Advanced search
Publication Cover
Clinical Toxicology Volume 54, 2016 - Issue 9
Submit an article Journal homepage
1,281
Views
11
CrossRef citations to date
0
Altmetric
Basic Research

Stability of high-dose insulin in normal saline bags for treatment of calcium channel blocker and beta blocker overdose

Dayne LaskeyUniversity of Saint Joseph School of Pharmacy, Hartford, CT, USA; Correspondence[email protected]
,
Rajesh VadlapatlaMarshall B. Ketchum University College of Pharmacy, Fullerton, CA, USA;
&
Katherine HartHartford Hospital, Hartford, CT, USA; ;Connecticut Poison Control Center, Farmington, CT, USA
Pages 829-832 | Received 21 Apr 2016, Accepted 01 Jul 2016, Published online: 19 Jul 2016

References

  • Shepherd G, Klein-Schwartz W. High-dose insulin therapy for calcium-channel blocker overdose. Ann Pharmacother. 2005;39: 923–930.
  • Engebretsen KM, Kaczmarek KM, Morgan J, et al. High-dose insulin therapy in beta-blocker and calcium channel-blocker poisoning. Clin Toxicol (Phila). 2011;49:277–283.
  • Holger JS, Engebretsen KM, Fritzlar SJ, et al. Insulin versus vasopressin and epinephrine to treat beta-blocker toxicity. Clin Toxicol (Phila). 2007;45:396–401.
  • Kerns W, Schroeder D, Williams C, et al. Insulin improves survival in a canine model of acute beta-blocker toxicity. Ann Emerg Med. 1997;29:748–757.
  • Page C, Hacket LP, Isbister GK. The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report. J Med Toxicol. 2009;5:139–143.
  • Yuan TH, Kerns WP, Tomaszewski CA, et al. Insulin-glucose as adjunctive therapy for severe calcium channel antagonist poisoning. J Toxicol Clin Toxicol. 1999;37:463–474.
  • Holger JS, Stellpflug SJ, Cole JB, et al. High-dose insulin: a consecutive case series in toxin-induced cardiogenic shock. Clin Toxicol (Phila). 2011;49:653–658.
  • Cole JB, Stellpflug SJ, Ellsworth H, et al. A blinded, randomized, controlled trial of three doses of high-dose insulin in poison-induced cardiogenic shock. Clin Toxicol (Phila). 2013;51:201–207.
  • Engebretsen KM, Holger JS, Harris C. Therapeutic misadventure of high dose insulin without adverse effects [abstract]. Clin Toxicol (Phila). 2008;46:604.
  • Stellpflug SJ, Harris CR, Engebretsen KM, et al. Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high-dose insulin. Clin Toxicol (Phila). 2010;48:227–229.
  • Rocchio MA, Belisle CD, Greenwood BC, et al. Evaluation of the maximum beyond-use-date stability of regular human insulin extemporaneously prepared in 0.9% sodium chloride in a polyvinyl chloride bag. Diabetes Metab Syndr Obes. 2013;6: 389–392.
  • Birnbaum K. Therapeutic drugs and antidotes: insulin. In: Olson, editor. Poisoning and drug overdose. 6th ed. New York: McGraw Hill Professional; 2011. p. 497–498.
  • Tarr BD, Campbell RK, Workman TM. Stability and sterility of biosynthetic human insulin stored in plastic insulin syringes for 28 days. Am J Hosp Pharm. 1991;48:2631–2634.
  • Lull ME, Piacentino JJ, Traina AN. Stability of U-500 regular insulin in prefilled syringes. J Am Pharm Assoc (2003). 2013;53:304–306.
  • The United States Pharmacopeia 32nd revision, and the National Formulary. 27th ed. Rockville (MD): United States Pharmacopeial Convention; 2010. p. 2777.
  • Institute for Safe Medication Practices. ISMP list of high-alert medications in acute care settings. 2014 [Internet]. Available from: http://www.ismp.org/tools/highalertmedications.pdf.
  • Lesar TS. Tenfold medication dose prescribing errors. Ann Pharmacother. 2002;36:1833–1839.
  • Institute for Safe Medication Practices. ISMP guidelines for standard order sets. 2010 [Internet]. Available from: http://www.ismp.org/tools/guidelines/StandardOrderSets.asp.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.