Advanced search
Publication Cover
Autophagy Volume 17, 2021 - Issue 10
Submit an article Journal homepage
1,008
Views
2
CrossRef citations to date
0
Altmetric
Commentary and Views

SQSTM1/p62 droplet -mediated autophagosome formation:insights into Huntington disease

Junsheng YangCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6425-8495View further author information
ORCID Icon,
Xiaoli ChenCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaView further author information
&
Huilin XuCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaView further author information
Pages 3256-3259 | Received 24 Mar 2021, Accepted 06 Jul 2021, Published online: 19 Jul 2021

References

  • Menzies FM, Fleming A, Rubinsztein DC. Compromised autophagy and neurodegenerative diseases. Nat Rev Neurosci. 2015 Jun;16(6):345–357.
  • Giovedì S, Ravanelli MM, Parisi B, et al. Dysfunctional autophagy and endolysosomal system in neurodegenerative diseases: relevance and therapeutic options. Front Cell Neurosci. 2020;14:602116.
  • Martin DD, Ladha S, Ehrnhoefer DE, et al. Autophagy in Huntington disease and huntingtin in autophagy. Trends Neurosci. 2015 Jan;38(1):26–35. .
  • Ochaba J, Lukacsovich T, Csikos G, et al. Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16889–16894.
  • Martinez-Vicente M, Talloczy Z, Wong E, et al. Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease. Nat Neurosci. 2010 May;13(5):567–576. .
  • Rui YN, Xu Z, Patel B, et al. Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol. 2015 Mar;17(3):262–275. .
  • Lamark T, Svenning S, Johansen T. Regulation of selective autophagy: the p62/SQSTM1 paradigm. Essays Biochem. 2017 Dec 12;61(6):609–624.
  • Bjørkøy G, Lamark T, Brech A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol. 2005 Nov 21;171(4):603–614.
  • Wurzer B, Zaffagnini G, Fracchiolla D, et al. Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy. eLife. 2015 Sep 28;4:e08941. .
  • Sun D, Wu R, Zheng J, et al. Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation. Cell Res. 2018 Apr;28(4):405–415. .
  • Zaffagnini G, Savova A, Danieli A, et al. p62 filaments capture and present ubiquitinated cargos for autophagy. EMBO J. 2018 Mar 1;37(5). DOI:https://doi.org/10.15252/embj.201798308.
  • Sánchez-Martín P, Sou YS, Kageyama S, et al. NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. EMBO Rep. 2020 Mar 4;21(3):e48902.
  • Kageyama S, Gudmundsson SR, Sou YS, et al. p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. Nat Commun. 2021 Jan 4;12(1):16.
  • Agudo-Canalejo J, Schultz SW, Chino H, et al. Wetting regulates autophagy of phase-separated compartments and the cytosol. Nature. 2021 Jan 20;591(7848):142–146.
  • Franco-Iborra S, Plaza-Zabala A, Montpeyo M, et al. Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease. Autophagy. 2020;24:1–18.
  • Berkamp S, Mostafavi S, Sachse C. Structure and function of p62/SQSTM1 in the emerging framework of phase separation. FEBS J. 2020 Dec 17. DOI:https://doi.org/10.1111/febs.15672.
  • Yang J, Yang X. Phase transition of Huntingtin: factors and pathological relevance. Front Genet. 2020;11:754.
  • Noda NN, Wang Z, Zhang H. Liquid-liquid phase separation in autophagy. J Cell Biol. 2020 Aug 3;219(8). DOI:https://doi.org/10.1083/jcb.202004062.
  • Fujioka Y, Noda NN. Biomolecular condensates in autophagy regulation. Curr Opin Cell Biol. 2021 Jan;11(69):23–29.
  • Melia TJ, Lystad AH, Simonsen A. Autophagosome biogenesis: from membrane growth to closure. J Cell Biol. 2020 Jun 1;219(6):e202002085.
  • Chang C, Jensen LE, Hurley JH. Autophagosome biogenesis comes out of the black box. Nat Cell Biol. 2021 May;23(5):450–456.
  • Valionyte E, Yang Y, Roberts SL, et al. Lowering mutant Huntingtin levels and toxicity: autophagy-endolysosome pathways in Huntington’s disease. J Mol Biol. 2020 Apr 3;432(8):2673–2691.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.