Advanced search
Publication Cover
Autophagy Volume 17, 2021 - Issue 5
Submit an article Journal homepage
1,988
Views
0
CrossRef citations to date
0
Altmetric
Editor’s Corner

New functions of a known autophagy regulator: VCP and autophagy initiation

Yuchen LeiLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USAView further author information
&
Daniel J. KlionskyLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7828-8118View further author information
ORCID Icon
Pages 1063-1064 | Received 15 Mar 2021, Published online: 31 Mar 2021

References

  • Meyer H, Weihl CC. The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. J Cell Sci. 2014 Sep;127(Pt 18):3877–3883. PubMed PMID: 25146396; PubMed Central PMCID: PMCPMC4163641. eng.
  • Watts GD, Wymer J, Kovach MJ, et al. Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Nat Genet. 2004 Apr;36(4):377–381. PubMed PMID: 15034582; eng.
  • Johnson JO, Mandrioli J, Benatar M, et al. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 2010 Dec;68(5):857–864. PubMed PMID: 21145000; PubMed Central PMCID: PMCPMC3032425. eng.
  • Tanaka A, Cleland MM, Xu S, et al. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol. 2010 Dec;191(7):1367–1380. PubMed PMID: 21173115; PubMed Central PMCID: PMCPMC3010068. eng.
  • Papadopoulos C, Kirchner P, Bug M, et al. VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. Embo J. 2017 1;36(2):135–150. PubMed PMID: 27753622; PubMed Central PMCID: PMCPMC5242375. eng.
  • Tresse E, Salomons FA, Vesa J, et al. VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy. 2010 Feb;6(2):217–227. PubMed PMID: 20104022; PubMed Central PMCID: PMCPMC2929010. eng.
  • Ju JS, Fuentealba RA, Miller SE, et al. Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol. 2009 Dec;187(6):875–888. PubMed PMID: 20008565; PubMed Central PMCID: PMCPMC2806317. eng.
  • Hill SM, Wrobel L, Ashkenazi A, et al. VCP/p97 regulates Beclin-1-dependent autophagy initiation. Nat Chem Biol. Jan 2021. PubMed PMID: 33510452; eng. Doi: 10.1038/s41589-020-00726-x
  • Chou TF, Brown SJ, Minond D, et al. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A. 2011 Mar;108(12):4834–4839. PubMed PMID: 21383145; PubMed Central PMCID: PMCPMC3064330. eng.
  • Ashkenazi A, Bento CF, Ricketts T, et al. Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature. 2017 5;545(7652):108–111. PubMed PMID: 28445460; PubMed Central PMCID: PMCPMC5420314. eng.
  • Zhong X, Pittman RN. Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet. 2006 Aug;15(16):2409–2420. PubMed PMID: 16822850; eng.
  • He C, Levine B. The Beclin 1 interactome. Curr Opin Cell Biol. 2010 Apr;22(2):140–149. PubMed PMID: 20097051; PubMed Central PMCID: PMCPMC2854269. eng.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.