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Autophagy Volume 17, 2021 - Issue 7
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Autophagic Punctum

Lipid-mediated impairment of axonal lysosome transport contributing to autophagic stress

Joseph C. Roneya Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA;b Department of Pharmacology, University of Oxford, Oxford, UKView further author information
,
Sunan Lia Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USAView further author information
,
Tamar Farfel-Beckera Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USAView further author information
,
Ning Huanga Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USAView further author information
,
Tao Suna Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USAView further author information
,
Yuxiang Xiea Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USAView further author information
,
Xiu-Tang Chenga Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USAORCID Iconhttps://orcid.org/0000-0001-9385-2031View further author information
ORCID Icon,
Mei-Yao Lina Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USAView further author information
,
Frances M. Plattb Department of Pharmacology, University of Oxford, Oxford, UKView further author information
&
Zu-Hang Shenga Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USACorrespondence[email protected]
View further author information
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Pages 1796-1798 | Received 19 May 2021, Accepted 01 Jun 2021, Published online: 30 Jun 2021

Reference

  • Roney JC, Li S, Farfel-Becker T, et al. Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C. Dev Cell. 2021 Apr 13;56(10):1452–1468.e8.

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