Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death

References

• Gastaldelli A, Cusi K. From NASH to diabetes and from diabetes to NASH: mechanisms and treatment options. JHEP Rep. 2019;1(4):312–328.
   PubMedGoogle Scholar
• Garg K, Brackett S, Hirsch IB, et al. NAFLD/NASH and diabetes. Diabetes Technol Ther. 2020;22(S1:S174–S186.
   Web of Science ®Google Scholar
• Younossi ZM, Marchesini G, Pinto-Cortez H, et al. Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: implications for liver transplantation. Transplantation. 2019;103(1):22–27.
   PubMed Web of Science ®Google Scholar
• Cho CS, Park H-W, Ho A, et al. Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. Hepatology. 2018;68(4):1331–1346.
   PubMed Web of Science ®Google Scholar
• Galindo-Moreno M, Giráldez S, Sáez C, et al. Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer. Sci Rep. 2017;7(1):10078.
   PubMedGoogle Scholar
• Yang L, Li P, Fu S, et al. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010;11(6):467–478.
   PubMed Web of Science ®Google Scholar
• Wang Y, Singh R, Xiang Y, et al. Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress. Hepatology. 2010;52(1):266–277.
   PubMed Web of Science ®Google Scholar
• Delgado M, Singh S, De Haro S, et al. Autophagy and pattern recognition receptors in innate immunity. Immunol Rev. 2009;227(1):189–202.
   PubMedGoogle Scholar
• Singh R, Xiang Y, Wang Y, et al. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest. 2009;119(11):3329–3339.
   PubMed Web of Science ®Google Scholar
• Czaja MJ. Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications. Am J Physiol Cell Physiol. 2010;298(5):C973–8.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Rodriguez A, Mayoral R, Agra N, et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 2014;5(4):e1179.
   PubMedGoogle Scholar
• Fukuo Y, Yamashina S, Sonoue H, et al. Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease. Hepatol Res. 2014;44(9):1026–1036.
   PubMed Web of Science ®Google Scholar
• Geetha T, Viswaprakash N, Sycheva M, et al. Sequestosome 1/p62: across diseases. Biomarkers. 2012;17(2):99–103.
   PubMed Web of Science ®Google Scholar
• Komatsu M, Kageyama S, Ichimura Y. p62/SQSTM1/A170: physiology and pathology. Pharmacol Res. 2012;66(6):457–462.
   PubMed Web of Science ®Google Scholar
• Brisse M, Ly H. Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5. Front Immunol. 2019;10:1586.
   PubMed Web of Science ®Google Scholar
• Oh JE, Lee HK. Pattern recognition receptors and autophagy. Front Immunol. 2014;5:300.
   PubMed Web of Science ®Google Scholar
• Lee NR, Ban J, Lee N-J, et al. Activation of RIG-I-mediated antiviral signaling triggers autophagy through the MAVS-TRAF6-beclin-1 signaling axis. Front Immunol. 2018;9:2096.
   PubMed Web of Science ®Google Scholar
• Du Y, Duan T, Feng Y, et al. LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation. EMBO J. 2018;37(3):351–366.
   PubMed Web of Science ®Google Scholar
• Matsumoto M, Hada N, Sakamaki Y, et al. An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis. Int J Exp Pathol. 2013;94(2):93–103.
   PubMed Web of Science ®Google Scholar
• Chen CZ, Raghunath M. Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art. Fibrogenesis Tissue Repair. 2009;2:7.
   PubMedGoogle Scholar
• Cissell DD, Link JM, Hu JC, et al. A modified hydroxyproline assay based on hydrochloric acid in ehrlich’s solution accurately measures tissue collagen content. Tissue Eng Part C Methods. 2017;23(4):243–250.
   PubMed Web of Science ®Google Scholar
• Luo X, Li H, Ma L, et al. Expression of STING is increased in liver tissues from patients with NAFLD and promotes macrophage-mediated hepatic inflammation and fibrosis in mice. Gastroenterology. 2018;155(6):1971–1984 e4.
   PubMed Web of Science ®Google Scholar
• Yu Y, Liu Y, An W, et al. STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis. J Clin Invest. 2019;129(2):546–555.
   PubMed Web of Science ®Google Scholar
• Zatloukal K, Stumptner C, Fuchsbichler A, et al. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am J Pathol. 2002;160(1):255–263.
   PubMed Web of Science ®Google Scholar
• Stumptner C, Fuchsbichler A, Heid H, et al. Mallory body–a disease-associated type of sequestosome. Hepatology. 2002;35(5):1053–1062.
   PubMed Web of Science ®Google Scholar
• Nan L, Wu Y, Bardag-Gorce F, et al. p62 is involved in the mechanism of mallory body formation. Exp Mol Pathol. 2004;77(3):168–175.
   PubMed Web of Science ®Google Scholar
• Su W, Mao Z, Liu Y, et al. Role of HSD17B13 in the liver physiology and pathophysiology. Mol Cell Endocrinol. 2019;489:119–125.
   PubMed Web of Science ®Google Scholar
• Crowe AR, Yue W. Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an integrated protocol. Biol Protoc. 2019;9(24):e3465.
   Web of Science ®Google Scholar
• Ricchi M, Odoardi MR, Carulli L, et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol. 2009;24(5):830–840.
   PubMed Web of Science ®Google Scholar
• Joshi-Barve S, Barve SS, Amancherla K, et al. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology. 2007;46(3):823–830.
   PubMed Web of Science ®Google Scholar
• Schlee M, Hartmann E, Coch C, et al. Approaching the RNA ligand for RIG-I? Immunol Rev. 2009;227(1):66–74.
   PubMedGoogle Scholar
• Schlee M, Roth A, Hornung V, et al. Recognition of 5′ triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity. 2009;31(1):25–34.
   PubMed Web of Science ®Google Scholar
• Schmidt A, Schwerd T, Hamm W, et al. 5ʹ-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I. Proc Natl Acad Sci U S A. 2009;106(29):12067–12072.
   PubMed Web of Science ®Google Scholar
• Yu Y, Zhao N, An J, et al. CCAAT/enhancer-binding protein β mediates the killing of toxoplasma gondii by inducing autophagy in nonhematopoietic cells. DNA Cell Biol. 2017;36(3):212–218.
   PubMed Web of Science ®Google Scholar
• Jung CH, Ro S-H, Cao J, et al. mTOR regulation of autophagy. FEBS Lett. 2010;584(7):1287–1295.
   PubMed Web of Science ®Google Scholar
• Linares JF, Duran A, Reina-Campos M, Aza-Blanc P, Campos A, Moscat J, Diaz-Meco MT. Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade. Cell Rep. 2015 Aug 25;12(8):1339–1352.
   Google Scholar
• Baliga BS, Pronczuk AW, Munro HN. Mechanism of cycloheximide inhibition of protein synthesis in a cell-free system prepared from rat liver. J Biol Chem. 1969;244(16):4480–4489.
   PubMed Web of Science ®Google Scholar
• Gao B, Tsukamoto H. Inflammation in alcoholic and nonalcoholic fatty liver disease: friend or foe? Gastroenterology. 2016;150(8):1704–1709.
   PubMed Web of Science ®Google Scholar
• Sutti S, Bruzzi S, Albano E. The role of immune mechanisms in alcoholic and nonalcoholic steatohepatitis: a 2015 update. Expert Rev Gastroenterol Hepatol. 2016;10(2):243–253.
   PubMed Web of Science ®Google Scholar
• Loo YM, Gale M Jr. Immune signaling by RIG-I-like receptors. Immunity. 2011;34(5):680–692.
   PubMed Web of Science ®Google Scholar
• Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140(6):805–820.
   PubMed Web of Science ®Google Scholar
• Li W, Fang Q, Zhong P, et al. EGFR inhibition blocks palmitic acid-induced inflammation in cardiomyocytes and prevents hyperlipidemia-induced cardiac injury in mice. Sci Rep. 2016;6(1):24580.
   PubMedGoogle Scholar
• Choung S, Kim JM, Joung KH, et al. Epidermal growth factor receptor inhibition attenuates non-alcoholic fatty liver disease in diet-induced obese mice. PLoS One. 2019;14(2):e0210828.
   PubMed Web of Science ®Google Scholar
• Liu L, Martin R, Kohler G, et al. Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes. Exp Neurol. 2013;248:482–490.
   PubMed Web of Science ®Google Scholar
• Niu J, Sun Y, Chen B, et al. Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. Nature. 2019;573(7772):139–143.
   PubMed Web of Science ®Google Scholar
• Kwan HY, Liu B, Huang C, et al. Signal transducer and activator of transcription-3 drives the high-fat diet-associated prostate cancer growth. Cell Death Dis. 2019;10(9):637.
   PubMedGoogle Scholar
• Hoo RL, Shu L, Cheng KK, Wu X, Liao B, Wu D, Zhou Z, Xu A. Adipocyte fatty acid binding protein potentiates toxic lipids-induced endoplasmic reticulum stress in macrophages via inhibition of janus kinase 2-dependent autophagy. Sci Rep. 2017;7:40657.
   PubMed Web of Science ®Google Scholar
• Yu Y, Li C, Liu J, et al. Palmitic acid promotes virus replication in fish cell by modulating autophagy flux and TBK1-IRF3/7 pathway. Front Immunol. 2020;11:1764.
   PubMed Web of Science ®Google Scholar
• Xian H, Yang S, Jin S, et al. LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I. Autophagy. 2020;16(3):408–418.
   PubMed Web of Science ®Google Scholar
• Csak T, Dolganiuc A, Kodys K, et al. Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. Hepatology. 2011;53(6):1917–1931.
   PubMed Web of Science ®Google Scholar
• Ji D, Qin E, Xu J, et al. Non-alcoholic fatty liver diseases in patients with COVID-19: a retrospective study. J Hepatol. 2020;73(2):451–453.
   PubMed Web of Science ®Google Scholar
• Jeong WI, Park O, Radaeva S, et al. STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology. 2006;44(6):1441–1451.
   PubMed Web of Science ®Google Scholar
• Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science. 1999;286(5443):1358–1362.
   PubMed Web of Science ®Google Scholar
• Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999;13(22):2905–2927.
   PubMed Web of Science ®Google Scholar
• Zhu S, Xiang X, Xu X, et al. TIR domain-containing adaptor-inducing interferon-beta (TRIF) participates in antiviral immune responses and hepatic lipogenesis of large yellow croaker (larimichthys crocea). Front Immunol. 2019;10:2506.
   PubMed Web of Science ®Google Scholar
• Umemura A, He F, Taniguchi K, et al. p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell. 2016;29(6):935–948.
   PubMed Web of Science ®Google Scholar
• Aigelsreiter A, Neumann J, Pichler M, et al. Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis. Liver Int. 2017;37(4):600–610.
   PubMed Web of Science ®Google Scholar
• Bao L, Chandra PK, Moroz K, et al. Impaired autophagy response in human hepatocellular carcinoma. Exp Mol Pathol. 2014;96(2):149–154.
   PubMed Web of Science ®Google Scholar
• Hou J, Zhou Y, Zheng Y, et al. Hepatic RIG-I predicts survival and interferon-alpha therapeutic response in hepatocellular carcinoma. Cancer Cell. 2014;25(1):49–63.
   PubMed Web of Science ®Google Scholar
• Liu Z, Dou C, Jia Y, et al. RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9. Int J Oncol. 2015;46(4):1710–1720.
   PubMed Web of Science ®Google Scholar
• Kato H, Sato S, Yoneyama M, et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity. 2005;23(1):19–28.
   PubMed Web of Science ®Google Scholar