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Editor’s Corner

A novel role of UBQLNs (ubiquilins) in regulating autophagy, MTOR signaling and v-ATPase function

& ORCID Icon
Pages 1-2 | Received 04 Sep 2019, Accepted 04 Sep 2019, Published online: 13 Sep 2019

References

  • Hjerpe R, Bett JS, Keuss MJ, et al. UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome. Cell. 2016;166(4):935–949.
  • Itakura E, Zavodszky E, Shao S, et al. Ubiquilins chaperone and triage mitochondrial membrane proteins for degradation. Mol Cell. 2016;63(1):21–33.
  • Zhang KY, Yang S, Warraich ST, et al. Ubiquilin 2: a component of the ubiquitin–proteasome system with an emerging role in neurodegeneration. Int J Biochem Cell Biol. 2014;50:123–126.
  • Şentürk M, Lin G, Zuo Z, et al. Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Nat Cell Biol. 2019;21(3):384–396.
  • Deng H-X, Chen W, Hong S-T, et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature. 2011;477(7363):211–215.
  • Goode A, Butler K, Long J, et al. Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD. Autophagy. 2016;12(7):1094–1104.
  • Hiesinger PR, Fayyazuddin A, Mehta SQ, et al. The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell. 2005;121(4):607–620.
  • Bourdenx M, Daniel J, Genin E, et al. Nanoparticles restore lysosomal acidification defects: implications for Parkinson and other lysosomal-related diseases. Autophagy. 2016;12(3):472–483.

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