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Research Paper - translational

Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction

, , , , , , , , , , , , , & ORCID Icon show all
Pages 2372-2385 | Received 06 Sep 2022, Accepted 03 Feb 2023, Published online: 22 Feb 2023

References

  • Feng Y, He D, Yao Z, et al. The machinery of macroautophagy. Cell Res. 2014;24:24–41.
  • Levine B, Kroemer G. Biological Functions of Autophagy Genes: a Disease Perspective. Cell. 2019;176:11–42.
  • Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ. 2005 Nov;12(Suppl 2):1542–1552.
  • White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer. 2012;12:401–410.
  • Kocaturk NM, Akkoc Y, Kig C, et al. Autophagy as a molecular target for cancer treatment. Eur J Pharm Sci. 2019 [2019 Jun 15];134:116–137.
  • Russell RC, Guan KL. The multifaceted role of autophagy in cancer. EMBO J. 2022 Jul 4;41(13):e110031.
  • Degenhardt K, Mathew R, Beaudoin B, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 2006;10:51–64.
  • Hu YL, DeLay M, Jahangiri A, et al. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 2012;72:1773–1783.
  • Yang S, Wang X, Contino G, et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011;25:717–729.
  • Guo JY, Chen HY, Mathew R, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011;25:460–470.
  • Bryant KL, Stalnecker CA, Zeitouni D, et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nat Med. 2019;25:628–640.
  • Kinsey CG, Camolotto SA, Boespflug AM, et al. Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat Med. 2019;25:620–627.
  • Amaravadi R, Kimmelman AC, White E. Recent insights into the function of autophagy in cancer. Genes Dev. 2016 Sep 1;30(17):1913–1930.
  • Singh SS, Vats S, Chia AY-Q, et al. Dual role of autophagy in hallmarks of cancer. Oncogene. 2018;37:1142–1158.
  • Cavalli G, Cenci S. Autophagy and Protein Secretion. J Mol Biol. 2020;432:2525–2545.
  • Claude-Taupin A, Jia J, Mudd M, et al. Autophagy’s secret life: secretion instead of degradation. Essays Biochem. 2017;61:637–647.
  • New J, Thomas SM. Autophagy-dependent secretion: mechanism, factors secreted, and disease implications. Autophagy. 2019;15:1682–1693.
  • Duran JM, Anjard C, Stefan C, et al. Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol. 2010;188:527–536.
  • Thorburn J, Horita H, Redzic J, et al. Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death Differ. 2009;16:175–183.
  • Lu LH, Chao CH, Yeh TM. Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage. J Infection. 2019;78:178–186.
  • Xu Y, Jagannath C, Liu XD, et al. Toll-like Receptor 4 Is a Sensor for Autophagy Associated with Innate Immunity. Immunity. 2007;27:135–144.
  • Sui X, Chen R, Wang Z, et al. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis. 2013;4:1–12.
  • Egan DF, Chun MGH, Vamos M, et al. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Mol Cell. 2015;59:285–297.
  • Pasquier B, El-ahmad Y, Filoche-romme B, et al. Discovery of (2S)‑8-[(3R)‑3-Methylmorpholin-4-yl]-1-(3-methyl-2- oxobutyl)-2-(trifluoromethyl)-3,4-dihydro‑2H‑ pyrimido[1,2‑a]pyrimidin-6-one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors. J Med Chem. 2015;58(1):376–400.
  • Hanada T, Noda NN, Satomi Y, et al. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem. 2007;282:37298–37302.
  • Metlagel Z, Otomo C, Takaesu G, et al. Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12. Proc Natl Acad Sci USA. 2013;110:18844–18849.
  • Otomo C, Metlagel Z, Takaesu G, et al. Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat Struct Mol Biol. 2013;20:59–66.
  • Ben-Shimon A, Eisenstein M. Computational Mapping of Anchoring Spots on Protein Surfaces. J Mol Biol. 2010;402:259–277.
  • Rajamani D, Thiel S, Vajda S, et al. Anchor residues in protein-protein interactions. Proc Natl Acad Sci USA. 2004;101:11287–11292.
  • Radoshevich L, Murrow L, Chen N, et al. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell. 2010;142(4):590–600.
  • Remy I, Michnick SW. A highly sensitive protein-protein interaction assay based on Gaussia luciferase. Nat Methods. 2006 Dec;3(12):977–979.
  • Gilad Y, Shiloh R, Ber Y, et al. Discovering protein-protein interactions within the programmed cell death network using a protein-fragment complementation screen. Cell Rep. 2014;8:909–921.
  • Gewert K, Svensson U, Andersson K, et al. Dexamethasone differentially regulates cytokine transcription and translation in macrophages responding to bacteria or okadaic acid. Cell Signal. 1999;11:665–670.
  • Jeon YJ, Han SH, Lee YW, et al. Dexamethasone inhibits IL-1β gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-κB/Rel and AP-1 activation. Immunopharmacology. 2000;48:173–183.
  • Palhegyi AM, Seranova E, Dimova S, et al. Biomedical Implications of Autophagy in Macromolecule Storage Disorders. Front Cell Dev Biol. 2019;7:1–17.
  • Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med. 2013;19:983–997.
  • Rubinsztein DC, Mariño G, Kroemer G. Autophagy and aging. Cell. 2011;146:682–695.
  • Nah J, Yuan J, Jung Y-K. Autophagy in Neurodegenerative Diseases: from Mechanism to Therapeutic Approach. Mol Cells. 2015;38:381–389.
  • Yang A, Herter-Sprie G, Zhang H, et al. Autophagy sustains pancreatic cancer growth through both cell-autonomous and nonautonomous mechanisms. Cancer Discov. 2018;8:276–287.
  • Dekel-Bird NP, Bialik S, Itzhaki O, et al. A functional pre-screening platform for identifying points of vulnerability in the cell death map of human melanoma tumors. J Cancer Sci Clin Therap. 2022;6:39–60.
  • Mulcahy Levy JM, Zahedi S, Griesinger AM, et al. Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. Elife. 2017 Jan 17;6:1–24.
  • Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Nat Rev Cancer. 2017;17:528–542.
  • Y-p Y, L-f H, H-f Z, et al. Application and interpretation of current autophagy inhibitors and activators. Acta Pharmacol Sin. 2013;34:625–635.
  • Kocak M, Ezazi Erdi S, Jorba G, et al. Targeting autophagy in disease: established and new strategies. Autophagy. 2021;00:1–23.
  • Pasquier B. Autophagy inhibitors. Cell Mol Life Sci. 2016;73:985–1001.
  • Michnick SW, Ear PH, Manderson EN, et al. Universal strategies in research and drug discovery based on protein-fragment complementation assays. Nat Rev Drug Discov. 2007;6:569–582.
  • McKnight NC, Jefferies HBJ, Alemu EA, et al. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. EMBO J. 2012;31:1931–1946.
  • Kingston RE, Chen CA, Rose JK. Calcium phosphate transfection. Curr Protoc Mol Biol. 2003;Chapter 9:91
  • Peleg Y, Unger T. Resolving bottlenecks for recombinant protein expression in E. coli. Zanders Eeditor Chemical Genomics and Proteomics. Methods in Molecular BiologyVol. 800. 2011 oct 04 ed: Humana Press; 2012. 173–186
  • Studier FW. Protein production by auto-induction in high density shaking cultures. Protein Expr Purif. 2005 May;41(1):207–234.