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Autophagy Volume 20, 2024 - Issue 8
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Autophagic Punctum

Mitochondrial import stress and PINK1-mediated mitophagy: the role of the PINK1-TOMM-TIMM23 supercomplex

Mohamed A. Eldeeba Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada;b Structural Genomics Consortium, McGill University, Montreal, Québec, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9671-9340View further author information
ORCID Icon,
Armaan Fallahia Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada;b Structural Genomics Consortium, McGill University, Montreal, Québec, CanadaORCID Iconhttps://orcid.org/0000-0001-8559-8213View further author information
ORCID Icon,
Andrea Soumbasisa Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada;b Structural Genomics Consortium, McGill University, Montreal, Québec, CanadaView further author information
,
Andrew N. Bayneb Structural Genomics Consortium, McGill University, Montreal, Québec, Canada;c Department of Pharmacology and Therapeutics and Centre de Recherche en Biologie Structurale, McGill University, Montréal, Québec, CanadaView further author information
,
Jean-François Trempeb Structural Genomics Consortium, McGill University, Montreal, Québec, Canada;c Department of Pharmacology and Therapeutics and Centre de Recherche en Biologie Structurale, McGill University, Montréal, Québec, CanadaView further author information
&
Edward A. Fona Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada;b Structural Genomics Consortium, McGill University, Montreal, Québec, CanadaCorrespondence[email protected]
View further author information
Pages 1903-1905 | Received 25 Mar 2024, Accepted 04 Apr 2024, Published online: 14 Apr 2024

Reference

  • Eldeeb MA, Bayne AN, Fallahi A, et al. Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress. Proc Natl Acad Sci, USA. 2024;121(10):e2313540121. doi:10.1073/pnas.2313540121

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