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Clinical Toxicology Volume 55, 2017 - Issue 2
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Clinical Research

Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine?*

Mark C. YaremaPoison and Drug Information Service, Alberta Health Services, Alberta, Canada; ;Department of Emergency Medicine, University of Calgary, Alberta, Canada; ;Section of Clinical Pharmacology and Toxicology, Alberta Health Services, Alberta, Canada; Correspondence[email protected]
,
Jason P. GreenDepartment of Pediatrics, McMaster University, Ontario, Canada;
,
Marco L. A. SivilottiDepartment of Emergency Medicine, Queen’s University, Ontario, Canada; ;Department of Biomedical & Molecular Sciences, Queen’s University, Ontario, Canada;
,
David W. JohnsonPoison and Drug Information Service, Alberta Health Services, Alberta, Canada; ;Department of Pediatrics, University of Calgary, Alberta, Canada;
,
Alberto Nettel-AguirreDepartment of Pediatrics, University of Calgary, Alberta, Canada; ;Alberta Children’s Hospital Research Institute for Child & Maternal Health, Alberta, Canada; ;Department of Community Health Sciences, University of Calgary, Alberta, Canada;
,
Charlemaigne VictorinoPrairie Regional Research Data Centre, Statistics Canada, Alberta, Canada;
,
Daniel A. SpykerDepartment of Emergency Medicine, Oregon Health Sciences University, Portland, OR, USA;
&
Barry H. RumackDepartment of Pediatrics, University of Colorado School of Medicine, Denver, CO, USA
 show all
Pages 102-108 | Received 09 Aug 2016, Accepted 07 Oct 2016, Published online: 28 Oct 2016

References

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  • Bateman DN, Carroll R, Pettie J, et al. Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment. Br J Clin Pharmacol. 2014;78:610–618.
  • Seifert S, Kirschner RI, Martin TG, et al. Acetaminophen concentrations prior to 4 hours of ingestion: impact on diagnostic decision-making and treatment. Clin Toxicol. 2015;53:618–623.
  • Waring WS, Stephen AF, Robinson OD, et al. Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose. Clin Toxicol. 2008;46:496–500.
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  • Kirschner RI, Rozier CM, Smith LM, et al. Nomogram line crossing after acetaminophen combination product overdose. Clin Toxicol. 2016;54:40–46.

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