Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis

References

• Bhome R, Bullock MD, Al Saihati HA, et al. A top-down view of the tumor microenvironment: structure, cells and signaling. Front Cell Dev Biol. 2015;3:33.
   PubMed Web of Science ®Google Scholar
• Schiavoni G, Gabriele L, Mattei F. The tumor microenvironment: a pitch for multiple players. Front Oncol. 2013;3:90.
   PubMedGoogle Scholar
• Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357:539–545.
   PubMed Web of Science ®Google Scholar
• Polyak K, Haviv I, Campbell IG. Co-evolution of tumor cells and their microenvironment. Trends Genet. 2009;25:30–38.
   PubMed Web of Science ®Google Scholar
• Frank S, Madlener M, Werner S. Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing. J Biol Chem. 1996;271:10188–10193.
   PubMed Web of Science ®Google Scholar
• Ronnov-Jessen L, Petersen OW. Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab Invest. 1993;68:696–707.
   PubMed Web of Science ®Google Scholar
• Seong GJ, Hong S, Jung SA, et al. TGF-beta-induced interleukin-6 participates in transdifferentiation of human Tenon’s fibroblasts to myofibroblasts. Mol Vis. 2009;15:2123–2128.
   PubMed Web of Science ®Google Scholar
• Akkoc Y, Gozuacik D. Autophagy and liver cancer. Turk J Gastroenterol. 2018;29:270–282.
   PubMed Web of Science ®Google Scholar
• Kocaturk NM, Akkoc Y, Kig C, et al. Autophagy as a molecular target for cancer treatment. Eur J Pharm Sci. 2019;134:116–137.
   PubMed Web of Science ®Google Scholar
• Pennica D, Wood WI, Chien KR. Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways. Cytokine Growth Factor Rev. 1996;7:81–91.
   PubMedGoogle Scholar
• Bauer S, Kerr BJ, Patterson PH. The neuropoietic cytokine family in development, plasticity, disease and injury. Nat Rev Neurosci. 2007;8:221–232.
   PubMed Web of Science ®Google Scholar
• Robledo O, Fourcin M, Chevalier S, et al. Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component. J Biol Chem. 1997;272:4855–4863.
   PubMed Web of Science ®Google Scholar
• Rossi JF, Lu ZY, Jourdan M, et al. Interleukin-6 as a therapeutic target. Clin Cancer Res. 2015;21:1248–1257.
   PubMed Web of Science ®Google Scholar
• Sheng Z, Pennica D, Wood WI, et al. Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. Development. 1996;122:419–428.
   PubMed Web of Science ®Google Scholar
• Lopez-Yoldi M, Moreno-Aliaga MJ, Bustos M. Cardiotrophin-1: a multifaceted cytokine. Cytokine Growth Factor Rev. 2015;26:523–532.
   PubMed Web of Science ®Google Scholar
• Karakas HE, Kim J, Park J, et al. A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy-inducing crosstalk in the stroma niche. Sci Rep. 2017;7:2050.
   PubMed Web of Science ®Google Scholar
• Kiyono K, Suzuki HI, Matsuyama H, et al. Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells. Cancer Res. 2009;69:8844–8852.
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Whitaker-Menezes D, Lin Z, et al. Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator. Cell Cycle. 2011;10:1784–1793.
   PubMed Web of Science ®Google Scholar
• Jonchere B, Belanger A, Guette C, et al. STAT3 as a new autophagy regulator. Jakstat. 2013;2:e24353.
   PubMedGoogle Scholar
• Bach M, Larance M, James DE, et al. The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochem J. 2011;440:283–291.
   PubMed Web of Science ®Google Scholar
• Albrengues J, Bertero T, Grasset E, et al. Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts. Nat Commun. 2015;6:10204.
   PubMed Web of Science ®Google Scholar
• Subramaniam KS, Omar IS, Kwong SC, et al. Cancer-associated fibroblasts promote endometrial cancer growth via activation of interleukin-6/STAT-3/c-Myc pathway. Am J Cancer Res. 2016;6:200–213.
   PubMed Web of Science ®Google Scholar
• Fritzenwanger M, Meusel K, Foerster M, et al. Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells. Cytokine. 2006;36:101–106.
   PubMed Web of Science ®Google Scholar
• Qi Y, Xu R. Roles of PLODs in collagen synthesis and cancer progression. Front Cell Dev Biol. 2018;6:66.
   PubMed Web of Science ®Google Scholar
• Kinugasa Y, Matsui T, Takakura N. CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the stemness and drug resistance of malignant cancer cells in the tumor microenvironment. Stem Cells. 2014;32:145–156.
   PubMed Web of Science ®Google Scholar
• Chen CH, Ho YC, Ho HH, et al. Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration. Cardiovasc Res. 2013;100:461–471.
   PubMed Web of Science ®Google Scholar
• Deuel TA, Liu JS, Corbo JC, et al. Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron. 2006;49:41–53.
   PubMed Web of Science ®Google Scholar
• Dunne PD, Dasgupta S, Blayney JK, et al. EphA2 expression is a key driver of migration and invasion and a poor prognostic marker in colorectal cancer. Clin Cancer Res. 2016;22:230–242.
   PubMed Web of Science ®Google Scholar
• Gao H, Yu G, Zhang X, et al. BZW2 gene knockdown induces cell growth inhibition, G1 arrest and apoptosis in muscle-invasive bladder cancers: a microarray pathway analysis. J Cell Mol Med. 2019;23:3905–3915.
   PubMed Web of Science ®Google Scholar
• Kuo JC, Han X, Hsiao CT, et al. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for beta-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol. 2011;13:383–393.
   PubMed Web of Science ®Google Scholar
• Nishikawa Y, Miyazaki T, Nakashiro K, et al. Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of beta-catenin. Oncol Rep. 2011;26:587–592.
   PubMed Web of Science ®Google Scholar
• Rigacci S, Rovida E, Dello Sbarba P, et al. Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading. J Biol Chem. 2002;277:41631–41636.
   PubMed Web of Science ®Google Scholar
• Zaoui K, Honore S, Isnardon D, et al. Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells. J Cell Biol. 2008;183:401–408.
   PubMed Web of Science ®Google Scholar
• Caldas H, Herman GE. NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets. Hum Mol Genet. 2003;12:2981–2991.
   PubMed Web of Science ®Google Scholar
• Kim HY, Kim DK, Bae SH, et al. Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness. Exp Mol Med. 2018;50:137.
   PubMed Web of Science ®Google Scholar
• Nakamura K, Mori F, Tanji K, et al. Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies. Neuropathology. 2015;35:432–440.
   PubMed Web of Science ®Google Scholar
• Parini P, Jiang ZY, Einarsson C, et al. ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients. Atherosclerosis. 2009;207:266–271.
   PubMed Web of Science ®Google Scholar
• Tsui C, Martinez-Martin N, Gaya M, et al. Protein kinase C-beta dictates B cell fate by regulating mitochondrial remodeling. Metab Reprogramming, Heme Biosynthesis. Immun. 2018;48:1144–59 e5.
   Google Scholar
• Zhao L, Fan J, Xia S, et al. HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers. J Biol Chem. 2017;292:10142–10152.
   PubMed Web of Science ®Google Scholar
• Katheder NS, Khezri R, O’Farrell F, et al. Microenvironmental autophagy promotes tumour growth. Nature. 2017;541:417–420.
   PubMed Web of Science ®Google Scholar
• Poillet-Perez L, Xie X, Zhan L, et al. Autophagy maintains tumour growth through circulating arginine. Nature. 2018;563:569–573.
   PubMed Web of Science ®Google Scholar
• Sousa CM, Biancur DE, Wang X, et al. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016;536:479–483.
   PubMed Web of Science ®Google Scholar
• El Sayed R, El Jamal L, El Iskandarani S, et al. Endocrine and targeted therapy for hormone-receptor-positive, HER2-negative advanced breast cancer: insights to sequencing treatment and overcoming resistance based on clinical trials. Front Oncol. 2019;9:510.
   PubMed Web of Science ®Google Scholar
• Guan J, Zhang H, Wen Z, et al. Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells. Cancer Lett. 2014;345:132–139.
   PubMed Web of Science ®Google Scholar
• Ghavami S, Cunnington RH, Gupta S, et al. Autophagy is a regulator of TGF-beta1-induced fibrogenesis in primary human atrial myofibroblasts. Cell Death Dis. 2015;6:e1696.
   PubMed Web of Science ®Google Scholar
• Kim SI, Na HJ, Ding Y, et al. Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-beta1. J Biol Chem. 2012;287:11677–11688.
   PubMed Web of Science ®Google Scholar
• Gozuacik D, Bialik S, Raveh T, et al. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ. 2008;15:1875–1886.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yamamoto A, Matsui M, et al. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell. 2004;15:1101–1111.
   PubMed Web of Science ®Google Scholar
• Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature. 2004;432:1032–1036.
   PubMed Web of Science ®Google Scholar
• Erbil S, Oral O, Mitou G, et al. RACK1 is an interaction partner of ATG5 and a novel regulator of autophagy. J Biol Chem. 2016;291:16753–16765.
   PubMed Web of Science ®Google Scholar