Web of Science ®Google Scholar
• Goodman T, Hajihosseini MK. Hypothalamic tanycytes-masters and servants of metabolic, neuroendocrine, and neurogenic functions. Front Neurosci. 2015;9:387. PubMed PMID: 26578855; PubMed Central PMCID: PMCPMC4624852.
   PubMed Web of Science ®Google Scholar
• Kalsbeek A, Bruinstroop E, Yi CX, et al. Hypothalamic control of energy metabolism via the autonomic nervous system. Ann N Y Acad Sci. 2010 Nov;1212:114–129. PubMed PMID: 21070249.
   PubMed Web of Science ®Google Scholar
• Roh E, Song DK, Kim MS. Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism. Exp Mol Med. 2016 Mar 11;48:e216. PubMed PMID: 26964832; PubMed Central PMCID: PMCPMC4892882.
   PubMed Web of Science ®Google Scholar
• Elizondo-Vega R, Cortes-Campos C, Barahona MJ, et al. Inhibition of hypothalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression. Sci Rep. 2016 Sep 28;6:33606. PubMed PMID: 27677351; PubMed Central PMCID: PMCPMC5039692.
   PubMed Web of Science ®Google Scholar
• Frayling C, Britton R, Dale N. ATP-mediated glucosensing by hypothalamic tanycytes. J Physiol. 2011 May 1;589(Pt 9):2275–2286. PubMed PMID: 21486800; PubMed Central PMCID: PMCPMC3098703.
   PubMed Web of Science ®Google Scholar
• Yang L, Qi Y, Yang Y. Astrocytes control food intake by inhibiting AGRP neuron activity via adenosine A1 receptors. Cell Rep. 2015 May 5;11(5):798–807. PubMed PMID: 25921535.
   PubMed Web of Science ®Google Scholar
• Yoo SJ, Lee JH, Kim SY, et al. Differential spatial expression of peripheral olfactory neuron-derived BACE1 induces olfactory impairment by region-specific accumulation of beta-amyloid oligomer. Cell Death Dis. 2017 Aug 10;8(8):e2977. PubMed PMID: 28796251; PubMed Central PMCID: PMCPMC5596540.
   PubMedGoogle Scholar