Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion

References

• Zhao YG, Codogno P, Zhang H. Machinery, regulation and pathophysiological implications of autophagosome maturation. Nat Rev Mol Cell Biol. 2021;22(11):733–750.
   PubMed Web of Science ®Google Scholar
• Nishimura T, Tooze SA. Emerging roles of ATG proteins and membrane lipids in autophagosome formation. Cell Discov. 2020;6(1):32.
   PubMed Web of Science ®Google Scholar
• Morishita H, Mizushima N. Autophagy and ageing. Nihon Rinsho. 2016;74(9):1461–1466.
   PubMedGoogle Scholar
• Mizushima N. Physiological functions of autophagy. Curr Top Microbiol Immunol. 2009;335:71–84.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B, Longo DL. Autophagy in human diseases. N Engl J Med. 2020;383(16):1564–1576.
   PubMed Web of Science ®Google Scholar
• Itakura E, Kishi-Itakura C, Mizushima N. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomesFLysosomes. Cell. 2012;151(6):1256–1269.
   PubMed Web of Science ®Google Scholar
• Yu S, Melia TJ. The coordination of membrane fission and fusion at the end of autophagosome maturation. Curr Opin Cell Biol. 2017;47:92–98.
   PubMed Web of Science ®Google Scholar
• Corona AK, Jackson WT. Finding the middle ground for autophagic fusion requirements. Trends Cell Biol. 2018;28(11):869–881.
   PubMed Web of Science ®Google Scholar
• Sudhof TC, Rothman JE. Membrane fusion: grappling with SNARE and SM proteins. Science. 2009;323(5913):474–477.
   PubMed Web of Science ®Google Scholar
• Verhage M, Maia AS, Plomp JJ, et al. Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science. 2000;287(5454):864–869.
   PubMed Web of Science ®Google Scholar
• Li Y, Gallwitz D, Peng R. Structure-based functional analysis reveals a role for the SM protein Sly1p in retrograde transport to the endoplasmic reticulum. Mol Biol Cell. 2005;16(9):3951–3962.
   PubMed Web of Science ®Google Scholar
• Huang H, Ouyang Q, Zhu M, et al. mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation. Nat Commun. 2021;12(1):6622.
   PubMed Web of Science ®Google Scholar
• Shen Q, Shi Y, Liu J, et al. Acetylation of STX17 (syntaxin 17) controls autophagosome maturation. FAutophagy. 2021;17(5):1157–1169.
   PubMed Web of Science ®Google Scholar
• Huang R, Xu Y, Wan W, et al. Deacetylation of nuclear LC3 drives autophagy initiation under starvation. Mol Cell. 2015;57(3):456–466.
   PubMed Web of Science ®Google Scholar
• Lee IH, Finkel T. Regulation of autophagy by the p300 acetyltransferase. J Biol Chem. 2009;284(10):6322–6328.
   PubMed Web of Science ®Google Scholar
• Kim J, Kim Y, Fang C, et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell. 2013;152(1–2):290–303.
   PubMed Web of Science ®Google Scholar
• Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011;331(6016):456–461.
   PubMed Web of Science ®Google Scholar
• Kim YM, Jung C, Seo M, et al. mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation. Mol Cell. 2015;57(2):207–218.
   PubMed Web of Science ®Google Scholar
• Su H, Yang F, Wang Q, et al. VPS34 acetylation controls its lipid kinase activity and the initiation of canonical and non-canonical autophagy. Mol Cell. 2017;67(6):907-+.
   Web of Science ®Google Scholar
• Jin Q, Yu L-R, Wang L, et al. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J. 2011;30(2):249–262.
   PubMed Web of Science ®Google Scholar
• Schiltz RL, Mizzen CA, Vassilev A, et al. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. J Biol Chem. 1999;274(3):1189–1192.
   PubMed Web of Science ®Google Scholar
• Yang XJ. Lysine acetylation and the bromodomain: a new partnership for signaling. Bioessays. 2004;26(10):1076–1087.
   PubMed Web of Science ®Google Scholar
• Hu H, Zhu W, Qin J, et al. Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis. Hepatology. 2017;65(2):515–528.
   PubMed Web of Science ®Google Scholar
• Lin R, Tao R, Gao X, et al. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013;51(4):506–518.
   PubMed Web of Science ®Google Scholar
• Ni HM, Bockus A, Wozniak AL, et al. Dissecting the dynamic turnover of GFP-LC3 in the autolysosome. Autophagy. 2011;7(2):188–204.
   PubMed Web of Science ®Google Scholar
• Archbold JK, Whitten AE, Hu SH, et al. SNARE-ing the structures of Sec1/Munc18 proteins. Curr Opin Struct Biol. 2014;29:44–51.
   PubMed Web of Science ®Google Scholar
• Hu SH, Christie MP, Saez NJ, et al. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci U S A. 2011;108(3):1040–1045.
   PubMed Web of Science ®Google Scholar
• Colbert KN, Hattendorf DA, Weiss TM, et al. Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation. Proc Natl Acad Sci U S A. 2013;110(31):12637–12642.
   PubMed Web of Science ®Google Scholar
• Hackmann Y, Graham SC, Ehl S, et al. Syntaxin binding mechanism and disease-causing mutations in Munc18-2. Proc Natl Acad Sci U S A. 2013;110(47):E4482–91.
   PubMed Web of Science ®Google Scholar
• Hu SH, Latham CF, Gee CL, et al. Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A. 2007;104(21):8773–8778.
   PubMed Web of Science ®Google Scholar
• Misura KMS, Scheller RH, Weis WI. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature. 2000;404(6776):355–362.
   PubMed Web of Science ®Google Scholar
• Burkhardt P, Hattendorf DA, Weis WI, et al. Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptid. EMBO J. 2008;27(7):923–933.
   PubMed Web of Science ®Google Scholar
• Jiang P, Nishimura T, Sakamaki Y, et al. The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol Biol Cell. 2014;25(8):1327–1337.
   PubMed Web of Science ®Google Scholar
• Rieder SE, Emr SD. A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole. Mol Biol Cell. 1997;8(11):2307–2327.
   PubMed Web of Science ®Google Scholar
• Wurmser AE, Sato TK, Emr SD. New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion. J Cell Biol. 2000;151(3):551–562.
   PubMed Web of Science ®Google Scholar
• You ZY, Jiang W-X, Qin L-Y, et al. Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nat Commun. 2019;10(1). DOI:10.1038/s41467-019-13718-w.
   Google Scholar
• Cheng X, Ma X, Zhu Q, et al. Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism. Mol Cell. 2019;73(4):788-+.
   Web of Science ®Google Scholar
• Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy. 2007;3(5):452–460.
   PubMed Web of Science ®Google Scholar