TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation

References

• Loomba R, Sanyal AJ. The global NAFLD epidemic. Nat Rev Gastroenterol. 2013;10(11):686.
   PubMed Web of Science ®Google Scholar
• Ponziani FR, Pecere S, Gasbarrini A, et al. Physiology and pathophysiology of liver lipid metabolism. Expert Rev Gastroenterol Hepatol. 2015;9(8):1055–1067.
   PubMed Web of Science ®Google Scholar
• Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology. 2012;142(4):711–725. e6.
   PubMed Web of Science ®Google Scholar
• Tiniakos DG, Vos MB, Brunt EM. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol -Mech. 2010;5:145–171.
   PubMed Web of Science ®Google Scholar
• Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol. 2015;62(1):S47–S64.
   PubMed Web of Science ®Google Scholar
• Takamura A, Komatsu M, Hara T, et al. Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 2011 Apr 15;25(8):795–800.
   PubMed Web of Science ®Google Scholar
• Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol. 2010;12(9):814.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Rodriguez A, Mayoral R, Agra N, et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 2014;5(4):e1179.
   PubMedGoogle Scholar
• Mei S, Ni H-M, Manley S, et al. Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. J Pharmacol Exp Ther. 2011;339(2):487–498.
   PubMed Web of Science ®Google Scholar
• Zeng T-S, Liu F-M, Zhou J, et al. Depletion of Kupffer cells attenuates systemic insulin resistance, inflammation and improves liver autophagy in high-fat diet fed mice. Endocr J. 2015;62(7):615–626.
   Google Scholar
• Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature. 2009;458(7242):1131.
   PubMed Web of Science ®Google Scholar
• Harada M, Hanada S, Toivola DM, et al. Autophagy activation by rapamycin eliminates mouse Mallory‐Denk bodies and blocks their proteasome inhibitor‐mediated formation. Hepatology. 2008;47(6):2026–2035.
   PubMed Web of Science ®Google Scholar
• Lin C-W, Zhang H, Li M, et al. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J Hepatol. 2013;58(5):993–999.
   PubMed Web of Science ®Google Scholar
• Chen R, Wang Q, Song S, et al. Protective role of autophagy in methionine–choline deficient diet-induced advanced nonalcoholic steatohepatitis in mice. Eur J Pharmacol. 2016;770:126–133.
   PubMed Web of Science ®Google Scholar
• Chen K-S, DeLuca HF. Isolation and characterization of a novel cDNA from HL-60 cells treated with 1, 25-dihydroxyvitamin D-3. BBA-Gene Struct Expression. 1994;1219(1):26–32.
   PubMed Web of Science ®Google Scholar
• Junn E, Han SH, Im JY, et al. Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol. 2000;164(12):6287–6295.
   PubMed Web of Science ®Google Scholar
• Nishiyama A, Matsui M, Iwata S, et al. Identification of thioredoxin-binding protein-2/vitamin D3 up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J Biol Chem. 1999;274(31):21645–21650.
   PubMed Web of Science ®Google Scholar
• Parikh H, Carlsson E, Chutkow WA, et al. TXNIP regulates peripheral glucose metabolism in humans. PLoS Med. 2007;4(5):e158.
   PubMed Web of Science ®Google Scholar
• Chutkow WA, Patwari P, Yoshioka J, et al. Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production. J Biol Chem. 2008;283(4):2397–2406.
   PubMed Web of Science ®Google Scholar
• O’neill HM. AMPK and exercise: glucose uptake and insulin sensitivity. Diabetes Metab J. 2013;37(1):1–21.
   PubMedGoogle Scholar
• Chen J, Hui ST, Couto FM, et al. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. Faseb J. 2008;22(10):3581–3594.
   PubMed Web of Science ®Google Scholar
• Oka S-I, Liu W, Masutani H, et al. Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. Faseb J. 2006;20(1):121–123.
   PubMedGoogle Scholar
• Park M-J, Kim D-I, Lim S-K, et al. Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo. J Hepatol. 2014;61(5):1151–1157.
   PubMed Web of Science ®Google Scholar
• Donnelly KL, Margosian MR, Sheth SS, et al. Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip−/− mice. J Nutr. 2004;134(6):1475–1480.
   PubMed Web of Science ®Google Scholar
• Neuschwander‐Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology. 2010;52(2):774–788.
   PubMed Web of Science ®Google Scholar
• Li M, Xu C, Shi J, et al. Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway. Gut. 2018;67(12):2169–2180.
   PubMed Web of Science ®Google Scholar
• Inokuchi-Shimizu S, Park EJ, Roh YS, et al. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014;124(8):3566–3578.
   PubMed Web of Science ®Google Scholar
• Kominami E, Hashida S, Khairallah E, et al. Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin. J Biol Chem. 1983;258(10):6093–6100.
   PubMed Web of Science ®Google Scholar
• Mauthe M, Orhon I, Rocchi C, et al. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy. 2018;14:1435–1455.
   PubMed Web of Science ®Google Scholar
• Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018;19(2):121.
   PubMed Web of Science ®Google Scholar
• Settembre C, Di Malta C, Polito VA, et al. TFEB links autophagy to lysosomal biogenesis. Science. 2011;332(6036):1429–1433.
   PubMed Web of Science ®Google Scholar
• Kwon H-J, Won Y-S, Suh H-W, et al. Vitamin D3 upregulated protein 1 suppresses TNF-α–induced NF-κB activation in hepatocarcinogenesis. J Immunol. 2010;185(7):3980–3989.
   PubMed Web of Science ®Google Scholar
• Kwon H-J, Won Y-S, Yoon Y-D, et al. Vitamin D3 up-regulated protein 1 deficiency accelerates liver regeneration after partial hepatectomy in mice. J Hepatol. 2011;54(6):1168–1176.
   PubMed Web of Science ®Google Scholar
• Kwon H-J, Hong S-K, Yoon W-K, et al. Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration. J Vet Sci. 2013;14(3):257–262.
   PubMed Web of Science ®Google Scholar
• Huang C, Zhang Y, Kelly DJ, et al. Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway. Sci Rep. 2016;6:29196.
   PubMed Web of Science ®Google Scholar
• Qiao S, Dennis M, Song X, et al. A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity. Nat Commun. 2015;6:7014.
   PubMed Web of Science ®Google Scholar
• Wu N, Zheng B, Shaywitz A, et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 2013;49:1167–1175.
   PubMed Web of Science ®Google Scholar
• Kim J, Kundu M, Viollet B, et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011;13(2):132.
   PubMed Web of Science ®Google Scholar
• Li Y, Ding W-X. A gene transcription program decides the differential regulation of autophagy by acute vs chronic ethanol?. Alcohol Clin Exp Res. 2016;40(1):47.
   PubMed Web of Science ®Google Scholar
• Mao Y, Yu F, Wang J, et al. Autophagy: a new target for nonalcoholic fatty liver disease therapy. Hepat Med. 2016;8:27.
   PubMed Web of Science ®Google Scholar
• Sengupta S, Peterson TR, Laplante M, et al. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature. 2010;468(7327):1100.
   PubMed Web of Science ®Google Scholar
• Settembre C, De Cegli R, Mansueto G, et al. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol. 2013;15(6):647.
   PubMed Web of Science ®Google Scholar
• Ni HM, Bockus A, Boggess N, et al. Activation of autophagy protects against acetaminophen‐induced hepatotoxicity. Hepatology. 2012;55(1):222–232.
   PubMed Web of Science ®Google Scholar
• Matsuda T, Yamaguchi Y, Matsumura F, et al. Immunosuppressants decrease neutrophil chemoattractant and attenuate ischemia/reperfusion injury of the liver in rats. J Trauma Acute Care Surg. 1998;44(3):475–484.
   Google Scholar
• Ezquerro S, Mendez-Gimenez L, Becerril S, et al. Acylated and desacyl ghrelin are associated with hepatic lipogenesis, beta-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats. Sci Rep. 2016;6(1):1–12.
   PubMedGoogle Scholar
• Lodder J, Denaes T, Chobert MN, et al. Macrophage autophagy protects against liver fibrosis in mice. Autophagy. 2015;11(8):1280–1292.
   PubMed Web of Science ®Google Scholar
• Komatsu M, Waguri S, Ueno T, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005;169(3):425–434.
   PubMed Web of Science ®Google Scholar
• Lee KN, Kang H-S, Jeon J-H, et al. VDUP1 is required for the development of natural killer cells. Immunity. 2005;22(2):195–208.
   PubMed Web of Science ®Google Scholar
• Sun R, Jaruga B, Kulkarni S, et al. IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: regulation by SOCS3. Biochem Biophys Res Commun. 2005;338(4):1943–1949.
   PubMed Web of Science ®Google Scholar